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| 1 | Clinical approaches to non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)ranges from simple steatosis to nonalcoholic steatohepatitis(NASH),leading to fibrosis and potentially cirrhosis,and it is one of the most common causes of liver disease worldwide.NAFLD is associated with other medical conditions such as metabolic syndrome,obesity,cardiovascular disease and diabetes.NASH can only be diagnosed through liver biopsy,but noninvasive techniques have been developed to identify patients who are most likely to have NASH or fibrosis,reducing the need for liver biopsy and risk to patients.Disease progression varies between individuals and is linked to a number of risk factors.Mechanisms involved in the pathogenesis are associated with diet and lifestyle,influx of free fatty acids to the liver from adipose tissue due to insulin resistance,hepatic oxidative stress,cytokines production,reduced very low-density lipoprotein secretion and intestinal microbiome.Weight loss through improved diet and increased physical activity has been the cornerstone therapy of NAFLD.Recent therapies such as pioglitazone and vitamin E have been shown to be beneficial.Omega 3 polyunsaturated fatty acids and statins may offer additional benefits.Bariatric surgery should be considered in morbidly obese patients.More research is needed to assess the impact of these treatments on a long-term basis.The objective of this article is to briefly review the diagnosis,management and treatment of this disease in order to aid clinicians in managing these patients. | Katherine JP Schwenger Johane P Allard | 2014 | World Journal of Gastroenterology2014，20，7： | 21 |
| 2 | Ecological and Economic Benefits of Vegetation Management Measures in Citrus Orchards on Red Soils显示文摘A three-year experiment was conducted to investigate and compare the economic and ecological benefits of six types of vegetation management measures in citrus orchards of the hilly red soil region of the eastern part of China.Six vegetation treatments,including tillage without herbicide(clean tillage)and no tillage without herbicide(sod culture) and with herbicide paraquat(paraquat),glyphosate(glyphosate),glyphosate-glyphosate-paraquat(G-G-P),and paraquat- paraquat-glyphosate(P-P-G),were applied in the citrus orchards on a clayey red soil with slopes of 8°and 13°and a sandy soil with slope of 25°.The results showed that the sod culture,paraquat,glyphosate,G-G-P,and P-P-G treatments reduced surface runoff by 38.8%,42.5%,18.7%,28.7%,and 37.5%,then the soil-water losses by 55.5%,51.7%,39.9%,46.8%, and 50.0%,and the N,P,and K nutrient losses by 60.3%,50.2%,37.0%,41.8%,and 45.4%,respectively,as compared with the clean tillage treatment.The weed regeneration ratios with the treatments of clean tillage without herbicide,paraquat, glyphosate,G-G-P,and P-P-G were reduced by 55.1%,67.2%,30.3%,36.8%,and 51.2%,respectively,as compared with the sod culture.The sod culture,paraquat,glyphosate,G-G-P,and P-P-G treatments could increase the soil fertility (annual accumulation of N,P,K,and OM)by 7.1%,6.9%,5.3%,6.2%,and 6.6%,respectively,whereas the clean tillage treatment without herbicide reduced soil fertility by 4.4% after the three-year experiment.The citrus fruit yields in the treatments of paraquat,glyphosate,G-G-P,and P-P-G increased by 7%-10%;the soluble solid,total sugar,total acidity,sugar-acid ratio,and single fruit weight of citrus fruits of all treatments except sod culture significantly(P>0.05) exceeded that of the clean tillage treatment.In general,the paraquat treatment showed the best economic and ecological benefits among the six treatments;therefore,it could be regarded as the best available vegetation management measure in citrus orchards of hilly red soil region to retain water and soil,enhance soil fertility,and improve the yield and quality of citrus. | SHUI Jian-Guo WANG Qiu-Zhen LIAO Gen-Qing J. AU J. L. ALLARD | 2008 | Pedosphere2008，18，2： | 16 |
