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| 1 | Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors显示文摘从锥蜗牛(Conus ) 的毒液的充满半胱氨酸的肽指向许多不同离子隧道。conopeptides 的一个家庭,伪 - conotoxins,明确地指向在神经与肌的连接和中央神经系统两个都发现的烟碱的醋胆素受体(nAChRs ) 的不同 isoforms。这个家庭进一步基于在半胱氨酸残余之间的氨基酸的数字被划分成亚科。某些伪 - conotoxins 的优美子类型选择对涉及 neurotransmitter 版本的调整的本国的 nAChR isoforms 的描述关键, Parkinson 的疾病和 nociception 的 pathophysiology。伪 - conotoxins 的结构 / 功能描述与改进力量或子类型选择导致了类似物的发展。脊梁结构的环合和脂性的一半的增加导致了伪 - conotoxins 的改进稳定性和 bioavailability,因此为口头上地可得到的治疗学铺平道路。在发展史, exogenomics 和分子的建模诺言的最近的进展有为 nAChRs 的特定的子类型的改进选择的伪 - conotoxins 和类似物的一个甚至更大的数字的发现。 | Layla AZAM J Michael MCINTOSH | 2009 | Acta Pharmacologica Sinica2009，30，6： | 25 |
| 2 | Biofilm formation in clinical isolates of nosocomial Acinetobacter baumannii and its relationship with multidrug resistance显示文摘Objective: To check biofilm formation by Acinetobacter baumannii(A. baumannii)clinical isolates and show their susceptibility to different antibiotics and investigate a possible link between establishment of biofilm and multidrug resistance.Methods: This study was performed on clinical samples collected from patients with nosocomial infections in three hospitals of Tehran. Samples were initially screened by culture and biochemical tests for the presence of different species of Acinetobacter. Identifications were further confirmed by PCR assays. Their susceptibilities to 11 antibiotics of different classes were determined by disc diffusion method according to Clinical and Laboratory Standards Institute guidelines. The ability to produce biofilm was investigated using methods: culture on Congo red agar, microtiter plate, and test tube method.Results: From the overall clinical samples, 156 specimens were confirmed to contain A. baumannii. The bacteria were highly resistant to most antibiotics except polymyxin B.Of these isolates, 10.26% were able to produce biofilms as shown on Congo red agar.However, the percentage of bacteria with positive biofilm in test tube, standard microtiter plate, and modified microtiter plate assays were 48.72%, 66.66%, and 73.72%, respectively. At least 92% of the biofilm forming isolates were multidrug resistant.Conclusions: Since most of the multidrug resistant strains produce biofilm, it seems necessary to provide continuous monitoring and determination of antibiotic susceptibility of clinical A. baumannii. This would help to select the most appropriate antibiotic for treatment. | Ebrahim Babapour Azam Haddadi Reza Mirnejad Seyed-Abdolhamid Angaji Nour Amirmozafari | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，6： | 13 |
| 3 | Evolving paradigms in biological carbon cycling in the ocean显示文摘Carbon is a keystone element in global biogeochemical cycles.It plays a fundamental role in biotic andabiotic processes in the ocean,which intertwine to mediate the chemistry and redox status of carbon in the ocean and the atmosphere.The interactions between abiotic and biogenic carbon(e.g.CO_2,Ca CO_3,organic matter)in the ocean are complex,and there is a half-century-old enigma about the existence of a huge reservoir of recalcitrant dissolved organic carbon(RDOC)that equates to the magnitude of the pool of atmospheric CO_2.The concepts of the biological carbon pump(BCP)and the microbial loop(ML)shaped our understanding of the marine carbon cycle.The more recent concept of the microbial carbon pump(MCP),which is closely connected to those of the BCP and the ML,explicitly considers thesignificance of the ocean’s RDOC reservoir and provides a mechanistic