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| 1 | Helicobacter pylori vs coronary heart disease-searching for connections显示文摘In this review,we discussed the findings and concepts underlying the potential role of Helicobacter pylori(H.pylori) infections in the initiation,development or persistence of atherosclerosis and coronary heart disease(CHD).This Gram-negative bacterium was described by Marshall and Warren in 1984.The majority of infected subjects carries and transmits H.pylori with no symptoms; however,in some individuals these bacteria may cause peptic ulcers,and even gastric cancers.The widespread prevalence of H.pylori infections and the fact that frequently they remain asymptomatic may suggest that,similarly to intestinal microflora,H.pylori may deliver antigens that stimulate not only local,but also systemic inflammatory response.Recently,possible association between H.pylori infection and extragastric disorders has been suggested.Knowledge on the etiology of atherosclerosis together with current findings in the area of H.pylori infections constitute the background for the newly proposed hypothesis that those two processes may be related.Many research studies confirm the indirect association between the prevalence of H.pylori and the occurrence of CHD.According to majority of findings the involvement of H.pylori in this process is based on the chronic inflammation which might facilitate the CHDrelated pathologies.It needs to be elucidated,if the infection initiates or just accelerates the formation of atheromatous plaque. | Magdalena Chmiela Adrian Gajewski Karolina Rudnicka | 2015 | World Journal of Cardiology2015，7，4： | 33 |
| 2 | Innate immune signaling and regulation in cancer immunotherapy显示文摘先存在的 T 煽动房间的肿瘤微型环境有预示的用途并且能也为对当代的癌症免疫疗法的反应预兆。对联系肿瘤的抗原的自发的 T 房间回答的产生取决于天生的有免疫力的激活,运动打它我干扰素(IFN ) 生产。最近的工作为在这个过程察觉到的 cytosolic DNA 的 STING 小径揭示了一个主要角色。事件的这串联贡献 Batf3 系树枝状的房间(DC ) 的激活,它看起来对反肿瘤免疫中央。Non-T 煽动房间的肿瘤为 Batf3 DC 招募缺乏 chemokines,有很少 Batf3 DC,并且缺乏一种类型我 IFN 基因签名,建议那没有通过天生的有免疫力的激活可以是因缺乏自发的 T 房间激活和累积的最终的原因。与手里的这个信息,为触发天生的有免疫力的激活和 Batf3 DC 招募的新策略正在被开发,包括为 de novo 免疫者 priming 的新奇圈套收缩筋。最终,有效天生的有免疫力的使活跃之物的成功的发展应该扩展能对免疫疗法作出回应的病人的部分,例如与检查点封锁抗体。 | Leticia Corrales Vyara Matson Blake Flood Stefani Spranger Thomas F Gajewski | 2017 | Cell Research2017，27，1： | 13 |
| 3 | Impact of Helicobacter pylori on the healing process of the gastric barrier显示文摘AIM To determine the impact of selected well defined Helicobacter pylori(H. pylori) antigens on gastric barrier cell turnover.METHODS In this study,using two cellular models of gastric epithelial cells and fibroblasts,we have focused on exploring the effects of well defined H. pylori soluble components such as glycine acid extract antigenic complex(GE),subunit A of urease(Ure A),cytotoxin associated gene A protein(Cag A) and lipopolysaccharide(LPS) on cell turnover by comparing the wound healing capacity of the cells in terms of their proliferative and metabolic activity as well as cell cycle distribution. Toxic effects of H. pylori components have been assessed in an association with damage to cell nuclei and inhibition of signal transducer and activator of transcription 3(STAT3) phosphorylation. RESULTS We showed that H. pylori GE,Cag A and Ure A promoted regeneration of epithelial cells and fibroblasts,which is necessary for effective tissue healing. However,in vivo increased proliferative activity of these cells may constitute an increased risk of gastric neoplasia. In contrast,H. pylori LPS showed a dose-dependent influence on the process of wound healing. At a low concentration(1 ng/m L) H. pylori LPS accelerated of healing epithelial cells,which was linked to significantly enhanced cell proliferation and MTT reduction