|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 3 | Buffering in optical packet switches显示文摘 | D K Hunter M C Chia I Andonovic | 1998 | IEEE Journal of Lightwave Technology1998，16，12： | 2 |
| 4 | Irreversible adsorption of naphthalene and tetrachlorobiphenyl to Lula and surrogate sediments显示文摘 | Kan A T Fu G Hunter M A | 1997 | Environ Sci Technol1997，31，： | 2 |
| 5 | Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve显示文摘 | Berry M Carlile J Hunter A | 1996 | J Neurocytol1996，25，2： | 1 |
| 6 | Irreversible adsorption of naphthalene and tetrachorobiphenyl to lulu and surrogate sediment 显示文摘 | Kan A T Fu G M Hunter M A | 1997 | Environmental Science and Technology1997，31，8： | 1 |
| 7 | Partial discharge monitoring for power transformers using UHF sensors, part 1 : sensors and signal interpretation显示文摘 | Judd M D Yang L Hunter B B | 2005 | IEEE Electrical Insulation Magazine2005，21，2： | 1 |
| 8 | Cytokine gene expression patterns associated with immunization against Mareks disease in chickens 显示文摘 | ABDUL-CAREEM M F HUNTER B D PARVIZI P | 2007 | Vaccine2007，25，3： | 1 |
| 9 | Apramycin-resistant Escheriehia coli isolated from pigs and a stockman显示文摘 | Hunter J E B Bennett M Hart C A | 1994 | Epidemiol infect1994，112，： | 1 |
| 10 | Long-circulating and target-specific nanoparticles :theory to practice显示文摘 | MOGHIMI S M HUNTER A C MURRAY J C | 2001 | Pharmacol Rev2001，53，2： | 1 |
| 11 | Numerical index of the discriminatory ability of typing systems : an application of Simpson' s index of diversity显示文摘 | Hunter P R Gaston M A | 1988 | Clin Microbiol1988，26，： | 1 |
| 12 | Sepsis and the heart显示文摘 | Hunter JD Doddi M | | 0，，01： | 1 |
| 13 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 14 | PremenstrualSyndrome 显示文摘 | Dickerson L M Mazyck P J Hunter M H | 2003 | American Family Physician2003，67，8： | 1 |
| 15 | Associations between bodymassindex,lean and fat bodymass and bone mineral density in middle-aged Austr^ians : The Bussel-ton Healthy Ageing Study 显示文摘 | Zhu K Hunter M James A | 2015 | Bone2015，74，： | 1 |
| 16 | PRC1显示文摘 | Wei Jiang Gretchen Jimenez Nicholas J Wells Thomas J Hope Geoffrey M Wahl Tony Hunter Rikiro Fukunaga | 1998 | Molecular Cell1998，，： | 1 |
| 17 | Host responses are induced in feathers of chickens infected with Marek's disease virus显示文摘 | Abdul-Careem M F Hunter B D Sarson A J | 2008 | Virology2008，370，2： | 1 |
| 18 | A chimeric avian retrovirus containing the influenza virus hemagglutinin gene has an expanded host range显示文摘 | DONG J ROTH M G HUNTER E | 1992 | J Virol1992，66，： | 1 |
| 19 | Gemcitabine and cisplatin chemotherapy is an active combination in the treatment of platinum-resistant ovarian and peritoneal carcinoma显示文摘 | Tewari D Monk B J Hunter M | 2004 | Invest New Drugs2004，22，4： | 1 |
| 20 | Intrapleural immunotherapy with corynebacterium parvum in recurrent malignant pleural effusions显示文摘 | Millar J W Hunter A M Horne N W | 1980 | Thorax1980，35，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员