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| 1 | Validation of the Rockall scoring system for outcomes from non-variceal upper gastrointestinal bleeding in a Canadian setting显示文摘AIM: To validate the Rockall scoring system for predicting outcomes of rebleeding, and the need for a surgical procedure and death. METHODS: We used data extracted from the Registry of Upper Gastrointestinal Bleeding and Endoscopy including information of 1869 patients with non-variceal upper gastrointestinal bleeding treated in Canadian hospitals. Risk scores were calculated and used to classify patients based on outcomes. For each outcome, we used χ2 goodness-of-fit tests to assess the degree of calibration, and built receiver operating characteristic curves and calculated the area under the curve (AUC) to evaluate the discriminative ability of the scoring system. RESULTS: For rebleeding, the χ2 goodness-of-fit test indicated an acceptable fit for the model [χ2 (8) = 12.83, P = 0.12]. For surgical procedures [χ2 (8) = 5.3, P = 0.73] and death [χ2 (8) = 3.78, P = 0.88], the tests showed solid correspondence between observed proportions and predicted probabilities. The AUC was 0.59 (95% CI: 0.55-0.62) for the outcome of rebleeding and 0.60 (95% CI: 0.54-0.67) for surgical procedures, representing apoor discriminative ability of the scoring system. For the outcome of death, the AUC was 0.73 (95% CI: 0.69-0.78), indicating an acceptable discriminative ability. CONCLUSION: The Rockall scoring system provides an acceptable tool to predict death, but performs poorly for endpoints of rebleeding and surgical procedures. | Robert A Enns Yves M Gagnon Alan N Barkun David Armstrong Jamie C Gregor Richard N Fedorak RUGBE Investigators Group | 2006 | World Journal of Gastroenterology2006，12，48： | 14 |
| 2 | ACC/AHA/ASE 2003 guideline update for the clinical application of echocardiography: summary article显示文摘 | Melvin D Cheitlin William F Armstrong Gerard P Aurigemma George A Beller Fredrick Z Bierman Jack L Davis Pamela S Douglas David P Faxon Linda D Gillam Thomas R Kimball William G Kussmaul Alan S Pearlman John T Philbrick Harry Rakowski Daniel M Thys Elliot | 2003 | Journal of the American College of Cardiology2003，，5： | 1 |
| 3 | Chief Executive officer Equity Incentives and Accounting Ir- regularities 显示文摘 | Armstrong Christopher S Jagolinzer Alan D Larcker David F | 2010 | Journal of Accounting Reaserch2010，，48： | 1 |
| 4 | Critical power in adolescents: physiological bases and assessment using all-out exercise显示文摘 | Alan R. Barker Bert Bond Cali Toman Craig A. Williams Neil Armstrong | 2012 | European Journal of Applied Physiology2012，，4： | 1 |
| 5 | Muscle phosphocreatine and pulmonary oxygen uptake kinetics in children at the onset and offset of moderate intensity exercise显示文摘 | Alan R. Barker Joanne R. Welsman Jonathan Fulford Deborah Welford Craig A. Williams Neil Armstrong | 2008 | European Journal of Applied Physiology2008，，6： | 1 |
| 6 | EUS: a meta-analysis of test performance in suspected choledocholithiasis显示文摘 | Frances Tse Louis Liu Alan N. Barkun David Armstrong Paul Moayyedi | 2008 | Gastrointestinal Endoscopy2008，，2： | 1 |
| 7 | Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 713C and SARS-CoV-2 main protease显示文摘RNA viruses are critically dependent upon virally encoded proteases to cleave the viral polyproteins into functional proteins.Many of these proteases exhibit a similar fold and contain an essential catalytic cysteine,offering the opportunity to inhibit these enzymes with electrophilic small molecules.Here we describe the successful application of quantitative irreversible tethering(qIT)to identify acrylamide fragments that target the active site cysteine of the 3C protease(3Cpro)of Enterovirus 71,the causative agent of hand,foot and mouth disease in humans,altering the substrate binding region.Further,we re-purpose these hits towards the main protease(Mpro)of SARS-CoV-2 which shares the 3C-like fold and a similar active site.The hit fragments covalently link to the catalytic cysteine of Mpro to inhibit its activity.We demonstrate that targeting the active site cysteine of Mpro can have profound allosteric effects,distorting secondary structures to disrupt the active dimeric unit. | Bo Qin Gregory B.Craven Pengjiao Hou Julian Chesti Xinran Lu Emma S.Child Rhodri M.L.Morgan Wenchao Niu Lina Zhao Alan Armstrong David J.Mann Sheng Cui | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 0 |
| 8 | New Methods and Synthetic Applications of Asymmetric Nitrogen Transfer显示文摘N-alkoxycarbonyl- 和 N-carboxamidooxaziridines 的结构 / 反应关系被探索,并且条件为硫化物和主要的胺的有效胺化作用被发现。有链烯的这些 oxaziridines 的反应也被检验,并且导致有趣的新 heteroatom 转移反应产品。最后, 2-alkoxydihydropyrans 的 aminative 重新整理导致能经历合成操作给的 pyrrolidines 的有用 stereocontrolled 合成[2.2.1 ]- 并且[3.2.1 ]-azabicycles。 | ARMSTRONG, Alan EDMONDS, lan COOKE, Richard S. SHANAHAN, Stephen E. KNIGHT, Jamie D. CUMMING, Graham R. | 2005 | Chinese Journal of Chemistry2005，23，9： | 0 |
| 9 | 对儿童运动代谢的新认识(英文)显示文摘Research in paediatric exercise metabolism has been constrained by being unable to interrogate muscle in vivo.Conventionally,research has been limited to the estimation of muscle metabolism from observations of blood and respiratory gases during maximal or steady state exercise and the analysis of a few muscle biopsies taken at rest or post-exercise.The purpose of this paper is to review how the introduction of 31P-magnetic resonance spectroscopy and breath-by-breath oxygen uptake kinetics studies has contributed to current understanding of exercise metabolism during growth and maturation.Methodologically robust studies using 31P-magnetic resonance spectroscopy and oxygen uptake kinetics with children are sparse and some data are in conflict.However,it can be concluded that children respond to exercise with enhanced oxygen utilization within the myocyte compared with adults and that their responses are consistent with a greater recruitment of type I muscle fibres.Changes in muscle metabolism are age,maturation- and sex-related and dependent on the intensity of the exercise challenge.The introduction of experimental models such as 'priming exercise' and 'work-to-work' transitions provide intriguing avenues of research into the mechanisms underpinning exercise metabolism during growth and maturation. | Neil Armstrong Alan R.Barker | 2012 | Journal of Sport and Health Science2012，1，1： | 0 |
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