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| 1 | 上海26万妇女乳房自我检查随机试验显示文摘目的论证指导妇女进行乳房自我检查(BSE)是否能有效降低乳腺癌患者的死亡率。方法自1989年10月起,上海26.6万名年龄在30~64岁的妇女,随机进入指导组(132979名)和对照组(133085名)。在指导组,最初先由医务人员做规范的BSE手法演示,随后的4年中,使用BSE录像带进行二次强化教育,并定期进行BSE指导和在医务人员监察下进行BSE操作。本研究进行5年,全部活动均被记录。队列人群随访到2000年7月,乳腺癌患者的生存状况随访到2001年12月。统计分析采用Kaplan-Meier方法、Logrank检验以及Cox模型。结果指导组检出乳腺癌864例,其中死于乳腺癌133例;对照组检出乳腺癌896例,其中死于乳腺癌130例。两组乳腺癌病例的肿块大小、TNM分期和累积死亡率的差异均无统计学意义(P均>0.05)。但是指导组比对照组有较多和较小的纤维腺瘤被检出(P<0.01)。结论对人群开展BSE教育和指导,未能降低人群的乳腺癌死亡率;接受BSE教育的妇女比没有接受教育的妇女可检出较多的和较小的良性乳房肿块。 | 高道利 David BThomas Roberta M Ray 王文婉 Charlene J Allison 陈范良 Peggy Porter 胡永伟 赵关林 潘雷达 李雯瑾 武春园 Zakia Coriaty Ilonka Evans 林明纲 Helge Stalsberg Steven Gself | 2005 | 中华肿瘤杂志2005，27，6： | 14 |
| 2 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 3 | ESPEN Guidelines for Nutrition Screening 2002显示文摘 | J Kondrup S.P Allison M Elia B Vellas M Plauth | 2003 | Clinical Nutrition2003，，4： | 11 |
| 4 | Macrophage polarization in response to wear particles in vitro显示文摘全部的联合代替是为有停用关节炎和联合机能障碍的病人的治疗的一个高度成功的外科的过程。随着时间的过去,与活动的高水平和关节的用法,然而植入穿粒子从明白表示的表面被产生。这些穿粒子能在 implant (periprosthetic osteolysis ) 附近导致煽动性的反应,和随后的骨头再吞的激活。单核白血球 / 巨噬细胞系的房间安排这长期的煽动性的回答,它被支持 inflammatory (M1 ) 统治巨噬细胞显型而非一反煽动性的支持织物的愈合(M2 ) 巨噬细胞显型。当它被显示出时,那 interleukin-4 (IL-4 ) 有选择地极化向支持骨头愈合的 M2 反煽动性的显型的巨噬细胞,而非发炎,很少对这在通过 IL-4 的极化在哪个是很有效的在发生或调节的时间功课被知道。这个工作的目标是与 polymethyl methacrylate (PMMA ) 的联合响应挑战学习鼠科的巨噬细胞极化和 cytokine 版本的时间功课粒子, lipopolysaccharide (LPS ) 和在 vitro 的 IL-4。有 IL-4 的质问粒子的单核白血球 / 巨噬细胞的处理导致了支持 inflammatory cytokines 和可诱导的氮的氧化物 synthase (iNOS ) 的起始的抑制生产和随后的极化进 M2 反煽动性的显型。当 IL-4 在 PMMA 粒子挑战前被交付时,这结果被优化,到 M1 显型而非到未遂(M0 ) 巨噬细胞。这极化的效果在一堂 5 天的时间功课上被支撑。进 M2 显型的 M1 巨噬细胞的极化可以是策略减轻穿粒子联系 periprosthetic osteolysis。 | Joseph K Antonios Zhenyu Yao Chenguang Li Allison J Rao Stuart B Goodman | 2013 | Cellular & Molecular Immunology2013，10，6： | 10 |
| 5 | Successful surgical management of ruptured umbilical hernias in cirrhotic patients显示文摘Acute umbilical hernia rupture in patients with hepatic cirrhosis and ascites is an unusual,but potentially lifethreatening complication,with postoperative morbidity about 70% and mortality between 60%-80% after supportive care and 6%-20% after urgent surgical repair.Management options include primary surgical repair with or without concomitant portal venous system decompression for the control of the ascites.We present a retrospective analysis of our centre's experience over the last 6 years.Our cohort consisted of 11 consecutive patients(median age:53 years,range:36-63 years) with advanced hepatic cirrhosis and refractory ascites.Appropriate patient resuscitation and optimisation with intravenous fluids,prophylactic antibiotics and local measures was instituted.One failed attempt for conservative management was followed by a successful primary repair.In all cases,with one exception,a primary repair with non-absorbable Nylon,interrupted sutures,without mesh,was performed.The perioperative complication rate was 25% and the recurrence rate 8.3%.No mortality was recorded.Median length of hospital stay was 14 d(range:4-31 d).Based on our experience,the management of ruptured umbilical hernias in patients with advanced hepatic cirrhosis and refractory ascites is feasible without the use of transjugular intrahepatic portosystemic shunt routinely in the preoperative period,provided that meticulous patient optimisation is performed. | Nikolaos A Chatzizacharias J Andrew Bradley Simon Harper Andrew Butler Asif Jah Emmanuel Huguet Raaj K Praseedom Michael Allison Paul Gibbs | 2015 | World Journal of Gastroenterology2015，21，10： | 4 |
