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| 1 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 2 | Chronic hepatitis C:Treat or wait? Medical decision making in clinical practice显示文摘AIM:To analyzes the decision whether patients with chronic hepatitis C virus (HCV) infection are treated or not.METHODS:This prospective cohort study included 7658 untreated patients and 6341 patients receiving pegylated interferon α2 a/ribavirin,involving 434 physicians/institutions throughout Germany (377 in private practice and 57 in hospital settings).A structured questionnaire had to be answered prior to the treatment decision,which included demographic data,information about the personal life situation of the patients,anamnesis and symptomatology of hepatitis C,virological data,laboratory data and data on concomitant diseases.A second part of the study analyzes patients treated with pegylated interferon α2a.All questionnaires included reasons against treatment mentioned by the physician.RESULTS:Overall treatment uptake was 45%.By multivariate analysis,genotype 1/4/5/6,HCV-RNA ≤ 520 000 IU/mL,normal alanine aminotransferase (ALT),platelets ≤ 142 500/μL,age > 56 years,female gender,infection length > 12.5 years,concomitant diseases,human immunodeficiency virus co-infection,liver biopsy not performed,care in private practice,asymptomatic disease,and unemployment were factors associated with reduced treatment rate.Treatment and sustained viral response rates in migrants (1/3 of cohort) were higher than in German natives although 1/3 of migrants had language problems.Treatment rate and liver biopsy were higher in clinical settings when compared to private practice and were low when ALT and HCV-RNA were low.CONCLUSION:Some reasons against treatment were medically based whereas others were related to fears,socio-economical problems,and information deficits both on the side of physicians and patients. | Claus Niederau Dietrich Hüppe Elmar Zehnter Bernd Mller Renate Heyne Stefan Christensen Rainer Pfaff Arno Theilmeier Ulrich Alshuth Stefan Mauss | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 3 | Global Gene Expression Profiling of Progesterone Receptor Modulators in T47D Cells Provides a New Classfication System显示文摘 | Afhüppe W Sommer A Müller J | | 0，，： | 1 |
| 4 | The integral basis method for integer programming显示文摘 | Utz-Uwe Haus Matthias K?ppe Robert Weismantel | 2001 | Mathematical Methods of Operations Research2001，，3： | 1 |
| 5 | Different aspects of assessing indoor and outdoor thermal comfort显示文摘 | Hppe P | 2002 | Energy Build2002，34，： | 1 |
| 6 | Evaluation of Different Laboratory Tests and Activity Indices Reflecting the Inflammatory Activity of Crohn’s Disease显示文摘 | A. Tromm C. D. Tromm D. Hü ppe U. Schwegler M. Krieg B. May | 1992 | Scandinavian Journal of Gastroenterology1992，，： | 1 |
| 7 | Delphi公司压电直接控制式喷油器共轨喷射系统显示文摘2008年,Delphi公司的新型压电直接控制式柴油机喷射系统投入批量生产。这种200MPa喷油压力共轨系统的喷油嘴针阀直接由1个压电陶瓷执行器驱动,而无须经过伺服阀的转换,针阀能非常迅速地开闭,并与喷油压力无关,这样在降低燃油耗的同时,能使排放降至最低,并能达到更高的升功率和扭矩。该系统对最小先导喷油量进行优化控制,并与整个使用寿命期内稳定的喷油量相结合,能确保达到一流的燃油喷射性能。 | Schōppe D【法】 Ziilch S【英】 Hardy M Jorach R W Bakel N Geurts D【卢森堡】 范明强(译) | 2010 | 国外内燃机2010，，1： | 1 |
| 8 | Bone mineral density in female junior,senior and former football players显示文摘 | Düppe H | 1996 | Osteoporosis Int1996，6，： | 1 |
| 9 | Bone mineral density in female junior, senior and former football players显示文摘 | D u ppe H | 1996 | Osteoporosis lnt1996，6，： | 1 |
| 10 | The physiological equivalent temperature – a universal index for the biometeorological assessment of the thermal environment显示文摘 | P. H?ppe | 1999 | International Journal of Biometeorology1999，，2： | 1 |
| 11 | The physiological equivalent temperature – a universal index for the biometeorological assessment of the thermal environment显示文摘 | P. H?ppe | 1999 | International Journal of Biometeorology1999，，2： | 1 |
| 12 | SC vs SC competition 显示文摘 | RICE J B HO PPE R M | 2001 | Supply Chain Management Review2001，29，1： | 1 |
| 13 | Clinical strategies for success in Proximoincisal composite restorations Part II composite application technique显示文摘 | Feli ppe LA Mon teiro S Jr DeAnd rada CA | 2005 | Esthet Restor Dent2005，17，1： | 1 |
| 14 | Vascular infarction by subcutaneous application of tissue factor targeted to tumor vessels with NGR-peptides: activity and toxicity profile显示文摘 | Dreischalück J Schw?ppe C Spieker T | 2010 | Int J Oncol2010，37，6： | 1 |
| 15 | Bedload layer thickness and disturbance depth in gravel bed streams显示文摘 | DeVries PPE | 2002 | Journal of Hydraulic Engineering ASCE2002，128，11： | 1 |
| 16 | Bcl-2 expression in higher-grade human glioma:a clinical and experimental study显示文摘 | FELS C SCH(A)FER C H(U)PPE B | 2000 | J Neurooncol2000，48，3： | 1 |
| 17 | Vascular infarction bysubcutaneous application of tissue factor targeted to tumor vessels withNGR-peptides:activity and toxicity profile显示文摘 | Dreischalück J Schwppe C Spieker T | 2010 | Int J Oncol2010，37，6： | 1 |
| 18 | Stochastic modeling of tropical cyclone tracks 显示文摘 | Rumpf J Weindl H Ht~ppe P | 2007 | Mathematical Methods of Operations Research2007，66，： | 1 |
| 19 | Therapieergebnisse für die chronische Hepatitis C mit Genotyp-5- und -6-Infektion in Deutschland显示文摘 | S. Mauss F. Berger M. Vogel H. Pfeiffer-Vornkahl U. Alshuth J. Rockstroh C. Niederau D. Hüppe | 2012 | Z Gastroenterol2012，，05： | 1 |
| 20 | The use of the flexible laryngeal mask in children with adenoidectomy a retrospective comparison with endotracheal intubation显示文摘 | Rehberg S Wienstroth SS H ti ppe M | 2007 | Anasthesiol Intensivmed Notfallmed Schmerzther2007，42，2： | 1 |
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