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| 1 | Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death显示文摘 | Jiang H Gomez-Manzano C Aoki H Alonso MM Kondo S McCormick F Xu J Kondo Y Bekele BN Colman H Lang FF Fueyo J | 2007 | 中国神经肿瘤杂志2007，5，3： | 24 |
| 2 | Biomarkers and subtypes of deranged lipid metabolism in nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD)is a heterogeneous and complex disease that is imprecisely diagnosed by liver biopsy.NAFLD covers a spectrum that ranges from simple steatosis,nonalcoholic steatohepatitis(NASH)with varying degrees of fibrosis,to cirrhosis,which is a major risk factor for hepatocellular carcinoma.Lifestyle and eating habit changes during the last century have made NAFLD the most common liver disease linked to obesity,type 2 diabetes mellitus and dyslipidemia,with a global prevalence of 25%.NAFLD arises when the uptake of fatty acids(FA)and triglycerides(TG)from circulation and de novo lipogenesis saturate the rate of FAβ-oxidation and verylow density lipoprotein(VLDL)-TG export.Deranged lipid metabolism is also associated with NAFLD progression from steatosis to NASH,and therefore,alterations in liver and serum lipidomic signatures are good indicators of the disease’s development and progression.This review focuses on the importance of the classification of NAFLD patients into different subtypes,corresponding to the main alteration(s)in the major pathways that regulate FA homeostasis leading,in each case,to the initiation and progression of NASH.This concept also supports the targeted intervention as a key approach to maximize therapeutic efficacy and opens the door to the development of precise NASH treatments. | José M Mato Cristina Alonso Mazen Noureddin Shelly C Lu | 2019 | World Journal of Gastroenterology2019，25，24： | 19 |
| 3 | Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation显示文摘BACKGROUND Arachidyl amido cholanoic acid(Aramchol)is a potent downregulator of hepatic stearoyl-CoA desaturase 1(SCD1)protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis.In a phase IIb clinical trial in patients with nonalcoholic steatohepatitis(NASH),52 wk of treatment with Aramchol reduced blood levels of glycated hemoglobin A1c,an indicator of glycemic control.AIM To assess lipid and glucose metabolism in mouse hepatocytes and in a NASH mouse model[induced with a 0.1%methionine and choline deficient diet(0.1MCD)]after treatment with Aramchol.METHODS Isolated primary mouse hepatocytes were incubated with 20μmol/L Aramchol or vehicle for 48 h.Subsequently,analyses were performed including Western blot,proteomics by mass spectrometry,and fluxomic analysis with 13C-uniformly labeled glucose.For the in vivo part of the study,male C57BL/6J mice were randomly fed a control or 0.1MCD for 4 wk and received 1 or 5 mg/kg/d Aramchol or vehicle by intragastric gavage for the last 2 wk.Liver metabolomics were assessed using ultra-high-performance liquid chromatography-time of flight-MS for the determination of glucose metabolism-related metabolites.RESULTS Combination of proteomics and Western blot analyses showed increased AMPK activity while the activity of nutrient sensor mTORC1 was decreased by Aramchol in hepatocytes.This translated into changes in the content of their downstream targets including proteins involved in fatty acid(FA)synthesis and oxidation[PACCα/β(S79),SCD1,CPT1A/B,HADHA,and HADHB],oxidative phosphorylation(NDUFA9,NDUFB11,NDUFS1,NDUFV1,ETFDH,and UQCRC2),tricarboxylic acid(TCA)cycle(MDH2,SUCLA2,and SUCLG2),and ribosome(P-p70S6K[T389]and P-S6[S235/S236]).Flux experiments with 13Cuniformely labeled glucose showed that TCA cycle cataplerosis was reduced by Aramchol in hepatocytes,as indicated by the increase in the number of rounds that malate remained in the TCA cycle.Finally,liver metabolomic analysis showed that glucose homeostasis was improved by Aramchol in 0.1MCD fed mice in a dose-dependent manner,showing