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| 1 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | Controversies in fluid therapy: Type, dose and toxicity显示文摘Fluid therapy is perhaps the most common intervention received by acutely ill hospitalized patients; however, a number of critical questions on the efficacy and safety of the type and dose remain. In this review, recent insights derived from randomized trials in terms of fluid type, dose and toxicity are discussed. We contend that the prescription of fluid therapy is context-specific and that any fluid can be harmful if administered inappropriately. When contrasting ‘‘crystalloid vs colloid'', differences in efficacy are modest but differences in safety are significant. Differences in chloride load and strong ion difference across solutions appear to be clinically important. Phases of fluid therapy in acutely ill patients are recognized, including acute resuscitation, maintaining homeostasis, and recovery phases. Quantitative toxicity(fluid overload) is associated with adverse outcomes and can be mitigated when fluid therapy basedon functional hemodynamic parameters that predict volume responsiveness and minimization of non-essential fluid. Qualitative toxicity(fluid type), in particular for iatrogenic acute kidney injury and metabolic acidosis, remain a concern for synthetic colloids and isotonic saline, respectively. Physiologically balanced crystalloids may be the ‘‘default'' fluid for acutely ill patients and the role for colloids, in particular hydroxyethyl starch, is increasingly unclear. We contend the prescription of fluid therapy is analogous to the prescription of any drug used in critically ill patients. | Robert C McDermid Karthik Raghunathan Adam Romanovsky Andrew D Shaw Sean M Bagshaw | 2014 | World Journal of Critical Care Medicine2014，3，1： | 5 |
| 3 | Enemy at the gates: dendritic cells and immunity to mucosal pathogens显示文摘树枝状的房间(DC ) 是用作在天生、适应的免疫之间的一座必要的桥的多样、专业化的造血的房间。DC 在淋巴的所有和 nonlymphoid 机关存在并且在到在包括 mucosal 纸巾的上皮的表面的感染的第一个应答者之中。肺,内脏,和阴道 mucosa 显示的 DC 反映各独特的织物的不同显型和功能并且与他们在怒气和淋巴节点的对应物相对照,常常暴露于他们的环境的有害、良性的因素。Mucosal DC 认出并且通过模式识别的约会回答受体,和激活的 DC 移居到排干淋巴节点导致适应有免疫力的回答到病原体。DC 的专业化函数在 mucosa 帮助免疫和病原体控制的正式就职。如此的专门化包括有势力到病毒的 nucleic 酸,到在内脏腔的俘获有机体的 mucosal DC 的能力,到从另外的感染的房间的跨礼品的抗原的 DC 的能力,和开始 IgA 班在 B 房间切换的 mucosal DC 的能力的 plasmacytoid DC 的抗病毒的干扰素反应。DC 粘性在对 mucosal 病原体的有免疫力的反应也是批评的,当 DC 能对微型环境作出回应并且在附近的上皮的房间察觉到导致病原体的应力。最后, DC 通过串音与对方一起交往支持抗原表示和 T 房间免疫。一起,为对病原体的定制的有免疫力的回答的正式就职的这些过程条件 mucosal DC。 | Adam C Soloff | 2010 | Cell Research2010，20，8： | 4 |
| 4 | Barrett’s metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor显示文摘 | Anna M Nicholson Trevor A Graham Ashley Simpson Adam Humphries Nicola Burch Manuel Rodriguez-Justo Marco Novelli Rebecca Harrison Nicholas A Wright Stuart A C McDonald Janusz A Jankowski | 2012 | Gut2012，，10： | 3 |
| 5 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 6 | A theory for the ablation of glassy materials显示文摘 | BETHE H A ADAMS M C | 1959 | Journal of the Aero/Space Sciences1959，26，6： | 1 |
| 7 | The sequence of the human genome显示文摘 | Venter J C Adams M D Myers E W | 2001 | Science2001，291，： | 1 |
| 8 | Leptin receptor and neuropeptide Y gene expression in the sheep brain显示文摘 | Williams L M Adam C L Mercer J C | 1999 | Journal of Neuroendocrinology1999，11，： | 1 |
| 9 | Friedel - Crafts reactions in room temperature ionic liquids 显示文摘 | Adams C J Earle M J Roberts G | 1998 | Chem Commun1998，，19： | 1 |
| 10 | Discrete particle simulation ofagglomerate impact coalescence 显示文摘 | Lian G Thomtont C Adams M J | 1998 | Chemical Engineering Science(S0009-2509)1998，53，19： | 1 |
| 11 | Hydroch|orina tion of acetylene using carbon-supported gold cata- lysts:A study of catalyst reactivation显示文摘 | Bongani N Adams M D Neil ] C | 1991 | Journal of Catalysis1991，，37： | 1 |
| 12 | Gas chromatography inductively coupled plasma time-of-flight mass spectrometry for the speciation analysis of organolead compounds in environmental water samples 显示文摘 | Heisterkam P M Adams F C | 2001 | Fresenius J Anal Chem2001，370，： | 1 |
| 13 | Trade offs between the persistence of foliage and productivity in two Pinus species显示文摘 | Warren C R Adams M A | | 0，，： | 1 |
| 14 | Analytical models of adhesively bonded joints-Part I:literature survey显示文摘 | da Silva L F M das Neves P J C Adams R D | 2009 | International Journal of Adhesion and Adhesives2009，29，3： | 1 |
| 15 | Cerebral sinovenous thrombosis in children显示文摘 | Deveber G Andrew M Adams C | 2001 | N Engl J Med2001，345，6： | 1 |
| 16 | The sequence of human genome显示文摘 | Venter J C Adams M D Myers E W | 2001 | Science2001，291，5507： | 1 |
| 17 | Evidence for Functional Differentiation among Drosophila Septins in Cytokinesis and Cellularization显示文摘 | Adam J C Pringle J R Peifer M | 2000 | Molecular Biology of the Cell2000，11，9： | 1 |
| 18 | ACC/AHA2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction显示文摘 | Anderson J L Adams C D Antman E M | 2007 | Journal of the American College of Cardiology2007，50，7： | 1 |
| 19 | Streaming eovariance selection with applications to adaptive querying in sensor networks 显示文摘 | Anagnostopoulos C Adams N M Hand D J | 2010 | Computer Journal2010，53，9： | 1 |
| 20 | MRI appearance of placen- ta percreta and placenta accreta显示文摘 | Maldjian C Adam R Pelosi M ct al | 1999 | Magn Reson Imaging1999，17，7： | 1 |
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