framework for the exploration of its formation and persistence.Understanding of the MCP has benefited from advanced‘omics’and novel research in biological oceanography and microbial biogeochemistry.The need to predict the ocean’sresponse to climate change makes an integrative understanding of the BCP,ML and MCP a high priority.In this review,we summarize and discuss progress since the proposal of the MCP in 2010 and formulate research questions for the future. | Chuanlun Zhang Hongyue Dang Farooq Azam Ronald Benner Louis Legendre Uta Passow Luca Polimene Carol Robinson Curtis A.Suttle Nianzhi Jiao | 2018 | National Science Review2018，5，4： | 12 |
| 4 | Unveiling the enigma of refractory carbon in the ocean显示文摘INTRODUCTION The ocean holds a tremendous reservoir of refractory dissolved organic carbon (RDOC)that plays an important role in carbon cycling and climate change [1].However,the origin of the RDOC has been an enigma for half a century. This perspective is to address why the enigma deserves scientific efforts and illustrate a robust scheme--the Microbial Carbon Pump (MCP)-to unveil the enigma from molecular to ecosystem levels,Through generation of intrinsic RDOC (RDOCt)under specific biotic and abiotic environmental conditions,as well as through derivation of diverse organic molecules at extremely low concentrations (RDOCc). | Nianzhi Jiao Ruanhong Cai Qiang Zheng Kai Tang Jihua Liu Fanglue Jiao Douglas Wallace Feng Chen Chao Li Rudolf Amann Ronald Benner Farooq Azam | 2018 | National Science Review2018，5，4： | 10 |
| 5 | Effects of cinnamon on perineal pain and healing of episiotomy: a randomized placebo-controlled trial显示文摘BACKGROUND: Analgesic and wound-healing effects of cinnamon, a widely used spice, have been shown in laboratory rats. However, we found no human studies in this area.OBJECTIVE: The aim of this study was to assess the effect of cinnamon on perineal pain and healing of episiotomy incision.DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: In this double-blind, randomized, placebo-controlled trial, 144 postpartum women were allocated into two groups, using stratifi ed block randomization, 1 h after completion of episiotomy repair. They received cinnamon or placebo ointment, 2 mL every 12 h for 10 d.MAIN OUTCOME MEASURES: Perineal pain and wound healing were assessed using visual analogue scale(0-10) and Redness, Edema, Ecchymosis, Discharge, Approximation scale(0-15), respectively. General linear model was used to compare the groups on the outcomes adjusted for baseline values and stratifi ed factors.RESULTS: Follow-up rate was 100% up to the 8 h time point in both groups, and 86%(62 of 72) in the cinnamon group and 85%(61 of 72) in the placebo group at day 10-11 after delivery. Pain score in the cinnamon group was signifi cantly lower than that in the placebo group at(4±1) h(adjusted difference:-0.6, 95% confi dence interval:-1.0 to-0.2) and(8±1) h(-0.9,-1.4 to-0.3) after intervention, and on the 10-11 th day after delivery(-1.4,-2.0 to-0.7). Also the cinnamon group showed signifi cantly more improvement than the control group in healing score at(8±1) h(-0.2,-0.4 to-0.04) and the 10-11 th day after delivery(-1.6,-2.0 to-1.1). CONCLUSION: Cinnamon can be used for reducing perineal pain and improving healing of episiotomy incision. | Azam Mohammadi Sakineh Mohammad-Alizadeh-Charandabi Mojgan Mirghafourvand Yousef Javadzadeh Zahra Fardiazar Fatemeh Effati-Daryani | 2014 | Journal of Integrative Medicine2014，12，4： | 7 |
