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| 1 | Influence of ellagic acid on prostate cancer cell proliferation:A caspase-dependent pathway显示文摘Objective:To evaluate the effect of allagic acid treatment on the cell viability of human prostate cancer cells.Methods:Ellagic acid(10-100 mol/L) treatment(48 h) of human prostate carcinoma PC3 cells was found to result in a dose-dependent inhibition of cell growth and apoptosis of PC3 cells as assessed by MTT assay,western blotting.flow cytometry and confocal microscopy.Results:We observed that ellagic acid treatment of PC3 cells resulted in a dose dependent inhibition of cell growth/cell viability.This ellagic acid caused cell growth inhibition was found to be accompanied by induction of apoptosis,as assessed by the cleavage of poly (ADP-ribose) polymerase(PARP) and morphological changes.Further,induction of apoptosis accompanied a decrease in the levels of antiapoptotic protein Bcl-2 and increase in proapoptotic protein Bax.thus shifting the Bax:Bcl-2 ratio in favor of apoptosis.Ellagic acid treatment of PC3 cells was also found to result in significant activation of caspases,as shown by the dose dependent decrease in the protein expression of procaspase-3,-6.-8 and -9.This ellagic acid-mediated induction of apoptosis was significantly(80%-90%) inhibited by the caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone(Z-VAD-FMK).Thus these data suggested an essential role of caspases in ellagic acid-mediated apoptosis of PC3 cells.Conclusions:It is tempting to suggest that consumption of tropical pigmented fruits and vegetables could be an effective strategy to combat prostate cancer. | Arshi Malik Sarah Afaq Mohammad Shahid Kafil Akhtar Abdullah Assiri | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，7： | 18 |
| 2 | Spatial distribution and source identification of heavy metal pollution in roadside surface soil:a study of Dhaka Aricha highway,Bangladesh显示文摘Introduction:In this study,metal pollution and their sources in surface soils were evaluated by pollution indices and multivariate statistical techniques in association with a geographical information system(GIS).Methods:Surface soil samples were collected in dry season from different locations of Dhaka Aricha highway and analyzed by energy dispersive X-ray fluorescence(EDXRF).Results:Thirteen different metals were found in the tested samples.Pollution indices are determined by enrichment factor in an order of Zr>Sn>P>Mn>Zn>Rb>Fe>Ba>Sr>Ti>K>Ca>Al.The resulting geoaccumulation index(Igeo)value shows the following order:Sn>Zr>P>Mn>Zn>Rb>Fe>Ba>Ti>Sr>K>Ca>Al.Contamination factors(CFs)of the metals range from 1.422 to 3.979(Fe);0.213 to 1.089(Al);0.489 to 3.484(Ca);1.496 to 2.372(K);1.287 to 3.870(Ti);2.200 to 14.588(Mn);5.938 to 56.750(Zr);0.980 to 3.500(Sr);2.321 to 4.857(Rb);2.737 to 6.526(Zn);16.667 to 27.333(Sn);3.157 to 16.286(P);and 0.741 to 3.328(Ba).Pollution load index calculated from the CFs indicates that soils are strongly contaminated by Zr and Sn.Principal component analysis(PCA)of parameters exhibits three major components.R-mode cluster analysis reveals three distinct groups in both site and metal basis clustering that shows a similar pattern with the PCA.Conclusions:These results might be helpful for future monitoring of further increase of heavy metal concentrations in surface soils along highways. | Fahad Ahmed A.N.M.Fakhruddin M.D.Toufick Imam Nasima Khan Tanzir Ahmed Khan Md.Mahfuzur Rahman Abu Tareq Mohammad Abdullah | 2016 | Ecological Processes2016，5，1： | 11 |
| 3 | INTERMOLECULAR INTERACTION OF A NEUTRAL POLYMERIC BONDING AGENT CONTAINING N-VINYLPYRROLIDONE UNITS WITH AMMONIUM PERCHLORATE AND KETO-RDX显示文摘The interaction of a new neutral polymeric bonding agent(NPBA) containing N-Vinylpyrrolidone units with two types of oxidizers(ammonium perchlorate and Keto-RDX) was investigated by X-ray photoelectron spectroscopy(XPS) and Fourier transform infrared spectroscopy(FTIR). NPBA forms a layer of film on the surface of oxidizers. The paper gives hypothetical mechanisms for improving significantly mechanical properties by addition of the neutral polymeric bonding agent(NPBA). | Forouzan Gholamian Mahdi Ansari Mohammad Abdullah Farideh Bataghva Sara Ghariban-Lavasani | 2013 | Chinese Journal of Polymer Science2013，31，10： | 4 |
