|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cytokine profile in Egyptian hepatitis C virus genotype-4 in relation to liver disease progression显示文摘AIM: To observe the imbalance between T helper cell Th1 and Th2 cytokines in several chronic hepatitis disease at different stages of disease progression.METHODS: We measured the cytokine levels of Th1 (IL-2 and IL-2R), Th2 (IL-10) and the pro-inflammatory cytokines (IL-6 and IL-6R and TNF and TNF-RⅠ and Ⅱ)by the ELISA technique in the sera of 33 hepatocellular carcinoma (HCC) patients and 20 chronic liver disease (CLD) patients. In addition, 20 asymptomatic hepatitis C virus carriers and 20 healthy subjects negative for hepatitis C virus(HCV) markers served as controls.RESULTS: Anti-HCV antibodies were found to be positive in 94% of HCC cases and 75% of CLD cases.On the other hand, HCV viremia was detected using RTPCR in 67% of HCC cases and 65% of CLD cases. HBsAg was positive in 9% of HCC cases and 30% of CLD cases.Also bilharzial-Ab was positive in 55% of HCC cases,65% of CLD cases and in 70% of asymptomatic carriers (ASC). HCC patients had significantly higher values of IL-2R, TNF-RⅡ (P<0.001), and TNF-RⅠ (P>0.05), but lower TNFα (P<0.001) and IL-6 (P = 0.032) in comparison to ASC. But, in comparison to non-cancer controls, HCC patients had higher values of IL-2R, IL-6R, TNF-RⅠ and TNF-RⅡ, but lower TNF-α (P<0.001). CLD patients had higher IL-2R, TNF-RⅠ, and TNF-RⅡ (P<0.001) than ASC. But, in comparison to non-cancer controls, CLD patients had higher values of IL-2R, TNF-RⅠ and TNF-RⅡ, but lower TNF-α (P<0.001). IL-10 was higher (though not significantly) in HCC and CLD patients than in symptomatic carriers and non-cancer controls.CONCLUSION: Liver disease progression from CLD to HCC due to HCV genotype-4 infection is associated with an imbalance between Th1 and Th2 cytokines. IL-2R,TNF-RⅠ, and TNF-RⅡ could be used as potential markers. | Abdel-Rahman N Zekri Mohammed S El-Din Ashour Ahmed Hassan Hanaa M Alam El-Din Amal MR El-Shehaby Maha A Abu-Shady | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | Alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a systematic review of published studies显示文摘 | Alam M Dokainish H Lakkis N | 2006 | J Interv Cardiol2006，19，4： | 1 |
| 3 | Hypoxia-inducible factors HIF-lalpha and HIF-2alpha in head and neck cancer: Relationship to tumor biology and treatment outcome in surgically resected patients显示文摘 | Beasley N J Leek R Alam M | 2002 | Cancer Res2002，62，9： | 1 |
| 4 | Hepatic tissue endothelin-1 levels in chronic disease correlate with disease severity and ascites显示文摘 | ALAM I BASS N M BACCHETTI P | 2000 | Am J Gastroenterol2000，95，： | 1 |
| 5 | Enteric protein loss and intestinal permeability changes in children during acute shigellosis and after recovery:effect of zinc supplementation显示文摘 | Alam A N Sarker S A Wahed M A | 1994 | Gut1994，35，12： | 1 |
| 6 | Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action 显示文摘 | Alam M A Subhan N Rahman M M | 2014 | Adv Nutr2014，5，4： | 1 |
| 7 | Gwemline transmission and expression of a lacZ containing transgene in tilapia (Oreochromis niloticus)显示文摘 | Alam M S Popplewell A Maclean N | 1996 | Transgenic Res1996，5，： | 1 |
| 8 | Distinctiveness of Mycobacterium tuberculosis genotypes from Human immunodeficiency virus typel seropositive and seronegative patients in lima 显示文摘 | Ahmed N Caviedes L Alam M | 2003 | Peru J Clin Microbiol2003，41，4： | 1 |
| 9 | Distribution of aminoglycoside resistance genes in recent clinical isolates of Enterococcus faecalis, Enterococcus f aecium and Enterococcus avium显示文摘 | Kobayashi N Alam M Nishimoto Y | 2001 | Epidemiol Infect2001，126，2： | 1 |
| 10 | Comparative effectiveness of nonpurpuragenic 595-nm pulsed dye laser and microsecond 1064nm neodymium: yttrium-aluminum-garnet laser for treatment of diffuse facial erythema: A double-blind randomized controlled trial 显示文摘 | Alam M Voravutinon N Warycha M | 2013 | J Am Acad Dermatol2013，69，3： | 1 |
| 11 | Effect of reaction time and P-content on mechanical strength of the interfaces formed between eutectic Sn-Ag solder and Au/electro- less Ni( P)/Cu bond pad 显示文摘 | Alam M O Chan Y C Tu K N | 2003 | Journal of Applied Phy- sics2003，94，6： | 1 |
| 12 | Solid state bioconversion of oil palm empty fruit bunches for cellulase enzyme production using a rotary drum bioreactor显示文摘 | I Alam M Z Mahmat M E Muhammad N | 2007 | Biochemical Engineering Journal2007，46，： | 1 |
| 13 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 14 | Concrete Moisture Content Measurement Using Interdigitated Near-Field Sensors显示文摘 | Alam M N Bhuiyan R H Dougal R A | 2010 | Sensors Journal IEEE2010，10，7： | 1 |
| 15 | Constitutive and tissue-specific differential expression of the cryIA(b)gene in transgenic rice plants conferring resistance to rice insect pest显示文摘 | Datta K Vasquez A Tu J M Tonizo L Alam M F Oliva N Abrigo E Cohen M Khush G S and Datta SK | | 0，，： | 1 |
| 16 | Rapid synthesis of silver nanoparticles using dried medicinal plant of basil 显示文摘 | AHMAD N SHARMA S ALAM M K SINGH V SHAMSI S MEHTA BFATMA A | 2010 | Colloids and Surfaces B: Biointerfaces2010，81，： | 1 |
| 17 | Adenosinergic modulation of rat basal forebrain neurons during sleep and waking: Neuronal recording with microdialysis显示文摘 | ALAM M N SZYMUSIAK R GONG H | 1999 | J Physiol1999，521，3： | 1 |
| 18 | Durability of brown planthopper, Nilaparvata lugens, resistance in flee variety IR64 in greenhouse selection studies显示文摘 | Alam S N Cohen M B | 1998 | Entomol Exp Appl1998，89，： | 1 |
| 19 | Functional anatomy of the Achilles tendon显示文摘 | Doral M N Alam M Bozkurt M | 2010 | Knee Surg Sports Traumatol Arthrosc2010，18，5： | 1 |
| 20 | Biosynthesis of the immunosuppressants FK506,FK520,and rapamycininvolves a previously undescribed family of enzymes acting on chorismate显示文摘 | Andexer J N Kendrew S G Alam M N | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员