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| 1 | Strategies for regeneration of components of nervous system: scaffolds, cells and biomolecules显示文摘Nerve diseases including acute injury such as peripheral nerve injury(PNI),spinal cord injury(SCI)and traumatic brain injury(TBI),and chronic disease like neurodegeneration disease can cause various function disorders of nervous system,such as those relating to memory and voluntary movement.These nerve diseases produce great burden for individual families and the society,for which a lot of efforts have been made.Axonal pathways represent a unidirectional and aligned architecture allowing systematic axonal development within the tissue.Following a traumatic injury,the intricate architecture suffers disruption leading to inhibition of growth and loss of guidance.Due to limited capacity of the body to regenerate axonal pathways,it is desirable to have biomimetic approach that has the capacity to graft a bridge across the lesion while providing optimal mechanical and biochemical cues for tissue regeneration.And for central nervous system injury,one more extra precondition is compulsory:creating a less inhibitory surrounding for axonal growth.Electrospinning is a cost-effective and straightforward technique to fabricate extracellular matrix(ECM)-like nanofibrous structures,with various fibrous forms such as random fibers,aligned fibers,3D fibrous scaffold and core-shell fibers from a variety of polymers.The diversity and versatility of electrospinning technique,together with functionalizing cues such as neurotrophins,ECM-based proteins and conductive polymers,have gained considerable success for the nerve tissue applications.We are convinced that in the future the stem cell therapy with the support of functionalized electrospun nerve scaffolds could be a promising therapy to cure nerve diseases. | Lingling Tian Molamma P.Prabhakaran Seeram Ramakrishna | 2015 | Regenerative Biomaterials2015，2，1： | 17 |
| 2 | Effects of miR-219/miR-338 on microglia and astrocyte behaviors and astrocyte-oligodendrocyte precursor cell interactions显示文摘MiR-219 and miR-338(miR-219/miR-338)are oligodendrocyte-specific microRNAs.The overexpression of these miRs in oligodendrocyte precursor cells promotes their differentiation and maturation into oligodendrocytes,which may enhance axonal remyelination after nerve injuries in the central nervous system(CNS).As such,the delivery of miR-219/miR-338 to the CNS to promote oligodendrocyte precursor cell differentiation,maturation and myelination could be a promising approach for nerve repair.However,nerve injuries in the CNS also involve other cell types,such as microglia and astrocytes.Herein,we investigated the effects of miR-219/miR-338 treatment on microglia and astrocytes in vitro and in vivo.We found that miR-219/miR-338 diminished microglial expression of pro-inflammatory cytokines and suppressed astrocyte activation.In addition,we showed that miR-219/miR-338 enhanced oligodendrocyte precursor cell differentiation and maturation in a scratch assay paradigm that re-created a nerve injury condition in vitro.Collectively,our results suggest miR-219/miR-338 as a promising treatment for axonal remyelination in the CNS following nerve injuries.All experimental procedures were approved by the Institutional Animal Care and Use Committee(IACUC),Nanyang Technological University(approval No.A0309 and A0333)on April 27,2016 and October 8,2016. | Lan Huong Nguyen William Ong Kai Wang Mingfeng Wang Dean Nizetic Sing Yian Chew | 2020 | Neural Regeneration Research2020，15，4： | 11 |
