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| 1 | Climate variation since the Last Interglaciation recorded in the Guliya ice core显示文摘The climatic and environmental variations since the Last Interglaciation are reconstructed based on the study of the upper 268 m of the 309-m-long Guliya ice core. Five stages can be distinguished since the Last Interglaciation from the δ18O record in the Guliya ice core: Stage 1 (Deglaciation), Stage 2 (the Last Glacial Maximum), Stage 3 (interstadial), Stage 4 (interstadial in the early glacial maximum) and Stage 5 (the Last Interglaciation). Stage 5 can be divided further into 5 substages; a, b, c, d, e. The δ18O record in the Guliya ice core indicates clearly the close correlation between the temperature variation on the Tibetan Plateau and the solar activities. The study indicates that the solar activity is a main forcing to the climatic variation on the Tibetan Plateau. Through a comparison of the ice core record in Guliya with that in the Greenland and the Antarctic, it can be found that the variation of large temperature variation events in different parts of the world is generally the same, | 姚檀栋 L.G.Thompson 施雅风 秦大河 焦克勤 杨志红 田立德 E.M.Thompson | 1997 | Science China Earth Sciences1997，40，6： | 68 |
| 2 | Distant hybridization leads to different ploidy fishes显示文摘Distant hybridization makes it possible to transfer the genome of one species to another, which results in changes in phenotypes and genotypes of the progenies. This study shows that distant hybridization or the combination of this method with gynogenesis or androgenesis lead to different ploidy fishes with genetic variation, including fertile tetraploid hybrids, sterile triploid hybrids, fertile diploid hybrids, fertile diploid gynogenetic fish, and their derived progenies. The formations of the different ploidy fishes depend on the genetic relationship between the parents. In this study, several types of distant hybridization, including red crucian carp (Carassius auratus red var.) (2n=100, abbreviated as RCC) (♀)×common carp (Cyprinus carpio L.) (2n=100, abbreviated as CC) (♂), and RCC (2n=100) (♀)×blunt snout bream (Megalobrama amblycephala) (2n=48, abbreviated as BSB) (♂) are described. In the distant hybridization of RCC (♀)×CC (♂), bisexual fertile F3–F18 allotetraploid hybrids (4n=200, abbreviated as 4nAT) were formed. The diploid hybrid eggs and diploid sperm generated by the females and males of 4nAT developed into diploid gynogenetic hybrids and diploid androgenetic hybrids, respectively, by gynogenesis and androgenesis, without treatment for doubling the chromosome. Improved tetraploid hybrids and improved diploid fishes with genetic variation were derived from the gynogenetic hybrid line. The improved diploid fishes included the high-body RCC and high-body goldfish. The formation of the tetraploid hybrids was related to the occurrence of unreduced gametes generated from the diploid hybrids, which involved in premeiotic endoreduplication, endomitosis, or fusion of germ cells. The sterile triploid hybrids (3n=150) were produced on a large scale by crossing the males of tetraploid hybrids with females of diploid fish (2n=100). In another distant hybridization of RCC (♀)×BSB (♂), different ploidy fishes were obtained, including diploid bisexual fertile natural gynogenetic fish (2n=100), sterile triploid hybrids (3n=124), and bisexual fertile tetraploid hybrids (4n=148). Furthermore, two kinds of pentaploid hybrids (5n=172 and 5n=198) were formed. The biological characteristics and the mechanisms of formation of the different ploidy fish were compared and discussed at the cellular and molecular level. The results indicated distant hybridization or the combination of this method with gynogenesis or androgenesis affects the formation of different ploidy fish with genetic variation. | LIU ShaoJun Key Laboratory of Protein Chemistry and Fish Developmental Biology of Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha 410081, China | 2010 | Science China(Life Sciences)2010，53，4： | 39 |