| 3 | 不同自然植被管理措施对红壤丘陵果园水土流失的影响(英文)显示文摘丘陵是“山—丘—谷”的过渡地带 ,生态系统脆弱 ,一旦植被遭破坏 ,极易水土流失。在红壤丘陵园地应用除草剂调控水土流失试验结果表明 :与传统的清耕法相比 ,克无踪、草甘膦、草草克、克克草和生草法可使地表径流量分别减少47.7%,2 0 .8%,31.4%,41.3%和 45 .5 %;可使土壤侵蚀量分别减少 5 2 .4%,39.0 %,48.1%,5 0 .7%和 5 5 .2 %;可使土壤养分分别减少 5 0 .2 %,37.0 %,41.8%,45 .8%和 6 0 .3%。除草剂对杂草再生率影响 ,与生草法比较 ,克无踪可达 6 7.2 %,草甘膦达 30 .3%,草草克 36 .8%,克克草 5 1.2 %和清耕法 5 5 .1%;克无踪调控杂草效果分别是草甘膦的 2 .2倍 ,清耕法的 1.2倍。克无踪调控杂草效果显著 ,有望成为红壤丘陵园地培肥与水保相得益彰的有效措施。 | 水建国 柳俊 廖根清 程岩兴 区越富 周权康 Allard Jean-louis | 2003 | 农业工程学报2003，19，5： | 16 |
| 4 | Implication of the intestinal microbiome in complications of cirrhosis显示文摘The intestinal microbiome(IM) is altered in patients with cirrhosis,and emerging literature suggests that this impacts on the development of complications.The Pub Med database was searched from January 2000 to May 2015 for studies and review articles on the composition,pathophysiologic effects and therapeutic modulation of the IM in cirrhosis.The following combination of relevant text words and MeS H terms were used,namely intestinal microbiome,microbiota,or dysbiosis,and cirrhosis,encephalopathy,spontaneous bacterial peritonitis,hepatorenal syndrome,variceal bleeding,hepatopulmonary syndrome,portopulmonary hypertension and hepatocellular carcinoma.The search results were evaluated for pertinence to the subject of IM and cirrhosis,as well as for quality of study design.The IM in cirrhosis is characterized by a decreased proportion of Bacteroides and Lactobacilli,and an increased proportion of Enterobacteriaceae compared to healthy controls.Except for alcoholic cirrhosis,the composition of the IM in cirrhosis is not affected by the etiology of the liver disease.The percentage of Enterobacteriaceae increases with worsening liver disease severity and decompensation and is associated with bacteremia,spontaneous bacterial peritonitis and hepatic encephalopathy.Lactulose,rifaximin and Lactobacillus-containing probiotics have been shown to partial y reverse the cirrhosis associated enteric dysbiosis,in conjunction with improvement in encephalopathy.The IM is altered in cirrhosis,and this may contribute to the development of complications associated with end-stage liver disease.Therapies such as lactulose,rifaximin and probiotics may,at least partially,reverse the cirrhosisassociated changes in the IM.This,in turn,may prevent or alleviate the severity of complications. | Mamatha Bhat Bianca M Arendt Venkat Bhat Eberhard L Renner Atul Humar Johane P Allard | 2016 | World Journal of Hepatology2016，8，27： | 13 |
| 5 | The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass显示文摘 | Richard G. Moore Amy K. Brown M. Craig Miller Steven Skates W. Jeffrey Allard Thorsten Verch Margaret Steinhoff Geralyn Messerlian Paul DiSilvestro C.O. Granai Robert C. Bast | 2007 | Gynecologic Oncology2007，，2： | 7 |
| 6 | Tetraphenylethylene-BODIPY aggregation-induced emission luminogens for near-infrared polymer light-emitting diodes显示文摘The aggregation-induced emission(AIE) phenomenon provides a new direction for the development of organic light-emitting devices. Here, we present a new class of emitters based on 4,4-difluoro-4-bora-3 a,4 a-diaza-s-indacene(BODIPY), functionalized at different positions with tetraphenylethylene(TPE), which is one of the most famous AIE luminogens. Thanks to this modification, we were able to tune the photoluminescence of the BODIPY moiety from the green to the near-infrared(NIR)spectral range and achieve PL efficiencies of ~50% in the solid state. Remarkably, we observed an enhancement of the AIE and up to ~100% photoluminescence efficiencies by blending the TPE-substituted BODIPY fluorophores with a poly[(9,9-di-noctylfluorene-2,7-diyl)-alt-(benzo[2,1,3]thiadiazol-4,7-diyl)](F8 BT) matrix. By incorporating these blends in organic lightemitting diodes(OLEDs), we obtained electroluminescence peaked in the range 650–700 nm with up to 1.8% external quantum efficiency and ~2 m W/cm2 radiance, a remarkable result for red/NIR emitting and solution-processed OLEDs. | Sebnem Baysec Alessandro Minotto Patrick Klein Simone Poddi Andrea Zampetti Sybille Allard Franco Cacialli Ullrich Scherf | 2018 | Science China Chemistry2018，61，8： | 6 |