| 3 | Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer显示文摘Diabetes is one of the most prevalent diseases in the world with high-mortality and complex complications including diabetic foot ulcer(DFU). It has been reported that the difficulties in repairing the wound related to DFU has much relationship with the wound infection,change of inflammatory responses, lack of extracellular matrix(ECM), and the failure of angiogenesis. Following the development of medical materials and pharmaceutical technology, nanofibers has been developed by electrospinning with huge porosity, excellent humidity absorption, a better oxygen exchange rate, and some antibacterial activities. That is to say, as a potential material, nanofibers must be a wonderful candidate for the DFU treatment with so many benefits. Careful selection of polymers from natural resource and synthetic resource can widen the nanofibrous application. Popular methods applied for the nanofibrous fabrication consist of uniaxial electrospinning and coaxial electrospinning. Furthermore, nanofibers loading chemical, biochemical active pharmaceutical ingredient(API)or even stem cells can be wonderful dosage forms for the treatment of DFU. This review summarizes the present techniques applied in the fabrication of nanofibrous dressing(ND)that utilizes a variety of materials and active agents to offer a better health care for the patients suffering from DFU. | Yan Liu Shiya Zhou Yanlin Gao Yinglei Zhai | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，2： | 10 |
| 4 | Enhanced Electromagnetic Wave Absorption Properties of Poly(3,4-ethylenedioxythiophene) Nanofi ber-Decorated Graphene Sheets by Non-covalent Interactions显示文摘Graphene sheets(GNs) have high conductivity, but they exhibit weak electromagnetic(EM) wave absorption performance. Here, poly(3,4-ethylenedioxythiophene)(PEDOT) nanofibers were decorated on the surface of GNs in which the residual defects and groups act as the active sites and therefore are beneficial for the deposition of PEDOT nanofibers.The SEM images display that PEDOT nanofibers are successfully decorated on the surface of GNs through in situ polymerization. The diameter of the PEDOT nanofibers were ranged from 15 to 50 nm with hundreds of nanometers in length. The EM wave absorption properties of graphene, PEDOT, and GNs-PEDOT were also investigated. Compared to pure graphene and PEDOT, the EM wave absorption properties of GNs-PEDOT improved significantly. The maximum value of RLwas up to-48.1 d B at 10.5 GHz with a thickness of only 2 mm. Meanwhile, the absorption bandwidth of RL values below-10 d B was 9.4 GHz(5.8–12.3, 12.9–15.8 GHz) in the thickness of 1.5–3 mm. The enhancement is attributed to the modification of PEDOT and the unique structure of nanofibers. On one hand, the deposition of PEDOT nanofibers on the surface of GNs decreases the conductivity of graphene, and makes impedance match better. On the other hand, the unique structure of PEDOT nanofibers results in relatively large specific surfaces areas, providing more active sites for reflection and scattering of EM waves. Therefore, our findings demonstrate that the deposition of conducting polymers on GNs by non-covalent bond is an efficient way to fabricate strong EM wave absorbers. | Xiang Zhang Ying Huang Panbo Liu | 2016 | Nano-Micro Letters2016，8，2： | 9 |
| 5 | Electrospinning of ceramic nanofibers:Fabrication,assembly and applications显示文摘This paper provides a brief review of current research activities that focus on the synthesis and controlled assembly of inorganic nano-bers by electrospinning,their electrical,optical and magnetic properties,as well as their applications in various areas including sensors,catalysts,batteries,filters and separators.We begin with a brief introduction to electrospinning technology and a brief method to produce ceramic nanofibers from electrospinning.We then discuss approaches to the controlled assembly and patterning of electrospun ceramic nanofibers.We continue with a highlight of some recent applications enabled by electrospun ceramic nano-bers,with a focus on the physical properties of functional ceramic nanofibers as well as their applications in energy and environmental technologies.In the end,we conclude this review with some perspectives on the future directions and implications for this new class of functional nanomaterials.It is expected that this review paper can help the readers quickly become acquainted with the basic principles and particularly the experimental procedure for preparing and assembly of 1D ceramic nanofiber and its arrays. | Hui WU Wei PAN Dandan LIN Heping LI | 2012 | Journal of Advanced Ceramics2012，1，1： | 9 |