| 4 | Clinical features and visual outcomes of scleritis patients presented to tertiary care eye centers in Saudi Arabia显示文摘AIM: To describe the clinical features, systemic associations, treatment and visual outcomes in Saudi patients with scleritis.·METHODS: A retrospective chart review was performed for patients with scleritis presenting to two tertiary care eye hospitals in Riyadh, Saudi Arabia, from 2001 to 2011.Data were collected on the clinical features of scleritis,subtypes of scleritis, associated systemic disease,history of previous ocular surgery and medical therapy,including the use of immunosuppressants. Treatment outcomes were evaluated based on best-corrected visual acuity(BCVA) and response to treatment.·RESULTS: Of the 52 patients included in the study,non-necrotizing anterior scleritis was the most common type of scleritis in 22 patients(42.3%), followed by posterior scleritis in 14 patients(26.9%). The majority of cases, 31 patients(59.6%), were idiopathic in nature.Systemic associations were present in 12 patients(23.1%). Infectious scleritis was confirmed in 6 patients(11.5%): 3 with bacterial scleritis after pterygium excision, 2 patients with scleritis related to tuberculosis and 1 patient with scleritis resulting from herpes simplex infection. For the various subtypes of scleritis, BCVA values after treatment and time to remission significantly differed(P <0.05, all cases).Systemic immunosuppressive therapies in addition to steroids were administered to 46.2% of all patients. The T-sign was present on B-scan ultrasonography in 9(64.3%) of the 14 posterior scleritis patients.·CONCLUSION: Non-necrotizing anterior scleritis was the most common subtype of scleritis. Final visualoutcome and time to remission differed among the various scleritis subtypes. | Mohammad Al Barqi Ashley Behrens Abdullah M.Alfawaz | 2015 | International Journal of Ophthalmology(English edition)2015，8，6： | 4 |
| 5 | Improvement of the efficacy of influenza vaccination (H5N1) in chicken by using extract of Cochinchina momordica seed (ECMS)显示文摘Seeds of a Chinese traditional medicine plant, Cochinchina momordica were used in the present study for the improvement of influenza vaccine (H5N1) in chicken. Crude extraction from Cochinchina momordica seed (ECMS) was obtained by ethanol extraction method. In experiment No. 1, two weeks old chickens were immunized with influenza vaccine (H5N1) alone or combined with ECMS (5, 10, 20, 40 and 80 μg/dose). Serum IgG antibody levels (by ELISA) as well as effects on daily weight gain were measured on 0, 7, 14 and 28th day after immunization. Results revealed that all ECMS groups numerically increased the antibody levels while 10 and 20 μg/dose groups significantly (P<0.05) enhanced total IgG antibody on day 28, when compared with control. Average daily weight gain was also significantly higher in 20 μg/dose ECMS group. Adjuvant effect was also confirmed in experiment No. 2 when chickens were immunized with 20 μg/dose ECMS and antibody titer was measured through hemagglutination inhibition (HI). It is concluded that ECMS has potential to improve the immune responses and deserve further study as an adjuvant. | RAJPUT Zahid Iqbal XIAO Chen-wen HU Song-hua ARIJO Abdullah G. SOOMRO Noor Mohammad | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，5： | 4 |
