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| 1 | Effects of creep feeding and supplemental glutamine or glutamine plus glutamate (Aminogut) on pre- and post-weaning growth performance and intestinal health of piglets显示文摘Background: Creep feeding is used to stimulate piglet post-weaning feed consumption.L-Glutamine(GLN) is an important source of fuel for intestinal epithelial cells.The objective of this study was to determine the impact of creep feeding and adding GLN or AminoGut(AG;containing glutamine + glutamate) to pre-and post-weaning diets on pig performance and intestinal health.Litters(N = 120) were allotted to four treatments during 14–21 d of lactation: 1) No creep feed(NC,n = 45);2) creep fed control diet(CFCD,n = 45);3) creep fed 1% GLN(CFGLN,n = 15);4) creep fed.88% AG(CFAG,n = 15).After weaning,the NC and CFCD groups were sub-divided into three groups(n = 15 each),receiving either a control nursery diet(NC-CD,CFCD-CD) or a diet supplemented with either GLN(NC-GLN,CFCD-GLN) or with AG(NC-AG,CFCD-AG).Litters that were creep fed with diets containing GLN or AG also were supplemented with those amino acids in the nursery diets(CFGLN-GLN,CFAG-AG).Glutamine was added at 1% in all three post-weaning diet phases and AG was added at.88% in phase 1 and 2 and at.66% in phase 3.Results: Feed conversion(feed/gain) showed means among treatment means close to significance(P = 0.056) and Tukey's test for pairwise mean comparisons showed that Pigs in the CFGLN-GLN group had the best feed conversion(feed/gain) in the first three-week period post-weaning,exceeding(P = 0.044) controls(CFCD-CD) by 34%.The NC-AG group had(P = 0.02) the greatest feed intake in the last three week of the study,exceeding controls(CFCD-CD) by 12%.CFGLN-GLN,CFCD-GLN and sow reared(SR) pigs had the greatest(P = 0.049) villi height exceeding the CFCD-AG group by 18%,20% and 19% respectively.The CFAG-AG group had the deepest(P = 0.001) crypts among all treatments.CFGLN-GLN,CFCD-GLN and SR groups had the greatest(P = 0.001) number of cells proliferating(PCNA) exceeding those in the NC-CD group by 43%,54% and 63% respectively.Sow reared pigs showed the greatest(P = 0.001) intestinal absorption capacity for xylose and mannitol.Conclusion: Supplementation of creep feed and nursery diets with GLN and/or AminoGut in the first three week improved feed conversion possibly due to improved intestinal health. | Rafael A Cabrera James L Usry Consuelo Arrellano Eduardo T Nogueira Marianne Kutschenko Adam J Moeser Jack Odle | 2013 | Journal of Animal Science and Biotechnology2013，4，3： | 17 |
| 2 | Clinical application of concentrated bone marrow aspirate in orthopaedics:A systematic review显示文摘AIM To examine the evidence behind the use of concentrated bone marrow aspirate(c BMA) in cartilage, bone, and tendon repair; establish proof of concept for the use of cB MA in these biologic environments; and provide the level and quality of evidence substantiating the use of cB MA in the clinical setting.METHODS We conducted a systematic review according to PRISMA guidelines. EMBASE, MEDLINE, and Web of Knowledge databases were screened for the use of cB MA in the repair of cartilage, bone, and tendon repair. We extracted data on tissue type, cB MA preparation, cB MA concentration, study methods, outcomes, and level of evidence and reported the results in tables and text.RESULTS A total of 36 studies met inclusion/exclusion criteria and were included in this review. Thirty-one of 36(86%) studies reported the method of centrifugation and preparation of cB MA with 15(42%) studies reporting either a cell concentration or an increase from baseline. Variation of c BMA application was seen amongst the studies evaluated. Twenty-one of 36(58%) were level of evidence Ⅳ, 12/36(33%) were level of evidence Ⅲ, and 3/36(8%) were level of evidence Ⅱ. Studies evaluated full thickness chondral lesions(7 studies), osteochondral lesions(10 studies), osteoarthritis(5 studies), nonunion or fracture(9 studies), or tendon injuries(5 studies). Significant clinical improvement with the presence of hyaline-like values and lower incidence of fibrocartilage on T2 mapping was found in patients receiving cB MA in the treatment of cartilaginous lesions. Bone consolidation and time to bone union was improved in patients receiving cB MA. Enhanced healingrates, improved quality of the repair surface on ultrasound and magnetic resonance imaging, and a decreased risk of re-rupture was demonstrated in patients receiving cB MA as an adjunctive treatment in tendon repair. CONCLUSION The current literature demonstrates the potential benefits of utilizing c BMA for the repair of cartilaginous lesions, bony defects, and tendon injuries in the clinical setting. This study also demonstrates discrepancies between the literature with regards to various methods of centrifugation, variable cell count concentrations, and lack of standardized outcome measures. Future studies should attempt to examine the integral factors necessary for tissue regeneration and renewal including stem cells, growth factors and a biologic scaffold. | Arianna L Gianakos Li Sun Jay N Patel Donald M Adams Frank A Liporace | 2017 | World Journal of Orthopedics2017，8，6： | 5 |