| 6 | In-situ fabricated anisotropic halide perovskite nanocrystals in polyvinylalcohol nanofibers: Shape tuning and polarized emission显示文摘We report an in-situ fabrication of halide perovskite (CH3NH3PbX3,CH3NH3 =methylammonium,MA,X =Cl,Br,I) nanocrystals in polyvinylalcohol (PVA) nanofibers (MAPbX3@PVA nanofibers) through electrospinning a perovskite precursor solution.With the content of the precursors increased,the resulting MAPbBr3 nanocrystals in PVA matrix changed the shape from ellipsoidal to pearl-like,and finely into rods-like.Optimized MAPbBr3@PVA nanofibers show strong polarized emission with the photoluminescence quantum yield of up to 72%.We reveal correlations between the shape of in-situ fabricated perovskite nanocrystals and the polarization degree of their emission by comparing experimental data from the single nanofiber measurements with theoretical calculations.Polarized emission of MAPbBr3@PVA nanofibers can be attributed to the dielectric confinement and quantum confinement effects.Moreover,nanofibers can be efficiently aligned by using parallel positioned conductor strips with an air gap as collector.A polarization ratio of 0.42 was achieved for the films of well-aligned MAPbBr3@PVA nanofibers with a macroscale size of 0.5 cm × 2 cm,which allows potential applications in displays,lasers,waveguides,etc. | Linghai Meng Changgang Yang Jingjia Meng Yongzhi Wang Yong Ge Ziqiang Shao Guofeng Zhang Andrey L.Rogach Haizheng Zhong | 2019 | Nano Research2019，12，6： | 9 |
| 7 | Flexible, Porous, and Metal–Heteroatom?Doped Carbon Nanofibers as Efficient ORR Electrocatalysts for Zn–Air Battery显示文摘Developing an e cient and durable oxygen reduction electrocatalyst is critical for clean-energy technology, such as fuel cells and metal–air batteries. In this study, we developed a facile strategy for the preparation of flexible, porous, and well-dispersed metal–heteroatom-doped carbon nanofibers by direct carbonization of electrospun Zn/Co-ZIFs/PAN nanofibers(Zn/Co-ZIFs/PAN). The obtained Zn/Co and N co-doped porous carbon nanofibers carbonized at 800 °C(Zn/Co–N@PCNFs-800) presented a good flexibility, a continuous porous structure, and a superior oxygen reduction reaction(ORR) catalytic activity to that of commercial 20 wt% Pt/C, in terms of its onset potential(0.98 V vs. RHE), half-wave potential(0.89 V vs. RHE), and limiting current density(-5.26 mA cm^(-2)). In addition, we tested the suitability and durability of Zn/Co–N@PCNFs-800 as the oxygen cathode for a rechargeable Zn–air battery. The prepared Zn–air batteries exhibited a higher power density(83.5 mW cm^(-2)), a higher specific capacity(640.3 mAh g^(-1)), an excellent reversibility, and a better cycling life than the commercial 20 wt% Pt/C + RuO_2 catalysts. This design strategy of flexible porous non-precious metal-doped ORR electrocatalysts obtained from electrospun ZIFs/polymer nanofibers could be extended to fabricate other novel, stable, and easy-to-use multi-functional electrocatalysts for clean-energy technology. | Qijian Niu Binling Chen Junxia Guo Jun Nie Xindong Guo Guiping Ma | 2019 | Nano-Micro Letters2019，11，1： | 7 |
| 8 | 简单合成连续介孔结构的T-Nb_2O_5纳米纤维用作锂离子电池负极(英文)显示文摘五氧化二铌Nb_2O_5由于其良好的倍率性能和安全性,作为锂离子电池负极材料被广泛研究.但是其固有的低电子电导率在很大程度上限制了其电化学性能的发挥.在本论文中,我们通过静电纺丝和后续空气热处理构建了具有连续介孔结构的T-Nb_2O_5纳米纤维.介孔结构彼此互连,确保高表面积的同时也促进了电解液的渗透.当用作锂离子电池负极时在电压窗口为0.01–3.0 V,电流密度为1 A g^(-1)的条件下,循环1000圈后可逆比容量达到238 mA h g^(-1).即使提高电压窗口到1.0–3.0 V,在循环200圈后仍然有166 mA h g^(-1)的可逆比容量.此外,电极材料还表现出优异的倍率性能.多孔纳米纤维结构和T-Nb_2O_5独特晶体结构的协同效应,增大了电极和电解质的接触面积,改善了电子传导性,从而使电化学性能得到提高. | 楼林震 孔祥忠 朱挺 林建德 梁叔全 刘菲 曹国忠 潘安强 | 2019 | Science China Materials2019，62，4： | 6 |
