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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Periodontitis and arthritis interaction in mice involves a shared hypeF inflammatory genotype and functional immunological interferences显示文摘 | Trombone AP Claudino M Colavite P | 2010 | Genes Immun2010，11，6： | 1 |
| 3 | Salt tolerance coffered by overexpression of a vacuolar Na^+/H^+ antiporter in Arabidopsis显示文摘 | APES M P AHARON G S SNEDDEN W A | 1999 | Science1999，285，： | 1 |
| 4 | Christensen, present and long-term composition of MSW landfill leachate: a review 显示文摘 | KJELDSEN P BARLAZ M AB ROOKER AP | 2002 | Crit Rev Environ Sci Technol2002，32，： | 1 |
| 5 | Effect of ischemia and reperfusion on protein oxidation in isolated rabbit hearts 显示文摘 | Tatarkova Z Ap lan P Matejovicova M | 2005 | Physiol Res2005，54，2： | 1 |
| 6 | Least limiting water range:A potential indicator of changes in near-surface soil physical quality afterthe conversion of Brazilian Savanna into pasture显示文摘 | LEO T P DA SILVA AP MACEDO M C M | 2006 | Soil&Tillage Re-search2006，88，： | 1 |
| 7 | Cell dysfunction in atherosclerosis and the inchemic manifestations of coronary artery disease 显示文摘 | Kinlay S Creager M Libby P Ganz P | 1997 | Am J Cardiol1997，79，5： | 1 |
| 8 | Magnification chromoen- doscopy for the detection of intestinal metaplasia and dysplasia in Barrettg oesophagus显示文摘 | Sharma P Weston AP Topalovski M | 2003 | Gut2003，52，1： | 1 |
| 9 | Apert syndrome: the current role of prenatal ultrasound and genetic analysis in diagnosis and counselling 显示文摘 | Athanasiadis AP Zafrakas M Polychronou P | 2008 | Fetal Diagn Ther2008，24，4： | 1 |
| 10 | The use of Merocel nasal pack in the treatment of epistaxis显示文摘 | Pringle M B Baseley P Brightwell AP | 1996 | J Laryngol Otol1996，110，6： | 1 |
| 11 | Magnification chromoendoscopy for detection of intestinal metaplasia and dysplasia in Barrett'oesophagus显示文摘 | Sharma P Weston AP Topalovski M | 2003 | Gut2003，52，： | 1 |
| 12 | Effect of mast cell stabilizers in hyperhomocysteinemia-induced cardiac hypertrophy in rats 显示文摘 | Singh AP Singh M Balakumar P | 2008 | J Cardiovasc Pharmacol2008，51，6： | 1 |
| 13 | A mutant telomerase defective in nuclear-cyto- plasmic shuttling fails to immortalize ceils and is associated with mitochondrial dysfunction 显示文摘 | Kovalenko OA Caron M J Ulema P Medrano C Thomas AP Kimura M | 2010 | Aging Cell2010，9，2： | 1 |
| 14 | Hepatitis B virus DNA level,precore mutations,genotypes and histological activity in chronic hepatitis B显示文摘 | Lindh M Horal P Dhillon AP | 2000 | Viral Hepat2000，7，： | 1 |
| 15 | Hepatitis B virus DNA levels,precore mutations,genotypes and histological activity in chronic hepatitis B显示文摘 | Lindh M Horal P Dhillon AP | | 0，，4： | 1 |
| 16 | Hemodynamic, autonomic and baroreflex changes after one night sleep deprivation in healthy volunteers 显示文摘 | Pagani M Pizzinelli P Traon AP | 2009 | Auto Neurosci2009，145，12： | 1 |
| 17 | Measurement of the inorganic pyrophosphate in tissure of Pisum sntivum L 显示文摘 | Edwards J ap Rees T Wilson P M | 1984 | Planta1984，162，： | 1 |
| 18 | Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea 显示文摘 | Mueller C Scholer A Laule-Kilian K Martina B Schindler C Buser P Pfisterer M Perruchoud AP | 2004 | N Engl J Med2004，350，： | 1 |
| 19 | Host density predicts presence of cuckoo parasitism in reed warblers显示文摘 | Stokke BG Hafstad I Rudolfsen G Bargain B Beier J Campàs DB Dyrcz A Honza M Leisler B Pap PL Patapavicius R Procházka P Schulze-Hagen K Thomas R Moksnes A M(o)ller AP R(o)skaft E Soler M | | 0，，： | 1 |
| 20 | Prolonged exposure of T cells to TNF down-regulates TCR zeta and expression of the TCR/CD3complex at the cell surface显示文摘 | Isomki P Panesar M Annenkov A Clark JM Foxwell BM Chernajovsky Y Cope AP | 2001 | J Immunol2001，166，9： | 1 |
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