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1Abstract from: Pharmacologic treatment of hypertension in adults aged 60 years or older to higher versus lower blood pressure targets: A clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians显示文摘Description: The American College of Physicians (ACP) and the American Academy of Family Physicians (AAFP) jointly developed this guideline to present the evidence and provide clinical recommendations based on the benefits and harms of higher versus lower blood pressure targets for the treatment of hypertension in adults aged 60 years or older.Amir Qaseem Timothy J. Wilt Robert Rich Linda L. Humphrey Jennifer Frost Mary Ann Forciea 2017Chinese Nursing Research2017,4,4:43
23D bioactive composite scaffolds for bone tissue engineering显示文摘Bone is the second most commonly transplanted tissue worldwide,with over four million operations using bone grafts or bone substitute materials annually to treat bone defects.However,significant limitations affect current treatment options and clinical demand for bone grafts continues to rise due to conditions such as trauma,cancer,infection and arthritis.Developing bioactive three-dimensional(3D)scaffolds to support bone regeneration has therefore become a key area of focus within bone tissue engineering(BTE).A variety of materials and manufacturing methods including 3D printing have been used to create novel alternatives to traditional bone grafts.However,individual groups of materials including polymers,ceramics and hydrogels have been unable to fully replicate the properties of bone when used alone.Favourable material properties can be combined and bioactivity improved when groups of materials are used together in composite 3D scaffolds.This review will therefore consider the ideal properties of bioactive composite 3D scaffolds and examine recent use of polymers,hydrogels,metals,ceramics and bio-glasses in BTE.Scaffold fabrication methodology,mechanical performance,biocompatibility,bioactivity,and potential clinical translations will be discussed.Gareth Turnbull Jon Clarke Frederic Picard Philip Riches Luanluan Jia Fengxuan Han Bin Li Wenmiao Shu 2018Bioactive Materials2018,3,3:40
3国外青少年生活满意度研究概况显示文摘田丽丽 刘旺 Rich Gilman 2003中国心理卫生杂志2003,17,12:24
4Role of antispasmodics in the treatment of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a long-lasting,relapsing disorder characterized by abdominal pain/discomfort and altered bowel habits.Intestinal motility impairment and visceral hypersensitivity are the key factors among its multifactorial pathogenesis,both of which require effective treatment.Voltage-gated calcium channels mediate smooth muscle contraction and endocrine secretion and play important roles in neuronal transmission.Antispasmodics are a group