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| 1 | 华北平原不同粮作模式下作物水分利用显示文摘利用田间定位试验的研究方法,对在华北地区通过种植模式调整实现农业节水的潜力进行了研究。通过系统比较3种不同种植模式单季和周年作物水分利用效率以及水量平衡方程,获得如下结论:1)冬小麦-夏玉米一年两熟常规模式(对照)具有显著产量优势,但水分利用率较低,对地下水消耗较大,不利于本地区农业的可持续发展;2)与对照相比,春玉米一熟模式可以实现最小灌溉或者零灌溉,充分利用自然降雨的同时,还有助于地下水的恢复,但周年产量降低较多(降低41%),考虑到粮食安全的需求,该模式不适宜在当前推广;3)与对照相比,两年三熟模式3年总灌溉量降低48%,产量降低11%,节水效果明显,水分利用效率显著提高,该模式进一步完善后可适当推广。本研究结果为在华北平原地区兼顾粮食安全基础上拓展节水农业提供了新的思路,对发展可持续性农业做了有益探索。 | 郭步庆 陶洪斌 王璞 Heike KNRZER Wilhelm CLAUPEIN | 2013 | 中国农业大学学报2013，18，1： | 27 |
| 2 | Antioxidant and antipyretic properties of methanolic extract of Amaranthus spinosus leaves显示文摘Objective:Methanolic extract of Amaranthus spinosus(A.spinosus) leaves was screened for antioxidant and antipyretic activities.Methods:Antioxidant activity was measured by l,l-diphenyl-2-picryl-hydrazile(DPPH) free radical scavenging,superoxide anion radical scavenging,hydroxyl free radical scavenging,nitric oxide radical scavenging,2,2 -azinobis-3- ethylbenzothiazole-6-sulfonic acid(ABTS) radical scavenging assays and total phenolic content was also determined.Antipyretic activity of methanolic extract of A.spinosus was measured by yeast induced pyrexia method at concentration of 200 and 400 mg/kg using paracetamol as standard drug.Results:Methanolic extract of A.spinosus showed potent antioxidant activity.The IC50 value was(87.50±3.52)μg/mL,(98.80±1.40)μg/mL,(106.25±0.20)μg/mL,(88.70±0.62)μg/mL and(147.50±2.61)μg/mL for DPPH,superoxide,hydroxyl,nitric oxide and ABTS radical scavenging activities.Methanolic extract of A spinosus showed significant(P<0.01) antipyretic activity. | Bagepalli Srinivas Ashok Kumar Kuruba Lakshman Jayaveera KN Devangam Sheshadri Shekar Avalakondarayappa Arun Kumar Bachappa Manoj | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，9： | 15 |
| 3 | 用智能手机高血压指导或追踪应用程序进行家庭血压监测对未控制高血压患者的影响显示文摘移动应用程序(App)可能有助于改善高血压的自我管理。该文旨在探究促进家庭监测和高血压相关行为的人工智能手机指导App与血压追踪App对收缩压水平的影响。设计、设置和参与者:该研究为2组开放性随机临床试验。在2016-2017年招募高血压未控制的参与者,并随访6个月。在2019年4-12月进行数据分析。干预:干预组参与者接受智能手机指导App以促进家庭监测和高血压自我管理相关行为改变,并进行家庭血压监测。 | Persell SD Peprah YA Lipiszko D Lee JY Li JJ Ciolino JD Karmali KN Sato H 袁源(摘译) 练桂丽(审校) | 2020 | 中华高血压杂志2020，28，12： | 11 |
| 4 | 小胶质细胞再激活可缓解脑损伤后炎症反应并促进脑功能恢复显示文摘中枢神经系统疾病或损伤后,小胶质细胞介导的慢性神经炎症反应会损伤局部脑组织,加重病情,不利于神经功能的恢复。小胶质细胞的激活通过集落刺激因子1受体(CSF1R)信号通路,CSF1R抑制剂可阻断小胶质细胞的激活。抑制慢性神经炎症反应是治疗中枢神经系统疾病的有效方法,但长时间抑制小胶质细胞在临床实践中无法实现。值得注意的是,去掉CSF1R抑制剂可刺激中枢神经系统内新的小胶质细胞的彻底重激活。本课题组建立小鼠广泛性神经元丢失模型,在该模型中探讨急性小胶质细胞的消除及再激活的作用。神经元的丢失导致了较长时间的神经炎性反应,表现为小胶质细胞肿胀,并表达CD68和CD45;同时,细胞因子、趋化因子、补体及其他炎症信号的表达增加。小胶质细胞的再激活可以缓解上述炎症反应,还可以促进小鼠神经功能的恢复,即使该小鼠的海马神经元丢失80%,其在水迷宫测试中的得分与正常小鼠的得分相差无几。对突触的分析结果显示,小胶质细胞的再激活可增加PSD95和突触泡蛋白点状突触体的表达,提示小胶质细胞有助于重塑和调节突触的形态和功能。综上所述,本研究结果显示,小胶质细胞的短时间消除及再激活可能是一种新颖有效的方法用于减少神经炎性反应并促进脑功能恢复。 | Rice RA Pham J Lee RJ Najafi AR West BL Green KN 唐颖馨(编译) | 2017 | 神经损伤与功能重建2017，12，3： | 9 |