| 3 | Characteristics of volatile organic compounds,NO_2,and effects on ozone formation at a site with high ozone level in Chengdu显示文摘Chengdu is a megacity in the southwest of China with high ozone(O_3) mixing ratio.Observation of volatile organic compounds(VOCs), NO_2 and O_3 with high temporal resolution was conducted in Chengdu to investigate the chemical processes and causes of high O_3 levels. The hourly mixing ratios of VOCs, NO2, and O_3 were monitored by an online system from 28 August to 7 October, 2016. According to meteorological conditions,Chengdu, with relative warm weather and low wind speed, is favorable to O_3 formation.Part of the O_3 in Chengdu may be transported from the downtown area. In O_3 episodes,the average mixing ratios of NO_2 and O_3 were 20.20 ppbv and 47.95 ppbv, respectively. In non-O_3 episodes, the average mixing ratios of NO_2 and O_3 were 16.38 ppbv and 35.15 ppbv,respectively. The average mixing ratio of total VOCs(TVOCs) was 40.29 ppbv in non-O_3 episodes, which was lower than that in O_3 episodes(53.19 ppbv). Alkenes comprised51.7% of the total O_3 formation potential(OFP) in Chengdu, followed by aromatics which accounted for 24.2%. Ethylene, trans-pentene, propene, and BTEX(benzene, ethylbenzene,toluene, m/p-xylene, o-xylene) were also major contributors to the OFP in Chengdu. In O_3 episodes, intensive secondary formations were observed during the campaign. Oxygenated VOCs(OVOCs), such as acetone, Methylethylketone(MEK), and Methylvinylketone(MVK)were abundant. Isoprene rapidly converted to MVK and Methacrolein(MACR) during O_3 episodes. Acetone was mainly the oxidant of C3-C5 hydrocarbons. | Yuanyuan Deng Jing Li Yaqi Li Rongrong Wu Shaodong Xie | 2019 | Journal of Environmental Sciences2019，31，1： | 29 |
| 4 | 华北克拉通东北缘岩石圈深部物质组成的不均一性:来自吉林南部中生代火山岩元素及Sr-Nd同位素地球化学的证据显示文摘本文报导了吉林南部果松组和三棵榆树组火山岩的全岩K-Ar和角闪石^(40)Ar/^(39)Ar定年结果和岩石地球化学资料,并讨论了吉林南部早白垩世火山岩岩浆源区性质以及空间变异。定年结果显示,果松组和三棵榆树纽火山岩的形成时代分别为130.2±0.3Ma和118.3±1.9Ma。果松组火山岩主要由玄武岩-玄武质粗面安山岩-粗面安山岩-英安岩组成;它们的SiO_2含量介于46%~64%,Mg~#介于31~50之间,Al_2O_3含量介于14.9%~18.9%之间,全碱含量(Na_2O+K_2O)介于4.61%~9.23%之间,属于亚碱性系列,具钙碱性演化趋势;并以富集大离子亲石元素(LILEs)和轻稀土元素(LREEs),亏损重稀土元素(HREEs)和Nb、Ta、Ti等高场强元素(HFSEs)为特征;(^(87)Sr/^(86)Sr)_i值和ε_(Nd)(t)值分别介于0.7065~0.7077和-2.67~ -19.71之间。果松组火山岩的成分具有较好的空间变异趋势,由东向西,火山岩的基性程度增高,东部果松组火山岩具有较高的(^(87)Sr/^(86)Sr)。值,而西部具有较低的ε_(Nd)(t)值。三棵榆树组火山岩由粗面安山岩和粗面英安岩组成;三棵榆树组火山岩的SiO_2含量介于55.5%~65.8%之间,Mg~#介于42~50,Al_2O_3含量介于15.0%~15.7%,全碱含量偏高(Na_2O+K_2O=6.93%~9.24%),主体属于亚碱性系列,具钙碱性系列的演化趋势;并以较高的Th/U(5.36~5.82)、Ba/Nh(50.2~120.0)、(La/Yh)_N(32.9~47.9)和Sr/Y(50.0~72.4)比值为特征;它们的(^(87)Sr/^(86)Sr)_i值和ε_(Nd)(t)值分别变化于0.7056~0.7057和-8.99~-19.71之间。上述特征揭示,果松组火山岩(130Ma)的形成主要与古太平洋板块的俯冲作用有关,岩浆来源于受流体/熔体交代的地幔楔,东西部受到不同程度陆壳物质的混染。与果松组火山岩相比,三棵榆树组火山岩(118Ma)形成于俯冲背景下的相对引张环境,岩浆来源于受交代的岩石圈地幔,但受到深部陆壳物质的混染。 | 裴福萍 许文良 杨德彬 于洋 孟恩 | 2009 | 岩石学报2009，25，8： | 28 |
| 5 | Magnetostratigraphy and palaeoclimate of Red Clay sequences from Chinese Loess Plateau显示文摘Two Red Clay profiles near Xi’ an and Xifeng were investigated in an attempt to determine magne-tostratigraphic and palaeoclimatic records. The results show that aeolian dust accumulation and the related East Asia palaeomonsoon system had begun by 6.5 Ma, and it is deduced that the Tibetan Plateau had reached a significant elevation at that time. The late Tertiary palaeoclimatic history of the Red Clay as reflected by magnetic susceptibility is reconstructed during the period of 6.5-2.5 Ma. Stepwise increase in susceptibility of aeolian dust accumulation appears to have a close correlation to the uplift processes of the Tibetan Plateau. The remarkable increase of aeolian dust accumulation at 3.2 Ma appears to be due to the influence of global ice volume on the East Asia monsoon. Palaeomonsoon variation during the late Tertiary as recorded in the Red Clay sequences from the Chinese Loess Plateau can be regarded as the product of a number of interacting factors, such as uplift of the Tibetan Plateau, | 孙东怀 刘东生 陈明扬 安芷生 John Shaw | 1997 | Science China Earth Sciences1997，40，4： | 27 |