| 6 | 大豆主要营养品质性状相关分子标记的育种应用潜力评价显示文摘大豆营养品质性状多为数量性状,受多基因调控。目前,已定位到大量与营养品质性状相关的分子标记,但经过大豆育种群体验证的可用标记却很少。本研究以288份黄淮海地区选育的大豆品种和19份野生/半野生大豆种质为材料组成大豆自然群体,利用近红外光谱法、气相色谱法和高效液相色谱法分析其蛋白质、脂肪、脂肪酸和异黄酮组分含量;选用已报道的与营养品质性状紧密连锁的18个SSR标记,采用毛细管电泳方法进行基因型鉴定。采用关联分析方法验证分子标记的选择效果,共检测出与脂肪含量关联的标记3个,与蛋脂总和关联的标记3个,与棕榈酸关联的标记1个,与硬脂酸关联的标记1个,与油酸关联的标记2个,与亚麻酸关联的标记2个,同时发掘出这些位点的优异等位变异,表明上述验证的分子标记可用于大豆营养品质分子育种中。 | 怀园园 张晟瑞 武婷婷 AZAM Muhammad 李静 孙石 韩天富 李斌 孙君明 | 2022 | 作物学报2022，48，8： | 6 |
| 7 | Myricetin protects hippocampal CA3 pyramidal neurons and improves learning and memory impairments in rats with Alzheimer's disease显示文摘There is currently no treatment for effectively slowing the progression of Alzheimer's disease, so early prevention is very important. Numerous studies have shown that flavonoids can improve memory impairment. The present study investigated the effects of myricetin, a member of the flavonoids, on intracerebroventricular streptozotocin induced neuronal loss and memory impairment in rat models of Alzheimer's disease. Myricetin at 5 or 10 mg/kg was intraperitoneally injected into rats over 21 days. Control rats were treated with 10 m L/kg saline. Behavioral test(the shuttle box test) was performed on day 22 to examine learning and memory in rats. Immediately after that, hematoxylin-eosin staining was performed to observe the morphological change in hippocampal CA3 pyramidal neurons. Myricetin greatly increased the number of hippocampal CA3 pyramidal neurons and improved learning and memory impairments in rats with Alzheimer's disease. These findings suggest that myricetin is beneficial for treatment of Alzheimer's disease. | Matin Ramezani Niloufar Darbandi Fariba Khodagholi Azam Hashemi | 2016 | Neural Regeneration Research2016，11，12： | 6 |
| 8 | Fatty Acid Composition of Tobacco Seed Oil and Synthesis of Alkyd Resin显示文摘烟草种子油的丰满的酸作文表明油富于不饱和的丰满的酸,有罂酸的酸(71.63%) ,油的酸(13.46%) 和十六酸酸(8.72%) 作为最丰富的不饱和、浸透的丰满的酸分别地。烟草油因此根据丰满的酸作文作为弄干半的类型被描绘。醇酸树脂树脂的合成被醇解执行或用碱的 monoglyceride 过程精制了烟草种子油, pentaerythritol,与锂氢氧化物一起的 cis-1,2,3,6-tetrahydrophthalic 酐是催化剂。那么准备的醇酸树脂树脂被发现是明亮并且有高注释的低颜色。弄干和坚硬性质和烟草种子油的粘附发源醇酸树脂树脂也一样的油长度的另外的醇酸树脂树脂被发现有点优异到那些。另外,水和说的醇酸树脂的酸抵抗也被发现可比较到另外的醇酸树脂。 | MUKHTAR, Azam ULLAH, Habib MUKHTAR, Hamid | 2007 | Chinese Journal of Chemistry2007，25，5： | 5 |
| 9 | Toward point-of-care management of chronic respiratory conditions:Electrochemical sensing of nitrite content in exhaled breath condensate using reduced graphene oxide显示文摘We present a portable non-invasive approach for measuring indicators of inflammation and oxidative stress in the respiratory tract by quantifying a biomarker in exhaled breath condensate(EBC).We discuss the fabrication and characterization of a miniaturized electrochemical sensor for detecting nitrite content in EBC using reduced graphene oxide.The nitrite content in EBC has been demonstrated to be a promising biomarker of inflammation in the respiratory tract,particularly in asthma.We utilized the unique properties of reduced graphene oxide(rGO);specifically,the material is resilient to corrosion while exhibiting rapid electron transfer with electrolytes,thus allowing for highly sensitive electrochemical detection with minimal fouling.Our rGO sensor was housed in an electrochemical cell fabricated from polydimethyl siloxane(PDMS),which was necessary to analyze small EBC sample volumes.The sensor is capable of detecting nitrite at a low over-potential of 0.7 V with respect to an Ag/AgCl reference electrode.We characterized the performance of the sensors using standard nitrite/buffer solutions,nitrite spiked into EBC,and clinical EBC samples.The sensor