| 6 | Interaction of cetyltrimethylammonium bromide with drug in aqueous/electrolyte solution:A combined conductometric and molecular dynamics method study显示文摘Interaction between beta-lactum antibiotic drug ciprofloxacin hydrochloride(CFH)and cationic surfactant cetyltrimethylammonium bromide(CTAB)was performed conductometrically in aqueous as well as in the occurrence of different salts(NaCl,KCl as well as NH_4Cl)over the temperature range of 298.15–323.15 K at the regular interval of 5 K.CFH drug has been suggested for the treatment of bacterial infections such as urinary tract infections and acute sinusitis.A clear critical micelle concentration(CMC)was obtained for pure CTAB as well as(CFH+CTAB)mixed systems.The decrease in CMC values of CTAB caused by the addition of CFH reveals the existence of the interaction between the components and therefore it is the indication of micelle formation at lower concentration of CTAB and their CMC values further decrease in attendance of salts.A nonlinear behavior in the CMC versus T plot was observed in all the cases.The ΔG_m^0 values are found to be negative in present study systems demonstrated the stability of the solution.The values of ΔH_m^0 and ΔS_m^0 reveal the existence of hydrophobic and electrostatic interactions between CFH and CTAB.The thermodynamic properties of transfer for the micellization were also evaluated and discussed in detail.Molecular dynamic simulation disclosed that environment of water and salts have impact on the hydrophobic interaction between CFH and CTAB.In water and salts,CTAB adopts spherical micelle in which charged hydrophilic groups are interacted with waters whereas hydrophobic tails form the core of the micelle.This hydrophobic core region is highly conserved and protected.In addition,micelle formation is more favorable in aqueous Na Cl solution than other solutions. | Md.Anamul Hoque Md.Masud Alam Mohammad Robel Molla Shahed Rana Malik Abdul Rub Mohammad A.Halim Mohammed Abdullah Khan Farida Akhtar | 2018 | Chinese Journal of Chemical Engineering2018，26，1： | 3 |
| 7 | Glutathione (GSH) improves sperm quality and testicular morphology in streptozotocin-induced diabetic mice显示文摘Diabetes mellitus(DM)is known to cause reproductive impairment.In men,it has been linked to altered sperm quality and testicular damage.Oxidative stress(OS)plays a pivotal role in the development of DM complications.Glutathione(GSH)is a part of a nonenzymatic antioxidant defense system that protects lipid,protein,and nucleic acids from oxidative damage.However,the protective effects of exogenous GSH on the male reproductive system have not been comprehensively examined.This study determined the impact of GSH supplementation in ameliorating the adverse effect of type 1 DM on sperm quality and the seminiferous tubules of diabetic C57BL/6NTac mice.GSH at the doses of 15 mg kg^(-1)and 30 mg kg^(-1)was given intraperitoneally to mice weekly for 6 consecutive weeks.The mice were then weighed,euthanized,and had their reproductive organs excised.The diabetic(D Group)showed significant impairment of sperm quality and testicular histology compared with the nondiabetic(ND Group).Diameters of the seminiferous lumen in diabetic mice treated with 15 mg kg^(-1) GSH(DGSH15)were decreased compared with the D Group.Sperm motility was also significantly increased in the DGSH15 Group.Improvement in testicular morphology might be an early indication of the protective roles played by the exogenous GSH in protecting sperm quality from effects of untreated type 1 DM or diabetic complications.Further investigation using different doses and different routes of GSH is necessary to confirm this suggestion. | Fathiah Abdullah Mohamed Noor Khan Nor-Ashikin Renu Agarwal Yuhaniza Shafinie Kamsani Mastura Abd Malek Nor Salmah Bakar Aqila-Akmal Mohammad Kamal Mimi-Sophia Sarbandi Nor-Shahida Abdul Rahman Nurul Huda Musa | 2021 | Asian Journal of Andrology2021，23，3： | 3 |