| 6 | Air pollution characteristics and their relationship with emissions and meteorology in the Yangtze River Delta region during 2014–2016显示文摘With rapid economic growth and urbanization, the Yangtze River Delta(YRD) region in China has experienced serious air pollution challenges. In this study, we analyzed the air pollution characteristics and their relationship with emissions and meteorology in the YRD region during 2014–2016. In recent years, the concentrations of all air pollutants, except O3,decreased. Spatially, the PM2.5, PM10, SO2, and CO concentrations were higher in the northern YRD region, and NO2 and O3 were higher in the central YRD region. Based on the number of non-attainment days(i.e., days with air quality index greater than 100), PM2.5 was the largest contributor to air pollution in the YRD region, followed by O3, PM10, and NO2.However, particulate matter pollution has declined gradually, while O3 pollution worsened.Meteorological conditions mainly influenced day-to-day variations in pollutant concentrations. PM2.5 concentration was inversely related to wind speed, while O3 concentration was positively correlated with temperature and negatively correlated with relative humidity.The air quality improvement in recent years was mainly attributed to emission reductions.During 2014–2016, PM2.5, PM10, SO2, NOx, CO, NH3, and volatile organic compound(VOC)emissions in the YRD region were reduced by 26.3%, 29.2%, 32.4%, 8.1%, 15.9%, 4.5%, and0.3%, respectively. Regional transport also contributed to the air pollution. During regional haze periods, pollutants from North China and East China aggravated the pollution in the YRD region. Our findings suggest that emission reduction and regional joint prevention and control helped to improve the air quality in the YRD region. | Tao Ma Fengkui Duan Kebin He Yu Qin Dan Tong Guannan Geng Xuyan Liu Hui Li Shuo Yang Siqi Ye Beiyao Xu Qiang Zhang Yongliang Ma | 2019 | Journal of Environmental Sciences2019，31，9： | 26 |
| 7 | Characteristics of one-year observation of VOCs,NOx, and O_3 at an urban site in Wuhan, China显示文摘A continuous online observation of ozone and its precursors(NOx, VOCs) was carried out in central urban Wuhan from September 2016 to August 2017. The concentration levels of ozone,NOx, VOCs and their variations in urban Wuhan were analyzed, as well as effects of VOCs on ozone photochemical generation and the main controlling factors for ozone production. During the observation period, the average concentrations of ozone and NOx in Wuhan was 22.63 and30.14 ppbv, respectively, and the average concentration of VOCs was 32.61 ppbv(42.3% alkanes,13.0% alkenes, 10.0% aromatics, 7.3% acetylene, 9.9% OVOCs, and 10.5% halohydrocarbons).Ozone concentration was higher in spring and summer as compared with autumn and winter,wheras VOCs and NOx concentratios were lower in spring and summer but higher in autumn and winter. Aromatics and alkenes, two of VOCs species, showed the highest contributions to ozone formation potential in Wuhan(35.7% alkenes, 35.4 aromatics, 17.5% alkanes, 8.6% OVOCs,1.6% halogenated hydrocarbons, and 1.4% acetylene). Among all VOCs species, those with the highest contribution were ethylene, m-xylene, toluene, propylene and o-xylene. The contribution of these five compounds to the total ozone formation potential concentration was 43.90%.Ozone-controlling factors in Wuhan changed within one day; during the early morning hours(6:00–9:00), VOCs/NOx was low, and ozone generation followed a VOCs-limited regime.However, during the peak time of ozone concentration(12:00–16:00), the ratio of VOCs/NOx was relatively high, suggesting that ozone generation followed a NOx-limited regime. | Yichang Yang Xingang Liu Jun Zheng Qinwen Tan Miao Feng Yu Qu Junling An Nianliang Cheng | 2019 | Journal of Environmental Sciences2019，31，5： | 26 |
| 8 | Genetic variation of hepatitis B virus and its significance forpathogenesis显示文摘Hepatitis B virus(HBV)has a worldwide distribution and is endemic in many populations.Due to its unique life cycle which requires an error-prone reverse transcriptase for replication,it constantly evolves,resulting in tremendous genetic variation in the form of genotypes,sub-genotypes,and mutations.In recent years,there has been considerable research on the relationship between HBV genetic variation and HBV-related pathogenesis,which has profound implications in the natural history of HBV infection,viral detection,immune prevention,drug treatment and prognosis.In