demonstrated a sensitivity of 0.21μAμM^(−1) cm^(−2) in the range of 20–100μM and of 0.1μAμM^(−1) cm^(−2) in the range of 100–1000μM nitrite concentration and exhibited a low detection limit of 830 nM in the EBC matrix.To benchmark our platform,we tested our sensors using seven pre-characterized clinical EBC samples with concentrations ranging between 0.14 and 6.5μM.This enzyme-free and label-free method of detecting biomarkers in EBC can pave the way for the development of portable breath analyzers for diagnosing and managing changes in respiratory inflammation and disease. | Azam Gholizadeh Damien Voiry Clifford Weisel Andrew Gow Robert Laumbach Howard Kipen Manish Chhowalla Mehdi Javanmard | 2017 | Microsystems & Nanoengineering2017，3，1： | 5 |
| 10 | Electronical and thermoelectric properties of half-Heusler ZrNiPb under pressure in bulk and nanosheet structures for energy conversion显示文摘The pressure dependence of structural,electronic and thermoelectric properties of half-Heusler ZrNiPb was investigated in the bulk and nanosheet structures.In order to obtain the accurate results,the full-potential(linearized) augmented plane-wave(FP(L)APW)calculations were performed with the Perdew-BurkeErnzerhof generalized gradient approximation(PBE-GGA)and modified Becke-Johnson(mBJ) plus spin-orbit coupling(SOC).Obtained band gap values are in close agreement with the experimental results(<0.5 eV).The variations of the thermoelectric properties of the ZrNiPb were studied under different temperatures,carrier concentrations and the hydrostatic pressures.The results show that the hydrostatic pressure decreases the lattice constant value.The band structure calculations display that the band gap increases with pressure for the bulk state and it is 0 for the nanosheet of ZrNiPb [010].The highest value of figure of merit(ZT)=0.95 is found at 9.378 GPa at a carrier concentration of n=1 × 10^18 cm^-3 at 250 K for p-type of ZrNiPb. | Hossein Asghar Rahnamaye Aliabad Zahra Nodehi Behrooz Maleki Azam Abareshi | 2019 | Rare Metals2019，38，11： | 5 |
| 11 | Profiling of seed fatty acid composition in 1025 Chinese soybean accessions from diverse ecoregions显示文摘The stability of soybean(Glycine max L.Merrill)oil is determined mainly by its fatty acid(FA)composition.We evaluated the FA composition of 1025 Chinese soybean accessions collected from diverse ecoregions and grown in multiple locations and years.We observed highly significant differences(P<0.001)between accessions in palmitic acid(PA),stearic acid(SA),oleic acid(OA),linoleic acid(LA),and linolenic acid(LNA)contents.Growth year affected(P<0.001)the abundance of all FAs except PA.The mean PA,SA,OA,LA,and LNA contents were 12.2%,3.8%,21.5%,54.2%,and 8.3%,respectively.The geographical origin of the accession influenced seed FA composition,indicating that accessions originating in each ecoregion tend to have distinct FA composition.We observed significant positive correlations among the three locations and between the two years,suggesting the high heritability and stability of individual accessions across contrasting environments.We also observed a relatively high negative correlation between the contents of OA and both LA and LNA(r=-0.90 and-0.59,respectively,each significant at P<0.001),providing a potential entry point for developing strains producing oil with higher OA and lower LA and LNA levels.These would be appropriate for specialized use in the food industry.Our results will be useful in breeding soybean with improved quality to meet human nutritional and industrial needs. | Ahmed M.Abdelghany Shengrui Zhang Muhammad Azam Abdulwahab S.Shaibu Yue Feng Yanfei Li Yu Tian Huilong Hong Bin Li Junming Sun | 2020 | The Crop Journal2020，8，4： | 4 |