| 5 | Effect of alloying elements on valence electron structure (VES) of Fe-3Al intermetallic compounds显示文摘The hybridized state of each atom changes with various changes of alloying elements and different alloying degrees. It is shown that during the course of alloying, the changes in the microsolid_state reflection such as atomic hybridized state make the corresponding VES parameters change, and that affects the mechanical properties of Fe-3Al alloys. | Sun, KN Zhang, JD Yin, YS | 1998 | Chinese Science Bulletin1998，43，2： | 7 |
| 6 | 慢性压力和内皮功能障碍:多种族动脉粥样硬化研究显示文摘内皮功能障碍可能是慢性压力与心血管病风险之间的一个重要环节。然而,极少研究探讨慢性压力对内皮功能障碍的影响。该研究旨在一个多种族的成人样本(年龄45~84岁)中探讨慢性压力是否与血流介导的血管舒张功能(flow-mediated dilation,FMD)相关,以及是否和内皮功能障碍的2个生物标记物[细胞间黏附分子1(intercellular cell adhesion molecule-1,ICAM-1)和E选择素]相关。 | Kershaw KN Lane-Cordova AD Carnethon MR Tindle HA Liu K 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 4 |
| 7 | Multiple haploids, triploids, and tetraploids found in modern-day “living fossil” Ginkgo biloba显示文摘Ginkgo biloba,the last extant representative of a lineage of Mesozoic gymnosperms,is one of the few seed plants with an exceptionally long(~300 Myr)evolutionary history free of genome-wide duplications(polyploidy).Despite this genome conservatism,we have recently found a viable spontaneous tetraploid Ginkgo sapling during routine screening of several plants,demonstrating that natural polyploidy is possible in Ginkgo.Here we provide a much wider flow cytometry survey of ploidy in some European Ginkgo collections,and own seedlings(>2200 individuals and~200 cultivars).We found a surprisingly high level of ploidy variation in modern-day Ginkgo and documented altogether 13 haploid,3 triploid,and 10 tetraploid Ginkgo plants or cultivars,most of them being morphologically distinct from common diploids.Haploids frequently produced polyploid(dihaploid)buds or branches.Tetraploids showed some genome size variation.The surveyed plants provide a unique resource for future Ginkgo research and breeding,and they might be used to accelerate the modern diversification of this nearly extinct plant lineage. | PetrŠmarda Lucie Horová Ondřej Knápek Heidi Dieck Martin Dieck Katarína Ražná Pavel Hrubík Laszlo Orlóci Laszlo Papp Kristýna Veselá Pavel Veselý Petr Bureš | 2018 | Horticulture Research2018，5，1： | 4 |
| 8 | Serological pattern “anti-HBc alone”:Characterization of 552 individuals and clinical significance显示文摘瞄准:调查流行和临床的意义“ anti-HBc 独自一个”在病人的一张 unselected 人口和在南部的德国的一所大学医院的雇员。方法:有模式的所有个人“ anti-HBc 独自一个”在 82 瞬间的时间跨度上被登记。HBV-DNA 在浆液和肝样品被测量,并且临床的图表被考察。结果:五百和 52 个个人是“ anti-HBc 独自一个”(3004 anti-HBc 积极个人;18.4%) ,并且这个模式比女性更经常影响了男性(20.5%)(15.3% ;P<0.001 ) 。HBV-DNA 在 545 中的 44 个的浆液被检测“ anti-HBc 独自一个”个人(8.1%) ,并且在石蜡,在 39 个病人中的 16 个的嵌入的肝织物测试了(41.0%) 。在 HBV 染色体的察觉和肝损坏的生物化学、超声或组织学的符号的存在之间没有协会。38 “ anti-HBc 独自一个”有肝硬化或主要的肝癌的病人有至少一个另外的风险因素。HCV-coinfection 在 20.4% 所有个人与是在场的“ anti-HBc 独自一个”并且唯一的因素与更坏的临床的结果被联系。结论:在一个 HBV 低流行区域,没有证据被发现那 HBV 独自一个在个人引起严重的肝损坏与“ anti-HBc 独自一个”。为这些个人的管理的建议被给。 | Antje Knll Arndt Hartmann Harald Hamoshi Karin Weislmaier Wolfgang Jilg | 2006 | World Journal of Gastroenterology2006，12，8： | 3 |
| 9 | Review methylotrophic yeasts as factories for the production of foreign proteins显示文摘 | Faber KN Harder W Ab G | 1995 | Yeast1995，11，14： | 2 |
