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| 1 | IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treat- ment of Cancer Brain Tumor Group显示文摘 | van den Bent M J Dubbink HJ Marie Y Brandes AA Taphoorn MJ Wesseling P Frenay M Tijssen CC Lacombe D ldbaih A van Marion R Kros JM Dinjens WN Gorlia T. Sanson M. | 2010 | 中国神经肿瘤杂志2010，8，1： | 22 |
| 2 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 3 | Vasculogenic mimicry is a prognostic factor for postoperative survival in patients with glioblastoma显示文摘A previous report has confirmed the existence and clinical significance of vasculogenic mimicry(VM)in glioma.However,its conclusions about the negative clinical significance of VM in glioblastoma are based on a small group of patients and,thus,might be unconvincing.The aim of the present study was to reevaluate the clinical significance of VM in glioblastoma.Patients were classified as VM-positive or | Wang SY Ke YQ Lu GH Song ZH Yu L Xiao S Sun XL Jiang XD Yang ZL Hu CC | 2013 | 中国神经肿瘤杂志2013，11，3： | 22 |
| 4 | Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations显示文摘 | Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A Gilbertson RJ | 2006 | 中国神经肿瘤杂志2006，4，1： | 17 |
| 5 | Effect of metabolic structures and energy requirements on curdlan production by Alcaligenes faecalis显示文摘 | Zheng, ZY Lee, AW Zhan, XB Shi, Z Wang, L Zhu, L Wu, JR Lin, CC | 2007 | 中国生物学文摘2007，21，10： | 13 |
| 6 | 新生儿复苏培训降低新生儿死亡率的效能分析:文献综述,meta分析与Delphi法的应用显示文摘[背景]全球每年13600万新生儿中,约1000万需要外界的帮助才能建立自主呼吸,每年有约814000例新生儿死亡是由分娩相关足月儿死亡(以往定义为'出生窒息')所导致的。目前尚缺乏关于新生儿复苏培训降低新生儿死亡率效能的系统性评价。[目的]对在医院和社区层面开展的快速评估及初步刺激、基本的复苏措施这两种新生儿复苏培训干预方法在降低足月新生儿分娩相关死亡率('出生窒息')、早产相关并发症死亡率这两个生命指标方面的效能进行评价。[方法]采用系统综述的方法,检索并筛选符合标准的新生儿复苏培训研究文献。采用GRADE方法对文献的质量进行评价。对符合要求的文件进行Meta分析。对数据质量较低的文献采用专家咨询法估计效能大小。[结果]通过文献检索筛选了24篇新生儿复苏培训干预研究(20篇观察性研究,2篇半试验研究,2篇随机对照研究)。对其中3篇文献进行Meta分析结果显示,以医院为基础的新生儿复苏培训可使分娩相关足月儿死亡降低30%(RR=0.70,95%CI0.59~0.84);文献中涉及早产儿死亡率效能的数据质量不高,因此采用专家咨询法进行估计。以社区为基础的新生儿复苏培训干预研究具有较高的异质性,复苏培训通常是一系列培训包的一部分,且对早产儿和足月儿的定义标准不一致。专家咨询法估计结果显示,新生儿快速评估和初步刺激可使分娩相关新生儿死亡、早产儿死亡均降低10%;以医院为基础的培训可使早产儿死亡进一步降低10%,以社区为基础的培训可使分娩相关足月儿死亡率进一步降低20%,早产儿死亡率进一步降低5%。[结论]新生儿复苏培训在医院层面可以使足月新生儿分娩相关死亡率降低30%,然而中低收入水平的国家培训覆盖率仍较低。专家咨询法估计新生儿复苏培训在社区层面降低足月儿及早产儿死亡率的效能较小。需要对新生儿复苏培训的效果、成本、实施策略等进行更深入的研究与评价。 | Anne CC Lee Simon Cousens Stephen N Wall 徐韬 | 2012 | 中国妇幼卫生杂志2012，3，2： | 11 |
| 7 | 腹膜外径路腹腔镜前列腺癌根治术(附65例报告)显示文摘目的:探讨腹膜外径路腹腔镜PCa根治术的初步体会。方法:经腹膜外径路进行腹腔镜PCa根治术65例。结果:64例(98.5%)成功,手术时间100~440min,平均172min。出血量150~800ml,平均340ml,7例(10.8%)患者输红细胞悬液2~4U。1例术中发生直肠损伤,2例术后发生尿外渗。6例(9.2%)患者术后病理提示切缘阳性。58例(89.2%)患者术后3个月尿控良好。结论:腹膜外径路腹腔镜PCa根治术是安全、可行的。且因避免了术中、术后对腹腔内肠管的干扰,降低了手术并发症,利于术后患者的恢复,值得在临床推广应用。 | 薛波新 单玉喜 ABBOU CC | 2007 | 中华男科学杂志2007，13，11： | 9 |
| 8 | 癌症治疗方案中的生活质量评价——方案发展的研究论题显示文摘最近,在癌症治疗临床试验的终点——反应和生存中,加入生活质量评价,已引起科研人员的关注,临床试验特别是癌症研究中生活质量评价的论文不断涌现.1991年由政府资助的许多研究中,生活质量评价成为研究终点之一,它已成为今后癌症治疗研究的趋势.然而,生活质量评价面临一些问题,处理不当,往往影响试验的成功完成,这些问题包括:生活质量研究仅作为治疗方案的备选添加项目或方案完成后的一项活动;奢望过高的评价表; | Gotay CC 唐举东 刘亚力 | 1993 | 国外医学(肿瘤学分册)1993，20，2： | 5 |
| 9 | 咽鼓管功能障碍定义、类型、临床表现及诊断的共识声明显示文摘1引言 英国NIHR卫生技术评估(HTA)计划发表的咽鼓管功能障碍治疗的系统回顾性研究指出,目前缺乏咽鼓管功能障碍统一的定义和诊断标准,推进这一领域研究进展的关键是针对咽鼓管功能障碍的诊断标准和重要临床结果达成共识。因此,2014年06月21日在荷兰阿姆斯特丹召开了由咽鼓管功能障碍领域的医学专家和科学家们参加的研讨会,旨在针对咽鼓管功能障碍的定义、临床表现、诊断及未来研究领域等方面达成共识。本文针对本次会议讨论结果总结如下。 | Schilder AG Bhutta MF Butler CC Holy C Levine LH Kvaerner KJ Norman G Pennings RJ Poe D Silvola JT Sudhoff H Lund VJ 翻曲腾飞 龚树生 | 2015 | 中国医学文摘(耳鼻咽喉科学)2015，30，6： | 5 |
