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| 1 | VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab. | Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann | 2008 | World Journal of Gastroenterology2008，14，26： | 15 |
| 2 | Stem cell treatment and cerebral palsy: Systemic review and meta-analysis显示文摘BACKGROUND Perinatal complications may result in life-long morbidities,among which cerebral palsy(CP)is the most severe motor disability.Once developed,CP is a nonprogressive disease with a prevalence of 1-2 per 1000 live births in developed countries.It demands an extensive and multidisciplinary care.Therefore,it is a challenge for our health system and a burden for patients and their families.Recently,stem cell therapy emerged as a promising treatment option and raised hope in patients and their families.AIM The aim is to evaluate the efficacy and safety of stem cell treatment in children with CP using a systematic review and meta-analysis METHODS We performed a systematic literature search on PubMed and EMBASE to find randomized controlled clinical trials(RCT)investigating the effect of stem cell transplantation in children with CP.After the review,we performed a randomeffects meta-analysis focusing on the change in gross motor function,which was quantified using the gross motor function measure.We calculated the pooled standardized mean differences of the 6-and/or 12-mo-outcome by the method of Cohen.We quantified the heterogeneity using the I-squared measure.RESULTS We identified a total of 8 RCT for a qualitative review.From the initially selected trials,5 met the criteria and were included in the meta-analysis.Patients’population ranged from 0.5 up to 35 years(n=282).We detected a significant improvement in the gross motor function with a pooled standard mean difference of 0.95(95%confidence interval:0.13-1.76)favoring the stem cell group and a high heterogeneity(I2=90.1%).Serious adverse events were rare and equally distributed among both intervention and control groups.CONCLUSION Stem cell therapy for CP compared with symptomatic standard care only,shows a significant positive effect on the gross motor function,although the magnitude of the improvement is limited.Short-term safety is present and further highquality RCTs are needed. | Simone Eggenberger Céline Boucard Andreina Schoeberlein Raphael Guzman Andreas Limacher Daniel Surbek Martin Mueller | 2019 | World Journal of Stem Cells2019，11，10： | 8 |
| 3 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 4 | Cachexia and pancreatic cancer: Are there treatment options?显示文摘Cachexia is frequently described in patients with pancreatic ductal adenocarcinoma(PDAC)and is associated with reduced survival and quality of life.Unfortunately,the therapeutic options of this multi-factorial and complex syndrome are limited.This is due to the fact that,despite extensive preclinical and clinical research,the underlying pathological mechanisms leading to PDAC-associated cachexia are still not fully understood.Furthermore,there is still a lack of consensus on the definition of cachexia,which complicates the standardization of diagnosis and treatment as well as the analysis of the current literature.In order to provide an efficient therapy for cachexia,an early and reliable diagnosis and consistent monitoring is required,which can be challenging especially in obese patients.Although many substances have been tested in clinical and preclinical settings,so far none of them have been proven to have a long-term effect in ameliorating cancer-associated cachexia.However,recent studies have demonstrated that multidimensional therapeutic modalities are able to alleviate pancreatic cancerassociated cachexia and ultimately improve patients’outcome.In this current review,we propose a stepwise and pragmatic approach to facilitate and standardize the treatment of cachexia in pancreatic cancer patients.This strategy consists of nutritional,dietary,pharmacological,physical and psychological methods. | Tara C Mueller Marc A Burmeister Jeannine Bachmann Marc E Martignoni | 2014 | World Journal of Gastroenterology2014，20，28： | 3 |
| 5 | The effects ofmergers:an international comparison显示文摘 | Gugler K Mueller DC Yurtoglu BB Zulehner C | 2003 | International Journal ofIndustrial Organization2003，21，： | 1 |
| 6 | The CM-SAF Oper-ational Scheme for the Satellite based Retrieval of Solar SurfaceIrradiance-A LUT based Eigenvector Hybrid Approach显示文摘 | Mueller R W Matsoukas C Gratzki A | 2009 | Re-mote Sensing of Environment2009，113，5： | 1 |
| 7 | Inflammation and long-term mortality after ono-ST elevation acute coronary syndrome treated with a very early invasive strategy in 1042 consecutive patients显示文摘 | Mueller C Buettner H J Hodgson J M | 2002 | Circula-tion2002，105，： | 1 |
| 8 | Suppression of virus accumulation in transgenic plants exhibiting silencing of nuclear gene 显示文摘 | English J J Mueller E Baulcombe D C | 1996 | Plant Cell1996，8，： | 1 |
| 9 | Primary stability of various forms of osteosynthesis in the treatment of fractures of the proximal tibia显示文摘 | Mueller CA Eingartner C Schreitmueller E et a1 | 2005 | J Bone Joint Surg(Br)2005，87，3： | 1 |
| 10 | Collagen typeIinduces disruption of E-cadherin-mediated cell-cell con-tacts and promotes proliferation of pancreatic carcinomacells 显示文摘 | KOENIG A MUELLER C HASELC | 2006 | Cancer Res2006，66，： | 1 |
| 11 | Recombinant AAV as a platform for translating the therapeutic potential of RNA interference 显示文摘 | Borel F Kay MA Mueller C | 2014 | Mol Ther2014，22，4： | 1 |
| 12 | Development of a multi-target screening analysis for 301 drugs using a QTrap liquid chromatography/tandem mass spectrometry system and automated library searching显示文摘 | Mueller C A Weinmann W Dresen S | 2005 | Rapid Comm Mass Spectrom2005，，19： | 1 |
| 13 | Fibre Production and SheepBreeding in South America, Proceedings of the 18th Conference Barossa Valley, South Australia 显示文摘 | Cardellino R C Mueller J P | 2009 | Proc Assoc Advmt Anim Breed Genet2009，18，： | 1 |
| 14 | Industrial Research and Development, Intangible Capital Stocks, and Firm Profit Rates 显示文摘 | Grabowski H G D C Mueller | 1978 | The Bell Journal of Economics1978，9，2： | 1 |
| 15 | Patents, research and development, and the measurement of inventive activity 显示文摘 | Mueller D C | 1966 | Journal of In- dustry Economics1966，15，1： | 1 |
| 16 | Primary stability of various forms of osteosynthesis in the treatment of fractures of the proximal tibia显示文摘 | Mueller CA Eingartner C Schreitmueller E | 2005 | J Bone Joint Surg Br2005，87，3： | 1 |
| 17 | Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea显示文摘 | Mueller C Scholer A Laule-Kilian K | 2004 | N Engl J Med2004，350，7： | 1 |
| 18 | The in- tergration of BNP and NT-proBNP into clinical medicine 显示文摘 | Mueller C Breidthardt T Laule-Kilian K | 2007 | Swiss Med Wkly2007，137，： | 1 |
| 19 | Association of transcription factor polymorphisms PITX3 and EN1 with Parkinson's disease 显示文摘 | Haubenberger D Reinthaler E Mueller J C | 2011 | Neurobiol Aging2011，32，2： | 1 |
| 20 | Multiple regions of alpha-synuclein are associated with Parkinson′s disease显示文摘 | MUELLER J C FUCHS J HOFER A | | 0，，04： | 1 |
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