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| 1 | Open label trial of granulocyte apheresis suggests therapeutic efficacy in chronically active steroid refractory ulcerative colitis显示文摘AIM:To study the efficacy, safety, and feasibility of a granulocyte adsorptive type apheresis system for the treatment of patients with chronically active ulcerative colitis despite standard therapy.METHODS: An open label multicenter study was carried out in 39 patients with active ulcerative colitis (CAI6-8) despite continuous use of steroids (a minimum total dose of 400 mg prednisone within the last 4 wk).Patients received a total of five aphereses using a granulocyte adsorptive technique (Adacolumn(R), Otsuka Pharmaceutical Europe, UK). Assessments at wk 6 and during follow-up until 4 mo comprised clinical (CAI) and endoscopic (EI) activity index, histology, quality of life(IBDQ), and laboratory tests.RESULTS: Thirty-five out of thirty-nine patients were qualified for intent-to-treat analysis. After the apheresis treatment at wk 6, 13/35 (37.1%) patients achieved clinical remission and 10/35 (28.6%) patients had endoscopic remission (CAI<4, EI<4). Quality of life (IBDQ) increased significantly (24 points, P<0.01)at wk 6. Apheresis could be performed in all but one patient. Aphereses were well tolerated, only one patient experienced anemia.CONCLUSION: In patients with steroid refractory ulcerative colitis, five aphereses with a granulocyte/monocyte depleting filter show potential short-term efficacy. Tolerability and technical feasibility of the procedure are excellent. | Wolfgang Kruis Axel Dignass Elisabeth Steinhagen-Thiessen Julia Morgenstern Joachim M(o|¨)ssner Stephan Schreiber Maurizio Vecchi Alberto Malesci Max Reinshagen Robert L(o|¨)fberg | 2005 | World Journal of Gastroenterology2005，11，44： | 4 |
| 2 | Accuracy of frozen section exami- nation of testicular tumors of uncertain origin显示文摘 | Achim E Peter O Axel H | 2002 | Euro Urol2002，41，3： | 1 |
| 3 | The use of a refined zebrafish embryo bioassay for the as- sessment of aquatic toxicity 显示文摘 | Axel O | 2000 | Res Note2000，29，7： | 1 |
| 4 | Cooperation among strangers with limited information about reputation 显示文摘 | GARY E BOLTON ELENA K AXEL O | 2005 | Journal of Public Economics2005，89，1： | 1 |
| 5 | Inhibition of the transforming growth factor-beta/Smad signaling pathway in the epithelium of oral lichen显示文摘 | Karatsaidis A Schreurs O Axell T | 2003 | J Invest Dermatol2003，121，6： | 1 |
| 6 | Tubules and donuts:a type Ⅵ secretion story显示文摘 | B(o)emann G Aleksandra P Axel M | 2010 | Molecular Microbiology2010，76，4： | 1 |
| 7 | Fairness versus efficiency: an experimental study of (mutual) gift giving 显示文摘 | Werner G Hattmut K Axel O | 2003 | Journal of Economic Behavior & Organzation2003，，50： | 1 |
| 8 | Functional asymmetry of human prefrontal cortex: encoding and retrieval of verbally and nonverbally coded information 显示文摘 | Bertram O Axel M Angela D F | 2000 | Journal of Cognitive Neuroscience2000，12，： | 1 |
| 9 | Combing Lithoclast and ultrasound power in one device for percutaneous nephrolithotomy: In vitro results of a novel and highly effective technology 显示文摘 | Peter O Jost W Axel H | 2003 | Urology2003，61，1： | 1 |
| 10 | Pancreatic involvement in von Hippel-Lindau disease显示文摘 | Pascal R. Hammel Valerie Vilgrain Benoit Terris Alfred Penfornis Alain Sauvanet Jean-Michel Correas Dominique Chauveau Axel Balian Catherine Beigelman Dermot O'Toole Pierre Bernades Philippe Ruszniewski Stephane Richard | 2000 | Gastroenterology2000，，4： | 1 |
| 11 | The use of a refined zebrafish embryo bioassay for the assessment of aquatic toxicity显示文摘 | Axel O | 2000 | Research Note2000，29，7： | 1 |
| 12 | Spectroscopy of nanoscopic semiconductor rings显示文摘 | AXELL L JOHANNES L R ALEXENDER G O | 2000 | Physical Review letters2000，，84： | 1 |
| 13 | Biomarkers of kidney injury显示文摘 | Anja U Nicholas O Axel H | | 0，，： | 1 |
| 14 | Influence of intralesional surgery on treatment outcome of chondrosarcoma显示文摘 | Toshifumi O Norbert L Axel H | 1996 | Cancer1996，77，7： | 1 |
| 15 | ERC: A Theory of Equity, Reciprocity, and Cooperation显示文摘 | Bolton G E Axel O | 2000 | American Economic Review2000，90，1： | 1 |
| 16 | How can toxicogenomics inform risk assessment? 显示文摘 | AXEL O LESLEY O URSULA GR | 2005 | Toxicol Appl Pharm2005，207，2： | 1 |
| 17 | Identity of TUNEL-positive cells in the oral buccal epithelium of normal mucosa and lichen lesions显示文摘 | Karatsaidis A Schreurs O Axell T | 2004 | J Oral Pathol Med2004，33，： | 1 |
| 18 | Inhibition of transforming growth factor-beta/Smad signaling pathway in the epthelium of oral lichen显示文摘 | Karatsaidis A Schreurs O Axell T | 2003 | Invest Dermatol2003，121，6： | 1 |
| 19 | Inhibition of the transforming growth factor-β/Smad singaling pathway in the epithelium of oral lichen 显示文摘 | Karatsaidis A Schreurs O Axell T | 2003 | J Invest Dermatol2003，121，6： | 1 |
| 20 | The Outcome of Patients Treated with Sunitinib Prior to Planned Nephrectomy in Metastatic Clear Cell Renal Cancer显示文摘 | Thomas Powles Christian Blank Simon Chowdhury Simon Horenblas John Peters Jonathan Shamash Naveed Sarwar Ekaterini Boleti Anju Sahdev Tim O’Brien Dan Berney Luis Beltran Paul Nathan John Haanen Axel Bex | 2011 | European Urology2011，，： | 1 |
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