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| 1 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 2 | Alpha-lipoic acid supplentation:tissue glutathione homeostasis at rest and after exercise显示文摘 | Khanna S Atalay M Laaksonen D E | 1999 | J Appl Physiol1999，86，： | 1 |
| 3 | Remaufacturing as a marketing strategy显示文摘 | Atalay Atasu M iklos Sarvary Wassenhove L N V | 2008 | Management Science2008，54，10： | 1 |
| 4 | Spontaneous resolution of lumbar vertebral eosinophilic granuloma 显示文摘 | Bavbek M Atalay B Altinors N | 2004 | Acta Neurochir (Wien)2004，146，6： | 1 |
| 5 | Cervical tuberculous spondylitis associated with systemic lupus erythematosus显示文摘 | Berker M Atalay B Soylemezoglu F | 2001 | Spinal Cord2001，10，： | 1 |
| 6 | Projection based method for segmentation of human face and its evaluation 显示文摘 | Baskan S Bulut M M Atalay V | 2002 | Pattern Rec- ognition Letters2002，23，14： | 1 |
| 7 | Anti-angiogenic property of edible berry in a model of hemangioma 显示文摘 | Atalay M Gordillo G Roy S | 2003 | FEBS Letters2003，544，13： | 1 |
| 8 | When the going gets tough, the tough go shopping: An examination of self-gifting behavior显示文摘 | Atalay A S and Meloy M G | 2006 | Advances in Consumer Research2006，33，1： | 1 |
| 9 | Anti-angiogenic Property of edible berry in a model of hemangioam显示文摘 | Atalay M G GayleRoy S | 2003 | Febs Letters2003，544，1： | 1 |
| 10 | Effect of zeolite particle size on the performance of polymer-zeolite mixed matrix membranes显示文摘 | Tantekin - Ersolmaz S B Atalay - Oral S Tatler M | 2000 | J Membr Sci2000，175，： | 1 |
| 11 | Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats 显示文摘 | Kohaie Szabo Z Atalay M | 2010 | Mech Ageing Dev2010，131，1： | 1 |
| 12 | Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats 显示文摘 | Koltai E Szabo Z Atalay M | 2010 | Mech Ageing Dev2010，131，1： | 1 |
| 13 | Microleakage and SEM evaluationof fissure sealants by use d self-etching priming agents 显示文摘 | H annig M Gr'Me A Atalay S | 2004 | J Dent2004，32，1： | 1 |
| 14 | Cost of paid transplantation abroad: possible donor-origin early multiple myeloma in a renal transplant recipient treated using bortezomib 显示文摘 | Solak Y Atalay H Anil M | 2010 | Transplant Proc2010，42，7： | 1 |
| 15 | The Topology of the Federal Funds Market 显示文摘 | BECH M L ATALAY E | 2010 | Physica A: Statistical Mechanics and Its Applications2010，389，22： | 1 |
| 16 | Exercise alters SIRT1,SIRT6,NAD and NAMPT levels in skeletal muscle of aged rats显示文摘 | Koltai E Szabo Z Atalay M | 2010 | Mech Ageing Dev2010，131，1： | 1 |
| 17 | Postoperative complicationsafter abdominal surgery in patients with chronic obstructive pul-monary disease显示文摘 | Atalay F Uygur F Comert M | 2011 | Turk J Gastroenterol2011，22，5： | 1 |
| 18 | Altered oxidative stress in overtrained athletes显示文摘 | Tanskanen M Atalay M Unsitalo A | 2010 | J Sports Sci2010，28，3： | 1 |
| 19 | Nogo-A inhibitory peptide (NEP 1-40) increases pan-cadherin expression following mild cortical contusion injury in rats显示文摘 | Atalay B Bavbek M Ozen O | 2008 | Turk Neurosurg2008，18，4： | 1 |
| 20 | Postoperative complicationsafter abdominal surgery in patients with chronic obstructivepulmonary disease 显示文摘 | Atalay F Uygur F Comert M | 2011 | Turk J Gastroenterol2011，22，5： | 1 |
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