| 9 | Large-scale blow spinning of heat-resistant nanofibrous air filters显示文摘Particulate matter(PM)pollution has become a serious problem worldwide and various kinds of nanofibrous filters aiming to solve the problem have been developed.It is urgent to remove PM from high-temperature pollution sources,such as industrial emissions,coal furnaces,and automobile exhaust gases.However,filtration at pollution sources remains challenging because most existing air filters are not resistant to high temperature.Herein,heat-resistant polyimide(PI)nanofibrous air filters are fabricated via a simple and scalable solution blow-spinning method.These air filters show excellent thermal stability at high temperature up to 420℃.They exhibit a filtration efficiency as high as 99.73%at ambient temperature and over 97%at 300℃.In addition,a field test shows that the filters remove>97%of PM from the car exhaust fumes.Hence,the blow-spun PI nanofibrous membranes combined with the facile preparation strategy have great potential in high temperature air filtration fields and other similar applications such as water purification and protein separation. | Ziwei Li Jianan Song Yuanzheng Long Chao Jia Zhenglian Liu Lei Li Cheng Yang Junchen Liu Sen Lin Haiyang Wang Yibo Liu Minghao Fang Hui Wu | 2020 | Nano Research2020，13，3： | 6 |
| 10 | Electrospun CoSe@N-doped carbon nanofibers with highly capacitive Li storage显示文摘One-dimensional nano-structured materials have attracted attention due to its unique properties afforded such as the across-linked structures and large aspect ratios.In this work,one-dimensional CoSe@N-doped carbon nanofibers(CoSe@NCNFs)are successfully by combining the techniques of electrospinning and annealing.Selenium powder are directly dispersed in the polyacrylonitrile/N,N-Dimethylformamide(DMF)solution containing cobalt salt to form the product.The performance of these materials was investigated in Li-ion batteries after the annealing at different temperatures.The Co Se@NC nanofibers annealed at 550℃(CoSe@NC-550)and displayed excellent storage properties,affording a high capacity of 796 m Ah·g-1at a current density of 1 A·g^-1 for 100 cycles.Moreover,it is confirmed that the pseudocapacitive contribution of CoSe@NC-550 is up to 72.8%at the scan rate of 1 mV/s through the cyclic voltammetry analysis. | Jiandong Liu Jiaojiao Liang Caiyun Wang Jianmin Ma | 2019 | Journal of Energy Chemistry2019，28，6： | 6 |
| 11 | Electrospinning nanofiber scaffolds for soft and hard tissue regeneration显示文摘Tissue engineering is an interdisciplinary field that integrates medical,biological,and engineering expertise to restore or regenerate the functionality of healthy tissues and organs.The three fundamental pillars of tissue engineering are scaffolds,cells,and biomolecules.Electrospun nanofibers have been successfully used as scaffolds for a variety of tissue engineering applications because they are biomimetic of the natural,fibrous extracellular matrix(ECM)and contain a three-dimensional(3D)network of interconnected pores.In this review,we provide an overview of the electrospinning process,its principles,and the application of the resultant electrospun nanofibers for tissue engineering.We first briefly introduce the electrospinning process and then cover its principles and standard equipment for biomaterial fabrication.Next,we highlight the most important and recent advances related to the applications of electrospun nanofibers in tissue engineering,including skin,blood vessels,nerves,bone,cartilage,and tendon/ligament applications.Finally,we conclude with current advancements in the fabrication of electrospun nanofiber scaffolds and their biomedical applications in emerging areas. | Xianrui Xie Yujie Chen Xiaoyu Wang Xiaoqing Xu Yihong Shen Atta ur Rehman Khan Ali Aldalbahi Allison E.Fetz Gary L.Bowlin Mohamed El-Newehy Xiumei Mo | 2020 | Journal of Materials Science & Technology2020，59，24： | 5 |
