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	题名	作者	年代	出处	被引量
1	Evaluation of cytotoxic and anti-tumor activity of partially purified serine protease isolate from the Indian earthworm Pheretima posthuma显示文摘Objective:To isolate,partially purify and evaluate the cytotoxic and antitumor activity of a serine protease from the chosen Indian earthworm Pheretima posthuma.Methods:Whole animal extract was prepared and purified its protein constituents by size and charge based chromatographic separation techniques using Sephadex G-50 and DEAE-Cellulose resin respectively.Average molecular weight of the protein isolate was determined and analyzed for its cytotoxic property against Vero cells in different dilutions(1:20 and 1:40)and anti-tumor activity by MTT assay(a colorimetric assay)using breast cancer cell line MCF-7,with tamoxifen as standard.Results:One of the protein constituents after purification was characterized as serine protease by Caseinolytic plate diffusion assay.Average molecular weight of this purified isolate was determined,by SDS-PAGE analysis with standard protein ladder,as of 15 kDa.The performed tests suggested that the 15kDa fraction has potent cytotoxic activity and satisfactory antitumor activity as well in vitro.Conclusions:Exact molecular mechanism of the cytotoxic and antitumor activities is yet to be explored and currently we are working on ultra-purification and biophysical characterization of this fraction.Further investigation into the mechanism(s)of cytotoxic and antitumor activities at molecular level would be useful in treatment of various classes of cancer and viral infections in future.	Mahendra Kumar Verma Francies Xavier Yogendra Kumar Verma Kota Sobha	2013	Asian Pacific Journal of Tropical Biomedicine2013，3，11：	3
2	Electrodeposition of Silver from Nonconventional Baths 显示文摘	Jayakrishnan Sobha	1996	Transactions of the SAEST1996，31，12：	1
3	Genetictransformation of Hevea brasiliensis with the gene coding forsuperoxide dismutase wth FMV 34S promoter 显示文摘	Sobha S Sushamakumari S Thanseem I	2003	CurrentScience2003，85，8：	1
4	Vertical diplopia following peribulbar anesthesia:the role of hyaluronidase显示文摘	Strouthidis NG Sobha S Lanigan L	2004	J Pediatr Ophthalmol Strabismus2004，41，：	1
5	A specifc and sensitive assay for gefitinib using methods in pharmaceutical dosage forms 显示文摘	Ratnakumari A Rajeswari A Sobha K	2010	An International Journal of Advances In Pharmaceu- tical Sciences2010，1，1：	1
6	Influence of Growth Regulators And Sucrose on Somatic Embryogenesis and plant Regeneration From Immature Inflorescence of Hevea Brasiliensis显示文摘	Sushamakumari S Sobha S Rekha K	2000	Indian Journal of natureal rubber research2000，13，12：	1
7	Blends of Nylon/Acrylonitrile Butadiene Rubber: Effects of Blend Ratio, Dynamic Vulcanization and Reactive Compatibilization on Rheology and Extrudate Morphology显示文摘	Radhesh Kumar C Sobha V Nair George K E	2003	Polymer Engineer ing and Science2003，43，9：	1
8	Hypoxia and Oxidative Stress in the Causation of Diabetic Retinopathy显示文摘	Geoffrey B. Arden Sobha Sivaprasad	2011	Current Diabetes Reviews2011，，5：	1
9	Electrodeposition of silver from nonconventional baths 显示文摘	Jayakrishnan sobha	1996	Transactions of the SAEST1996，31，12：	1
10	A Random- ized Trial to Assess Functional and Structural Effects of Ranibi- zumab versus Laser in Diabetic Macular Edema (the LUCIDATE Study)显示文摘	Oliver Comyn Sobha Sivaprasad Tunde Peto	2014	Am J Ophthalmol2014，157，5：	1
11	Imprints of environment pollution on laterite/clay and groundwater of Eloor-Kalamassary Industrial Belt,Kerala State,India显示文摘	Sobha V Anish M	2003	Environmental Geology2003，44，：	1
12	Influence of growth regulators and sucrose on somatic embryogenesis and plant regeneration from immature inflorescence of Hevea brasiliensis显示文摘	S ushamakumari S Sobha S Rekha K	2000	Indian J Nat Rubber Res2000，13，12：	1
13	Micropulsed Diode Laser Therapy:Evolution and Clinical Applications显示文摘	Sivaprasad Sobha Elagouz Mohammed McHugh Dominic		0，，06：	1
14	Genetic transformation of Hevea brasiliensis with the gene coding for superoxide dismutase with FMV 34S promoter显示文摘	Sobha S Sushamakumari S Thansem I	2003	Current Science2003，85，：	1
15	Cholinergic receptor alterations in the brain stem of spinal cord injured rats 显示文摘	Romeo C Raveendran A T Sobha N M	2013	Neuroehem Res2013，38，2：	1
16	Effect of additives on electrodeposition of tin and its structural and corrosion behaviour显示文摘	R. Sekar C. Eagammai Sobha Jayakrishnan	2010	Journal of Applied Electrochemistry2010，，1：	1
17	Electrodeposition of Silver from Nonconventional Baths显示文摘	Jayakrishnan Sobha	1996	Transactions of the SAEST1996，31，12：	1
18	Alkaline non-cyanide bath for electrodeposition of silver显示文摘	Sobha Jayakrishnan Natarajan S R	1996	Metal Finishing1996，，5：	1
19	Exploring the DNA binding mode of transition metal based biologically active compounds 显示文摘	Raman N Sobha S	2012	Speelrochimica Acla Parr A2012，85，1：	1
20	Genetic transformation and regeneration of rubber tree ( Hevea brasiliensis Muell. Arg) transgenic plants with a constitutive version of an anti-oxidative stress superoxide dismutase gene显示文摘	R. Jayashree K. Rekha P. Venkatachalam S. L. Uratsu A. M. Dandekar P. Kumari Jayasree R. G. Kala P. Priya S. Sushma Kumari S. Sobha M. P. Ashokan M. R. Sethuraj A. Thulaseedharan	2003	Plant Cell Reports2003，，3：	1

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