of drugs that have been used in the treatment of IBS for decades.Alverine citrate,a spasmolytic,decreases the sensitivity of smooth muscle contractile proteins to calcium,and it is a selective 5-HT1A receptor antagonist.Alverine,in combination with simethicone,has been demonstrated to effectively reduce abdominal pain and discomfort in a large placebo-controlled trial.Mebeverine is a musculotropic agent that potently blocks intestinal peristalsis.Non-placebo-controlled trials have shown positive effects of mebeverine in IBS regarding symptom control;nevertheless,in recent placebo-controlled studies,mebeverine did not exhibit superiority over placebo.Otilonium bromide is poorly absorbed from the GI tract,where it acts locally as an L-type calcium channel blocker,an antimuscarinic and a tachykinin NK2receptor antagonist.Otilonium has effectively reduced pain and improved defecation alterations in placebocontrolled trials in IBS patients.Pinaverium bromide is also an L-type calcium channel blocker that acts locally in the GI tract.Pinaverium improves motility disorders and consequently reduces stool problems in IBS patients.Phloroglucinol and trimethylphloroglucinol are non-specific antispasmodics that reduced pain in IBS patients in a placebo-controlled trial.Antispasmodics have excellent safety profiles.T-type calcium channel blockers can abolish visceral hypersensitivity in animal models,which makes them potential candidates for the development of novel therapeutic agents in the treatment of IBS.Anita Annaházi Richárd Róka András Rosztóczy Tibor Wittmann 2014World Journal of Gastroenterology2014,20,20:15
5中美两国中学生生活满意度的跨文化研究显示文摘目的:比较分析中美两国中学生生活满意度的差异。方法:采用“多维学生生活满意度量表”(MSLSS)对872名中、美两国的中学生进行测查。结果:(1)中国中学生的朋友、学校和一般生活满意度高于美国中学生,差异具有统计学显著性;(2)中国7、8、9三个年级学生的学校和一般生活满意度均高于美国同年级学生,差异具有统计学显著性;(3)美国男生生活环境的满意度高于中国男生,中国男生的自我满意度高于美国男生,美国女生的自我满意度高于中国女生,差异均具有统计学显著性;(4)中、美中学生的生活满意度都在各自国家内存在统计学意义的年级差异,均表现为7年级学生在存在差异维度上的满意度高于本国其他年级的学生;(5)中、美中学生的生活满意都在各自国家内存在统计学意义的性别差异,两国均表现为女生在存在差异维度上的满意度高于本国男生。结论:中美两国中学生的生活满意度存在差异,社会文化背景是影响青少年生活满意度的重要因素。刘旺 田丽丽 Rich Gilman 2005中国心理卫生杂志2005,19,5:13
6New insights into the role of PML in tumour suppression显示文摘PML 基因涉及 t (15; 17 ) 尖锐 promyelocytic 白血球过多症(APL ) 的 translocation,它产生 oncogenic 熔化蛋白质 PML (promyelocytic 白血球过多症蛋白质)-retinoic 酸受体高山哈。PML 蛋白质本地化称为 PML 原子领域(PML-ND ) 的原子结构到一个代用品,哪个 PML 是必要结构的部件。在 APL, PML-NDs 被破坏,因此含有在这白血球过多症的致病的这些结构。出人意料地,最近的研究显示 PML 和 PML-ND 玩一个瘤在除了 APL 的人的瘤的几种不同类型的镇压角色。因为 PML 在多重细胞的小径的极端通用性和参与,理解位于它的功能下面的机制,并且因此在瘤抑制的角色,是一项挑战性的任务。在这评论,我们试图非常在这个领域里估价更最近的进展并且建议调查的新大街。P Salomoni BJ Ferguson AH Wyllie T Rich 2008Cell Research2008,18,6:12
7奶牛与热应激显示文摘热应激在世界许多不同地区都对奶牛生产带来了某种程度的影响.在美国,热应激问题在潮湿的东南部地区和干旱的西南部地区表现最为突出.Rich Verbeck John F.Smith Dennis V.Armstrong James Ma(译) 王光文(校) 2004乳业科学与技术2004,27,1:9