| 8 | Effects of stand characteristics on tree species richness in and around a conservation area of northeast Bangladesh显示文摘We investigated the effect of tree cover,forest patch and disturbances on tree species richness in a highly diverse conservation area of northeast Bangladesh.A systematic sampling protocol was adopted and 80 sub-plots from twenty five 1 ha plots were used for the vegetation survey.Linear regression analysis was performed to understand the effect of patch area,disturbances and tree cover on tree species richness.Ordination using Redundancy analysis(RDA) and Non-metric Multi Dimensional Scaling(NMDS) were also performed to explore the tree species compositional similarities along the stand characteristics gradient and locations of the sample plots.Our study revealed that,forest patch size has greater influence on species richness.Areas with medium level of disturbances have shown greater species richness.In constrained ordination the selected explanatory variables regulated the richness of common species.Our findings can be useful for better forest management and restoration of landscapes of conservation needs using ecologically important species. | Muha Abdullah Al PAVEL SharifA.MUKUL Mohammad Belal UDDIN Kazuhiro HARADA Mohammed A.S.ARFIN KHAN | 2016 | Journal of Mountain Science2016，13，6： | 2 |
| 9 | Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases显示文摘Aging is linked to the deterioration of many physical and cognitive abilities and is the leading risk factor for Alzheimer’s disease. The growing aging population is a significant healthcare problem globally that researchers must investigate to better understand the underlying aging processes. Advances in microarrays and sequencing techniques have resulted in deeper analyses of diverse essential genomes(e.g., mouse, human, and rat) and their corresponding cell types, their organ-specific transcriptomes, and the tissue involved in aging. Traditional gene controllers such as DNA-and RNA-binding proteins significantly influence such programs, causing the need to sort out long non-coding RNAs, a new class of powerful gene regulatory elements. However, their functional significance in the aging process and senescence has yet to be investigated and identified. Several recent researchers have associated the initiation and development of senescence and aging in mammals with several well-reported and novel long non-coding RNAs. In this review article, we identified and analyzed the evolving functions of long non-coding RNAs in cellular processes, including cellular senescence, aging, and age-related pathogenesis, which are the major hallmarks of long non-coding RNAs in aging. | Syed Aoun Mehmood Sherazi Asim Abbasi Abdullah Jamil Mohammad Uzair Ayesha Ikram Shanzay Qamar Adediji Ayomide Olamide Muhammad Arshad Peter J.Fried Milos Ljubisavljevic Ran Wang Shahid Bashir | 2023 | Neural Regeneration Research2023，18，5： | 2 |
| 10 | SARS-CoV-2 involvement in central nervous system tissue damage显示文摘As the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to spread globally,it became evident that the SARS-CoV-2 virus infects multiple organs including the brain.Several clinical studies revealed that patients with COVID-19 infection experience an array of neurological signs ranging in severity from headaches to life-threatening strokes.Although the exact mechanism by which the SARS-CoV-2 virus directly impacts the brain is not fully understood,several theories have been suggested including direct and indirect pathways induced by the virus.One possible theory is the invasion of SARS-CoV-2 to the brain occurs either through the bloodstream or via the nerve endings which is considered to be the direct route.Such findings are based on studies reporting the presence of viral material in the cerebrospinal fluid and brain cells.Nevertheless,the indirect mechanisms,including blood-clotting abnormalities and prolonged activation of the immune system,can result in further tissue and organ damages seen during the course of the disease.This overview attempts to give a thorough insight into SARS-CoV-2 coronavirus neurological infection and highlights the possible mechanisms leading to the neurological manifestations observed in infected patients. | Muhammad Ali Haidar Zaynab Shakkour Mohammad Amine Reslan Nadine Al-Haj Perla Chamoun Karl Habashy Hasan Kaafarani Shima Shahjouei Sarah HFarran Abdullah Shaito Esber SSaba Bassam Badran Mirna Sabra Firas Kobeissy Maya Bizri | 2022 | Neural Regeneration Research2022，17，6： | 2 |
