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| 1 | Coagulopathy and transfusion therapy in pediatric livertransplantation显示文摘Bleeding and coagulopathy are critical issues complicating pediatric liver transplantation and contributing to morbidity and mortality in the cirrhotic child. The complexity of coagulopathy in the pediatric patient is illustrated by the interaction between three basic models. The first model, 'developmental hemostasis', demonstrates how a different balance between pro- and anticoagulation factors leads to a normal hemostatic capacity in the pediatric patient at various ages. The second, the 'cell based model of coagulation', takes into account the interaction between plasma proteins and cells. In the last, the concept of 'rebalanced coagulation' highlights how the reduction of both pro- and anticoagulation factors leads to a normal, although unstable, coagulation profile. This new concept has led to the development of novel techniques used to analyze the coagulation capacity of whole blood for all patients. For example, viscoelastic methodologies are increasingly used on adult patients to test hemostatic capacity and to guide transfusion protocols. However, results are often confounding or have limited impact on morbidity and mortality. Moreover, data from pediatric patients remain inadequate. In addition, several interventions have been proposed to limit blood loss during transplantation, including the use of antifibrinolytic drugs and surgical techniques, such as the piggyback and lowering the central venous pressure during the hepatic dissection phase. The rationale for the use of these interventions is quite solid and has led to their incorporation into clinical practice; yet few of them have been rigorously tested in adults, let alone in children. Finally, the postoperative period in pediatric cohorts of patients has been characterized by an enhanced risk of hepatic vessel thrombosis. Thrombosis in fact remains the primary cause of early graft failure and re-transplantation within the first 30 d following surgery, and it occurs despite prolongation of standard coagulation assays. Data, however, are currently lacking regarding the use of anti-aggregation/anticoagulation therapies and how to best monitor for thrombosis in the early postoperative period in pediatric patients. Therefore, further studies are necessary to elucidate the interaction between the development of the coagulation system and cirrhosis in children. Moreover, strategies to optimize blood transfusion and anticoagulation must be tested specifically in pediatric patients. In conclusion, data from the adult world can be translated with difficulty into the pediatric field as indication for transplantation, baseline pathologies and levels of pro- and anticoagulation factors are not comparable between the two populations. | Mirco Nacoti Davide Corbella Francesco Fazzi Francesca Rapido Ezio Bonanomi | 2016 | World Journal of Gastroenterology2016，22，6： | 5 |
| 2 | Inflammation, lipid metabolism and cardiovascular risk in rheumatoid arthritis: A qualitative relationship?显示文摘Life expectancy in patients with rheumatoid arthritis(RA)is reduced compared to the general population owing to an increase in cardiovascular diseases(CVD)not fully explained by traditional cardiovascular risk factors.In recent years,interest has been focused on the alterations in lipid metabolism in relation to chronic inflammation as one of the possible mechanisms involvedin the pathogenesis of atherosclerosis of RA patients.Research regarding this issue has revealed quantitative alterations in lipoproteins during the acute-phase reaction,and has also demonstrated structural alterations in these lipoproteins which affect their functional abilities.Although many alterations in lipid metabolism have been described in this regard,these structural changes associated with inflammation are particularly important in high-density lipoproteins as they affect their cardioprotective functions.In this respect,excessive oxidation in low-density lipoprotein(LDL)and increased lipoprotein(a)with a predominance of smaller apolipoprotein(a)isoforms has also been reported.This article will discuss proinflammatory high-density lipoproteins(pi HDL),oxidized LDL and lipoprotein(a).Elevated concentrations of these lipoproteins with marked pro-atherogenic properties have been observed in RA patients,which could help to explain the increased cardiovascular risk of these patients. | Carmen García-Gómez Maria Bianchi Diana de la Fuente Lina Badimon Teresa Padró Emili Corbella Xavier Pintó | 2014 | World Journal of Orthopedics2014，5，3： | 4 |