8目的地居民对旅游影响的评价研究——来自山东省的实证检验显示文摘运用Ap和Crompton(1998)提出的旅游影响量表,本文从经济、社会文化、拥挤程度、环境、服务和社区态度等方面实证检验了山东省的目的地居民对旅游影响的感知程度、对旅游影响的态度以及对旅游影响的综合评价,探讨了目的地居民对旅游影响的感知与他们对旅游影响的态度之间的关系。研究结果表明,多数情况下目的地居民对旅游影响的感知与态度之间并不相关。王素洁 Rich Harrill 2009旅游科学2009,23,2:9
9Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor显示文摘房间有大量的控制维持他们的完整并且阻止随机切换到另外一个一个生物状态。Raf Kinase 禁止的蛋白质(RKIP ) , phosphatidylethanolamine 绑定蛋白质(PEBP ) 的一个成员家庭,表明工作维持“ yin yang ”或生物系统的平衡的串联的调节的人的一个新类是代表性的。RKIP 禁止地图 kinase (Raf-MEK-ERK ) ,表明串联的 G 联合蛋白质的受体(GPCR ) kinase 和 NFkappaB。因为 RKIP 指向依赖于它磷酸化的状态的不同家族 ases, RKIP 也行动集成多重环境刺激开始的串音。RKIP 的损失或弄空导致正常细胞的壅滞和罐头的混乱导致象癌症那样的 chromosomal 畸形和疾病状态。因为 RKIP 和 PEBP 家庭以前被考察了,这分析的目标是提供更改并且加亮一些 RKIP 的唯一的特征在细胞的发信号的过程的规定使它成为一个批评播放器。Alexey E Granovsky Marsha Rich Rosner 2008Cell Research2008,18,4:9
10≥60岁高血压病人控制血压在较高或较低水平的药物治疗--美国医师协会和美国家庭医师学会临床实践指南显示文摘目的:针对≥60岁的高血压病人治疗中较高和较低降压目标的利弊,美国医师协会(ACP)和美国家庭医师学会(AAFP)共同制订了这一指南,为临床治疗提供证据及治疗建议。方法:本指南依据于已发表的主要疗效指标的随机对照试验以及针对危害的观察性研究的系统性评价。资料来源于EMBASE、系统性综述Cochrane数据库、MEDLINE和Clinical Trials.gov,搜索时间为从数据库建立开始至2015年1月,其中MEDLINE数据更新到2016年9月。评估指标包括全因死亡率、与卒中相关的发病率和死亡率、主要心脏事件(包括致死和非致死性心肌梗死和心源性猝死)和危害。本指南采用GRADE法(Grading of Recommendations,Assessment,Development,and Evaluation)对证据和建议进行分级。目标使用者和病人人群:本指南的目标使用者为所有临床医师,目标病人人群包括所有年龄≥60岁的高血压病人。建议1:对≥60岁、收缩压持续≥150mmHg(1mmHg=0.133kPa)的病人治疗时,ACP和AAFP建议临床医师应启动降压治疗以控制收缩压<150mmHg,从而减少死亡、脑卒中和心脏事件的风险(等级:强烈推荐,高质量证据)。对≥60岁高血压病人进行治疗时,建议临床医生定期与病人具体讨论降压目标的利弊,根据讨论情况选择治疗目标。建议2:对≥60岁的有脑卒中或短暂性脑缺血发作病史的病人,ACP和AAFP建议临床医生考虑启动或者加强药物治疗,以控制收缩压<140mmHg,降低脑卒中复发的风险(等级:弱推荐,中等质量证据)。对≥60岁高血压病人进行治疗时,建议临床医生定期与病人具体讨论降压目标的利弊,根据讨论情况选择治疗目标。建议3:对一部分≥60岁有高度心血管风险的病人,ACP和AAFP建议临床医生根据个体评估情况考虑启动或者强化降压药物治疗,控制收缩压到140mmHg以下,从而减少脑卒中或心脏事件发生的风险(等级:弱推荐,低质量证据)。对≥60岁高血压病人进行治疗时,建议临床医生定期与病人具体讨论降压目标的利弊,根据讨论情况选择治疗目标。Amir Qaseem Timothy J.Wilt Robert Rich Linda L.Humphrey Jennifer Frost Mary Ann Forciea 2017护理研究(下旬版)2017,31,8:8
11水力压裂监测新方法显示文摘深入了解水力压裂裂缝的几何形态和延伸情况有助于改善低渗油气藏压裂增产作业效果,改善油气井产能并提高油气采收率。应用地震方法对水力压裂裂缝进行监测和描述已经有多年了,而新的地震硬件和处理技术的出现使得这类监测更加有效、可靠。Les Bennett Joeol Le Calvez David R. ( Rich ) Sarver Kevin Tanner W.S.(Scott)Birk George Waters Julian Drew Gw e nola Michaud Paolo Primiero Leo Eisner Rob Jones David Leslie Michael John Williams Jim Govenlock Richard C. ( Rick ) Klein Kazuhiko Tezuka 2007国外测井技术2007,22,4:7
12开关模式LED驱动器的调光技术显示文摘线性电流源由于其耗电性而不再被节能意识日益增强的世界所接受,开关模式的LED驱动器早已取代其成为现今的标准。此处描述的是LED的一些基本理论,以及用于为开关模式LED驱动器提供调光控制的多种技术。Rich Rosen 2009电子产品世界2009,16,10:7
13给断奶仔猪饲喂颗粒料加粉料的混合料显示文摘断奶仔猪的日粮多为颗粒料.当然,这有很多理由,不仅仅是因为采用颗粒料可减少饲料浪费并提高养分的消化率.采用颗粒料的结果就是饲料利用率可得到改善,并且因而生长率也可在断奶后最初几周这一关键时期内改善5~15%.美国300多万头断奶猪今年不再简单地接受颗粒饲料,它们在进入保育舍内最初几天内被喂给一种颗粒料和粉料的混合料.刘建辉 Ioannis Mavromichalis Rich Fisher 2003国外畜牧学(猪与禽)2003,,2:6