| 12 | N-Halamine Functionalized Electrospun Poly(Vinyl Alcohol-co-Ethylene)Nanofibrous Membranes with Rechargeable Antibacterial Activity for Bioprotective Applications显示文摘Developing bioprotective materials with bactericidal activity is of great significance since it can effectively keep healthcare workers from infection by emerging infectious diseases;however,this is still a big challenge.Herein,we fabricate a novel rechargeable N-halamine antibacterial material by functionalizing electrospun poly(vinyl alcohol-co-ethylene)(EVOH)nanofibers with dimethylol-5,5-dimethylhydantoin(DMDMH).The premise of the design is that the N-halamine com-pound,DMDMH,can be covalently grafted on the nanofibers,endowing the EVOH nanofibrous membranes(ENM)with rechargeable and durable bactericidal activity.The as-prepared DMDMH functionalized ENM(EDNM)render rechargeable chlorination capacity(>2000 ppm),high inactivation efficacy against bacteria(>99.9999%within 3 min),high filtration efficiency(>99.5%)under low air resistance,and robust mechanical properties,which are due to the synergistic effect of the unique characters of N-halamines and electrospun nanofibrous architecture.The successful synthesis of the N-halamine antibacterial membranes can serve as a functional layer of protective equipment that capable of inactivating and intercepting pathogenic bioaerosols,providing new ways into the development of new-generation antibacterial bioprotective materials. | Mingguang Liang Fei Wang Mei Liu Jianyong Yu Yang Si Bin Ding | 2019 | Advanced Fiber Materials2019，1，2： | 5 |
| 13 | 自组装二氧化锰纳米片包覆嵌硫多通道碳纳米纤维复合物在锂硫电池阴极中的应用显示文摘由于可充电锂硫电池在能量密度方面具有显著的优势,因此被认为是很有前途的下一代储能体系.然而,多硫化物的穿梭和硫的绝缘特性,导致了锂硫电池严重的容量衰减和低硫利用率,阻碍了它们的实际应用.因此,本研究合理设计制备了一种二氧化锰纳米片包覆嵌硫多通道碳纳米纤维复合物用于锂硫电池阴极.多孔多通道碳纳米纤维的高导电性促进了电极中电子和离子的传输动力学,多孔结构将硫包裹并隔离在其内部空隙中,在物理上延缓了高阶多硫化物的溶解.此外,二氧化锰壳层对高阶多硫化物的物理限制和化学吸附相结合,可以隔离长时间充放电循环后从碳基体中泄漏的多硫化物,从而进一步提高电极的电化学性能. | 胡菁 王振宇 付宇 吕林龙 卢周广 周利民 | 2020 | Science China Materials2020，63，5： | 5 |
| 14 | Electrospun Sb2Se3@C nanofibers with excellent lithium storage properties显示文摘Antimony-based materials have become promising anodes within lithium-ion batteries(LIBs)due to their low cost and the high theoretical capacity.However,there is a potential to further enhance the electrochemical performance of such antimony-based materials.Herein,Sb2Se3@C nanofibers(Sb2Se3@CNFs)are designed and obtained via a novel electrospinning method.Upon electrochemically testing as an anode within LIBs,the Sb2Se3@CNFs(annealed at 600℃)delivers a remarkably good cycling performance of 625 mAh/g at 100 mA/g after 100 cycles.Moreover,it still remains at 490 mAh/g after 500 cycles with an applied current density of 1.0 A/g.The excellent performance of the Sb2 Se3@CNFs can be attributed to the fact that the N-doped C matrices not only remit the volume expansion of materials,but also enhance the electrical and ionic conductivity thusly increasing the lithium-ion diffusion.The obtained Sb2Se3@CNFs are promising anode for LIBs in the future. | Yan Dong Yuezhan Feng Jiwei Deng Pengbin He Jianmin Ma | 2020 | Chinese Chemical Letters2020，31，3： | 4 |
| 15 | An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing显示文摘Moderately regulating vascularization and immune microenvironment of wound site is necessary to achieve scarless wound healing of the skin.Herein,we have prepared an angiogenesis-promoting and scar-preventing band-aid with a core-shell structure,that consists of MXene-loaded nanofibers(MNFs)as the core and dopamine-hyaluronic acid hydrogel(H)as the shell(MNFs@V-H@DA)to encapsulate a growth factor(vascular endothelial growth factor,VEGF,abbreviated as V)and H2S donor(diallyl trisulfide,DATS,abbreviated as DA).The continuous release of DA from this system produced H2S,which would successfully induce macrophages to polarize into M2-lile phenotype,regulating the immune microenvironment and inhibiting an excessive inflammatory response at the wound sites.It is conducive to the proliferation