this review,we attempted to provide a brief account of the influence of HBV genotype on the pathogenesis of HBV infection and summarize our current knowledge on the effects of HBV mutations in different regions on HBV-associated pathogenesis,with an emphasis on mutations in the pre S/S proteins in immune evasion,occult HBV infection and hepatocellular carcinoma(HCC),mutations in polymerase in relation to drug resistance,mutations in HBV core and e antigen in immune evasion,chronicalization of infection and hepatitis B-related acute-on-chronic liver failure,and finally mutations in HBV x proteins in HCC. | Zhen-Hua Zhang Chun-Chen Wu Xin-Wen Chen Xu Li Jun Li Meng-Ji Lu | 2016 | World Journal of Gastroenterology2016，22，1： | 22 |
| 9 | Wx^lv、the Ancestral Allele of Rice Waxy Gene显示文摘In rice grains,the Waxy (Wx) gene is responsible for the synthesis of amylose,the most important determinant for eating and cooking quality.The effects of several Wx alleles on amylose content and the taste of cooked rice have been elucidated.However,the relationship between artificial selection and the evolution of various Wx alleles as well as their distribution remain unclear.Here we report the identification of an ancestral allele,Wx^lv,which dramatically affects the mouthfeel of rice grains by modulating the size of amylose molecules.We demonstrated that WF originated directly from wild rice,and the three major Wx alleles in cultivated rice (Wx^b,Wx^a,and Wx^in) differentiated after the substitution of one base pair at the functional sites.These data indicate that the Wx^lv allele played an important role in artificial selection and domestication.The findings also shed light on the evolution of various Wx alleles,which have greatly contributed to improving the eating and cooking quality of rice. | Changquan Zhang Jihui Zhu Shengjie Chen Xiaolei Fan Qianfeng Li Yan Lu Min Wang Hengxiu Yu Chuandeng Yi Shuzhu Tang Minghong Gu Qiaoquan Liu | 2019 | Molecular Plant2019，12，8： | 22 |
| 10 | Trends in particulate matter and its chemical compositions in China from 2013–2017显示文摘Accurate determination of the atmospheric particulate matter mass concentration and chemical composition is helpful in exploring the causes and sources of atmospheric enthalpy pollution and in evaluating the rationality of environmental air quality control strategies.Based on the sampling and chemical composition data of PM2.5 in different key regions of China in the CARE-China observation network,this research analyzes the environmental air quality data released by the China National Environmental Monitoring Centre during the studied period to determine the changes in the particulate matter mass concentration in key regions and the evolution of the corresponding chemical compositions during the implementation of the Action Plan for Prevention and Control of Air Pollution from 2013-2017.The results show the following.(1)The particulate matter mass concentration in China showed a significant downward trend;however,the PM2.5 annual mass concentration in 64%of cities exceeds the New Chinese Ambient Air Quality Standard(CAAQS)GradeⅡ(GB3095-2012).The region to the east of the Taihang Mountains,the Fenhe and Weihe River Plain and the Urumqi-Changji regions in Xinjiang,all have PM2.5 concentration loading that is still high,and heavy haze pollution occurred frequently in the autumn and winter.(2)During the heavy pollution in the autumn and winter,the concentrations of sulfate and organic components decreased significantly.The mean SO42-concentration in PM2.5 decreased by 76%,12%,81%and 38%in Beijing-Tianjin-Hebei(BTH),the Pearl River Delta(PRD),the Sichuan-Chongqing region(SC)and the Fenhe and Weihe River Plain,respectively.The mean organic matter(OM)concentration decreased by 70%,44%,48%and 31%,respectively,and the mean concentration of NH4+decreased by 68%,1.6%,38%and 25%,respectively.The mean elemental carbon(EC)concentration decreased by 84%and 20%in BTH and SC,respectively,and it increased by 61%and 11%in the PRD and Fenhe and Weihe River Plain,respectively.The mean concentration of mineral and unresolved chemical components(MI)dropped by 70%,24%and 13%in BTH,the PRD and the Fenhe and Weihe River Plain,respectively.The change in the PM2.5 chemical composition is consistent with the decrease of the PM2.5mass concentration.