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| 1 | Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography显示文摘Endoscopic retrograde cholangiopancrea tography(ERCP) is the most complex gastrointestinal procedure,which needs patients’ cooperation. The aim of this study was to observe the quality and safey of sedation with propofol in patients undergoing therapeutic ERCP. METHODS:Seventy patients who had undergone therapeutic ERCP were randomly divided into two groups.One group, given intravenously propofol, and the other sedated with routine method, served as the control. Blood pressure, heart rate,oxygen saturation were monitored and cardiorespiratory event was observed. Patient cooperation,performance, recovery time and amnesia served as variables postoperation. RESULTS:Blood pressure elevated in four patients in the propofol group, less than in the control group(P<0.01). Seven patients showed decreased blood pressure after administration of propofol,but none in the control group (P<0.01). Twelve patients in the control group showed mild or significant resistance, but none in the propofol group (P<0.01). The time for performance in the propofol group(P<0.05) was shorter than in the control group. Patient recovery was quicker in the propofol group than in the control group (P<0.01). The degree of amnesia better in the propofol group than in the control group ( P<0.01). The degree of amnesia was also better in the propofol group than in the control group (P<0.01). CONCLUSIONS:Propofol proves to be an excellent sedative for therapeutic ERCP. Being effective and safe, it shows a shorter ERCP duration but quick recovery and better amnesia. It is better than other routine sedatives. | Digestive Department (Chen WX, Lin HJ, Gu Q, Zhong XQ, Yu CH, Li YM and Gu ZY) and Department of Intensive Care Unit (Zhang WF), First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003 , China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 10 |
| 2 | Association of nonalcoholic fatty liver disease with type 2 diabetes: clinical features and independent risk factors in diabetic fatty liver patients显示文摘Nonalcoholic fatty liver disease(NAFLD) is a common chronic liver disease in China, of which diabetic fatty liver (DFL) accounts for a large proportion in clinic. DFL is a disease without specific clinical features and lacking of confirmatory laboratory tests, and the etiology of hepatic steatosis remains poorly understood. The aim of this paper was to explore the clinical characteristics and to determine associated risk factors in type 2 diabetes patients with fatty liver. METHODS: A total of 166 patients, 53 in DFL group and 113 in NDFL(diabetes without fatty liver) group participated in this study. Serum fasting blood glucose (FBG), alanine aminotransferase(ALT), aspartate aminotransferase (AST), alkaline phosphate (AKP), gamma glutamyl transpeptidase (GGT), total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C) were measured in both groups. And these variables were analyzed by using Student’ s t test and logistic regression model. RESULTS:A progressive increase in the level of FBG, ALT, AST, AKP, GGT, TG( P<0.05) and a decrease of HDL-C(P<0.01)were observed from DFL group to NDFL group. And there was no statistical difference in the level of TC between the two groups. CONCLUSIONS:Dyslipidemia, dysglycemia and elevation of liver enzyme can be seen more frequently in the DFL patients than in the NDFL patients. The successive escalation of serum ALT and TG levels and the lower HDL-C level are the independent risk factors of DFL. | Department of Digestive Medicine, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Jin HB, Gu ZY, Yu CH and Li YM) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 9 |