of skin cells,facilitating the wound healing.In addition,an appropriate amount of VEGF can be released from the MXene nanofibrous skeleton by adjusting the time of near-infrared(NIR)light exposure,preventing excessive neovascularization and extracellular matrix deposition at the wound sites.Collectively,this NIR photothermal-responsive band-aid achieved scarless wound healing through gradient-controlled vascularization and a related immune sequential reaction of damaged skin tissue. | Lin Jin Xiaoqing Guo Di Gao Yan Liu Jiahua Ni Zhiming Zhang Yiqiao Huang Guibin Xu Zhe Yang Xingcai Zhang Xianhan Jiang | 2022 | Bioactive Materials2022，7，10： | 4 |
| 16 | Electrospun Fe_(0.64)Ni_(0.36)/MXene/CNFs nanofibrous membranes with multicomponent heterostructures as flexible electromagnetic wave absorbers显示文摘Two-dimensional metal carbide or nitride materials(MXenes)are widely used in electromagnetic wave absorption because of their unique structure.Herein,a novel composite preparation strategy has been proposed to design dendritic nanofibers based on the electrostatic spinning methods.The multifunctional MXene nanosheets are used as the dendritic matrix,and magnetic nanoparticles are embedded in the nanosheets as magnetic loss units.Multidimensional nanocomposites have interlaced carbon fiber networks,large-scale magnetically coupled networks,and a lot of multi-heterojunction interface structures,which endow the composites with extraordinary conduction loss,magnetic loss,and polarization loss capabilities,respectively.The impedance matching and loss mechanisms of the composites are improved by optimizing the synergistic relationship between the components and building a suitable structure.The optimum reflection loss(RL)of−54.1 dB is achieved at 2.7 mm and a wide effective absorption bandwidth(EAB,RL below−10 dB)of 7.76 GHz is obtained at a small thickness of 2.1 mm for the nanocomposites.The distinctive microstructures of the nanofibrous membranes give rise to their flexibility,waterproof,and electromagnetic wave absorption performance and endow the nanofibrous membranes potential to be utilized as lightweight,efficient electromagnetic wave protective fabric in harsh environment. | Shuo Zhang Zirui Jia Yan Zhang Guanglei Wu | 2023 | Nano Research2023，16，2： | 4 |
| 17 | Incorporation of bioactive glass nanoparticles in electrospun PCL/chitosan fibers by using benign solvents显示文摘The use of bioactive glass(BG)particles as a filler for the development of composite electrospun fibers has already been widely reported and investigated.The novelty of the present research work is represented by the use of benign solvents(like acetic acid and formic acid)for electrospinning of composite fibers containing BG particles,by using a blend of PCL and chitosan.In this work,different BG particle sizes were investigated,namely nanosized and micron-sized.A preliminary investigation about the possible alteration of BG particles in the electrospinning solvents was performed using SEM analysis.The obtained composite fibers were investigated in terms of morphological,chemical and mechanical properties.An in vitro mineralization assay in simulated body fluid(SBF)was performed to investigate the capability of the composite electrospun fibers to induce the formation of hydroxycarbonate apatite(HCA). | Liliana Liverani Jonas Lacina Judith A.Roether Elena Boccardi Manuela S.Killian Patrik Schmuki Dirk W.Schubert Aldo R.Boccaccini | 2018 | Bioactive Materials2018，3，1： | 4 |