| 6 | 人参减少 γ射线照射的淋巴细胞微核量(英文)显示文摘目的 评价中国人参对减少辐射诱导的人周围血 G0 期淋巴细胞 (PBL)微核量的作用。方法 采用细胞因子阻滞的微核法检测健康志愿者的血标本。体外 1 37Cs照射之前 ,每份血标本的单个核细胞培养以不同浓度 (0~ 2 0 0 0μg· m l- 1 )的人参根水提取物孵育 2 4 h。结果 (1)在 0 Gy时 ,每 10 0 0个双核 (BN )细胞的微核量是 11.3± 2 .7,人参水提取物≥ 5 0 0μg· ml- 1 时微核量下降 ,但微核量和人参水提取物的浓度之间的差异是显著的。 (2 )单独射线照射显著增加微核量 ,当暴露于 1Gy的照射时 ,随着培养介质中人参水提取物浓度的增加 ,微核量呈显著的线性降低 (R2 =0 .0 5 ,P =0 .0 0 2 ) ;对暴露于 1Gy辐射诱导的微核量 ,人参水提取物浓度在 15 0 0μg· m l- 1 时减少 4 6 .6 % ,浓度在 2 0 0 0μg·m l- 1时减少 5 7.6 % ;对暴露于 2 Gy辐射诱导的微核量的减少呈更强的线性相关 (R2 =0 .7,P=0 .0 0 0 1) ;(3)微核数据分析的结果呈现出与 Poisson模型相关的过度离散趋势。结果表明 :(1)人参水提取物浓度达 2 0 0 0 μg· ml- 1时 ,对 PBL 细胞毒作用无明显影响 ;(2 )人参水提取物浓度在 5 0 0 μg· ml- 1和 2 0 0 0 μg· ml- 1之间时 ,对抗 1 37Cs照射诱导的 MN发挥保护作用。 | 李同光 Ron R Allison Kevin F O'Brien Prabhaker G Khazanie Larry J Dobbs Jr. Peter J Kragel | 2004 | 新乡医学院学报2004，21，3： | 3 |
| 7 | Accuracy of biometric formulae for intraocular lens power calculation in a teaching hospital显示文摘AIM: To evaluate the accuracy of three commonly used biometric formulae across different axial lengths(ALs) at one United States Veterans Affairs teaching hospital.METHODS: A retrospective chart review was conducted from November 2013 to May 2018. One eye of each patient who underwent cataract surgery with a monofocal intraocular lens(IOL) was included. The range of postoperative follow-up period was from 3 wk to 4 mo. The Holladay 2, Barrett Universal II, and Hill-Radial Basis Function(Hill-RBF) formulae were used to predict the postoperative refraction for all cataract surgeries. For each formula, we calculated the prediction errors [including mean absolute prediction error(MAE)] and the percentage of eyes within ±0.25 diopter(D) and ±0.5 D of predicted refraction. We performed subgroup analyses for short(AL<22.0 mm), medium(AL 22.0-25.0 mm), and long eyes(AL>25.0 mm).RESULTS: A total of 1131 patients were screened, and 909 met the inclusion criteria. Resident ophthalmologists were the primary surgeons in 710(78.1%) cases. We found no statistically significant difference in predictive accuracy among the three formulae over the entire AL range or in the short, medium, and long eye subgroups. Across the entire AL range, the Hill-RBF formula resulted in the lowest MAE(0.384 D) and the highest percentage of eyes with postoperative refraction within ±0.25 D(42.7%) and ±0.5 D(75.5%) of predicted. All three formulae had the highest MAEs(>0.5 D) and lowest percentage within ±0.5 D of predicted refraction(<55%) in short eyes.CONCLUSION: In cataract surgery patients at our teaching hospital, three commonly used biometric formulae demonstrate similar refractive accuracy across all ALs. Short eyes pose the greatest challenge to predicting postoperative refractive error. | Kevin S Tang Elaine M Tran Allison J Chen David R Rivera Jorge J Rivera Paul B Greenberg | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 3 |
| 8 | Variable change in renal function by hypertonic saline显示文摘AIM: To investigate the effects of hypertonic saline in the neurocritical care population.METHODS: We retrospectively reviewed our hospital's use of hypertonic saline(HS) since March of 2005, and prospectively since October 2010. Comparisons were made between admission diagnoses, creatinine change(Cr), and HS formulation(3% Na Cl, 3% Na Cl/sodium acetate mix, and 23.4% Na Cl) to patients receiving normal saline or lactated ringers. The patients(n = 1329) of the retrospective portion were identified. The data presented represents the first 230 patients with data. RESULTS: Significant differences in Acute Physiology and Chronic Health Evaluation Ⅱ scores and GlasgowComa Scale scores occurred between different saline formulations. No significant correlation of Cl- or Na+ with Cr, nor with saline types, occurred. When dichotomized by diagnosis, significant correlations appear. Traumatic brain injury(TBI) patients demonstrated moderate correlation between Na+ and Cr of 0.45. Stroke patients demonstrated weak correlations between Na+ and Cr, and Cl- and Cr(0.19 for both). Patients receiving HS and not diagnosed with intracerebral hemorrhage, stroke, subarachnoid hemorrhage, or TBI demonstrated a weak but significant correlation between Cl- and Cr at 0.29.CONCLUSION: Cr directly correlates with Na+ or Cl- in stroke, Na+ in TBI, and Cl- in other populations. Prospective comparison of HS and renal function is needed. | Jesse J Corry Panayiotis Varelas Tamer Abdelhak Stacey Morris Marlisa Hawley Allison Hawkins Michelle Jankowski | 2014 | World Journal of Critical Care Medicine2014，3，2： | 3 |