| 12 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 13 | Application of the Dermatology Life Quality Index in Clinical Trials of Biologics for Psoriasis显示文摘The significance of patient-reported outcomes(PROs) is increasingly being acknowledged and quality of life(QOL) has become an integral element of the assessment of overall burden of disease.Psoriasis has been known for its major impact on patients' QOL and various generic,dermatology-specific and psoriasis-specific self- administered psychometric instruments have been used over the years to assess the QOL of psoriasis patients.However,the Dermatology Life Quality Index(DLQI) is the most widely used QOL measure among these measures in psoriasis-related clinical trials. A number of topical and systemic treatments have been used in the management of psoriasis and lately biologics have emerged as a new and promising treatment modality for difficuIt-to-treat psoriasis.The evidence on the efficacy of these agents has been growing dramatically with QOL being used as one of the primary outcome measures in many clinical trials.The aim of this paper is to give an overview of the use of the DLQI as an outcome measure for assessing the QOL impact of biologies on psoriasis patients.Furthermore,the efficacy of five commonly used biologics has been compared in terms of their ability to improve the QOL assessed by the DLQI.This review has revealed that there is a variation in the efficacy of various biologies in terms of QOL improvement with the mean reduction in the DLQI scores being highest for ustekinumab 90 mg(mean DLQI score reduction=9.5),followed by infliximab(8.5),etanercept 50 mg,twice a week(7.7),adalimumab(6.3),and alefacept(4.0). | Mohammad Khu rshid Azam Basra Sadath Hussain | 2012 | Chinese Journal of Integrative Medicine2012，18，3： | 4 |
| 14 | 基于无人机平台多模态数据融合的小麦产量估算研究显示文摘作物产量估测关系到人民生活质量和国家粮食安全问题,在田块尺度下及时准确估算产量,对于农事操作管理、收获、销售及种植计划制定均具有重要意义。选择地势起伏及空间差异较大的农田为研究区,利用低空无人机遥感平台搭载多光谱相机、热红外相机和RGB相机,同步获取小麦关键生育时期的无人机遥感影像,并提取光谱反射率、热红外温度和数字高程信息。首先统计不同地形特征下遥感参数和生长指标的空间变异情况,分析植被指数和温度参数与小麦产量的相关性,然后利用多元线性回归(multiple linear regression,MLR)、偏最小二乘回归(partial least squares regression,PLSR)、支持向量机回归(support vector machine regression,SVR)和随机森林回归(random forest regression,RFR)4种机器学习方法以单模态数据和多模态遥感信息融合2种方式进行建模,比较单模态数据和多模态数据融合的产量估测能力。结果表明,坡度是影响作物生长和产量的重要因子,3个生育期内,不同坡度等级下遥感参数差异明显,土壤含水量、植株含水量和地上部生物量与坡度的相关性均达显著水平,植被指数和温度参数与产量的相关性均达显著水平。依据与产量的相关性,筛选7个植被指数(NDVI、GNDVI、EVI2、OSAVI、SAVI、NDRE、WDRVI)和2个温度参数(NRCT、CTD)作为模型输入变量,对于单模态数据而言,对产量的估算效应为植被指数>温度参数,以灌浆期植被指数的RFR模型效果最好(R2=0.724,RMSE=614.72 kg hm^(-2),MAE=478.08 kg hm^(-2));对于双模态数据融合来说,在植被指数基础上融入冠层温度参数表现最好,开花期RFR模型效果进一步提高(R2=0.865,RMSE=440.73 kg hm^(-2),MAE=374.86 kg hm^(-2));在双模态数据基础上引入坡度信息进行三模态数据融合,其产量估算效果明显优于单模态和双模态数据融合,其中以开花期植被指数、温度参数和坡度信息融合的RFR估算效果最好(R2=0.893,RMSE=420.06 kg hm^(-2),MAE=352.69 kg hm^(-2)),模型验证效果较好(R2=0.892,RMSE=423.55 kg hm^(-2),MAE=334.43 kg hm^(-2))。可见,在本试验条件下通过引入地形因子,结合随机森林回归算法将多模态数据有效融合,可充分发挥不同遥感信息源之间互补协同作用,有效提高了产量估算模型的精度与稳定性,为作物生长监测及产量估算提供思路参考和方法支持。 | 张少华 段剑钊 贺利 井宇航 Urs Christoph Schulthess Azam Lashkari 郭天财 王永华 冯伟 | 2022 | 作物学报2022，48，7： | 4 |