normalization of glucose,G6P,F6P,UDP-glucose,and Rbl5P/Xyl5P.CONCLUSION Aramchol exerts its effect on glucose and lipid metabolism in NASH through activation of AMPK and inhibition of mTORC1,which in turn activate FAβ-oxidation and oxidative phosphorylation. | David Fernández-Ramos Fernando Lopitz-Otsoa Laura Delacruz-Villar Jon Bilbao Martina Pagano Laura Mosca Maider Bizkarguenaga Marina Serrano-Macia Mikel Azkargorta Marta Iruarrizaga-Lejarreta Jesús Sot Darya Tsvirkun Sebastiaan Martijn van Liempd Felix M Goni Cristina Alonso María Luz Martínez-Chantar Felix Elortza Liat Hayardeny Shelly C Lu JoséM Mato | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 4 | Occurrence of Organochlorine Insecticides, PCBs and PCB Congeners in waters and Sediments of the Ebro River (Spain) 显示文摘 | Fernandez M A Alonso C Gonzalez M J | 1999 | Chemosphere1999，38，： | 2 |
| 5 | Is cisplatin-induced cell death always produced by apoptosis?显示文摘 | Gonzalez VM Fuertes MA Alonso C | 2001 | Mol Pharmacol2001，59，： | 1 |
| 6 | Tan pathology in Alzheimer disease and other tauopathies显示文摘 | Iqbal K Alonso Adel C Chen S | 2005 | Biochim BiophysActa2005，1739，23： | 1 |
| 7 | 3, 5-Bis (trifluoromethyl) phenyl sulfones in the modified julia olefination: application to the synthesis of resveratrol 显示文摘 | Alonso D A Najera C Varea M | 2004 | Tetrhaedron Lett2004，45，： | 1 |
| 8 | Is cisplatin-induced cell death always produced by apoptosis?显示文摘 | GONZALEZ V M FUERTES M A ALONSO C | 2001 | Mol Pharmaeol2001，59，4： | 1 |
| 9 | Assay for the measurement of copeptin,a stable peptide derived from the precursor of vasopressin显示文摘 | Morgenthaler NG Struck J Alonso C | 2006 | Clin Chem2006，52，1： | 1 |
| 10 | Factors Controlling Cracking of Concrete Mfected by Reinforcement Corrosion 显示文摘 | C Alonso C Andrade J Rodriguez | 1998 | Materials and Structures1998，31，211： | 1 |
| 11 | A new role of diacylglycerol kinase α on the secretion of lethal exosomes bearing FasL ligand during activation-induced cell death of T lymphocytes显示文摘 | Alonso R Mazzeo C Merida I | 2007 | Biochimie2007，89，： | 1 |
| 12 | On-line preconcentration using chelating and ion-exchange minicolumns for the speciation of chromium(iii) and chrontium(vi) and their quantitative determination in natural waters by inductively coupled plasma mass spectrometry显示文摘 | GUERRERO M M L ALONSO E V PAVON J M C | 2012 | Journal of Analytical Atomic Spectrometry2012，27，4： | 1 |
| 13 | D-Lactic acid pro- duction from waste cardboard 显示文摘 | Yannez R Alonso J L Parajo J C | 2005 | J of Chemical Tech- nol and BioTechnol2005，80，1： | 1 |
| 14 | A moisture -in -oil model tor power transformer monitoring - part II: experimental verification 显示文摘 | GARCIA B BURGOS J C ALONSO A | 2005 | IEEE Transactions on Power Delivery2005，20，2： | 1 |
| 15 | New regulatory CD19 + CD25 + B-cell subset in clinically isolated syndrome and multiple sclerosis relapse Changes after glucocorticoids 显示文摘 | de Andr6s C Tejera-Alhambra M Alonso B | 2014 | J Neuroimmunol2014，270，12： | 1 |
| 16 | Initiation of plasmid pC194 replication and its control in Bacillus subtilis显示文摘 | Alonso J C Tailo R H | | 0，，： | 1 |
| 17 | Memory and strategic process- ing in first-degree relatives of obsessive-compulsive patients显示文摘 | Segalas C Alonso P Real E | 2010 | Psychol Med2010，40，12： | 1 |
| 18 | Bile duct reconstruction using 3-dimensional collagen tubes 显示文摘 | Pérez Alonso AJ Del Olmo Rivas C Machado Romero I | 2013 | Cir Esp2013，91，9： | 1 |
| 19 | Daily activity and intake rate patterns of wintering common cranes Grus grus 显示文摘 | Alonso L6pez J C Alonso L6pez J A | 1992 | Ardea1992，80，3： | 1 |
| 20 | Chronic psychosocial stress induces reversible mitochondrial damage and corticotropin-releasing factor receptor type - 1 upregulation in the rat intestine and IBS - like gut dysfunction 显示文摘 | Vicario M Alonso C Guilarte M | 2012 | Psychoneuroendocrinology2012，37，1： | 1 |
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