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| 1 | Taming of macrophage and microglial cell activation by microRNA-124显示文摘 | Ashley T Conrad Bonnie N Dittel | 2011 | Cell Research2011，21，2： | 5 |
| 2 | Alcoholic hepatitis: The pivotal role of Kupffer cells显示文摘Kupffer cells play a central role in the pathogenesis of alcoholic hepatitis(AH). It is believed that alcohol increases the gut permeability that results in raised levels of serum endotoxins containing lipopolysaccharides(LPS). LPS binds to LPS-binding proteins and presents it to a membrane glycoprotein called CD14, which then activates Kupffer cells via a receptor called tolllike receptor 4. This endotoxin mediated activation of Kupffer cells plays an important role in the inflammatory process resulting in alcoholic hepatitis. There is no effective treatment for AH, although notable progress has been made over the last decade in understanding the underlying mechanism of alcoholic hepatitis. We specifically review the current research on the role of Kupffer cells in the pathogenesis of AH and the treatment strategies. We suggest that the imbalance between the pro-inflammatory and the anti-inflammatory process as well as the increased production of reactive oxygen species eventually lead to hepatocyte injury, the final event of alcoholic hepatitis. | Duminda B Suraweera Ashley N Weeratunga Robert W Hu Stephen J Pandol Richard Hu | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 3 |
| 3 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 4 | The pathway study: results of a pilot feasibility study in patients suspected of having lung carcinoma investigated in a conventional chest clinic setting compared to a centralised two-stop pathway显示文摘 | P.V Murray M.E.R O’Brien R Sayer N Cooke G Knowles A.C Miller V Varney N.P Rowell A.R Padhani D MacVicar A Norton S Ashley I.E Smith | 2003 | Lung Cancer2003，，3： | 1 |
| 5 | Prognostic value of heart rate incrase at onset of exercise testing显示文摘 | Leeper N J Dewey F E Ashley E A | 2007 | Circulation2007，115，4： | 1 |
| 6 | Synthesis, character- ization, and polymerization studies of ethylenebis(hexameth- ylindenyl) complexes of zirconium and hafnium 显示文摘 | Ransom P Ashley A Brown N etal | 2011 | Organo- metallics2011，30，4： | 1 |
| 7 | Planning for multipurpose greenways in Concord,North Carolina显示文摘 | Xiang W N Young J | 2004 | Landscape and Urban Planning2004，68，： | 1 |
| 8 | CpG-depleted adeno-associated virus vectors evade immune detection显示文摘 | Faust Susan M Bell Peter Cutler Benjamin J Ashley Scott N Zhu Yanqing Rabinowitz Joseph E Wilson James M | 2013 | Journal of Clinical Investigation2013，，7： | 1 |
| 9 | Elevated in-home sediment contaminant concentrations--The consequence of a particle settling-winnowing process from Hurricane Katrina floodwaters 显示文摘 | Ashley N A Valsaraj K T Thibodeaux L J | 2008 | Chemosphere2008，70，5： | 1 |
| 10 | Mitochondrial DNA is a direct target of anti - can- cer anthracycline drugs 显示文摘 | Ashley N Poulton J | 2009 | Biochem Biophys Res Commun2009，378，3： | 1 |
| 11 | Growth in children with congenital heart disease显示文摘 | Carrie D Ashley N Aaron P | 2013 | Pediatri2013，131，1： | 1 |
| 12 | In vivo and in vitro characterization of a novel neuroprotective strategy for stroke: isehemie postconditioning显示文摘 | Pignataro G Meller R Inoue K Ordonez A N Ashley M D Xiong Z | 2008 | J Cereb Blood Flow Metab2008，28，： | 1 |
| 13 | Cohort profile: the Jamaican 1986 birth cohort study显示文摘 | McCaw-Binns A Ashley D Samms-Vaughan M Wilks R Fer- guson T Younger N | 2011 | International journal of epidemiology2011，40，6： | 1 |
| 14 | Prognostic value of heart rate increase at onset of exercise testing 显示文摘 | Leeper N J Dewey FE Ashley FA | 2007 | Circulation2007，115，4： | 1 |
| 15 | An alginate-based fertilizer to reduce eutrophication of aquatic environments显示文摘 | Kay Ashley N | 2004 | Transactions of the Kansas Academy of Science2004，107，3： | 1 |
| 16 | Successful blood conservation during craniosynostotic correction with dual therapy using procrit and cell saver 显示文摘 | Krajewski K Ashley RK Pung N | 2008 | J Craniofac Surg2008，19，1： | 1 |
| 17 | The role of estrogen receptor and 13 in regulating vascular smooth muscle cell prolif eration is based on sex 显示文摘 | Melissa E Hogg M D Ashley K Vavra M D Monisha N Banerjee 13 S | 2011 | Journal of Surgical Re- search2011，9，21： | 1 |
| 18 | Ultrasonic extraction as a sample preparation technique for elemental analysis by atomic spectrometry显示文摘 | KEVIN ASHLEY RONNEE N ANDREWS LAURA CAVAZOS | 2001 | J Anal At Spectrom2001，，16： | 1 |
| 19 | Cognitive interventions to reduce diagnostic error: a narrative review显示文摘 | Mark L Graber Stephanie Kissam Velma L Payne Ashley N D Meyer Asta Sorensen Nancy Lenfestey Elizabeth Tant Kerm Henriksen Kenneth LaBresh Hardeep Singh | 2012 | BMJ Quality & Safety2012，，7： | 1 |
| 20 | Intrave- nous uterine leiomyosarcomatosis with intracardial ex- tension显示文摘 | MOORJANI N KUO J ASHLEY S | 2005 | J Card Surg2005，20，： | 1 |
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