| 10 | 补充甲状腺激素对亚临床甲状腺功能减退患者死亡率的影响显示文摘最新发表的一项荟萃分析入选了5项观察性研究和两项随机对照试验,共21055例成人患者。结果发现,在总人群中,甲状腺激素治疗与全因死亡或心血管死亡无关。但亚组分析显示,在年龄小于65岁的人群中,甲状腺激素治疗明显降低患者的全因死亡率(相对风险=0.50,95%可信区间:0.29~0.85,P=0.011)和心血管死亡率(相对风险=0.54,95%可信区间:0.37~0.80,P=0.002)。 | 杨菊红(摘译) Peng CC Huang HK Wu BB | 2021 | 国际内分泌代谢杂志2021，41，1： | 5 |
| 11 | 信息高速公路与电子全球图书馆:现实和挑战显示文摘信息高速公路与电子全球图书馆:现实和挑战[美]ching-chihChen原著李国秋编译吕斌校审多年前.托夫勒等未来学家曾预测过地球村的到来,现在我们正经历这样一个事实-地球在缩小。作者本人优先经历了这种缩小的全球村.1992年冬季.作者一月内对东欧... | Chen,CC 李国秋 | 1995 | 图书馆理论与实践1995，，3： | 4 |
| 12 | The discovery of eclogite dikes in low-greenschist facies volcaniclastic rocks of the Dabie Mountains显示文摘ECLOGITE occurs in different metamorphic rocks in the Dabie Mountains. Some dike-likeeclogite and garnet amphibolite were discovered when we investigated the newly founded low-greenschist facies volcaniclastic rocks in Changpu, Yuexi County and Siqian, Taihu County(fig.1). Coesite and quartz pseudomorphs exist in garnet and omphacite. By studying the oc-currence and petrography-mineralogy characteristic, we believe that the eclogite is of | Gao, TS Tang, JF Zhou, CT Hou, MJ Qian, CC | 1997 | Chinese Science Bulletin1997，42，20： | 3 |
| 13 | 水质控制及其在注水操作中的重要性显示文摘 | Patt.,CC 冯耀忠 | 1990 | 油气田开发工程译丛1990，，8： | 3 |
| 14 | 代谢型谷氨酸受体可作为一种新型恶性胶质瘤治疗靶点(英文)显示文摘Objective Metabotropic glutamate receptors(mG luR)are predominantly involved in maintenance of cellular homeostasis of central nervous system.However,evidences have suggested other roles of mG luR in human tumors.Aberrant mG luR signaling has been shown to participate in transformation and maintenance of various cancer types,including malignant brain tumors.This review intends to summarize recent findings regarding the involvement of mG luR-mediated intracellular signaling pathways in progression,aggressiveness,and recurrence of malignant gliomas,mainly glioblastomas(GBM),highlighting the potential therapeutic applications of mG luR ligands.In addition to the growing number of studies reporting mG luR gene or protein expression in glioma samples(resections,lineages,and primary cultures),pharmacological blockade in vitro of mG luR1 and mG luR3 by selective ligands has been shown to be anti-proliferative and anti-migratory,decreasing activation of MAPK and PI3K pathways.In addition,mG luR3 antagonists promoted astroglial differentiation of GBM cells and also enabled cytotoxic action of temozolomide(TMZ).mG luR3-dependent TMZ toxicity was supported by increasing levels of MGMT transcripts through an intracellular signaling pathway that sequentially involves PI3K and NF-κB.Further,continuous pharmacological blockade of mG luR1 and mG luR3 have been shown to reduced growth of GBM tumor in two independent in vivo xenograft models.In parallel,low levels of mG luR3 mRNA in GBM resections may be a predictor for long survival rate of patients.Since several Phase I,II and III clinical trials are being performed using group I and II mG luR modulators,there is a strong scientifically-based rationale for testing mG luR antagonists as an adjuvant therapy for malignant brain tumors. | Pereira MS Klamt F Thomé CC Worm PV de Oliveira DL | 2017 | 中华神经外科疾病研究杂志2017，16，1： | 3 |