| 7 | Utility of a novel serum tumor biomarker HE4 in patients with endometrioid adenocarcinoma of the uterus显示文摘 | Richard G. Moore Amy K. Brown M. Craig Miller Donna Badgwell Zhen Lu W. Jeffrey Allard C.O. Granai Robert C. Bast Karen Lu | 2008 | Gynecologic Oncology2008，，2： | 3 |
| 8 | A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass显示文摘 | Richard G. Moore D. Scott McMeekin Amy K. Brown Paul DiSilvestro M. Craig Miller W. Jeffrey Allard Walter Gajewski Robert Kurman Robert C. Bast Steven J. Skates | 2008 | Gynecologic Oncology2008，，1： | 3 |
| 9 | 丘陵红壤橘园不同地面管理措施的经济生态效益研究显示文摘在丘陵红壤橘园上,经过3年6种地面管理措施的经济生态效益研究.结果表明:(1)水土流失,以清耕法作对照,生草法、克无踪、草甘膦、草草克、克克草的地表径流量可显著减少分别为38.8%,42.5%,18.7%,28.7%和37.5%;土壤侵蚀量可显著减少分别为55.5%,51.7%,39.9%,46.8%和50.0%;流失的氮磷钾养分总量可分别减少60.3%,50.2%,37.0%,41.8%和45.4%.(2)杂草再生率,以生草法做对照,则处理中的清耕法、克无踪、草甘膦、草草克和克克草分别是生草法的55.1%,67.2%,30.3%,36.8%和51.2%.(3)土壤肥力,以土壤OM,N,P2O5,K2O总量增减率看,清耕法为-4.4%,生草法7.1%,克无踪6.9%,草甘膦5.3%,克克草6.2%,草草克6.6%.(4)柑橘的产量和品质,以清耕法作对照,除生草法外,克无踪、草甘膦、草草克、克克草均增产7%~10%;可溶性固形物、总糖量、总酸度、糖酸比以及单果重均达到显著差异水平.克无踪调控杂草效果显著,可作为丘陵红壤丘陵园地水保与培肥兼得的有效地面管理措施. | 水建国 王求真 廖根清 区越富 Jean-louis ALLARD | 2005 | 水土保持学报2005，19，5： | 2 |
| 10 | 普通话及台湾国语舌尖音与卷舌音的声学比较分析显示文摘文章对普通话和台湾国语的舌尖([ts]、[ts^h]、[s])及卷舌([ts]、[ts^h]、[s])辅音进行了对比研究。通过频谱动差分析探索两个问题,一是不同元音对这两组辅音发声参数有何影响,二是哪一组辅音在普通话及台湾国语中的声学差异最小。结果显示,元音的位置前后和发音时嘴唇的圆展均影响舌尖音、卷舌音的发声。同时,辅音是否送气对其发声位置的对立程度有影响作用,其中送气的舌尖音与卷舌音之间声学参数差异最小,而元音位置的前后与发音时嘴唇的圆展均对普通话及台湾国语舌尖音、卷舌音的生成有所影响。最后,声学参数显示普通话中舌尖音与卷舌音的差异较大,而台湾国语这组对立的差异较小。 | 严菡波 Allard Jongman | 2018 | 语言研究集刊2018，0，1： | 2 |
| 11 | Comparison of a novel multiple marker assay vs the Risk of Malignancy Index for the prediction of epithelial ovarian cancer in patients with a pelvic mass显示文摘 | Richard G. Moore Moune Jabre-Raughley Amy K. Brown Katina M. Robison M. Craig Miller W. Jeffery Allard Robert J. Kurman Robert C. Bast Steven J. Skates | 2010 | American Journal of Obstetrics and Gynecology2010，，3： | 2 |
| 12 | Intestinal microbiota in patients with nonalcoholic fatty liver disease显示文摘 | Marialena Mouzaki Elena M. Comelli Bianca M. Arendt Julia Bonengel Scott K. Fung Sandra E. Fischer Ian D. McGilvray Johane P. Allard | 2013 | Hepatology2013，，1： | 2 |
| 13 | Potential therapeutic benefits stemming from the thermal nature of irreversible electropora tion of solid cancers显示文摘To the Editor:Irreversible electroporation(IRE)is a CE-and FDAapproved treatment modality for pancreatic and liver tumors that is based on the site-confined destruction of tumor tissue by multiple short,high-intensity electrical pulses.^([1])Currently there is a heated debate about whether the therapy is thermal or non-thermal.The'non-thermal proponents'advocate | Michal Heger Allard C van der Wal Gert Storm Martin J van Gemert | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，3： | 2 |
| 14 | Sleep problems in children with autism显示文摘 | Gail WP Sears LL Allard A | 2004 | J Sleep Res2004，13，： | 1 |
| 15 | CT of Primary Adrenal Lymphoma显示文摘 | Allard JC | 1991 | J Comput Assist Tomogr1991，15，6： | 1 |
| 16 | NuA4,an Essential Transcription Adaptor/Histone H4 Acetyltransferase Complex Containing Esa1p and ATM-Related Cofactor Tra1p显示文摘 | Utley R T Savard J | 1999 | EMBO J1999，18，： | 1 |
| 17 | Modelling Consumer Responses to an Apparel Store Brand: Store Image as a Risk Reducer 显示文摘 | Veronica Liljandera Pia Polsaaand Allard van Rielb | 2009 | Journal of Retailing and Consumer Services2009，16，4： | 1 |
| 18 | Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with non-malignant diseases显示文摘 | Allard WJ Matera J Miller MC | 2004 | Clin Cancer Res2004，10，： | 1 |
| 19 | Indoor particle pollution: effect of wall textures on particle deposition 显示文摘 | Marc Abadie Karim Limam Francis Allard | 2001 | Building and Environment2001，36，7： | 1 |
| 20 | Typing of rhizobia by PCR DNA finger and PCR-restriction fragment length polymorphism analysis of chromosomal and symbiotic gene regions:application to Rhizobium leguminosarum and its different biovars显示文摘 | LAGUERRE G MAVINGUI P ALLARD M R | 1996 | Appl Environ Microbiol1996，62，： | 1 |
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