| 18 | Effect of High Pressure Homogenization Treatment on Structure and Properties of Soybean Residue Cellulose Nanofibers显示文摘To reduce the adverse effects of non-cellulose materials on subsequent homogenization,the effects of a high-pressure homogenization treatment on the structure and properties of cellulose nanofibers(CNF)prepared by acid treatment of soybean residue were studied.The effects of the number of homogenization step on the microfibrillation degree,crystalline structure and mechanical properties of the soybean residue were analyzed by SEM,FT-IR,XRD,TG and DTG.The results showed that an increase in the number of homogenization steps led to an increase in the degree of microfibrillation,a more uniform distribution of the CNF diameter,and an increase in the crystallinity of CNF.However,but when the number of homogenization steps exceeded 15,the rate of change decreased,and the crystallinity of CNF decreased.As the number of homogenization steps increased,the average degree of polymerization and average molecular weight of CNF decreased continuously,and after 15 homogenization steps,their rate of change also decreased.Therefore,15 steps of high-pressure homogenization represented a suitable number of steps to prepare the soybean residue CNF with an average diameter of 15 nm. | Peiyi Li Yumeng Wang Binyao Zhou Qingqing Hou Hezhen Liu Haozhe Lei Boxing Jian Xinping Li | 2019 | Paper And Biomaterials2019，4，4： | 4 |
| 19 | Aligned fibrin/functionalized self-assembling peptide interpenetrating nanofiber hydrogel presenting multi-cues promotes peripheral nerve functional recovery显示文摘Nerve guidance conduits with hollow lumen fail to regenerate critical-sized peripheral nerve defects(15 mm in rats and 25 mm in humans),which can be improved by a beneficial intraluminal microenvironment.However,individual cues provided by intraluminal filling materials are inadequate to eliminate the functional gap between regenerated nerves and normal nerves.Herein,an aligned fibrin/functionalized self-assembling peptide(AFG/fSAP)interpenetrating nanofiber hydrogel that exerting synergistic topographical and biochemical cues for peripheral nerve regeneration is constructed via electrospinning and molecular self-assembly.The hydrogel possesses an aligned structure,high water content,appropriate mechanical properties and suitable biodegradation capabilities for nerve repair,which enhances the alignment and neurotrophin secretion of primary Schwann cells(SCs)in vitro,and successfully bridges a 15-mm sciatic nerve gap in rats in vivo.The rats transplanted with the AFG/fSAP hydrogel exhibit satisfactory morphological and functional recovery in myelinated nerve fibers and innervated muscles.The motor function recovery facilitated by the AFG/fSAP hydrogel is comparable with that of autografts.Moreover,the AFG/fSAP hydrogel upregulates the regeneration-associated gene expression and activates the PI3K/Akt and MAPK signaling pathways in the regenerated nerve.Altogether,the AFG/fSAP hydrogel represents a promising approach for peripheral nerve repair through an integration of structural guidance and biochemical stimulation. | Shuhui Yang Jinjin Zhu Changfeng Lu Yi Chai Zheng Cao Jiaju Lu Zhe Zhang He Zhao Yin-Yuan Huang Shenglian Yao Xiangdong Kong Peixun Zhang Xiumei Wang | 2022 | Bioactive Materials2022，7，2： | 3 |
| 20 | Electrospinning Preparation and Mechanical Properties of Polymethyl Methacrylate (PMMA)/Halloysite Nanotubes (HNTs) Composite Nanofibers显示文摘The paper was aimed at the PMMA/HNTs composite nanofibers with well enhanced mechanical properties prepared by electrospinning technique for the first time. A series of characterizations were used to illustrate the structure and properties of the composite nanofibers by SEM, XRD, FTIR and DSC techniques. The effect of the PMMA/HNTs composite nanofibers in relationship to the mass percentage of HNTs was investigated. The results indicated that HNTs wrapped in polymer matrix were highly oriented and dispersed by the electrospinning technique, resulting in improved thermal stability of the polymer. Moreover, the mechanical properties of the PMMA/HNTs composite nanofibers which were dependent on HNTs mass content were measured, and good enhanced mechanical properties were obtained. | Cheng Zhilin Qin Xixi Qin Dunzhong | 2016 | China Petroleum Processing & Petrochemical Technology2016，18，2： | 3 |
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