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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | An evaluation of RANS turbulence modelling for aerodynamic applications显示文摘 | Catalano P Amato M | 2003 | Aerospace Science and Technology2003，7，： | 1 |
| 3 | Finite time stabilizationvia dynamic output feedback显示文摘 | Amato F Ariola M Dorato P | 2006 | Automatica2006，42，2： | 1 |
| 4 | The fate of nitrogen from legume and fertilizer sources in soils successively cropped with wheat under field conditions显示文摘 | Ladd J N Amato M | 1986 | Soil biochem1986，18，： | 1 |
| 5 | Finite-time control of linear systems subject to parametric uncertainties and disturbances显示文摘 | Amato F Ariola M Dorato P | 2001 | Automatica2001，37，9： | 1 |
| 6 | Mitrani-Rosenbaum S:Distinctive patterns of microRNA expression in primary muscular disorders显示文摘 | Eisenberg I Eran A Nishino I Moggio M Lamperti C Amato AA Lidov HG Kang PB North KN | | 0，，： | 1 |
| 7 | Epidemiology of nephrolithiasis today 显示文摘 | Amato M Lusini M L Nelli F | 2004 | Urol Int2004，72，1： | 1 |
| 8 | An evaluation of RANS turbulence modeling for aerodynamic applications 显示文摘 | CATALANO P AMATO M | 2003 | Aerospace Science and Technology2003，7，7： | 1 |
| 9 | Phase Ⅰ/Ⅱ study of thalidomide in combination with interleukin-2 in patients with matastatic renal cell carcinoma显示文摘 | Amato R J Morgan M Rawat A | 2006 | Cancer2006，106，7： | 1 |
| 10 | Finite- time stabilization via dynamic output feedback 显示文摘 | F Amato M Afiola C Cosentino | 2006 | Automatica2006，42，2： | 1 |
| 11 | Epidemiology of nephrolithiasis today显示文摘 | Amato M Lusini ML Nelli F | 2004 | Urol Int2004，721，： | 1 |
| 12 | Finite-time stabilization of impulsive dynamical linear systems显示文摘 | Amato F Ariola M Cosention C | 2011 | Non-liear Analysis: Hybird System2011，5，1： | 1 |
| 13 | Venous thromboembo- lism and lung cancer: a review显示文摘 | Vitale C D'Amato M Calabrb P | 2015 | Muhidiscip Respir Med2015，10，1： | 1 |
| 14 | Finite-time control of linear systems subject to parametric uncertainties and disturbance显示文摘 | Amato F Arolia M Dorato P | 2001 | Automatica2001，37，7： | 1 |
| 15 | Regional energy demand responses to climate change methodology and application to the commonwealth of Massachusetts 显示文摘 | Amato A D Ruth M Kirshen P | 2005 | Climate Change2005，71，1： | 1 |
| 16 | E - selecfin modulates the malignant properties of T84 colon显示文摘 | Flugy AM D Amato M Russo D et 81 | 2002 | Biochem Biophys Res Common2002，293，3： | 1 |
| 17 | Minimally invasive resection of benign esophageal tumors 显示文摘 | Kent M D'Amato T Nordman C | 2007 | J Thorac Car Diovasc Surg2007，134，1： | 1 |
| 18 | Postintervention serum TSH levels may be useful to diffenrentiate patients who should undergo levothyroxine suppressive therapy after thyroid surgery for multinodular goiter in a region with moderate iodine deficiency显示文摘 | Rotondi M Amato G Del Buono A | 2000 | Thyroid2000，10，12： | 1 |
| 19 | Formotero Turbuhaler for as-needed therapy in patiengs with mild acute exacerbations of COPD显示文摘 | Cazzola M Di perna F D Amato M | 2005 | Respir Med2005，95，11： | 1 |
| 20 | Soil microbial biomass: its assay and role in turnover organic matter C and N 显示文摘 | LADD J N AMATO M VEEN H A | 2004 | Soil Biology & Biochemistry2004，36，： | 1 |
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