| 15 | Differential reactivity of mouse monoclonal anti-HBs antibodies with recombinant mutant HBs antigens显示文摘AIM: To investigate the reactivity of a panel of 8 mouse anti-hepatitis B surface antigen (HBsAg) monoclonal antibodies (mAbs) using a collection of 9 recombinant HBsAg mutants with a variety of amino acid substitutions mostly located within the “a” region.METHODS: The entire HBs genes previously cloned into a mammalian expression vector were transiently transfected into COS7 cells. Two standard unmutated sequences of the ayw and adw subtypes served as controls. Secreted mutant proteins were collected and measured by three commercial diagnostic immunoassays to assess transfection efficiency. Reactivity of anti-HBs mAbs with mutated HBsAgs was determined by sandwich enzyme-linked immunosorbent assay (ELISA).RESULTS: Reactivity of anti-HBs mAbs with mutated HBsAgs revealed different patterns. While three mutants reacted strongly with all mAbs, two mutants reacted weakly with only two mAbs and the remaining proteins displayed variable degrees of reactivity towards different mAbs. Accordingly, four groups of mAbs with different but overlapping reactivity patterns could be envisaged. One group consisting of two mAbs (37C5-S7 and 35C6-S11) was found to recognize stable linear epitopes conserved in all mutants. Mutations outside the “a” determinant at positions 120 (P→S), 123(T→N) and 161(M→T) were found to affect reactivity of these mAbs.CONCLUSION: Our findings could have important implications for biophysical studies, vaccination strategies and immunotherapy of hepatitis B virus (HBV) mutants. | Azam Roohi Yaghoub Yazdani Jalal Khoshnoodi Seyed Mohammad Jazayeri William F Carman Mahmood Chamankhah Manley Rashedan Fazel Shokri | 2006 | World Journal of Gastroenterology2006，12，33： | 4 |
| 16 | Effects of the nitrification inhibitor nitrapyrin and tillage practices on yield-scaled nitrous oxide emission from a maize field in Iran显示文摘Nitrification inhibitors can effectively decrease nitrification rates and nitrous oxide(N_(2)O)emission while increasing crop yield under certain conditions.However,there is no information available on the effects of nitrification inhibitors and tillage practices on N_(2)O emissions from maize cropping in Iran.To study how tillage practices and nitrapyrin(a nitrification inhibitor)affect N_(2)O emission,a split factorial experiment using a completely randomized block design with three replications was carried out in Northeast Iran,which has a cold semiarid climate.Two main plots were created with conventional tillage and minimum tillage levels,and two nitrogen(N)fertilizer(urea)management systems(with and without nitrapyrin application)were created as subplots.Tillage level did not have any significant effect on soil ammonium(NH_(4)^(+))and nitrate(NO_(3)^(-))concentrations,cumulative amount and yield-scaled N_(2)O emission,and aboveground biomass of maize,whereas nitrapyrin application showed significant effect.Nitrapyrin application significantly reduced the cumulative amount of N_(2)O emission by 41%and 32%in conventional tillage and minimum tillage practices,respectively.A reduction in soil NO_(3)^(-)concentration by nitrapyrin was also observed.The average yield-scaled N_(2)O emission was 13.6 g N_(2)O-N kg^(-1)N uptake in both tillage systems without nitrapyrin application and was significantly reduced to 7.9 and 8.2 g N_(2)O-N kg^(-1)N uptake upon the application of nitrapyrin in minimum tillage and conventional tillage practices,respectively.Additionally,nitrapyrin application increased maize biomass yield by 4%and 13%in the minimum tillage and conventional tillage systems,respectively.Our results indicate that nitrapyrin has a potential role in reducing N_(2)O emission from agricultural systems where urea fertilizers are broadcasted,which is common in Iran due to the practice of traditional farming. | Azam BORZOUEI Ulo MANDER Alar TEEMUSK Alberto SANZ-COBENA Mohammad ZAMAN Dong-Gill KIM Christoph MÜLLER Ali Askary KELESTANIE Parvaneh SAYYAD AMIN Ebrahim MOGHISEH Khadim DAWAR Ana Gabriela PÉREZ-CASTILLO | 2021 | Pedosphere2021，31，2： | 4 |
