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11篇 您的检索式:作者名="ooper"
    题名 作者 年代 出处 被引量
1Developmental neu rotoxicity of pyrethroid insecticides in zebrafish embryos显示文摘Demiccoa Ooper KR Richardson JR 2010Toxicol Sci2010,113,1:1
2Nitrgen limitation in dryland eeosystems-responses to geographical and temporal variation in pre- eipitation显示文摘H ooper D U Johnson L 1999Biogeochemistry1999,46,:1
3Moden management of spine tuberculosis显示文摘REZAI AR LEE M C OOPER PR 1995Neurousurg1995,36,1:1
4The performance of vertical flow constructed wetland systems with special reference to the significance of oxygen transfer and hydraulic loading rates显示文摘ooper P 2005Water Science & Technology2005,51,:1
5T h e co m p u tatio n al com plexity of probabilisticinference using B ayesian belief netw orks 显示文摘C ooper G F 1990A rtificial In telligence1990,42,23:1
6Vegf mRNA levels in placentae from pregnancies comlicated by pre-eclampsia显示文摘 Sharkey AM Jones DSC 1996Br J Obstet Gynaecol1996,103,:1
7Obesity is not protective against fracture in postmenopausal women:GLOW显示文摘Compston JE W atts N B C hapurlat R C ooper C B oonen S Greenspan S Pfeilschifter J Silverman S Díez-Pérez A Lindsay R Saag KG Netelenbos JC Gehlbach S Hooven FH Flahive J Adachi J D R ossini M Lacroix A Z Roux C S ambrook PN S iris ES Glow Investigators 0,,:1
8Amylin evokes protein p20 phosphorylation and insulin resistance in rat skeletal muscle extensor digitorum longus显示文摘In the present study, we investigate effect of amylin on the insulin sensitivity of rat skeletal muscle extensor digitorum longus (EDL) using in vitro intact muscle incubation in combination with metabolic radioactive labeling. The molecular basis of the amylin action was further examined using proteomic analysis. In particular, proteins of interest were characterized using an integrated microcharacterization procedure that involved in-gel trypsin digestion, organic solvent extraction, high performance liquid chromatography separation, microsequencing and microsequence analysis. We found that amylin significantly decreased the insulin-stimulated glucose incorporation into glycogen (p < 0.01) and produced a protein spot of approximately 20 ku in size. This amylin responsive protein (hereby designated as amylin responsive protein 1, APR1) was identified to be protein p20. Moreover, ARP1 spots on gels were found to consistently produce a corresponding radioactive spot on X-ray films in 32Pi but not in 35S-methionine labeling experiments. In conclusion, our results showed that in vitro amylin concomitantly evoked the production of ARP1 and caused insulin resistance in EDL muscle. It is suggested that protein p20 may be involved in amylin signal transduction and the appearance of ARP1 may be a step in a molecular pathway leading to the development of insulin resistance. ARP1 might therefore be a useful molecular marker for amylin action, insulin resistance and Type 2 diabetes.李晓钦 Garth C ooper 2002Science China(Life Sciences)2002,45,2:1
9Electrical breakdown phenomena in (PEO)xLiF3CSO3显示文摘Sequeira C A C Нooper A 1992Journal of Power Sources1992,40,3:1
10The role of advanced glycation end products in progression and complicat ions of diabetes 显示文摘Goh S Y C ooper M E 2008J Clin Endocrinol Metab2008,93,4:1
11Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer 显示文摘ooper DS Doherty GM Haugen BR 2009Thyroid2009,19,:1
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