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	题名	作者	年代	出处	被引量
1	p16 promoter hypermethylation:A useful serum marker for early detection of gastric cancer显示文摘AIM: To determine p16 promoter hypermethylation in gastric tumoral tissue and serum samples, its impact on p16-protein expression, and correlation with clinical and histological features. METHODS: Samples were obtained from 52 histologically confirmed cases of gastric adenocarcinoma. Gastric tissue and serum of 50 age- and sex-matched individuals with normal gastroscopy and biopsy were obtained as control samples. Methylation-specific polymerase chain reaction (MSP) was used to evaluate methylation status of p16 promoter. p16-protein expression was analyzed by immunohistochemical staining on paraffin-embedded sections. RESULTS: Methylation was detected in 44.2% (23/52) of tumoral tissues. 60.9% of them were also methylated in serum, i.e., 26.9% of all patients (14/52). Methylation was not detected in tissue and sera of control samples. p16-protein expression was decreased in 61.5% of cases (32/52), and was significantly associated with promoter hypermethylation (P < 0.001). Methylation was significantly more frequent in higher pathological grades (P < 0.05). Methylation was not associated with other clinicopathological features and environmental factors including H pylori infection and smoking. CONCLUSION: p16 promoter hypermethylation is an important event in gastric carcinogenesis. It is the principle mechanism of p16 gene silencing. It is related to malignant tumor behavior. Detection of DNA methylation in serum may be a biomarker for early detection of gastric cancer.	Mohammad Reza Abbaszadegan Omeed Moaven Hamid Reza Sima Kamran Ghafarzadegan Azadeh A'rabi Mohammad Naser Forghani Hamid Reza Raziee Ali Mashhadinejad Mostafa Jafarzadeh Ehsan Esmaili-Shandiz Ezzat Dadkhah	2008	World Journal of Gastroenterology2008，14，13：	50
2	Assessment and improvement of integrated HSE and macro-ergonomics factors by fuzzy cognitive maps:the case of a large gas refinery显示文摘	Asadzadeh S M Azadeh A Negahban A Sotoudeh A		0，，4：	1
3	Secretory meningioma显示文摘	Ejeckam GC Azadeh B Hamad A		0，，05：	1
4	Location optimization of wind power generation-transmission systems under uncertainty using hierarchical fuzzy DEA: A case study显示文摘	Azadeh A Golkhandan A R Moghaddam M	2014	Renewable and Sustainable Energy Reviews2014，30，3：	1
5	Fuzzy sets显示文摘	aZadeh L A	1965	Information and Control1965，，8：	1
6	Anxiety and depression in patients with gastrointestinal cancer:Does knowledge of cancer diagnosis matter-显示文摘	Azadeh T Mohammad A Ali M	2007	BMC Gastroenterology2007，7，：	1
7	Integration of DEA and AH Pwith Computer Simulation for Railway System Improvement and Optimization显示文摘	AZADEH A GHADERI S F IZADBAKHSH H		0，，02：	1
8	Image quality measurement besides distortion type classifying 显示文摘	Aznaveh A M Azadeh M Azar F T	2009	Optical Revievo2009，16，1：	1
9	Integration of artificial neural networks and genetic algorithm to predict electrical energy consumption显示文摘	Azadeh A Ghaderi S F Tarverdian S	2007	Applied Mathematics and Computation2007，186，2：	1
10	An integrated Delphi/VAHP/DEA framework for evaluation of infor- marion technology/information system (IT/IS) investments 显示文摘	AZADEH A KERAMATI A SONGHORI M J	2009	The International Journal of Advanced Manufacturing Technology2009，45，1112：	1
11	Integration of artificial neural networks and genetic algorithm to predict electrical enerconsumption 显示文摘	Azadeh A Ghaderi S F Tarverdian S	2007	Applied Mathematics and Computation2007，186，2：	1
12	IntegrationofSimulationandFuzzyMulti-attributeDecisionMakingforModellingandAssessmentofFuzzyParameters显示文摘	AZADEH A SEIFOORY M ABBASIM	2010	InternationalJournalofIndustrialandSystemsEngineering2010，6，4：	1
13	Expression of epidermal growth factor receptor as a predictive factor for rectal cancer 显示文摘	Motlagh A Azadeh P Fazlalizadeh A	2007	Arch Iran Med2007，10，3：	1
14	Prediction of corrosion initiation in reinforce concrete members subjected to environmental stressors: A finite-element framework 显示文摘	Behrouz S Azadeh A Masanobu S	2012	Cement and Concrete Research2012，42，：	1
15	Retrieval of images from artistic repositories using a decision framework显示文摘	Azadeh K Panagiotis A Konstantinos N P	2004	IEEE Transaction on Image Processing2004，13，3：	1
16	An integrated artificial neural net- work - genetic algorithm clustering ensemble for per- formance assessment of decision making units 显示文摘	Azadeh A Saberi M	2011	Jour- nal of Intelligent Manufacturing2011，22，2：	1
17	An Integrated Artificial Neural Networks Approach for Predicting Global Radiation显示文摘	AZADEH A MAGHSOUDI A SOHRABKHANI S	2009	Energy Conversion and Management2009，50，6：	1
18	Novel ferrocene modified poly( amide ether amide)s and investigation of physical and thermal properties 显示文摘	Shahram M A Azadeh T Samal B	2007	European Polymer Journal2007，43，：	1
19	Integration of analytic hierarchy process and data envelopment analysis for assessment and optimization of personnel productivity in a large industrial bank显示文摘	Azadeh A Ghaderi S F Mirjalili M	2011	Expert Systems with Applications2011，38，52：	1
20	Total assessment of optimization of telecommunication sectors by an integrated multi- variate approach显示文摘	Azadeh A Izadbakhsh H R Bukhari A	2007	Journal of Scientific and Industrial Research2007，66，4：	1

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