| 17 | Non-invasive diagnosis of H pylori infection: Evaluation of serological tests with and without current infection marker CIM显示文摘AIM:To evaluate the performance of commercially available immunochromatographic (ICT) and immunoblot tests covering the current infection marker CIM and conventional ELISA for the diagnosis of H pylori infection in adult dyspeptic patients. METHODS:Consecutive non-treated dyspeptic patients undergoing diagnostic endoscopy were tested for H pylori infection by culture, rapid urease test, and histology of gastric biopsy specimens. Serum from 61 H pylori infected and 21 non-infected patients were tested for anti-H pylori IgG antibodies by commercial ELISA (AccuBindTM ELISA, Monobind, USA), ICT (Assure H pylori Rapid Test, Genelabs Diagnostics, Singapore), and immunoblot (Helico Blot 2.1, Genelabs Diagnostics, Singapore) assays. ICT and immunoblot kits cover CIM among other parameters and their performance with and without CIM was evaluated separately. RESULTS:Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of ELISA were 96.7%, 42.8%, 83.1%, 81.8%, and 82.9%, of ICT were 90.1%, 80.9%, 93.2%, 73.9%, and 87.8%, of ICT with CIM were 88.5%, 90.4%, 96.4%, 73.0%, and 89.0%, of immunoblot were 98.3%, 80.9%, 93.7%, 94.4%, and 93.9%, and of immunoblot with CIM were 98.3%, 90.4%, 96.7%, 95.0%, and 96.3%, respectively. CONCLUSION:Immunoblot with CIM had the best performance. ICT with CIM was found to be more specific and accurate than the conventional ELISA and may be useful for non-invasive diagnosis of H pylori infection. | Sufi HZ Rahman M Golam Azam M Anisur Rahman MS Arfin M Mahbub Alam Tareq M Bhuiyan Nasim Ahmed Motiur Rahman Shamsun Nahar MS Hassan | 2008 | World Journal of Gastroenterology2008，14，8： | 4 |
| 18 | Synthesis of Schiff bases of naphtha[1,2-d]thiazol-2-amine and metal complexes of 2-(2'-hydroxy)benzylideneaminonaphthothiazole as potential antimicrobial agents显示文摘Objective: A series of 2-benzylideneaminonaphthothiazoles were designed and synthesized incorporating the lipo- philic naphthalene ring to render them more capable of penetrating various biomembranes. Methods: Schiff bases were synthe- sized by the reaction of naphtha[1,2-d]thiazol-2-amine with various substituted aromatic aldehydes. 2-(2'-Hydroxy)ben- zylideneaminonaphthothiazole was converted to its Co(II), Ni(II) and Cu(II) metal complexes upon treatment with metal salts in ethanol. All the compounds were evaluated for their antibacterial activities by paper disc diffusion method with Gram positive Staphylococcus aureus and Staphylococcus epidermidis and Gram negative Escherichia coli and Pseudomonas aeruginosa bac- teria. The minimum inhibitory concentrations of all the Schiff bases and metal complexes were determined by agar streak dilution method. Results: All the compounds moderately inhibited the growth of Gram positive and Gram negative bacteria. In the present study among all Schiff bases 2-(2'-hydroxy)benzylideneaminonaphthothiazole showed maximum inhibitory activity and among metal complexes Cu(II) metal complex was found to be most potent. Conclusion: The results obtained validate the hypothesis that Schiff bases having substitution with halogens, hydroxyl group and nitro group at phenyl ring are required for the antibacterial activity while methoxy group at different positions in the aromatic ring has minimal role in the inhibitory activity. The results also indicated that the metal complexes are better antibacterial agents as compared to the Schiff bases. | AZAM Faizul SINGH Satendra KHOKHRA Sukhbir Lal PRAKASH Om | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，6： | 4 |
