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| 1 | Treatment with NADPH oxidase inhibitor apocynin alleviates diabetic neuropathic pain in rats显示文摘Increased reactive oxygen species by the activation of NADPH oxidase(NOX) contributes to the development of diabetic complications.Apocynin,a NOX inhibitor,increases sciatic nerve conductance and blood flow in diabetic rats.We investigated potential protective effect of apocynin in rat diabetic neuropathy and its precise mechanism of action at molecular level.Rat models of streptozotocin-induced diabetes were treated with apocynin(30 and 100 mg/kg per day,intragastrically) for 4 weeks.Mechanical hyperalgesia and allodynia were determined weekly using analgesimeter and dynamic plantar aesthesiometer.Western blot analysis and histochemistry/immunohistochemistry were performed in the lumbar spinal cord and sciatic nerve respectively.Streptozotocin injection reduced pain threshold in analgesimeter,but not in aesthesiometer.Apocynin treatment increased pain threshold dose-dependently.Western blot analysis showed an increase in catalase and NOX-p47 phox protein expression in the spinal cord.However,protein expressions of neuronal and inducible nitric oxide synthase(n NOS,i NOS),superoxide dismutase,glutathion peroxidase,nitrotyrosine,tumor necrosis factor-α,interleukin-6,interleukin-1β,aldose reductase,cyclooxygenase-2 or MAC-1(marker for increased microgliosis) in the spinal cord remained unchanged.Western blot analysis results also demonstrated that apocynin decreased NOX-p47 phox expression at both doses and catalase expression at 100 mg/kg per day.Histochemistry of diabetic sciatic nerve revealed marked degeneration.n NOS and i NOS immunoreactivities were increased,while S-100 immunoreactivity(Schwann cell marker) was decreased in sciatic nerve.Apocynin treatment reversed these changes dose-dependently.In conclusion,decreased pain threshold of diabetic rats was accompanied by increased NOX and catalase expression in the spinal cord and increased degeneration in the sciatic nerve characterized by increased NOS expression and Schwann cell loss.Apocynin treatment attenuates neuropathic pain by decelerating the increased oxidative stress-mediated pathogenesis in diabetic rats. | Murat Olukman Aytül onal Fatma Gül celenk Yigit Uyankgil Türker cavusoglu Neslihan Düzenli Sibel ülker | 2018 | Neural Regeneration Research2018，13，9： | 4 |
| 2 | Media effects on the development of cohesion and process satisfaction in computer-supported workgroups: An analysis of re- suits from two longitudinal studies显示文摘 | and conflict on work-group Journal of Conflict Manage- Burke K Aytes K Chidambaram L | 2001 | Information Technology & People2001，14，2： | 1 |
| 3 | Mode I Crack Problems by Fractal Two Level Finite Element Methods显示文摘 | Leung AYT Su RKL | 1994 | Engineering Fracture Mechanics1994，48，6： | 1 |
| 4 | Two-Level Finite Element Study of Axisymmtric Cracks显示文摘 | Su RKL leung AYT | 1998 | International Journal of Fracture1998，89，： | 1 |
| 5 | Structural Vibration Control by Shape Memory Alloy Damper 显示文摘 | Yu-Lin Han Q S Li Ai-Qun Leung AYT | 2003 | Earthquake Engineerlng and Structural Dynamics2003，32，： | 1 |
| 6 | Retrospective study of 145 supernumerary teeth显示文摘 | Fernandez Montenegro P Valmaseda Castellon E Berini Aytes L | 2006 | Med Oral Patol Oral Cir Bucal2006，11，4： | 1 |
| 7 | Dynamic analysis of a self-excited hysteretic system显示文摘 | Ding Q Leung AYT | 2001 | Journal of Sound and Vibration2001，245，15： | 1 |
| 8 | Retrospective study of 145 supernumerary teeth显示文摘 | Femandez Montenegro P Valmaseda Castell o n E Berini Aytes L | 2006 | Med Oral Patol Oral Cir Bucal2006，11，4： | 1 |
| 9 | Pilematrixoma Review of 205 cases 显示文摘 | Guinot Moya R Valmaseda CasteHon E Befm Aytes L | 2011 | Med Oral Patol Oral Cir BucaI2011，16，4： | 1 |
| 10 | The schizosaccharomyces pombe MBF complex requires heterodimerisation for entry into S phase显示文摘 | LEIS J E HERRER A | 1995 | Mol Cell Biol1995，15，： | 1 |
| 11 | PRL-3 is essentially overex-pressed in primary colorectal tumours and associates with tumour agg-ressiveness显示文摘 | MollevíDG Aytes A Padullés L | 2008 | Br J Cancer2008，99，10： | 1 |
| 12 | Incidence of acute respiratory distress syndrome:a comparison of two definitions显示文摘 | Goh AYT Chan PWK Lum LC S | 1998 | Arch Dis Child1998，79，3： | 1 |
| 13 | Managing vascular risk in hypertension with afocus on microalbuminuria : attitute and practices 显示文摘 | Wu AYT Low LP | 2009 | Singpore Med2009，50，10： | 1 |
| 14 | Microalbuminuria prevalence study in hypertensive patients with type 2 diabetes mellitus in Singapore显示文摘 | Wu AYT Tan CB Eng PHK | 2006 | Singapore Med J2006，47，4： | 1 |
| 15 | Predicting drug response in human prostate cancer from preclinical analysis of in vivo mouse models显示文摘 | Mitrofanova A Aytes A Zou M | 2015 | Cell Rep2015，12，12： | 1 |
| 16 | PRL-3 overexpres sion in epithelial ceils is induced by surrounding stromal fibro- blasts 显示文摘 | Mollevi DG Aytes A Berdiel M | 2009 | Molecular Cancer2009，8，： | 1 |
| 17 | Meydanli Compression Suture : New surgical procedure for postpartum hemorrhage due to uterine atony associated with abnormal placental adherence 显示文摘 | Mehmet Mutlu Meydanli Ilgin TUrkUollu Yaprak Engin lsttln Yusuf lsttln Ayt)e Kafkasli | 2008 | Journal of Obstetrics and Gynaecology Research2008，，： | 1 |
| 18 | Carbon Reduction of a Green Hotel beyond Platinum显示文摘 | WONG Kw LEUNG Ayt WONG Tc | 2014 | i:2014，，2： | 1 |
| 19 | Cross-species analysis of genome-wide regulatory networks identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy显示文摘 | Alvaro Aytes Antonina Mitrofanova Celine Lefebvre Mariano J. Alvarez Mireia Castillo-Martin Tian Zheng James A. Eastham Anuradha Gopalan Kenneth J. Pienta Michael M. Shen Andrea Califano Cory Abate-Shen | 2014 | Cancer Cell2014，，： | 1 |
| 20 | Mycophenolate mofetil during pregnancy: some words of caution 显示文摘 | Vento M Perez Aytes A Ledo A | 2008 | Pediatrics2008，122，： | 1 |
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