| 3 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 4 | Evolving role of magnetic resonance techniques in primary sclerosing cholangitis显示文摘Development of non-invasive methods to risk-stratify patients and predict clinical endpoints have been identified as one of the key research priorities in primary sclerosing cholangitis(PSC). In addition to serum and histological biomarkers, there has been much recent interest in developing imaging biomarkers that can predict disease course and clinical outcomes in PSC.Magnetic resonance imaging/magnetic resonance cholangiopancreatography(MRI/MRCP) continue to play a central role in the diagnosis and follow-up of PSC patients. Magnetic resonance(MR) techniques have undergone significant advancement over the last three decades both in MR data acquisition and interpretation. The progression from a qualitative to quantitative approach in MR acquisition techniques and data interpretation, offers the opportunity for the development of objective and reproducible imaging biomarkers that can potentially be incorporated as an additional endpoint in clinical trials. This review article will discuss how the role of MR techniques have evolved over the last three decades from emerging as an alternative diagnostic tool to endoscopic retrograde cholangiopancreatography, to being instrumental in the ongoing search for imaging biomarker of disease stage, progression and prognosis in PSC. | Emmanuel A Selvaraj Emma L Culver Helen Bungay Adam Bailey Roger W Chapman Michael Pavlides | 2019 | World Journal of Gastroenterology2019，25，6： | 2 |
| 5 | 三维大地电磁场相关测深曲线研究显示文摘本文着重讨论了三维MT问题中基于不同旋转不变量定义的响应定义与地下地形的相关程度,以一个真实的盆地模型为例比较各种定义对地下电性真实分布的反应能力。通过系统研究认为,由实部张量计算得到的旋转不变量函数比通常使用的模值形式有较高的横向分辨率。 | 张大海 Szarka L Adam A | 2004 | 石油地球物理勘探2004，39，B11： | 2 |
| 6 | ZNF265--a novel spliceosomal protein able to induce alternative splicing显示文摘 | Adams D J Van der Weyden L Mayeda A | 2001 | J Cell Biol2001，154，1： | 1 |
| 7 | Update on family psychoeducation for schizophrenia显示文摘 | Dixon L Adams C Lucksted A | 2000 | Schizoph Bull2000，26，11： | 1 |
| 8 | A maximum entropy approach to natural language processing显示文摘 | Adam L Berger Stephen A Della Pietra Vincent J Della Pietra | 1996 | Computational Linguistics1996，22，1： | 1 |
| 9 | Diffuse axonal in- jury and traumatic coma in the primate 显示文摘 | Gennarelli T A Thibault L E Adams J H | 1982 | Ann Neurol1982，12，6： | 1 |
| 10 | The exenatide analogue AC3174 attenuateshypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitiverats显示文摘 | Liu Q Adams L Broyde A | 2010 | Cardiovasc Diabetol2010，9，： | 1 |
| 11 | Design,Synthesis,and SAR of New Pyrrole-Oxindole Progesterone Receptor Modulators Leading to 5-(7-Fluoro-3,3-Dimethyl-2-Oxo-2,3-Dihydro-1H-Indol5-yl)-1-Methyl-1 H-Pyrrole-2-Carbonitrile (WAY-255348)显示文摘 | Fensome A Adams W R Adams A L | | 0，，： | 1 |
| 12 | Astroglial activation of extracellular-regulated kinase in early stages of Alzheimer disease显示文摘 | Webster B Hansen L Adame A | 2006 | J Neuropathol Exp Neurol2006，65，： | 1 |
| 13 | Effect of a chemical additive on Salmonella in poultry feed and host birds显示文摘 | WESTERFIELD B L ADAMS A W ERVIN L E | 1970 | Poult Sci1970，49，： | 1 |
| 14 | A social networkcaught in the Web显示文摘 | ADAMIC L A BUYUKKOKTEN O ADAR E | 2003 | First Monday2003，6，8： | 1 |
| 15 | Nonalcoholic fatty liver disease 显示文摘 | ADAMS L A LINDOR K D | 2007 | Ann Epidemiol2007，17，11： | 1 |
| 16 | Food consumption risks associated with animal clones: What should be investigated显示文摘 | RUDENKO L MATHESON J C ADAMS A L | 2004 | Cloning Stem Cells2004，6，2： | 1 |
| 17 | Viewpoint:experimental recovery of geometrically necessary dislocationdensity in polycrystals显示文摘 | EL-DASHER B S ADAMS B L ROLLETT A D | 2003 | Scripta Materialia2003，48，2： | 1 |
| 18 | Inhibition of herpes simplex virus type 1 with the modified green tea polyphenol palmitoyl-epigallocatechin gallate显示文摘 | de Oliveira A Adams S D Lee L H | | 0，，： | 1 |
| 19 | Variability in root production, phenology, and turnover rate among 12 temperate tree species 显示文摘 | MCCORMACK M L ADAMS T S SMITHWICK E A | 2014 | Ecology2014，95，8： | 1 |
| 20 | Friends and neighbors on the web显示文摘 | ADAMIC L A ADAR E | 2003 | Social Networks2003，25，3： | 1 |
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