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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Database techniques for the World Wide Web显示文摘 | DANIELA F ALON L ALBERTO M | 2005 | Sigmod Record2005，32，3： | 1 |
| 3 | Assessing patterns of geographic dispersal of Gelidium sesquipedale(Rhodophyta)through RAPD differentiation of populations显示文摘 | Alberto F Santos R Leitao J M | 1999 | Marine Ecology Progress Series1999，191，： | 1 |
| 4 | Docetaxel for treatment of solid tumours: a systematic review of clinical data 显示文摘 | Alberto M Frank F Gabriel H | 2005 | Lancet Oncot2005，6，7： | 1 |
| 5 | Liquid phase hydrogenation of cinnamaldehyde on Cu-based catalysts 显示文摘 | Alberto J M Diego A G Andres F T | 2003 | Applied Catalysis A : General2003，249，： | 1 |
| 6 | Fiat:Open Innovation in a Downturn(1993-2003)显示文摘 | ALBERTO D M FEDERICO F ANDREA P | 2010 | California Management Review2010，52，3： | 1 |
| 7 | Therapy of adrenal insufficiency:an up- date显示文摘 | Alberto F Viviana M | 2013 | Endocrine2013，43，3： | 1 |
| 8 | Evaluation of irrigation projects and water resomce manage- ment:A method-logical proposal 显示文摘 | RODRIGUFI M M SAEZ FERNANDFI F J ALBERTO ARAGON-COR- REA J | 2002 | Sustainable development2002，10，2： | 1 |
| 9 | Malignant pro- gression in pleomorphic xanthoastroeytoma: personal ex- perience and review of the literature显示文摘 | Elisabetta M Alberto F Enrico O | 2007 | J Neurological Sciences2007，252，2： | 1 |
| 10 | Docetaxel for treatment of solid tumours:a systematic review of clinical data显示文摘 | Alberto M Frank F Gabriel H | 2005 | Lancet Oncol2005，6，4： | 1 |
| 11 | Uniform invariance principle:robustness with respect to parameter variation显示文摘 | Rodrigues H M Alberto L F C Bretas N G | 2001 | Journal of Differential Equations2001，169，1： | 1 |
| 12 | Speed changes in the vicinity of horizontal curves on two-lane rural roads 显示文摘 | Alberto M F Medine Tarko P Andrew | 2007 | Journal of Transportation Engineering2007，133，4： | 1 |
| 13 | Studies on the mode of action of the antifungal hexapeptide PAF26 显示文摘 | ALBERTO M BELEN L G JOSE F M | 2006 | Antimicrob Agents Chemother2006，50，9： | 1 |
| 14 | Neutral and acidic hydrolysis reactions of the third generation anticancer drug oxaliplatin 显示文摘 | Lucas M F A Pavelka M Alberto M E | 2009 | J Phys Chem B2009，113，3： | 1 |
| 15 | Effect of copper and zinc on the activated sludge bacteria growth kinetics显示文摘 | Alberto C Sara F Fernando M | 1998 | Wat Res1998，32，： | 1 |
| 16 | A small fraction of dermatan sulfate with significantly increased anticoagulant activity was selected by interaction with the first complement protein显示文摘 | CALABRESE G C ALBERTO M F TUBIO R | 2004 | Thromb Res2004，113，： | 1 |
| 17 | Development of Cu-based oxygen carriers for chemical-looping combustion显示文摘 | Luis F de Diego Francisco Garc??a-Labiano Juan Adánez Pilar Gayán Alberto Abad Beatriz M Corbella Jose Mar??a Palacios | 2004 | Fuel2004，，13： | 1 |
| 18 | Determi-nation of SO2 in wines using a flow injection analysis system withpotentiometric detection显示文摘 | ALBERTO N A CRISTINA M C M C JOSEL F C L | 1998 | J Agric Food Chem1998，46，1： | 1 |
| 19 | Is asexual reproduction more important at geographical limits? A genetic study of the seagrass Zostera marina in the Ria Formosa, Portugal 显示文摘 | BELIJNGHAM M R REUSCH T B H ALBERTO F | 2003 | Mar Ecol-Prog Ser2003，265，： | 1 |
| 20 | EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer显示文摘 | Alberto FS Joan M Louis F | 2008 | J Clin Oncol2008，26，14： | 1 |
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