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| 1 | Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting显示文摘瞄准:如果与推延的 portasystemic 有关的 T 房间激活通过 RANKL 依赖的小径引起调停骨破折的骨头损失,学习。如果用 rapamycin 的 T 房间抑制将在老鼠免于骨头损失,我们也调查了。方法:推延的 Portasystemic 在男 Sprague-Dawley 老鼠和 rapamycin 被执行 0.1 mg/kg 被管饲法为 15 wk 管理。老鼠收到了 powderized 食物并且补加喂在骨头作文上阻止营养不良的效果。重量获得和生长在推延的动物在外科以后被恢复。在结束,骨头周转和量的骨头组织学的生物化学的参数被估计。T 房间激活,煽动性的 cytokine 生产,和 RANKL 依赖的小径的标记被测量。另外, IGF-1 和性腺机能减退的角色被调查。结果:推延的 Portasystemic 引起了是 RANKL 独立人士的低周转骨质疏松症。包括 IL-1, IL-6 和 TNFalpha,骨头再吞 cytokine 层次没在浆液和 TNFalpha 被增加, RANKL 表示不起来在 PBMC 调整了。推延的 Portasystemic 增加了传播 CD8+T 房间人口。Rapamycin 减少了传播 CD8+T 房间人口,增加了 CD8+CD25+T 规章的房间人口并且改进了骨头周转的所有参数。结论:推延的 portasystemic 引起的骨质疏松症可以被 rapamycin 部分在肝的骨营养不良的老鼠模型改善。 | Schalk W van der Merwe Maria M Conradie Robert Bond Brenda J Olivier Elongo Fritz Martin Nieuwoudt Rhena Delport Tomas Slavik Gert Engelbrecht Del Kahn Enid G Shephard Maritha J Kotze Nico P de Villiers Stephen Hough | 2006 | World Journal of Gastroenterology2006，12，28： | 2 |
| 2 | Cyclic histomorphological changes in the ovary of mudfish, Labeo capensis显示文摘 | van Vuren J H J Vermaak J F | 1988 | Aquac1988，72，： | 1 |
| 3 | Atrial fibrillation after radiofrequency ablation of atrial flutter: preventive effect of angiotensin converting enzyme inhibitors, angiotensin Ⅱ receptor blockers, and diuretics显示文摘 | ANNE W WILLEMS R VAN DER MERWE N | 2004 | Heart2004，90，： | 1 |
| 4 | Knee rotational laxity in a randomized comparison of single-versus double-bundle anterior cruciate ligament reconstruction显示文摘 | Hemmerich A van der Merwe W Batterham M | | 0，，： | 1 |
| 5 | Atrial fibrillation after radiofrequency ablation of atrial flutter: preventive effect of angiotensin converting enzyme inhibitors,angiotensin Ⅱ receptor blockers, and diuretics显示文摘 | Anne W Willems R Van der Merwe N | 2004 | Heart2004，90，10： | 1 |
| 6 | Testing the ability of a low grade sphalerite tailing to achieve autothermality during biooxidation heap leaching显示文摘 | SAMPSON M I van der MERWE W HARVEY T J BATH M D | | 0，，： | 1 |
| 7 | The application of the Geobiotics GEOCOAT显示文摘 | Harvey T J Van Der Merwe W | 2002 | Minerals Engineering2002，15，： | 1 |
| 8 | Mutations involved in Aicardi-Gouti6res syndrome implicate SAMHD1 as regulator of the innate immune response显示文摘 | Rice GI Bond J Asipu A Brunette R L Manfield I W Cart I M Fuller J C Jackson R M Lamb T Briggs TA Ali M Gornall H Couthard L R Aeby A Attard-Montalto S P Bertini E Bodemer C Brockmann K Brueton L A Corry P C Desguerre I Fazzi E Cazorla A G Gener B Hamel B C Heiberg A Hunter M van der Knaap M S Kumar R Lagae L Landrieu P G Lourenco C M Marom D McDer- mott M F van der Merwe W Orcesi S Prendiville J S Rasmussen M Shalev S A Soler D M Shinawi M Spiegel R Tan T Y Vanderver A Wakeling EL Wassmer E Whittaker E Lebon P Stetson D B Bonthron D T Crow Y J | 2009 | Nature Genetics2009，41，： | 1 |
| 9 | An exactly solvable model for calculating critical misfit and thickness in epitaxial superlattices: layers of equal elastic constants and thicknesses 显示文摘 | Jesser W A van der Merwe J H | 1988 | Journal of Applied Physics1988，63，5： | 1 |