| 3 | Role of CD56-expressing immature biliary epithelial cells in biliary atresia显示文摘AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary atresia(BA).METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.RESULTS: Differences in some clinical laboratoryparameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients(74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage(81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA. CONCLUSION: The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. | Rui-Zhong Zhang Jia-Kang Yu Jiao Peng Feng-Hua Wang Hai-Ying Liu Vincent CH Lui John M Nicholls Paul KH Tam Jonathan R Lamb Yan Chen Hui-Min Xia | 2016 | World Journal of Gastroenterology2016，22，8： | 8 |
| 4 | Phase Evolution during the Sintering of Submicron Ti(C,N)-Based Cermets显示文摘The submicron powder mixtures of TiC-TiN-WC-Mo-C-Ni sintered at 1400℃ or below in vacuum were studied by X-ray diffration (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses. The results showed that Mo2C fOrmed at 800℃ or below. Both WC and Mo2C disappeared at 1200 ℃, and TiN disappeared at 1250℃. In addihon, the variahons of lanice constans of the htanium carbonitride and nickel binder phase with sintering temperature were experimentally obtained, and the reason was analyzed. | Li, CH Xiong, WH Yu, LX | 2001 | Rare Metals2001，20，4： | 4 |
| 5 | Astrocytes produced and released interleukin-1, interleukin-6,tumor necrosis factor alpha and interferongamma under traumatic and metabolic injuries显示文摘 | Lau LT Yu CH | 2001 | J Neurotrauma2001，18，： | 2 |
| 6 | Cep57, a NEDDl-binding pericentriolar material component, is essential for spindle pole integrity显示文摘 | Qixi Wu Runsheng He Haining Zhou Albert CH Yu Bo Zhang Junlin Teng Jianguo Chen | 2012 | Cell Research2012，22，9： | 2 |
| 7 | Genistein stimulates the osteoblastic differentiation via NO/cGMP in bone marrow culture显示文摘 | Pan W Quarles LD Song LH Yu YH Jiao C Tang HB Jiang CH Deng HW Li YJ Zhou HH Xiao ZS | 2006 | 中国生物学文摘2006，20，5： | 2 |
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| 10 | Comparison of clinical outcomes of oral erythroleukoplakia treated with photodynamic therapy using either light-emitting diode or laser light显示文摘 | Yu CH Lin HP Chen HM Yang H | 2009 | Lasers Surg Med2009，41，： | 1 |
| 11 | CYP2C9 allele variants in Chinese hypertension patients and healthy controls显示文摘 | Yu BN Luo CH Wang D | 2004 | Clin Chim Acta2004，348，12： | 1 |
| 12 | Vertebroplasty for the treatment of osteoporotic compression spinal fracture: comparison of remedial action at different stages of injury显示文摘 | Yu SW Lee PC Ma CH | 2004 | J Trauma2004，，56： | 1 |
| 13 | Clinical manifestations of primary spontaneous pneumothorax in pediatric patients:an analysis of 78 patients显示文摘 | Shih CH Yu HW Tseng YC | 2011 | Pediatr Neonatol2011，52，3： | 1 |
| 14 | Prenatal diagnosis of z_lobar holoprosencephaly by two-dimensional and three-dimensional ultrasound 显示文摘 | Lai TH Chang CH Yu CH | 2000 | Prenatal Diagnosis2000，20，5： | 1 |
| 15 | 18F-FDG PET/CT-based gross tumor volume definition for radiotherapy in head and neck cancer: a correlation study between suitable uptake value threshold and tu- mor parameters显示文摘 | Kao CH Hsieh TC Yu CY | 2010 | Radiat Oncol2010，5，： | 1 |
| 16 | Exponential Synch- ronization of Cohen-Grossberg Neural Networks Via Periodi- cally Intermittent Control 显示文摘 | YU J HU CH JIANG H J | 2011 | Neurocomputing2011，74，10： | 1 |
| 17 | NMDA receptor-mediated K+efflux and neuronal apoptosis显示文摘 | Yeh CH Strasser U | 1999 | Science1999，284，5412： | 1 |
| 18 | Cosolvent effects on the spontaneous formation of vesicles from 1:1 anionic and cationic surfactant mixtures显示文摘 | YU WY YANG YM CHAN CH | 2005 | Langmuir2005，21，： | 1 |
| 19 | Intratumoral blood flow in uterine myoma correlated with a lower tumor size and volume,but not correlated with cell proliferation or angiogenesis显示文摘 | Huang SC YU CH Huang RT | 2001 | Obstet Gynecol2001，91，12： | 1 |
| 20 | A molecular signature of the Nottingham prognostic index in breast cancer显示文摘 | Yu K Lee CH Tan PH | 2004 | Cancer Res2004，64，9： | 1 |
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