(3)In 2015,the mean OM concentration contributions to fine particles and coarse particles were 13-46%and 46-57%,respectively,and the mean MI concentration contributions to fine particles and coarse and particles were 31-60%and 39-73%,respectively;these values are lower than the 2013 values from the key regions,which is the most important factor behind the decrease of the particulate matter mass concentration.From 2013 to 2015,among the chemical components of different particle size fractions,the peak value of the coarse particle size fraction decreased significantly,and the fine particle size fractions of SO42-,NO3-,and NH4+decreased with the decrease of the particulate matter mass concentration in different particle size fractions.The fine-particle size peaks of SO42-,NO3-and NH4+shifted from 0.65-1.1μm to the finer size range of0.43-0.65μm during the same time frame. | Yuesi WANG Wenjie LI Wenkang GAO Zirui LIU Shili TIAN Rongrong SHEN Dongsheng JI Shuai WANG Lili WANG Guiqian TANG Tao SONG Mengtian CHENG Gehui WANG Zhengyu GONG Jiming HAO Yuanhang ZHANG | 2019 | Science China Earth Sciences2019，62，12： | 23 |
| 11 | Relationship between HBV genotypes and anti-viral therapeutic efficacy of interferon-alpha显示文摘BACKGROUND: Much evidence demonstrates that the genotypes of hepatitis B virus (HBV) present differences in pathogenicity and outcomes owing to differences in genetic structure. This study aimed to investigate the influences of HBV genotypes on the anti-viral therapeutic efficacy of interferon-α (IFN-α) in chronic hepatitis B patients, and to determine the relationship between HBV genotypes and levels of viral replication or gene variations. METHODS: The chronic hepatitis B patients who were treated with IFN-α were selected randomly. Anti-viral therapeutic efficacy was monitored in these patients. The HBV genotypes were detected by PCR microplate hybridization ELISA. The levels of serum HBV-DNA were determined by fluorescence quantitative PCR. HBV gene variation at pre-C and basic core promoter (BCP) regions were assayed by gene chip technology. RESULTS: Genotypes B and C were predominant in 94 chronic hepatitis B patients. A, E and F genotypes were not found in these patients. The HBV-DNA levels of genotype C and mixed genotypes were significantly higher than those of genotype B. The response to IFN-α in patients with genotype B was markedly better than in those with genotypes C and D, and the complete response to IFN-α was only observed in genotype B. The response to IFN-α in patients with mixed genotypes was the least sensitive. The negative transition of HBeAg was correlated with variations in the HBV pre-C and BCP regions in patientswith partial or no response to IFN-α. The variation rates of HBV pre-C and BCP regions were clearly higher in genotype C than in genotype B. CONCLUSIONS: The results suggest that HBV genotype is correlated with the serum levels of HBV-DNA, HBV gene variations and therapeutic efficacy of IFN-α. The regular detection of HBV genotypes in the clinic will be of benefit for disease prognosis and planning of anti-viral therapeutic strategies. | Ma, Jin-Chun Wang, Lu-Wen Li, Xin-Jian Liao, Yong-Feng Hu, Xi-Ya Gong, Zuo-Jiong | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，2： | 21 |
| 12 | Soil contamination with antibiotics in a typical peri-urban area in eastern China: Seasonal variation, risk assessment, and microbial responses显示文摘The prevalence and persistence of antibiotics in soils has become an emerging environmental issue and an increasing threat to soil security and global public health. The problem is more severe in areas undergoing rapid urbanization; however, the ecological risks of antibiotics,seasonal variability, and associated soil microbial responses in peri-urban soils have not been well-explored. The seasonal soil sampling campaigns were conducted in a typical peri-urban watershed in eastern China to investigate distribution of antibiotics. The results demonstrated higher mean concentrations of most antibiotic compounds in winter than