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| 1 | 新加坡成人慢性呼吸系统疾病患者6分钟步行距离的最小临床重要差异值研究(英文)显示文摘目的:6 min步行距离(6MWD)是临床上常见的功能性运动能力测试,特别是对于慢性呼吸系统疾病患者。一些文献记载了关于白种人的6MWD的最小临床重要差异(MCID),但对亚洲人群的相关信息未见记载。本研究旨在建立亚洲成人慢性呼吸道疾病患者6MWD的最小临床重要差异。方法:采用'锚定'法和'分布'法对新加坡中央医院肺康复计划登记处的资料进行了分析。'锚定'法收集确诊为慢性呼吸道疾病的患者50例,其中男38例,女12例;平均年龄(64.2±12.3)岁,通过电话采访及使用整体变化评估量表(GROC)评价患者肺康复计划后的自觉改善程度,再将患者在肺康复计划中6MWD的改变数值与相对应的患者自觉改善程度进行比较,这种关系用操作特征曲线(ROC)统计表示。通过'分布'法确定6MWD的MCID,从门诊和住院的肺康复计划(PRP)参与者中检索医疗记录136例,其中男103例,女33例;平均年龄(60.1±14.1)岁。结果 :ROC曲线表明6MWD出现临床显著性变化的最佳临界值为17.4 m,其对应的敏感性为79.4%,特异性为81.3%,阳性似然比为4.23。由'分布'法确定6MWD的最小临床重要差异值为18.6 m。结论:18.6 m为新加坡华人6MWD的最小临床重要差异的估计值。 | Meredith T L YEUNG Alan W P WONG Katherine S L HUANG Alice Y M JONES | 2015 | 康复学报2015，25，1： | 3 |
| 2 | Outcomes and patients' perspectives of transition from paediatric to adult care in inflammatory bowel disease显示文摘AIM: To describe the disease and psychosocialoutcomes of an inflammatory bowel disease(IBD) transition cohort and their perspectives.METHODS: Patients with IBD, aged > 18 years, who had moved from paediatric to adult care within 10 years were identified through IBD databases at three tertiary hospitals. Participants were surveyed regarding demographic and disease specific data and their perspectives on the transition process. Survey response data were compared to contemporaneously recorded information in paediatric service case notes. Data were compared to a similar age cohort who had never received paediatric IBD care and therefore who had not undergone a transition process. RESULTS: There were 81 returned surveys from 46 transition and 35 non-transition patients. No statistically significant differences were found in disease burden, disease outcomes or adult roles and responsibilities between cohorts. Despite a high prevalence of mood disturbance(35%), there was a very low usage(5%) of psychological services in both cohorts. In the transition cohort, knowledge of their transition plan was reported by only 25/46 patients and the majority(54%) felt they were not strongly prepared. A high rate(78%) of discussion about work/study plans was recorded prior to transition, but a near complete absence of discussion regarding sex(8%), and other adult issues was recorded. Both cohorts agreed that their preferred method of future transition practices(of the options offered) was a shared clinic appointment with all key stakeholders. CONCLUSION: Transition did not appear to adversely affect disease or psychosocial outcomes. Current transition care processes could be optimised, with better psychosocial preparation and agreed transition plans. | Alice L Bennett David Moore Peter A Bampton Robert V Bryant Jane M Andrews | 2016 | World Journal of Gastroenterology2016，22，8： | 3 |
| 3 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 4 | Phylogeny ofRubus (Rosaceae) based on nuclear ribosomal DNA internal transcribed spacer region sequences 显示文摘 | Alice L A Campbell C S | 1999 | Am JBot1999，86，： | 1 |
| 5 | EHects of grazing on commu- nity structure and productivity o{ a Uruguayan Grassland显示文摘 | Alice A Mart O Elsa L etal | 2005 | Plant Ecology2005，179，1： | 1 |
| 6 | Acquisition of Mands,Tacts, and Intraverbals through Sign Exposure in an Individual with Autism 显示文摘 | Valentino Amber L Shillingsburg M Alice | 2011 | Analysis of Verbal Behavior2011，，1： | 1 |
| 7 | Numerical study on a pool fire using large eddy simulation 显示文摘 | Alice L K C Richard K K Y | 2007 | A Treatise on the 4th Conference on the Development of Performance- Based Fire Code2007，，10： | 1 |
| 8 | Effect of grazing on community structure and productivity of a Uruguayan grassland显示文摘 | ALICE A MARTIN O ELSA L | 2005 | Plant Ecology2005，179，： | 1 |
| 9 | The role of biop- hannaceutics in the development of a clinical uanoparticle formu- lation of MK0869 : A Beagle dog model predicts improved bio- availability and diminished food effect on absorption in human 显示文摘 | YUNHUI W ALICE L ELIZABETH L | 2004 | lnt JPharm2004，285，： | 1 |
| 10 | Heterogeneity in DCE-MRI parametric maps: A biomarker for treatment response显示文摘 | Alic L Vliet MV Dijke CF | 2011 | Phys Med Biol2011，56，6： | 1 |
| 11 | When will a brand scan- dal spill over, and how should competitors respond? 显示文摘 | Michelle L Roehm Alice M Tybout | 2006 | Jour- nal of Marketing Research2006，43，3： | 1 |
| 12 | Chemical characterization and ecotoxicity of three soil foaming agents used in mechanized tunneling显示文摘 | Diego B Eleonora L Alice P | 2015 | Journal of Hazardous Materials2015，296，： | 1 |
| 13 | Design of cylcohexane oxidation process using multiple neural networks显示文摘 | SARAH S Y L ALICE E S BADIE I MORSI | 2001 | J of Manufacturing Systems2001，1，： | 1 |
| 14 | Electricity Consumption and Economic Growth in China显示文摘 | ALICE S PUN L L | 2004 | Energy Policy2004，32，1： | 1 |
| 15 | When will a Brand Scandal Spill over,and how should Competitors Respond? 显示文摘 | MICHELLE L ROEHM ALICE M TYBOUT | 2006 | Journal of Marketing Research2006，43，3： | 1 |
| 16 | An overview of transcriptional regulation in response to toxicological insult显示文摘 | Paul J Alice L Luca F | 2013 | Arch Toxicol2013，87，1： | 1 |
| 17 | Evolution of the Fucaceae(Phaeophyceae)inferred from nrDNA-ITS显示文摘 | Serr?o E A Alice L A Brawley S H | 1999 | Journal of Phycology1999，35，2： | 1 |
| 18 | An Investigation of Decision - Making Styles of Consumers in China 显示文摘 | Hiu Alice S Y Noel Y M Siu Charlie C L Wang Ludwig M K Chang | 2001 | The Journal of Consumer Affairs2001，35，2： | 1 |
| 19 | Practical framework for strategic alliance in Pearl River Delta manufacturing supply chain: A total quality approach 显示文摘 | Victor H Y L Alice H W Y | 2004 | International Journal of Production Economics2004，87，2： | 1 |
| 20 | How Changing the Focus of Attention Affects Performance, Kinematics, and Electromyography in Dart Throwing 显示文摘 | Keith R L David E S Alice F H | 2010 | Human Movement Science2010，29，： | 1 |
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