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    题名 作者 年代 出处 被引量
1一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas.Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P 2014中华神经外科疾病研究杂志2014,13,5:6
2Death receptors:signaling and modulation显示文摘Ashkenazi A Dixit VM 0,,:3
3A LED-based smart illumination system for studying plant growth显示文摘Olvera-Gonzalez E Alaniz-Lumbreras D Torres-Arg?elles V Gonz?lez-Ram?rez E Villa-Hern?ndez J Araiza-Esquivel M Ivanov-Tsonchev R Olvera-Olvera C Casta?o VM 2014Lighting Research and Technology2014,,2:2
4Surgery of extra-axial tumors of the cerebral base显示文摘Because of the complex structure of the cranial base and its close proximity to cranial nerves and vessels, surgery in thisarea is associated with considerable risk of morbidity and mortality. Multiple approaches to each part of the cranial baseSamii M Gerganov VM 2008中国神经肿瘤杂志2008,6,3:2
5Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis显示文摘Celemajar DS Sorensen KE Gooch VM 1992Lancet1992,340,:2
6Immunomagnetic enrichment of disseminated epithelial tumor cells from peripheral blood by MACS显示文摘Martin VM Siewert C Scharl A 1998Exp Hematol1998,26,:2
7Regional, but not systemic recruitment/expansion of dendritic cells by a pluronic-formulated Flt3-ligand plasmid with vaccine adjuvant activity 显示文摘Sang H Pisarev VM Munger C 2003Vaccine2003,21,2122:2
8Flt3 ligand enhances the immunogenicity of a gag-based HIV-1 vaccine 显示文摘Pisarev VM Parajuli P Mosley RL 2000Int J Immunopharmacol2000,22,11:2
9Measuring the impact of a behaviour change intervention for commercial sex workers and their potential clients in Malawi显示文摘Walden VM 0,,:2
10Is cisplatin-induced cell death always produced by apoptosis?显示文摘Gonzalez VM Fuertes MA Alonso C 2001Mol Pharmacol2001,59,:1
11Chelators as antidotes of metal toxicity therapeutic and experimental aspects显示文摘Blanusa M Varnai VM Piasek M 2005Curt Med Chem2005,12,23:1
12Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas 显示文摘Doll JA Stellmach VM Bouck NP 2003Nat Med2003,9,6:1
13A double-blind randomized placebo-controlled study of oral glutamine in the prevention of mucositis in children undergoing hematopoietic stem cell transplantation: a pediatric blood and marrow transplant consortium study 显示文摘Aquino VM Harvey AR Garvin JH 2005Bone Marrow Transplant2005,36,7:1
14et al, Recombinant activated factor VII for coagulopattthy in fulminant hepatic failure compared with conventional therapy显示文摘Shami VM Caldwell SH Hespenheide EE 2003Liver transpl2003,9,:1
15Fetal cardiac bypass using an in-line axial flow pump to minimize extracorporeal surface and avoid priming volume 显示文摘Reddy VM Liddicoat JR Klein JR 1996Ann Thorac Surg1996,62,2:1
16Phase Ⅲ study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as fast-line therapy for advanced gastric cancer:a report of the V325 study group显示文摘Van Cutsem E Moiseyenko VM Tjulandin S 2006J Clin Oncol2006,24,31:1
17Nuclear expression of Snaill in borderline and malignant epithelial ovarian tumours is associated with tumour progression显示文摘Tubkanen H Soini Y Kosma VM 2009BMC Cancer2009,9,:1
18Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus显示文摘 Weaver VM Nickerson JA 1998Proc Natl Acad Sci USA1998,95,14:1
19Functional IL-2 receptor beta(CD122) and gamma (CD132) chains are expressed by fibroblast-like synoviocytes: activation by IL-2 stimulates monocyte chemoattractant protein-1production显示文摘 Arastu M Khan S 2001J Immunol2001,166,6:1
20The origin of bone formed in composite grafts of porous calcium phosphate ceramic loaded with marrow cells 显示文摘 Goldberg VM Caplan AI 1991Clin Orthop1991,269,:1
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