in summer in periurban soils. The seasonal variations of norfloxacin, enrofloxacin, and ciprofloxacin were more significant than those of other antibiotics, due to their higher migration ability and bioavailability.An ecological risk assessment demonstrated that chlortetracycline, ciprofloxacin, doxycycline,and ofloxacin can pose high risks to soil microorganisms. Furthermore, the coexistence of multiple antibiotics obviously poses higher risks than individual compounds. A redundancy analysis demonstrated that tetracyclines mainly showed negative correlations with Firmicutes and Chloroflexi, and quinolones showed obviously negative correlations with Acidobacteria,Gemmatimonadetes, and Nitrospirae, suggesting potential inhibition from antibiotics on biological activities or biodegradation processes. However, the persistence of antibiotics in soil results in a significant decrease in bacterial diversity and a change in dominant species.Our results provide an overview of the seasonal variability of antibiotics and the associated effects on bacterial communities in peri-urban soils. The results can provide scientific guidance on decreasing soil contamination with antibiotics to enhance soil security in similar areas. | Fangkai Zhao Lei Yang Liding Chen Qian Xiang Shoujuan Li Long Sun Xinwei Yu Li Fang | 2019 | Journal of Environmental Sciences2019，31，5： | 19 |
| 13 | GPS天线相位中心变化及测试显示文摘对GPS天线相位中心随卫星变化的情况及减小和消除天线相位中心误差的方法进行了阐述 。 | 翟清斌 齐维君 | 2004 | 测绘科学2004，29，2： | 19 |
| 14 | Distribution of Rb and Sr in the Luochuan loess-paleosol sequence of China during the last 800 ka——Implications for paleomonsoon variations显示文摘The concentrations of Rb and Sr, and magnetic susceptibility in loess and paleosol samples from the Luochuan profile have been measured. The loess units deposited in different geological periods display a very similar pattern of Rb and Sr distribution while paleosol units exhibit a dramatic increase in the Rb/Sr ratio, ranging from 20% to 120% in increase amplitude. Owing to different geochemical behavior of the two elements, Rb appears to be immobile while Sr appears to be mobile in the processes of weathering and pedogenesis. So variations of the Rb/Sr ratio in the loess-paleosol sequences could reflect intensities of weathering and pedogenesis, thus recording the relative wind strength of the East Asian summer monsoon circulation. This could be supported by the high degree of correlation between the Rb/Sr ratio and the magnetic susceptibility. A continuous record of the Rb/Sr ratio in the Luochuan profile over the last 800 ka bears a striking resemblance to the δ18O curve of the deep sea | 陈骏 安芷生 汪永进 季峻峰 陈旸 鹿化煜 | 1999 | Science China Earth Sciences1999，42，3： | 19 |
| 15 | Natural Variation in CCD4 Promoter Underpins Species-Specific Evolution of Red Coloration in Citrus Peel显示文摘Carotenoids and apocarotenoids act as phytohormones and volatile precursors that influence plant development and confer aesthetic and nutritional value critical to consumer preference.Citrus fruits display considerable natural variation in carotenoid and apocarotenoid pigments.In this study,using an integrated genetic approach we revealed that a 5;c/s-regulatory change at CCD4b encoding CAROTENOID CLEAVAGE DIOXYGENASE 4b is a major genetic determinant of natural variation in C3 0 apocarotenoids responsible for red coloration of citrus peel.Functional analyses demonstrated that in addition the known role in synthesizing 3-citraurin,CCD4b is also responsible for the production of another important C3 0 apocarotenoid pigment,p-citraurinene.Furthermore,analyses of the CCD4b promoter and transcripts from various citrus germplasm accessions established a tight correlation between the presence of a putative 5'c/s-regulatory enhancer within an MITE transposon and the enhanced allelic expression of CCD4b in C3 0 apocarotenoid-rich red-peeled accessions.Phylogenetic analysis provided further evidence that functional diversification of CCD4b and naturally occurring variation of the CCD4b promoter resulted in the stepwise evolution of red peels in mandarins and their hybrids.Taken together,our findings provide new insights into the genetic and evolutionary basis of apocarotenoid diversity in plants,and would facilitate breeding efforts that aim to improve the nutritional and aesthetic value of citrus and perhaps other fruit crops. | Xiongjie Zheng Kaijie Zhu Quan Sun Weiyi Zhang Xia Wang Hongbo Cao Meilian Tan Zongzhou Xie Yunliu Zeng Junli Ye Lijun Chai Qiang Xu Zhiyong Pan Shunyuan Xiao Paul D.Fraser Xiuxin Deng | 2019 | Molecular Plant2019，12，9： | 18 |