| 15 | Survival analysis of breast cancer liver metastasis treated by hepatectomy: A propensity score analysis for Chinese women in Hong Kong显示文摘Background: Survival of patients with breast cancer liver metastasis is very poor. This study aimed to analyze the survival outcome of hepatectomy for this patient population. Methods: From January 1995 to December 2014, 2522 patients with liver cancer received hepatectomy at our hospital. Twenty-one of them, all female, received the operation for breast cancer liver metastasis. Performance was compared with patients with colorectal liver metastasis treated with hepatectomy after propensity score analysis in a ratio of 1:3. Results: Twenty-one patients received hepatectomy for breast cancer. After propensity score matching, 63 patients who had hepatectomy for colorectal cancer were selected for comparison. There was no significant difference in immediate or short-term outcomes between the two groups of patients in terms of operative time, blood loss and surgical morbidities. All patients with breast cancer had R0 resection. No hospital death occurred. After hepatectomy, the 1-, 3- and 5-year overall survival rates were 100.0%, 58.9% and 58.9% respectively in patients with breast cancer. The 1-, 3- and 5-year overall survival rates were 95.0%, 57.2% and 39.7% respectively in patients with colorectal cancer (P = 0.572). On multivariate analysis, triple negative status was the only independent poor prognostic factor in breast cancer liver metastasis (OR = 6.411;95% CI: 1.351–30.435;P = 0.019). Conclusions: Hepatectomy is a safe and effective way of treating breast cancer liver metastasis at experienced centers where multidisciplinary adjuvant treatments are available. It can be considered more frequently as part of the multidisciplinary care for this patient population. | Tan To Cheung Kenneth SH Chok Albert CY Chan Simon HY Tsang Wing Chiu Dai Thomas CC Yau Ava Kwong Chung Mau Lo | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，5： | 3 |
| 16 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 17 | Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress显示文摘BACKGROUND:Liver ischemia reperfusion(IR)injury triggers a systemic inflammatory response and is the main cause of organ dysfunction and adverse postoperative outcomes after liver surgery.Pentoxifylline(PTX)and hypertonic saline solution(HTS)have been identified to have beneficial effects against IR injury.This study aimed to investigate if the addition of PTX to HTS is superior to HTS alone for the prevention of liver IR injury. | Vinicius Rocha-Santos Estela RR Figueira Joel A Rocha-Filho Ana MM Coelho Rafael Soraes Pinheiro Telesforo Bacchella Marcel CC Machado Luiz AC D'Albuquerque | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，2： | 3 |
| 18 | 妊娠前心血管功能与先兆子痫及胎儿生长受限的关系显示文摘妊娠期间的子痫前期和胎儿生长受限与后期母亲心血管病风险增加有关。目前尚不清楚这种关联是因果关系还是由类似的事先存在的风险因素导致。澄清这种关联需要在受孕前征募研究对象,但在方法上是困难的。 | Foo FL Mahendru AA Masini G Fraser A Cacciatore S MacIntyre DA McEniery CM Wilkinson IB Bennett PR Lees CC 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，8： | 3 |
| 19 | 心血管健康研究中血压轨迹与死亡率、心血管病事件和心力衰竭的关系显示文摘老年人的一般血压轨迹尚未明确,其与临床结局的关系也尚不确定。方法:本研究采用层次聚类分析法来确定心血管健康研究中4067参与者从0~7年重复测量血压值的血压轨迹。然后采用Cox比例风险回归模型评估每种血压轨迹聚类与全因死亡率、 | Smitson CC Scherzer R Shlipak MG Psaty BM Newman AB Sarnak MJ Odden MC Peralta CA 陈云 叶鹏 | 2018 | 中华高血压杂志2018，26，2： | 3 |
| 20 | 激活β_3肾上腺素能受体恢复一氧化氮/氧化还原平衡,增强高血糖患者的内皮功能显示文摘一氧化氮与O_2^-之间的平衡紊乱(即一氧化氮/氧化还原失衡)是糖尿病引起的血管功能障碍的中心病理环节。该研究目的为在高血糖动物模型中探索β_3肾上腺素能受体(β_3adrenergic receptor,β3AR)激活能否耦合激活内皮型一氧化氮合酶(endothelial nitric oxide synthase,eNOS)。 | 刘莉 叶鹏 Karimi Galougahi K Liu CC Garcia A Gentile C Fry NA Hamilton EJ Hawkins CL Figtree GA | 2016 | 中华高血压杂志2016，24，3： | 2 |
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