| 10 | Membranes of Class Ⅱa BacteriocinResistant Listeria monocytogenes Cells Contain Increased Levels of Desaturated and Short-Acyl-Chain Phosphatidylglycerols显示文摘 | Viveka Vadyvaloo John W Hastings Marthinus J van der Merwe Marina Rautenbach | 2002 | Applied And Environmental Microbiology2002，，： | 1 |
| 11 | Diets of Southern African Bovidae: Stable Isotope Evidence显示文摘 | Sponheimer M Lee-Thorp J A DeRuiter D J Smith J M van der Merwe N J Grant CC J M Ayliffe J K Robinson T F Heidelberger C Marcus W | 2003 | Journal of Mammalogy2003，84，2： | 1 |
| 12 | Domination and total domination critical trees with respect to relative complements 显示文摘 | HaynesT W Henning M A van der Merwe L C | 2001 | Ars Combin2001，59，： | 1 |
| 13 | The application of the Geo Biotics GEOCOAT biooxidation technology for the treatment of sphalerite at Kumba resources Rosh Pinah mine 显示文摘 | Harvey T J Van Der Merwe W | 2002 | Minerals Engineering2002，15，： | 1 |
| 14 | The application of the GeoBiotics GEOCOAT biooxidation technology for the treatment of sphalerite at Kumba resources' Rosh Pinah mine显示文摘 | Harvey TJ van der Merwe W Afewu K | 2002 | Minerals Engineering2002，15，11： | 1 |
| 15 | Vitamin requirements for the treatment of hyperhomocysteinemia in humans显示文摘 | Ubbink J B Vermaak W J Van der Merwe A | 1994 | J Nutr1994，124，10： | 1 |
| 16 | Testing the ability of a low grade sphalerite concentrate to achieve autothermality during biooxidation heap leaching显示文摘 | Sampson M L Van der Merwe J W Harvey T J | 2005 | Minerals Engineering2005，18，： | 1 |
| 17 | Reaction of oriental tobacco to spacing and topping treatments at three levels of nitrogenous fertilizer applition显示文摘 | Lamprecht M P Merwe W J C Van der | 1984 | South African Journal for Plant and Soil1984，1，4： | 1 |
| 18 | Mutations involved in Aicardi-Goutieres syndrome implicate SAMHD1 as regulator of the innate immune response 显示文摘 | Rice GI Bond J Asipu A Brunette RL Manfield IW Carr IM Fuller JC Jackson RM Lamb T Briggs TA Ali M GomaU H Couthard LR Aeby A Attard-Montalto SP Bertini E Bodemer C Brockmann K Bmeton LA Corry PC Desguerre I Fazzi E Cazorla AG Gener B Hamel BCJ Heiberg A Hunter M van der Knaap MS Kumar R Lagae L Landrieu PG Lourenco CM Marom D McDermott MF van der Merwe W Orcesi S PrendiviUe JS Rasmussen M Shalev SA Soler DM Shinawi M Spiegel R Tan TY Vanderver A Wakeling EL Wassmer E Whittaker E Lebon P Stetson DB Bonthron DT Crow YJ 2009 | 2009 | Nat Genet2009，41，7： | 1 |
| 19 | Knee rotational laxity: An investigation of bilateral asymmetry for comparison with the contralateral uninjured knee显示文摘 | Hemmerich A van der Merwe W Batterham M | | 0，，： | 1 |
| 20 | Double-bundle ACL surgery demonstrates superior rotational kinematics to single-bundle technique during dynamic task显示文摘 | Hemmerich A van der Merwe W Batterham M | 2011 | Clinical Biomechanics2011，26，10： | 1 |
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