| 16 | Global aridification in the second half of the 20th century and its relationship to large-scale climate background显示文摘The variation in surface wetness index (SWI), which was derived from global gridded monthly precipi- tation and monthly mean surface air temperature datasets of Climatic Research Unit (CRU), from 1951― 2002 over global land was analyzed in this paper. The characteristics of the SWI variation in global continents, such as North America, South America, Eurasia, Africa, and Australia, were compared. In addition, the correlation between the SWI variation of each continent (or across the globe) and the large-scale background closely related to SST variations, which affects climate change, was analyzed. The results indicate that the SWI variation shows distinct regional characteristics in the second half of the 20th century under global warming. A drying trend in the last 52 years occurred in Africa, Eurasia, Australia and South America, most obviously in Africa and Eurasia. North America shows a wetting trend after 1976. A 30-year period of dry-wet oscillation is found in South America and Australia; the latest is in a drying period in two regions. The results also revealed that global warming has changed the dry-wet pattern of the global land. South America and Australia have a drying trend despite in- creases in precipitation. This indicates that increases in surface air temperature cannot be ignored in aridification studies. Global dry-wet variation is closely related to large-scale SST variations: the drying trend in Africa and Eurasia and the wetting trend in North America are correlated with Pacific Decadal Oscillation (PDO); the interdecadal oscillation of SWI in South America and Australia is consistent with the interdecadal variation in Southern Oscillation Index (SOI). | MA ZhuGuo FU CongBin | 2007 | Science China Earth Sciences2007，50，5： | 17 |
| 17 | PM_(2.5)-bound polycyclic aromatic hydrocarbons(PAHs) in Beijing:Seasonal variations,sources,and risk assessment显示文摘Polycyclic aromatic hydrocarbons(PAHs) have been of health concern due to its carcinogenesis and mutagenesis. In this study, we aimed to assess the variations, sources, and lifetime excessive cancer risk(ECR) attributable to PAHs bound to ambient particulate matters with aerodynamic diameter less than 2.5 μm(PM_(2.5)) in metropolitan Beijing, China. We collected24-hour integrated PM_(2.5) samples on daily basis between November 2014 and June 2015 across both central heating(cold months) and non-heating(warm months) seasons, and further analyzed the PAH components in these daily PM_(2.5) samples. Our results showed that total concentrations of PM_(2.5)-bound PAHs varied between(88.6 ± 75.4) ng/m^3 in the cold months and(11.0 ± 5.9) ng/m^3 in the warm months. Benzo[a]pyrene(Ba P), the carcinogenic marker of PAHs,averaged at 5.7 and 0.4 ng/m^3 in the cold and warm months, respectively. Source apportionment analyses illustrated that gasoline, biomass burning, diesel, coal combustion and cooking were the major contributors, accounting for 12.9%, 17.8%, 24.7%, 24.3% and 6.4% of PM_(2.5)-bound PAHs, respectively. The BaP equivalent lifetime ECR from inhalation of PM_(2.5)-bound PAHs was 16.2 cases per million habitants. Our results suggested that ambient particulate reduction from energy reconstruction and adaption of clean fuels would result in reductions PM_(2.5)-bound PAHs and its associated cancer risks. However, as only particulate phased PAHs was analyzed in the present study, the concentration of ambient PAHs could be underestimated. | Baihuan Feng Lijuan Li Hongbing Xu Tong Wang Rongshan Wu Jie Chen Yi Zhang Shuo Liu Steven Sai Hang Ho Junji Cao Wei Huang | 2019 | Journal of Environmental Sciences2019，31，3： | 17 |