| 11 | Incidence of up- per limb venous thrombosis associated with peripherally inserted central catheters (PICC) 显示文摘 | Abdullah B J Mohammad N Sangkar JV | 2005 | Br J Radiol2005，78，： | 1 |
| 12 | Amblyopia screening for first and second-grade children in Jordan显示文摘AIM:To share the results of a national screening program for amblyopia in school children in the north of Jordan.METHODS:This is a prospective national screening study for amblyopia.The program rolls first and second-grade children(6 to 7 years old) in the north of Jordan.The eye examination included:best-corrected visual acuity,cover-uncover test,and cycloplegic retinoscopy.Monocular visual acuity was tested using an ETDRS visual acuity chart without correction.Moreover,children were tested with full cycloplegic refraction when the test criteria were met.Unilateral amblyopia was defined as a best-corrected visual acuity difference of 2 or more lines.In comparison,bilateral amblyopia was defined as a best-corrected visual acuity of 20/40 or worse in the best eye.RESULTS:The prevalence of amblyopia for the total sample tested(n=17 203) was 2.78%(n=479).The most common cause of amblyopia was hypermetropia(64.45%),followed by previous ocular surgeries(15.1%),myopia(10.43%),strabismus(9.39%),and congenital cataract(0.63%).CONCLUSION:This is the first and only study,identifing modifiable risk factors in Jordanian children with amblyopia.In their first couple of years of elementary education,many Jordanian children are affected by amblyopia and pass unnoticed.A more governmental effort is needed into screening programs to improve vision in the Jordanian population. | Khalil M.Al-Salem Mohammad S.Saleem Ismat Ereifej Hamzeh M.Alrawashdeh Rayed Falah Hussein Obeidat Asma Ali Abdlmohdi Raeda Zaki Al-Momani Layal Mohammed Hammad Omar Ahmad al-Habahbeh Yaqeen M.Assassfeh Laith Ramzi Najib Al-Qsous Ashraf Hatim Adeeb Nasraween Tariq A.Al Maaitah Deya'-Aldin Muneer Hasan Aqeel Ibtehal Eyadeh Awad Alabdulrazzg Abdullah Mahmoud Mohammad Murad Amany Jehad Faleh AL-Zurqan Enas Jamal Mohammad Jaradat Slsabela Emad Suliman Aldhoon Ala'a Majed Dmour Ahmad Talal Asassfeh Jeries Ayman Halaseh Abdel Aziz Ammar Daoud Waha Ayman Alkasasbeh Kholoud GH.Matar | 2022 | International Journal of Ophthalmology(English edition)2022，15，2： | 1 |
| 13 | Incidence of upper limb venous thrombosis associated with peripherally inserted cen tral catheters (PICC) 显示文摘 | Abdullah J J Mohammad N Sangkar JV | 2005 | British Journal of Radiology2005，78，931： | 1 |
| 14 | Improvement of reverse-engineered turbine blades using constructiongeometry显示文摘 | MOHAGHEGH K MOHAMMAD H ABDULLAH A | 2010 | International Journal Advanced Manufacturing Technology2010，49，7： | 1 |
| 15 | Effects of common inorganic anoins on rates of photocatalytic oxidation of organic carbon over illuminated显示文摘 | Abdullah Mohammad Low Gary K-C Matthews Ralph W | 1990 | Journal of Physical Chemistry1990，94，17： | 1 |
| 16 | Incidence of Upper Limb Venous Thrombosis Associated with Peripherally Inserted Central Catheters(PIC C)显示文摘 | Abdullah B J Mohammad N Sangkar JV | 2005 | Br J Radiol2005，78，931： | 1 |
| 17 | Incidence of upper limb venous thrombosis associated with peripherally inserted central catheters (PICC) 显示文摘 | Abdullah B J Mohammad N Sangkar JV | 2005 | Bri J Radiol2005，78，931： | 1 |
| 18 | Incidence of upper limb venous thrombosis associated with peripherally inserted central catheters (PICC) 显示文摘 | Abdullah B J Mohammad N Sangkar JV | 2005 | Br J Radiol2005，78，931： | 1 |
| 19 | Enhancement of propylene production in a downer FCC operation using a ZSM-5 additive 显示文摘 | Mohammad A Abul-Hamayel Abdullah M A Mian R S | 2005 | Chem Eng Technol2005，28，2： | 1 |
| 20 | Using GA for Optimi- zation of the fuzzy C-means clustering algorithm显示文摘 | Mohanad A Mohammad M Abdullah R | 2013 | Research Journal of Applied Sciences Engineering and Technology2013，5，3： | 1 |
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