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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | 左心质量与脑磁共振成像和认知功能的关系显示文摘左心室质量(1eft ventricularmass,LVM)被证实可以作为长期暴露于数个危险因素下时造成的靶器官损害的评估标准。有关中年LVM和晚期认知表现之间联系的资料很少。纳入StrongHeart研究(SHS,1993—1995)及其附属的CDCAI(脑血管病及其对美国印第安人的影响)研究(2010—2013)中721名成年研究对象(平均基础年龄56岁),这些人群心血管病风险较高。 | 黄洁 叶鹏 Haring B Omidpanah A Suchy Dicey AM Best LG Verney SP Shibata DK Cole SA Ali T Howard BV Buchwald D Devereux RB | 2017 | 中华高血压杂志2017，25，10： | 4 |
| 3 | 脂质组学改善传统危险因素预测的2型糖尿病患者的心血管事件显示文摘临床脂质测定并未显示出糖尿病或心血管病相关的脂质代谢改变的复杂性。脂质组学则能够评估可作为疾病风险潜在标志物的数百种脂质种类。方法:纳入来自糖尿病治疗和血管保护行动。 | 刘莉 叶鹏 Alshehry ZH Mundra PA Barlow CK Mellett NA Wong G McConville MJ Simes J Tonkin AM Sullivan DR Barnes EH Nestel PJ Kingwell BA Marre M Neal B Poulter NR Rodgers A Williams B Zoungas S Hillis GS Chalmers J Woodward M Meikle PJ | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 4 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 5 | Involvement of cell motility in tumor progreasion显示文摘 | Boyer B Valles AM Tucker GC | 1993 | Symp Soc Exp Biol1993，47，： | 2 |
| 6 | 在确诊并已接受治疗的原发性高血压患者中,炎症、内皮功能障碍和交感神经激活与血压之间的关系显示文摘研究结果表明,炎症、内皮功能紊乱、交感神经系统慢性激活在高血压发病机制中起重要作用。目前临床上关于血压与炎症、内皮功能紊乱以及交感神经系统激活之间的关系还不明确。该研究评估在确诊并已接受治疗的原发性高血压患者中,炎症[高敏C反应蛋白(high-sensitivity C-reactive protein,hsCRP)]、内皮细胞功能紊乱(内皮素1)和交感神经慢性激活(血浆肾上腺素和去甲肾上腺素)的生物标记物水平是否与血压的测量值相关。研究者同时试图应用血压和上述标记物之间的关系诊断顽固性高血压,并探讨降压药物对上述生物标记物的影响。 | Tycinska AM Mroczko B Musial WJ Sawicki R Kaminski K Borowska H Sobkowicz B Szmitkowski M. 叶鹏 | 2011 | 中华高血压杂志2011，19，11： | 2 |
| 7 | Identification of mycobacteria and other acid fast organisms associated with pulmonary disease显示文摘 | AE Ani B Diarra UR Dahle C Lekuk F Yetunde AM Somboro Tounkara Anatole J Idoko | 2011 | Asian Pacific Journal of Tropical Disease2011，，4： | 2 |
| 8 | Cardiomyocytes as effectors of nitric oxide signalling 显示文摘 | Seddon M Shah AM Casadei B | 2007 | Cardiovasc Res2007，75，2： | 1 |
| 9 | Assessment of hepatic perfusion parameters with dynamic MRI显示文摘 | Mateme B Smith AM Peelers F | 2002 | Mngn Rason Med2002，47，： | 1 |
| 10 | Simvastatin preserves the ischemia reperfusion myocardium in nomocholesterolemic rat hearts显示文摘 | LEFER AM CAMPLELL B SKIN YK | 1999 | Circulation1999，100，2： | 1 |
| 11 | Subcutaneous administration of nimodipine improves bioavailability in rabbits显示文摘 | Laslo AM Eastwood JD Urquhart B | 2004 | J Neurosci Methods2004，139，2： | 1 |
| 12 | Lower gastrointestinal bleeding显示文摘 | AM 3rd MOORE B A LONGOW E | 1997 | Disease of Colon & Rectum1997，40，7： | 1 |
| 13 | The Free Radical Theory of Aging Matures 显示文摘 | BECKMAN K B AMES B N | 1998 | Physiol Reu1998，78，： | 1 |
| 14 | Interleukin- 1beta- induced changes in blood - brain barrier permeability, apparent diffusion coefficient, and cerebral blood volume in the rat brain: a magnetic resonance study 显示文摘 | Blamire AM Anthony DC Rajagopalan B | 2000 | J Neurosci2000，20，21： | 1 |
| 15 | GM-CSF and SDF treatment induced neovasculogenesis in a mouse ischemic hindlimb model显示文摘 | Mireille AM Mark B Todd G | 2004 | Am Coll Surg2004，199，3： | 1 |
| 16 | Laparoscopic mesh hiatoplasty for paraesophageal hernias and fundoplieations: a critical analysis of the available literature显示文摘 | Johnson JM Carbonell AM Carmody B J | 2006 | Surg Endose2006，20，3： | 1 |
| 17 | Morphological and functional changes in cardiac myocytes isolated from mice overexpressing TNF-alpha 显示文摘 | Janczewski AM Kadokami T Lemster B | 2003 | Am J Physiol Heart Circ Physiol2003，284，3： | 1 |
| 18 | Dietary carcinogens and anticarcinogens: Oxygen radicals and degenerative diseases 显示文摘 | AMES B M | 1983 | Science1983，221，： | 1 |
| 19 | The incidence of phlebitis with intra-venous amiodarone at guideline dose recommendations显示文摘 | Slim AM Roth JE Duffy B | 2007 | Mil Med2007，172，12： | 1 |
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