| 18 | Peculiar Temporal Structure of the South China Sea Summer Monsoon显示文摘PeculiarTemporalStructureoftheSouthChinaSeaSummerMonsoonBinWang①andRenguangWuDepartmentofMeteorology,UniversityofHawai,USARec... | Bin Wang Renguang Wu | 1997 | Advances in Atmospheric Sciences1997，14，2： | 16 |
| 19 | Epidemiology of perforated peptic ulcer:Age-and gender-adjusted analysis of incidence and mortality显示文摘AIM:To investigate the epidemiological trends in inci-dence and mortality of perforated peptic ulcer(PPU)in a well-defined Norwegian population. METHODS:A retrospective,population-based,single-center,consecutive cohort study of all patients diag-nosed with benign perforated peptic ulcer.Included were both gastric and duodenal ulcer patients admitted to Stavanger University Hospital between January 2001 and December 2010.Ulcers with a malignant neoplasia diagnosis,verified by histology after biopsy or resection,were excluded.Patients were identified from the hospitals administrative electronic database using pertinent ICD-9 and ICD-10 codes(K25.1,K25.2,K25.5, K25.6,K26.1,K26.2,K26.5,K26.6).Additional searches using appropriate codes for relevant laparoscopic and open surgical procedures(e.g.,JDA 60,JDA 61,JDH 70 and JDH 71)were performed to enable a complete identification of all patients.Patient demographics,presentation patterns and clinical data were retrieved from hospital records and surgical notes.Crude and adjusted incidence and mortality rates were estimated by using national population demographics data. RESULTS:In the study period,a total of 172 patients with PPU were identified.The adjusted incidence rate for the overall 10-year period was 6.5 per 100 000 per year(95%CI:5.6-7.6)and the adjusted mortality rate for the overall 10-year period was 1.1 per 100 000 per year(95%CI:0.7-1.6).A non-significant decline in ad-justed incidence rate from 9.7 to 5.6 occurred during the decade.The standardized mortality ratio for the whole study period was 5.7(95%CI:3.9-8.2),while the total 30-d mortality was 16.3%.No difference in in-cidence or mortality was found between genders.However,for patients≥60 years,the incidence increased over 10-fold,and mortality more than 50-fold,compared to younger ages.The admission rates outside office hours were high with almost two out of three(63%) admissions seen at evening/night time shifts and/or during weekends.The observed seasonal variations in admissions were not statistically significant. CONCLUSION:The adjusted incidence rate,seasonal distribution and mortality rate was stable.PPU fre-quently presents outside regular work-hours.Increase in incidence and mortality occurs with older age. | Kenneth Thorsen Jon Arne Sreide Jan Terje Kvaly Tom Glomsaker Kjetil Sreide | 2013 | World Journal of Gastroenterology2013，19，3： | 14 |
| 20 | Seasonal Variations of Observed Raindrop Size Distribution in East China显示文摘Seasonal variations of rainfall microphysics in East China are investigated using data from the observations of a twodimensional video disdrometer and a vertically pointing micro rain radar. The precipitation and rain drop size distribution(DSD) characteristics are revealed for different rain types and seasons. Summer rainfall is dominated by convective rain,while during the other seasons the contribution of stratiform rain to rainfall amount is equal to or even larger than that of convective rain. The mean mass-weighted diameter versus the generalized intercept parameter pairs of convective rain are plotted roughly around the 'maritime' cluster, indicating a maritime nature of convective precipitation throughout the year in East China. The localized rainfall estimators, i.e., rainfall kinetic energy–rain rate, shape–slope, and radar reflectivity–rain rate relations are further derived. DSD variability is believed to be a major source of diversity of the aforementioned derived estimators. These newly derived relations would certainly improve the accuracy of rainfall kinetic energy estimation, DSD retrieval, and quantitative precipitation estimation in this specific region. | Long WEN Kun ZHAO Mengyao WANG Guifu ZHANG | 2019 | Advances in Atmospheric Sciences2019，36，4： | 14 |
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