| 10 | E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas显示文摘 | Tamura G Yin J Wang S Fleisher AS Zou T Abraham JM Kong D Smolinski KN Wilson KT James SP Silverberg SG Nishizuka S Terashima M Motoyama T Meltzer SJ | | 0，，： | 2 |
| 11 | The determination of l -carnitine in several food samples显示文摘 | Knüttel-Gustavsen Seline Harmeyer Johein | 2007 | Food Chemistry2007，，2： | 2 |
| 12 | Lipid-induced up-regulation of human acyl-CoA synthetase 5 promotes hepatocellular apoptosis显示文摘 | Andrea Reinartz Josef Ehling Andrea Leue Christian Liedtke Ursula Schneider Jürgen Kopitz Thomas Weiss Claus Hellerbrand Ralf Weiskirchen Ruth Knüchel Nikolaus Gassler | 2010 | BBA - Molecular and Cell Biology of Lipids2010，，9： | 2 |
| 13 | Role of angiotensin II in the development of nephropathy and podocytopathy of diabetes显示文摘 | Campbell KN Raij L Mundel P | | Curr Diabetes Rev0，，： | 2 |
| 14 | Pain management in mice using methanol extracts of three plants belongs to family Amaranthaceae显示文摘Objective:To investigate the analgesic activity of methanolic extract of Amaranthus viridis(A. viridis),Amaranthus caudatus(A.caudatus) and Amaranthus spinosus(A.spinosus).Methods:In this study,the analgesic activity of methanol extracts of all three plants at doses of 200 and 400 mg/kg were investigated by acetic acid-induced writhings test,hot plate test and tail immersion test for mice.Results:It was found that all the three plants showed significant pain management effect(P<0.01) at a dose of 400 mg/kg,but showed a less significant effect at a dose of 20 mg/kg in the entire tests used for evaluation of analgesic activities(P<0.05).Conclusions:Methanol extracts of A.viridis,A.caudatus and A.spinosus show potent analgesic activities,and this study provides the scientific proof for their traditional claims. | Ashok Kumar BS Lakshman K Jayaveera KN Vel Murgan C Arun Kumar PA Vinod Kumar R Meghda Hegade Sridhar SM | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 2 |
| 15 | 钙通道阻滞剂在哮喘中的作用显示文摘阐述细胞浆钙浓度变化所介导的效应在哮喘病理生理中的作用,并讨论钙通道阻滞剂对哮喘患者的治疗机制。对同时有高血压、冠心病的哮喘患者,应用钙通道阻滞剂以取代β-肾上腺素阻滞剂和血管紧张素转换酶抑制剂是适宜的和安全的。 | OLivier KN Yankaskas JR 杨明 | 1992 | 国外医学(呼吸系统分册)1992，12，2： | 2 |
| 16 | Thrombin-induced p65 homodimer binding to downstream NF-kappa B site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion显示文摘 | Rahman A Anwar KN True AL Malik AB | 1999 | J Immunol1999，162，： | 1 |
| 17 | Role of hepatocellular regeneration in CCl4 autoprotection显示文摘 | Thakore KN Mehendale HM | 1991 | Toxicol Pathol1991，19，1： | 1 |
| 18 | PPARct suppresses insulin secretion and induces UCP2 in insulinoma cells 显示文摘 | Tordjman K Standley KN Bernal-Mizrachi C | 2002 | J Lipid Res2002，43，6： | 1 |
| 19 | Results of modem therapy for patients with mediastinal nonseminomatous germ cell tumors显示文摘 | Rieger KM Kesler KA | 2000 | Cancer2000，88，5： | 1 |
| 20 | Respiratory symptomsand pulmonary function of traffic policemen in Thonburi显示文摘 | Maranetra KN Nana A | 1999 | J Med Assoc Thai1999，82，5： | 1 |
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