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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 3 | Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘 | D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik | 2008 | Ultraschall in Med2008，，05： | 2 |
| 4 | Loss of glom erular function and tubulointerstitial fibrosis cause or effect显示文摘 | Albert C M O Leon G F | 1994 | Kidney Internationall1994，45，： | 1 |
| 5 | Quantitative determination of metabolic fluxs during coutilization of two carbon sources:comparative analysis with Corynebacterium glutamicum durin growth on acetate and glucose显示文摘 | Volker F Wendisch Albert A DE Graaf Hermann Sahm | 2000 | Journal of Biotechnology2000，，： | 1 |
| 6 | Clinical predictors of health--related quality of life in obsessive--compulsive disorder 显示文摘 | Albert U Maina G Bogetto F | 2010 | Compr Psychiatry2010，51，2： | 1 |
| 7 | Mortality risk for dialysis patients with different levels of serum calcium, phosphorus, and PTH: The Dialysis Outcomes and Practice Patterns Study (DOPPS) 显示文摘 | Tentori F Blayney M J Albert J M | 2008 | Am J Kidney Dis2008，52，3： | 1 |
| 8 | Effect of temperature on moisture absorption in a bismaleimide resin and its carbon fiber composites显示文摘 | Li-Rong Bao Albert F Yee | 2002 | Polymer2002，43，14： | 1 |
| 9 | Runoff and soil losses as affected by corn and soybean tillage systems显示文摘 | F Ghidey E E Alberts | 1998 | Journal of Soil and Water Conservation1998，53，1： | 1 |
| 10 | Mortality risk for dialysis pa- tients with different levels of serum calcium, phosphorus, and PTH:the Dialysis Outcomes and Practice Patterns Study (DOPPS) 显示文摘 | Tentori F Blayney MJ Albert JM | 2008 | Am J Kidney Dis2008，52，3： | 1 |
| 11 | Microstructural alterations associated with friction drilling of steel,aluminum,and titanium显示文摘 | Scott F Miller Peter J Blau Albert J Shih | 2007 | Journal of Materials Engineering and Performance2007，，14： | 1 |
| 12 | Mortality risk for dialysis patients with different levels of serum calcium, phosphorus, and PTH: the Dialysis Outcomes and Practice Patterns Study (DOPPS) 显示文摘 | Tentori F Blayney M J Albert JM | 2008 | Am J Kidney Dis2008，52，3： | 1 |
| 13 | Snow physics as relevant to snow photochemistry 显示文摘 | Domine F Albert M Huthwelker T | 2008 | Atmos Chem Phys2008，8，2： | 1 |
| 14 | Astrocytic response to injury显示文摘 | Lawrence F Eng Albert Yu CH | 1992 | Prog Brain Res1992，94，： | 1 |
| 15 | Extremophilic organisms as an unexplored source of antifungal compounds显示文摘 | Phoebe C H Combie J Albert F G | 2001 | J Antibiot2001，54，1： | 1 |
| 16 | Mortality risk for dialysis patients with different levels of serum calcium, phosphorus, and PTH: the Dialysis Outcomes and Practice Patterns Study (DOPPS)显示文摘 | Tentori F Blayney M J Albert JM | 2008 | Am J Kidney Dis2008，52，3： | 1 |
| 17 | Moisture absorption and hygrothermal aging in a bismaleirnide resin 显示文摘 | Li Rongbao Albert F Y Charles Y C | 2001 | Polymer2001，42，17： | 1 |
| 18 | Nomenclature for factors of the HLA system显示文摘 | Marsh S G E Albert E D Bodmer W F | 2002 | Human Immunology2002，63，12： | 1 |
| 19 | An inlervention study to enhance postoperative pain management显示文摘 | Bardiau F B Nicole F T Albert A | 2003 | Aneslhesia Analgesics2003，96，： | 1 |
| 20 | Evaluation of liquid chromatography and capillary electrophoresis for the elucidation of the artificial colorants brilliant blue and azorubine in red wines 显示文摘 | VILLIERS A D ALBERTS F LYNEN F | 2003 | Chromatographia2003，58，78： | 1 |
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