14中学生生活满意度的跨文化比较研究显示文摘目的:比较不同国家(地区)中学生生活满意度的差异。方法:运用《多维学生生活满意度量表》对爱尔兰、美国、高加索、以色列、中国五个国家(地区)共计1345名中学生的生活满意度进行了测量。结果:(1)五国(地区)中学生高一般生活满意度组人数分布百分比由多到少依次为爱尔兰、美国、高加索、以色列、中国;(2)五国(地区)女生的家庭满意度高于男生,男生的学校满意度高于女生;(3)爱尔兰学生的家庭满意度最高,中国学生的朋友和学校满意度最高,以色列学生的生活环境满意度最低、自我满意度最高;(4)性别和国家(地区)对中学生的学校、生活环境、自我的满意度存在交互作用。结论:不同国家(地区)中学生的生活满意度存在差异,社会文化背景是影响中学生生活满意度的重要因素。田丽丽 刘旺 Rich Gilman 2005应用心理学2005,11,1:6
15New treatment strategies for malignant gliomas显示文摘Sathornsumetee S Rich JN 2006中国神经肿瘤杂志2006,4,2:5
16RAS Is Regulated by the let-7 MicroRNA Family显示文摘Steven M. Johnson Helge Grosshans Jaclyn Shingara Mike Byrom Rich Jarvis Angie Cheng Emmanuel Labourier Kristy L. Reinert David Brown Frank J. Slack 2005Cell2005,,5:5
17Epidemiologic characteristics of Helicobacter pylori infection in southeast Hungary显示文摘BACKGROUND Epidemiologic studies have revealed a decrease in the prevalence of Helicobacter pylori(H.pylori)infection in Western Europe.AIM To obtain data regarding the prevalence of H.pylori in Csongrád and Békés Counties in Hungary,evaluate the differences in its prevalence between urban and rural areas,and establish factors associated with positive seroprevalence.METHODS One-thousand and one healthy blood donors[male/female:501/500,mean age:40(19–65)years]were enrolled in this study.Subjects were tested for H.pylori IgG antibody positivity via enzyme-linked immunosorbent assay.Subgroup analysis by age,gender,smoking habits,alcohol consumption,and urban vs nonurban residence was also performed.RESULTS The overall seropositivity of H.pylori was 32%.It was higher in males(34.93%vs 29.2%,P=0.0521)and in rural areas(36.2%vs 27.94%,P=0.0051).Agricultural/industrial workers were more likely to be positive for infection than office workers(38.35%vs 30.11%,P=0.0095)and rural subjects in Békés County than those in Csongrád County(43.36%vs 33.33%,P=0.0015).CONCLUSION Although the prevalence of H.pylori infection decreased in recent decades in Southeast Hungary,it remains high in middle-aged rural populations.Generally accepted risk factors for H.pylori positivity appeared to be valid for the studied population.Lenke Bálint Andrea Tiszai Gábor Kozák Ilona Dóczi Veronika Szekeres Orsolya Inczefi Georgina Ollé Krisztina Helle Richárd Róka András Rosztóczy 2019World Journal of Gastroenterology2019,25,42:5
18Activated Pancreatic Stellate Cells Sequester CD8+ T-Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma显示文摘Abasi Ene-Obong Andrew J. Clear Jennifer Watt Jun Wang Rewas Fatah John C. Riches John F. Marshall Joanne Chin-Aleong Claude Chelala John G. Gribben Alan G. Ramsa Hemant M. Kocher 2013Gastroenterology2013,,:4
19Perioperative care in older adults显示文摘Giselle A Baquero Michael W Rich 2015Journal of Geriatric Cardiology2015,12,5:3
20温度和养护条件对砂浆和混凝土强度增长的影响Barbara Lothenbac Corinne Alder Frank Winnefeld Dübendorf/Schweiz und Peter Lunk Zürich/Schweiz 杨先坤 2007商品混凝土2007,0,2:3
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