as well as lack of alterations in cell cycle and downregulation of epidermal growth factor(EGF) production as well as cell nuclei destruction. By comparison,H. pylori LPS at a high concentration(25 ng/m L) inhibited the process of wound repair,which was related to diminished proliferative activity of the cells,cell cycle arrest,destruction of cell nuclei and downregulation of the EGF/STAT3 signalling pathway.CONCLUSION In vivo H. pylori LPS driven effects might lead to the maintenance of chronic inflammatory response and pathological disorders on the level of the gastric mucosal barrier. | Eliza Mnich Magdalena Kowalewicz-Kulbat Paulina Sicińska Krzysztof Hinc Michal Obuchowski Adrian Gajewski Anthony P Moran Magdalena Chmiela | 2016 | World Journal of Gastroenterology2016，22，33： | 4 |
| 4 | A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass显示文摘 | Richard G. Moore D. Scott McMeekin Amy K. Brown Paul DiSilvestro M. Craig Miller W. Jeffrey Allard Walter Gajewski Robert Kurman Robert C. Bast Steven J. Skates | 2008 | Gynecologic Oncology2008，，1： | 3 |
| 5 | MYC -- a thorn in the side of cancer immunity显示文摘 | Stefani Spranger Thomas F Gajewski Justin Kline | 2016 | Cell Research2016，26，6： | 2 |
| 6 | Measurements of ATP in mammalian cells显示文摘 | Manfredi G Yang L Gajewski C D | 2002 | Methods2002，26，： | 1 |
| 7 | Chemical Degradation of Polyurethane 显示文摘 | | 1990 | Rubber World1990，202，6： | 1 |
| 8 | On the TRAIL toward death receptor based cancer ther- apeutics显示文摘 | Gajewski TF | 2007 | J Clin 0ncol2007，25，： | 1 |
| 9 | Fresh- water diatom biogeography in the Canadian Arctic Archipela- go显示文摘 | BOUCHARD G GAJEWSKI K HAMILTON P B | 2004 | JournalofBiogeography2004，，31： | 1 |
| 10 | Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia显示文摘 | Musial J Undas A Gajewski P | 2001 | Int J Cardiol2001，77，23： | 1 |
| 11 | Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia显示文摘 | Musial J Undas A Gajewski P | 2001 | Int J Cardiol2001，77，： | 1 |
| 12 | Nurse staffing and patient falls on acute care hospital units 显示文摘 | Dunton N Gajewski B Taunton RL | 2004 | Nurs Outlook2004，52，1： | 1 |
| 13 | ITS data archiving: statistical techniques for determining optimal aggregation widths for inductance loop detectors 显示文摘 | Gajewski B J Turner S M Eisele W L | 2000 | Transportation Research Record2000，1719，： | 1 |
| 14 | Immune suppression inthe tumor microenvironment显示文摘 | Gajewski TF Meng Y Harlin H | 2006 | J Immunother2006，29，3： | 1 |
| 15 | Differen tiat- ing clinical and radiographic features of enchondroma and secondary chondrosarcoma in the foot 显示文摘 | Gajewski DA Burnette JB Murphey MD | 2006 | Foot Ankle Int2006，27，4： | 1 |
| 16 | Immunization lf HLA-A2+ melanoma patients with MAGE-3 or Melan A peptide-pulsed autologous peripheral blood mononuclear cells plus recombinant human interleukin 12显示文摘 | Gajewski TF Fallarino F Ashikari A | 2001 | Clin Caner Tes2001，7，3： | 1 |
| 17 | Investigation of the Electrification of Polypropylene Particles during the Fluidized Process显示文摘 | GAJEWSKI A | 1985 | Electrostatics1985，17，5： | 1 |
| 18 | Archived intelligent transportation system data quality: preliminary analyses of San Antonio transguide data 显示文摘 | TURNER S ALBERT L GAJEWSKI B | 2000 | Transportation Research Record2000，，1719： | 1 |
| 19 | Failure at the effector phase: immue barriers at the level of the melanoma tumor microenvironment 显示文摘 | Gajewski TF | 2007 | Clin Cancer Res2007，13，： | 1 |
| 20 | Use of leukemia dendritic cells for the generation of antileukemia cellular cytotoxicity against Philadelphia chromosome-positive chronic myelogenous leukemia显示文摘 | Choudhury A Gajewski JL Liang JC | 1997 | Blood1997，89，4： | 1 |
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