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| 1 | Consecutive fecal calprotectin measurements for predicting relapse in pediatric Crohn's disease patients显示文摘BACKGROUND Asymptomatic children with Crohn's disease(CD) require ongoing monitoring to ensure early recognition of a disease exacerbation.AIM In a cohort of pediatric CD patients, we aimed to assess the utility of serial fecal calprotectin measurements to detect intestinal inflammatory activity and predict disease relapse.METHODS In this prospective longitudinal cohort study, children with CD on infliximab therapy in clinical remission were included. Fecal calprotectin levels were assessed at baseline and at subsequent 2-5 visits. Clinical and biochemical disease activity were assessed using the Pediatric Crohn's Disease Activity Index, Creactive protein and erythrocyte sedimentation rate at baseline and at visits over the following 18 mo.RESULTS 53 children were included and eighteen patients(34%) had a clinical disease relapse during the study. Baseline fecal calprotectin levels were higher in patients that developed symptomatic relapse [median(interquartile range), relapse 723μg/g(283-1758) vs 244 μg/g(61-627), P = 0.02]. Fecal calprotectin levels > 250μg/g demonstrated good predictive accuracy of a clinical flare within 3 mo(area under the receiver operator curve was 0.86, 95% confidence limits 0.781 to 0.937).CONCLUSION Routine fecal calprotectin testing in children with CD in clinical remission is useful to predict relapse. Levels > 250 μg/g are a good predictor of relapse in the following 3 mo. This information is important to guide monitoring standards used in this population. | Alice Jane Foster Matthew Smyth Alam Lakhani Benjamin Jung Rollin F Brant Kevan Jacobson | 2019 | World Journal of Gastroenterology2019，25，10： | 3 |
| 2 | Glyphosate toxicity and the effects of long - term vegetation control on soil microbial communities 显示文摘 | Busse Matt D Ratcliff Alice W Shestak Carol J Powers Robert F | 2001 | Soil Biology and Biochemistry2001，33，： | 2 |
| 3 | Diet-induced iron deficiency anemia and pregnancy outcome in rhesus monkeys显示文摘 | Mari S Casey E Alice F | | 0，，03： | 1 |
| 4 | Rennet coagulation of skim milk and curd drainage: effect of pH, casein concentration, ionic strength and heat treatment显示文摘 | C LINA D MARIE-HILtNE F ALICE P | 2000 | Dairy Sciences and Technology2000，80，4： | 1 |
| 5 | Rennet coagulation of skim milk and curd drainage:Effect of pH,casein concentration,ionic strength and heat treatment显示文摘 | Cé1ina D Marie-Hé1ène F Alice P | | 0，，： | 1 |
| 6 | Inhibition of nucleoside transport By new analogues of nitrobenzylthioinosine显示文摘 | Deghati P Y F Alice B | 2003 | Bioorganic and Medicinal Chemistry2003，11，6： | 1 |
| 7 | The diversity of BVDV subgenotypes in a vaccinated dairy cattle herd in Brazil 显示文摘 | Rodrigo A Alice F A Stelamaris D | 2014 | Trop Anim Health Prod2014，46，1： | 1 |
| 8 | Visuospatial working memory, movement control and executive demandsSalway显示文摘 | Logie Robert H | 1995 | British Journal of Psychology1995，，86： | 1 |
| 9 | Diet - induced iron defi- ciency anemia and regnancy outcome in rhesus monkeys 显示文摘 | MARI S CASEY E ALICE F | 2006 | Am J Clin Nutr2006，83，3： | 1 |
| 10 | Oral antihyperglycemic ther- apy for type 2 diabetes mellitus 显示文摘 | Alice YY Cheng I George F | 2005 | CMAJ2005，172，2： | 1 |
| 11 | An overview of transcriptional regulation in response to toxicological insult显示文摘 | Paul J Alice L Luca F | 2013 | Arch Toxicol2013，87，1： | 1 |
| 12 | Molecular barcodes detect redundancy and contamination in hair pin-bisulfite PCR 显示文摘 | Brooks E M Reinhard J S Alice F B | 2004 | Nucleic Acids Research2004，32，17： | 1 |
| 13 | How Changing the Focus of Attention Affects Performance, Kinematics, and Electromyography in Dart Throwing 显示文摘 | Keith R L David E S Alice F H | 2010 | Human Movement Science2010，29，： | 1 |
| 14 | The role of the basal ganglia in bimanual coordination显示文摘 | KRAFT E ANTHONY W C ALICE W F | 2007 | Brain Res2007，1151，3： | 1 |
| 15 | The hyperglycemia and adverse pregnancy outcome study:Associations of GDMand obesity with pregnancy outcomes显示文摘 | Mari S G Casey E H Alice F T | 2012 | Diabetes Care2012，35，4： | 1 |
| 16 | Phylogeography and evo- lutionary history of reassortant H9N2 viruses with potential hu- man health implications 显示文摘 | Alice F Isabella M Annalisa S | 2011 | Virology2011，85，： | 1 |
| 17 | African Americans are less likely to receive curative treatment for hepatocellular carcinoma显示文摘AIM To determine if racial disparities continue to exist in the treatment of hepatocellular carcinoma(HCC).METHODS A retrospective database analysis using the Nationwide Inpatient Sample was performed including patients with a primary diagnosis of HCC. Univariate and multivariate analyses were utilized to determine racial disparities in liver decompensation, treatment, inpatient mortality, and metastatic disease.RESULTS A total of 62604 patients with HCC were included consisting of 32428 Caucasian, 9726 African-American, 8988 Hispanic, and 11462 patients of other races. Caucasian patients were more likely to undergo curative therapies of liver transplant(OR: 2.66, 95%CI: 1.92-3.68), resection(OR: 1.82, 95%CI: 1.48-2.23), and ablation(OR: 1.77, 95%CI: 1.36-2.30) than African-American patients. Hispanic patients were more likely to undergo transplant(OR: 2.18, 95%CI: 1.40-3.39) and ablation(OR: 1.46, 95%CI:1.05-2.03) than African-American patients. Patients of other races were more likely to receive a liver transplant(OR: 2.41, 95%CI: 1.62-3.61), resection(OR: 1.79 95%CI: 1.39-2.32), and ablation(OR: 2.03, 95%CI: 1.47-2.80) than African-American patients. There are no differences in the rates of transarterial chemoembolization between races.CONCLUSION Racial disparities in HCC treatment exist despite emphasis to support equality in healthcare. African-American patients are less likely to undergo curative treatments for HCC. | Lindsay A Sobotka Alice Hinton Lanla F Conteh | 2018 | World Journal of Hepatology2018，10，11： | 1 |
| 18 | Differential antigen p rocessing by dendritic cell subsets in vivo 显示文摘 | DIANA D ALICE O K GORDON F H | 2007 | Science2007，315，： | 1 |
| 19 | Dodecylbenzene transformations:Dealkylation and disproportionation over immobilized ionic liquid catalysts显示文摘 | Alice L Petre Hoelderich Wolfgang F Martin L Gorbaty | 2009 | Applied Catalysis A:General2009，363，： | 1 |
| 20 | Predictors of congestive heart failure in the elderly: the cardiovascular health study显示文摘 | John S Gottdiener Alice M Arnold Gerard P Aurigemma Joseph F Polak Russell P Tracy Dalane W Kitzman Julius M Gardin John E Rutledge Robin C Boineau | 2000 | Journal of the American College of Cardiology2000，，6： | 1 |
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