| 9 | ESPEN Guidelines for Nutrition Screening 2002显示文摘 | J Kondrup S.P Allison M Elia B Vellas M Plauth | 2003 | Clinical Nutrition2003，，4： | 2 |
| 10 | Outcomes after arthroscopic repair of rotator cuff tears in the setting of mild to moderate glenohumeral osteoarthritis显示文摘BACKGROUND Rotator cuff pathology is a very common source of shoulder pain.Similarly,osteoarthritis of the glenohumeral joint can cause shoulder pain and produce similar symptoms.Surgical management can be indicated for both pathologies,however,outcomes data is limited when examining rotator cuff repair(RCR) in the setting of glenohumeral arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of GHOA.AIM To evaluate if a relationship exists between outcomes of RCR in the setting of GHOA.METHODS This was a retrospective analysis of patients who underwent arthroscopic rotator cuff repair with concurrent glenohumeral osteoarthritis between 2010-2017.Patients were stratified based on rotator cuff tear size and glenohumeral osteoarthritis severity.Cohorts were paired 1:1 with patients without glenohumeral osteoarthritis.Patients included had a minimum two year follow-up.Rate of conversion to total shoulder arthroplasty,complication rates following initial surgery,and patient-reported outcome measures were collected.RESULTS A total of 142 patients were included.The number of patients that required total shoulder arthroplasty within two years after index surgery was low.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without GHOA.Following rotator cuff repair,both groups showed favorable patientreported outcomes.CONCLUSION Patients with glenohumeral osteoarthritis who underwent arthroscopic rotator cuff repair showed comparable outcomes to patients without glenohumeral osteoarthritis. | Ian S Hong Allison J Rao Tyler L CarlLee Joshua D Meade Daniel J Hurwit Gregory Scarola David P Trofa Shadley C Schiffern Nady Hamid Patrick M Connor James E Fleischli Bryan Michael Saltzman | 2022 | World Journal of Orthopedics2022，13，7： | 2 |
| 11 | Lmpact of axillary lymph node disscction on the therapy of brest cancer paticnts显示文摘 | Lin PP Allison DC Wainstdck J | 1993 | J Clin Oncol1993，11，8： | 1 |
| 12 | Predictors of flight nurse job satisfaction显示文摘 | Whitley TW Benson NH Allison E J | 1990 | J Air Med Transp1990，9，10： | 1 |
| 13 | ESPON Guidelines for Nutrition risk screening 2002 显示文摘 | Kondrup J Allison SP Elia M | 2003 | Clin Nutr2003，22，4： | 1 |
| 14 | Requirement for FlhA in flagella assembly and swarm-cell differentiation by Proteus mirabilis显示文摘 | Gygi D Bailey M J Allison C | 1995 | Mol Microbiol1995，15，4： | 1 |
| 15 | Behavioral features in semantic dementia vs other forms of progressive aphasias显示文摘 | Rosen H J Allison S C Ogar J M | 2006 | Neurology2006，67，： | 1 |
| 16 | ESPEN Guidelines for nutrition screening 2002 显示文摘 | Kondrup J Allison P Elia M | 2003 | Clin Nutr2003，22，4： | 1 |
| 17 | Postoperative cognitive deficit in the elderly slitgalpatient显示文摘 | Dodds C Allison J | 1998 | Br J Anaesth1998，81，3： | 1 |
| 18 | ESPEN guidelines for nutri tion screening 2002显示文摘 | Kondrup J Allison S P Elia M | 2003 | Clin Nutr2003，22，4： | 1 |
| 19 | ESPEN guidelines fnr nutrition screening 2002显示文摘 | KONDMP J ALLISON S P ELIA M | 2003 | Clin Nutr2003，22，4： | 1 |
| 20 | Current status and future trends for disposable technology in the biopharmaceutical industry 显示文摘 | ALLISON N RICHARDS J | 2014 | Journal of Chemical Technology and Biotechnology2014，89，9： | 1 |
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