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| 1 | Mechanical and cellular processes driving cervical myelopathy显示文摘Cervical myelopathy is a well-described clinical syndrome that may evolve from a combination of etiological mechanisms. It is traditionally classified by cervical spinal cord and/or nerve root compression which varies in severity and number of levels involved. The vast array of clinical manifestations of cervical myelopathy cannot fully be explained by the simple concept that a narrowed spinal canal causes compression of the cord, local tissue ischemia, injury and neurological impairment. Despite advances in surgical technology and treatment innovations, there are limited neuro-protective treatments for cervical myelopathy, which reflects an incomplete understanding of the pathophysiological processes involved in this disease. The aim of this review is to provide a comprehensive overview of the key pathophysiological processes at play in the development of cervical myelopathy. | Roisin T Dolan Joseph S Butler John M O'Byrne Ashley R Poynton | 2016 | World Journal of Orthopedics2016，7，1： | 5 |
| 2 | Small artery structure and hypertension: adaptive changes and target organ damage显示文摘 | Ashley S Izzard Damiano Rizzoni Enrico Agabiti-Rosei Anthony M Heagerty | 2005 | Journal of Hypertension2005，，2： | 5 |
| 3 | Bone marrow- generated dendritic cells pulsed with tumor extracts or tumor RNA induc ed antitumor immunity against central nervous system tumors显示文摘 | Ashley DM Faiola B Nair S | 1997 | J Exp Med1997，186，7： | 2 |
| 4 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 5 | 2009年南极冰穹A的双色天光背景统计和分析显示文摘天光背景是天文台址的一个重要指标。利用2009年位于南极冰穹A的CSTAR望远镜两个波段的观测数据,对南极冰穹A的天光背景进行了统计和分析。结果表明约74%的g波段天光背景的ADU值小于每像素100/s;90.5%的r波段的天光背景的ADU值小于每像素100/s。在不考虑大气消光的情况下,定标后的结果为2009年冰穹A的观测数据中天光背景亮度的中值:g波段为19.9 mag/arcsec2,r波段为20.1 mag/arcsec2。 | 宗伟凯 付建宁 牛家树 Ashley Michael C B 宫雪非 Lawrence J S 刘强 Luong-Van Daniel Pennypacker C R Storey John W V 王灵芝 王力帆 杨惠根 袁祥岩 York Donald G 朱镇熹 | 2014 | 天文研究与技术2014，11，1： | 2 |
| 6 | Tmmunohistochemical distrbution of C-erbB-2 in situ breast carcinoma dedailed morphological analysis 显示文摘 | 11,Ramachandra S Machin L Ashley S | 1990 | J1990，161，1： | 1 |
| 7 | Warp Drive Underwater显示文摘 | Ashley S | 2002 | Scientific American Special Online Issue2002，，2： | 1 |
| 8 | Basal-like breastcarcinomas:clinical outcome and response to chemotherapy显示文摘 | Banerjee S Reis-Filho JS Ashley S | 2006 | J Clin Pathol2006，59，： | 1 |
| 9 | Keep up the pace: declines in simple repetitive timing differentiate healthy aging from the earliest stages of Alzheimer's disease显示文摘 | Ashley S Bangert David A Balota | 2012 | J Int Neuropsychol Soc2012，18，6： | 1 |
| 10 | Clinical detection of sarcopenic obesity by bioelectrical impedance analysis显示文摘 | Heber D Ingles S Ashley JM | | 0，，3： | 1 |
| 11 | Management of anemia in pa- tients receiving chemotherapy 显示文摘 | Waters JS OB rien ME Ashley S | 2002 | J Clin Oncol2002，20，： | 1 |
| 12 | Capecitabine and oxaliplatin foradvanced esophagogastric cancer显示文摘 | Cunningham D Okines AF Ashley S | 2010 | NEngl J Med2010，358，1： | 1 |
| 13 | The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria显示文摘 | Elizabeth MH Wellington Alistair BA Boxall Paul Cross Edward J Feil William H Gaze Peter M Hawkey Ashley S Johnson-Rollings Davey L Jones Nicholas M Lee Wilfred Otten Christopher M Thomas A Prysor Williams | 2013 | The Lancet Infectious Diseases2013，，2： | 1 |
| 14 | Cystatin C and cystatin glomerular filtration rate as markers of early renal disease in Asian Indian subjects with glucose intolerance(CURES-32)显示文摘 | Surendar J Anuradha S Ashley B | 2009 | Metab Syndr Relat Disord2009，7，5： | 1 |
| 15 | Intraoperative local an- aesthesia for reduction of postoperative pain following general an- aesthesia for dental treatment in children and adolescents显示文摘 | Parekh S Gardener C Ashley PF | 2014 | Co- chrane Database Syst Rev2014，12，00： | 1 |
| 16 | The association of chemotherapy induced neutropenia on treatment outcomes in small ceLl lung cancer显示文摘 | Banerji U Ashley S Coward J | 2006 | Lung Cancer2006，54，3： | 1 |
| 17 | Early response to platinum-based first-line chemotherapy in non-small cell lung cancer may predict survival显示文摘 | Sirohi B Ashley S Norton A | 2007 | J Thorac Oncol2007，2，8： | 1 |
| 18 | Triplet repeat expansion mutations:the example of fragile X syndrome显示文摘 | Warren S T Ashley C T Jr | 1995 | Annu Rev Neurosci1995，18，： | 1 |
| 19 | Determination of 10 carcinogenic polyeyclic aromatic hydrocarbons in mainst-ream cigarette smoke显示文摘 | Ding Y S Ashley D L Watson C H | 2007 | J Agri & Food Chem2007，55，： | 1 |
| 20 | Basal-like breast carcinomas:clinical outcome and response to chemotherapy显示文摘 | BANERJEE S REIS FILHO J S ASHLEY S | 2006 | J Clin Pathol2006，59，7： | 1 |
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