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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | 脂质组学改善传统危险因素预测的2型糖尿病患者的心血管事件显示文摘临床脂质测定并未显示出糖尿病或心血管病相关的脂质代谢改变的复杂性。脂质组学则能够评估可作为疾病风险潜在标志物的数百种脂质种类。方法:纳入来自糖尿病治疗和血管保护行动。 | 刘莉 叶鹏 Alshehry ZH Mundra PA Barlow CK Mellett NA Wong G McConville MJ Simes J Tonkin AM Sullivan DR Barnes EH Nestel PJ Kingwell BA Marre M Neal B Poulter NR Rodgers A Williams B Zoungas S Hillis GS Chalmers J Woodward M Meikle PJ | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 3 | Cardiomyocytes as effectors of nitric oxide signalling 显示文摘 | Seddon M Shah AM Casadei B | 2007 | Cardiovasc Res2007，75，2： | 1 |
| 4 | Dietary carcinogens and anticarcinogens: Oxygen radicals and degenerative diseases 显示文摘 | AMES B M | 1983 | Science1983，221，： | 1 |
| 5 | Urinary 8-hydroxy-2' -deoxyguanosine as a biological marker of in vivo oxidative DNA damage显示文摘 | Shigenaga M K Gimeno C J Ames B N | 1989 | Proc Natl Aead Sci USA1989，86，24： | 1 |
| 6 | The relevance of WHO injury surveillance guidelines for evaluation: learning from the aboriginal community-centered injury surveillance system (ACCISS) and two institution-based systems 显示文摘 | Auer AM Dobmeier TM Haglund B J et M | 2011 | BMC Public Heahh2011，11，： | 1 |
| 7 | Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease显示文摘 | SCHLCHINGER V BRITTEN M B ZEIHER AM | 2000 | Circulation2000，101，： | 1 |
| 8 | Prognostic significance of the admission plasma B-type brain natriuretic peptide measurement in patients with first STelevation myocardial infarction in comparion with C-reactive protein and TIMI risk score显示文摘 | Sobkowicz B Barbara M | 2007 | Clin Chim Acta2007，382，： | 1 |
| 9 | Cardiomyocytes as effectors of nitric oxide signaling 显示文摘 | Seddon M Shah AM Casadei B | 2007 | Cardiovasc Res2007，75，2： | 1 |
| 10 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 11 | Role of the dopaminer- gic system in the development of myopia in children and ado- leseents显示文摘 | Nebbioso M Plateroti AM Pueei B | 2014 | J Child Neurol2014，29，12： | 1 |
| 12 | Albumin mediated regulation of cellular glutathione and nuclear factor kappa B acti- vation 显示文摘 | Cantin AM Paquette B Richter M | 2000 | Am J RespirCrit Care Med2000，162，41： | 1 |
| 13 | Differential interaction of the CD2 extracellular and intracellular domains with the tyrosine phosphatase CD45 and the zeta chain of the TCR/CD3/zeta complex显示文摘 | Verhagen AM Schraven B Wild M | 1996 | Eur J Immunol1996，26，12： | 1 |
| 14 | Oxidants, antioxidants, and the degeneration disease of the aging显示文摘 | Ames B N Shigenaga M K Hagen T M | 1993 | Pro Natl Acad Sci USA1993，90，： | 1 |
| 15 | Genetic alterations during colorectal-tumor development显示文摘 | Vogelstein B Fearon ER Hamilton SR Kern SE Preisinger AC Leppert M Nakamura Y White R Smits AM Bos JL | 1988 | N Engl J Med1988，319，9： | 1 |
| 16 | Oxidative damage and mitochondrial decay in aging显示文摘 | Shigenaga M K Hagen T M Ames B N | 1994 | Proc Nat Acad Sci USA1994，91，10： | 1 |
| 17 | Gas phase oxidants of cite smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma : Protective effects of ascorbic acid 显示文摘 | FREI B FOR7I'E T M AMES B N | 1991 | Biochem J1991，277，： | 1 |
| 18 | Immunohistologic characterization of gastroinstinal stromal tumors:a study of 82 cases compared with 11 cases of leiomyomas显示文摘 | Ma C K Am in M B Kintanar E | 1993 | Mod Pathol1993，6，2： | 1 |
| 19 | A multi-stage decisiowmaking process for multi pie attributes analysis under an internal-valued fuzzy environ- ment显示文摘 | MOUSAVI S M VAHDANI B TAVAKKOL1 MOGHADD- AM R eta | 2012 | International Journal of Advanced Manufacturing Teehnology2012，64，912： | 1 |
| 20 | Patient-perceivedoutcomes of the AdVance sling up to 40 months post procedure显示文摘 | Suskind AM Bemstein B Murphy-Setzko M | 2011 | Neurourol Urodyn2011，30，7： | 1 |
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