| 3 | Structure of diamond-like carbon films containing transition metals deposied by reactive magnetron sputtering 显示文摘 | Corbella C Oncins G Gomez M A | 2005 | Diamond & Related Meterials2005，14，： | 1 |
| 4 | L- band sea surface emissivity: Preliminary results of the WISE- 2000 campaign and its application to salinity retrieval in the SMOS mission显示文摘 | CAMPS A CORBELLA I VALL-LLOSSERA M | 2003 | Radio Science2003，38，4： | 1 |
| 5 | Clinical relevance of Acinetobacter baumannii ventilator-associated pneumonia显示文摘 | Montero A Corbella X Ariza J | 2003 | Crit Care Med2003，31，： | 1 |
| 6 | Characterization Study and Five-Cycle Tests in a Fixed-Bed Reactor of Titania-Supported Nickel Oxide as Oxygen Carriers for the Chemical-Looping Combustion of Methane显示文摘 | Corbella B Diego L F Francisco-Garcia L | 2005 | Environmental Science & Technology2005，39，15： | 1 |
| 7 | An altemative to steroids for prevention of respiratory distress syndrome (RDS):Multieenter controlled study to compare ambroxol and betametha-sone显示文摘 | Luerti M Lazzarin A Corbella E Zavattini G | 1987 | J Perinat Med1987，15，3： | 1 |
| 8 | Emergence and rapid spread of carbapenem resistance during a large and sustained hospital outbreak of multiresistant Acinetobacter baumannii 显示文摘 | Corbella X Montero A Pujol M | 2000 | J Clin Microbiol2000，38，11： | 1 |
| 9 | Scoringsystem for the selection of high-risk patients in the In-tensive Care Unit显示文摘 | Lapichino G Mistraletti G Corbella D | 2006 | Crit Care Med2006，34，4： | 1 |
| 10 | High-dose carboplatin superselective intraarterial chemotherapy in advanced head and neck cancer 显示文摘 | Benazzo M Bernardo G Corbella F | 1996 | Acta Otorhinolaryngol Ital1996，16，1： | 1 |
| 11 | Composition and morphology of metal-containing diamond-like carbon films obtained by reactive magnetron sputtering 显示文摘 | Corbella C Pascual E Oncins G | 2005 | Thin Solid Films2005，482，： | 1 |
| 12 | Emergence and rapid spread of carbapenem resistance during a large and sustained hospital outbreak of multiresistant Acinetobacter baumannii 显示文摘 | Corbella X Montero A Pujol M | 2000 | Clin Microbiol2000，38，11： | 1 |
| 13 | Synthesis, characterization and structures of copper( II ) complexes with amide-base ligands : unusual formation of a linear tri- mer and a zig-zig chain and their contrast magnetic be- havior显示文摘 | SINGH J HUNDAL G CORBELLA M | 2007 | Polyhedron2007，26，14： | 1 |
| 14 | The visibility function in interferometric aperture synthesis radiometry显示文摘 | Corbella I Duffo N Vall-llossera M | 2004 | IEEE Trans Geosci Remote Sens2004，42，8： | 1 |
| 15 | MIRAS end-to-end calibration: application-to SMOS L1 processor显示文摘 | Corbella I Torres F Camps A | 2005 | IEEE Transactions on Geoscience and Remote Sensing2005，43，5： | 1 |
| 16 | Titania2supported iron oxide as oxygen carrier for chemical-looping combustion of methane显示文摘 | Corbella B M Palacio J M | 2007 | Fuel2007，86，： | 1 |
| 17 | Embryofetotoxicity of uranium in mice:Variability with the day of exposure显示文摘 | Bosque MA Domingo JL Corbella J | 1992 | Rev Toxicol1992，9，： | 1 |
| 18 | Development of Cu-based oxygen carriers for chemical-looping combustion显示文摘 | de DIEGO L F GARCíA-LABIANO F ADANEZ J GAYAN P ABAD A CORBELLA B M PALACIOS J M | 2004 | Fuel2004，83，13： | 1 |
| 19 | The use of visible and near infrared spectroscopy to classify the floral origin of honey samples produced in Uruguay显示文摘 | Corbella E Cozzolino D | 2005 | Journal of Near Infrared Spectroscopy2005，13，： | 1 |
| 20 | Emergence and rapid spread of carbapenem resistance during a large and sustained hospital outbreak of multiresistant Acinetobacter baumannii 显示文摘 | Corbella X Montero A Pujol M | 2000 | J Clin Microbiol2000，38，11： | 1 |
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