| 19 | Intestinal protozoa and intestinal helminthic infections among schoolchildren in Central Sudan显示文摘Objective:To determine the prevalence of intestinal parasitic infections and soil-transmitted helminths(STHs) among primary schoolchildren in El dhayga,Central Sudan.Methods:In this cross-sectional study,three fresh faecal samples were collected from each child,which were examined by direct wet mount,brine flotation,formalin-ether and Kato-Katz techniques.The intensity of each STH infection was expressed as the mean of eggs per gram counts of the three samples.Results:In total,142(90.4%) of 157 children harboured at least one type of intestinal parasite.Ascaris lumbricoides,Hymenolepis nana,Entamoeba histolytica and Giardia lamblia were the most common parasites found,with prevalence rates of 32.5%,30.6%,33.1%and 19.7%,respectively.Out of these 157 children,29(18.5%) harboured more than two intestinal parasitic infections.No cases of Schistosoma mansoni or Enterobius vermicularis were identified. Conclusions:The study demonstrates significant burden of intestinal protozoa and STH infections in this part of Sudan and highlights the need for preventive and intervention measures. | Abdel-aziz M.Ahmed Azam A.Afifi Elfatih M.Malik Ishag Adam | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，4： | 3 |
| 20 | Predicting the presence of adenomatous polyps during colonoscopy with National Cancer Institute Colorectal Cancer Risk-Assessment Tool显示文摘AIM To evaluate the National Cancer Institute(NCI)Colorectal Cancer(CRC)Risk Assessment Tool as a predictor for the presence of adenomatous polyps(AP) found during screening or surveillance colonoscopy.METHODS This is a retrospective single center observational study.We collected data of adenomatous polyps in each colonoscopy and then evaluated the lifetime CRC risk.We calculated the AP prevalence across risk score quintiles,odds ratios of the prevalence of AP across risk score quintiles,area under curves(AUCs)and Youden’s indexes to assess the optimal risk score cut off value for AP prevalence status.RESULTS The prevalence of AP gradually increased throughout the five risk score quintiles:i.e.,27.63%in the first and 51.35%in the fifth quintile.The odd ratios of AP prevalence in the fifth quintile compared to the first and second quintile were 2.76[confidence interval(CI):1.71-4.47]and 2.09(CI:1.32-3.30).The AUC for all patients was 0.62(CI:0.58-0.66).Youden’s Index indicated the optimal risk score cutoff value discriminating AP prevalence status was 3.60.CONCLUSION Patients with the higher NCI risk score have higher risk of AP and subsequent CRC;therefore,measures to increase the effectiveness of CRC detection in these patients include longer withdrawal time,early surveillance colonoscopy,and choosing flexible colonoscopy over other CRC screening modalities. | Hassan Tariq Muhammad Umar Kamal Harish Patel Ravi Patel Muhammad Ameen Shehi Elona Maram Khalifa Sara Azam Aiyi Zhang Kishore Kumar Ahmed Baiomi Danial Shaikh Jasbir Makker | 2018 | World Journal of Gastroenterology2018，24，34： | 3 |
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