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| 1 | 世代特征,信息环境变迁与大学生信息素养教育创新显示文摘当前世代大学生偏好的教育活动是个性化服务,电子媒介交互式学习,任务参与型学习甚至自主的学习;他们具备一定的信息素养能力,但差异巨大。本文指出:随着Internet技术及应用的深入发展,大学生信息素养能力包括三个层次,低层次是信息检索技能,然后是批判性思维能力和与自己专业密切相关的IT能力,更高层次是独立思考、认识论认知能力,最终达到解决实际问题的目的;高校图书馆已经不能独立满足学生多层次信息素养能力的要求及当前世代大学生对教育培训的偏好。本文提出信息素养教育五分策略:培养目标分层,教学内容分级,学科专业分类,培养过程分段,学生管理分流,并建议从网络课堂、图书馆、学院、学校、教育部、第三方平台等多个层面,共同推动我国大学生信息素养教育。 | 周剑 王艳 Iris XIE | 2015 | 中国图书馆学报2015，41，4： | 90 |
| 2 | 照料孙子女的经历对农村老年人生理健康的影响显示文摘本文利用'安徽省老年人生活状况'纵贯数据进行路径分析,研究照料孙子女的经历对农村老年人生理健康的影响,并且讨论了成年子女提供的代际支持在其影响路径中的作用。研究发现,相比于未曾照料过孙子女的农村老年人,提供持续性隔代照料的农村老年人的自陈健康状况和日常生活自理能力更好,而曾经提供过隔代照料的农村老年人也有更好的自陈健康状况。同时,对于提供持续性隔代照料的农村老年人而言,情感支持在照料经历对其自陈健康状况的影响路径中发挥了一定的中介作用,即能否从其成年子女处获得情感支持影响了他们的自陈健康状况。 | 周晶 韩央迪 Weiyu Mao Yura Lee Iris Chi | 2016 | 中国农村经济2016，，7： | 42 |
| 3 | Predictors of esophageal varices and first variceal bleeding in liver cirrhosis patients显示文摘AIM To assess 'predictors' of esophageal varices(EV) and variceal bleeding using non-invasive markers in Albanian patients diagnosed with liver cirrhosis.METHODS One hundred thirty-nine newly diagnosed cirrhotic patients without variceal bleeding were included in this analysis. Model for end-stage liver disease(MELD), aspartate aminotransferase(AST) to alanine aminotransferase(ALT) ratio(AST/ALT), AST to platelet ratio index(APRI), platelet count to spleen diameter(PC/SD), fibrosis-4-index(FIB-4), fibrosis index(FI) and King's Score were measured for all participants. All patients underwent endoscopic assessment within two days of hospitalization. The major end point was the first esophageal variceal bleeding(EVB) event. The diagnostic performance of 'predictors' for the presence of EV and EVB were assessed by sensitivity and specificity values obtained from the receiver operating characteristics procedure.RESULTS FIB-4 was the only strong and significant 'predictor' of esophageal varices(multivariable-adjusted OR = 1.57 for one unit increment; 95%CI: 1.15-2.14). Furthermore, a cut-off value of 3.23 for FIB-4 was a significant predictor of esophageal varices, with a sensitivity of 72%, a specificity of 58% and a proportion of area under the curve(AUC) of 66%(P = 0.01). During the follow-up(median: 31.5 mo; interquartile range: 11-59 mo), 34 patients(24%) experienced a first EVB. FIB-4 was a poor predictor of EVB(the AUC was only 51%) for a cut-off value of 5.02. Furthermore, the AUC of AST/ALT, APRI, PC/SD, FI, MELD and King's Score ranged from 45% to 55%. None of the non-invasive markers turned out to be a useful predictor of EVB.CONCLUSION Despite the low diagnostic accuracy, FIB-4 appears the most efficient non-invasive liver fibrosis marker which can be used as an initial screening tool for cirrhotic patients. | Bledar Kraja Iris Mone Ilir Akshija Adea Kocollari Skerdi Prifti Genc Burazeri | 2017 | World Journal of Gastroenterology2017，23，26： | 40 |
| 4 | 定性系统评价的撰写方法介绍显示文摘循证医学强调将医师的经验、最佳的研究证据与患者的价值观相结合以保证最佳的防治效果。'证据'是循证医学的核心,定量系统评价能够综合高质量的干预性研究,但不能提供患者的需求、观点与态度等证据综合结果,定性系统评价则可弥补此类不足。随着定性研究及其系统评价方法学的发展,定性研究数量逐年增长并为公共卫生、社会工作、管理学、教育学的循证实践提供证据支持,同时为决策者知证决策提供证据。国际上Cochrane协作网、Campbell协作网和3ie等研究机构已经有成熟的定性系统评价撰写方法,但国内缺少定性系统评价撰写方法介绍。本文将简要介绍定性系统评价的撰写方法。 | 黄崇斐 拜争刚 吴淑婷 盖琼艳 樊景春 杨克虎 Iris Chi | 2015 | 中国循证医学杂志2015，15，9： | 30 |
| 5 | Experimental obstructive jaundice alters claudin-4 expression in intestinal mucosa: Effect of bombesin and neurotensin显示文摘瞄准:调查试验性的妨碍的黄疸和外长的 bombesin 和 neurotensin (NT )(BBS ) 的影响紧密的连接(TJ ) 的表示上的管理在老鼠的肠上皮的蛋白质 claudin-4。方法:四十只男 Wistar 老鼠随机被划分成五个组:我 = 控制, II = 假冒操作, III = 胆汁管结扎(BDL ) , IV = BDL+BBS (30 microg/kg 每 d ) , V = BDL+NT (300 microg/kg 每 d ) 。在 d 的实验的结束 10,内毒素在门和大动脉的血被测量。终端回肠的织物节组织学地被检验并且免疫组织化学地为在肠上皮的 claudin-4 表示的评估。结果:妨碍的黄疸导致了重要的门和大动脉的 endotoxemia 表明的肠的障碍失败。Claudin-4 表示显著地被增加在上面在 jaundiced 老鼠的第三根绒毛并且一起来它的侧面的分发的规定被注意。BBS 或 NT 的管理恢复了 claudin-4 表示到控制状态并且显著地减少了门和大动脉的 endotoxemia。结论:在肠上皮的试验性的妨碍的黄疸增加 claudin-4 表示,它可以是贡献粘膜障碍的混乱的一个关键因素。毁坏规章的肽 BBS, NT 能阻止这扇改变和还原剂门和全身的 endotoxemia。 | Stelios F Assimakopoulos Constantine E Vagianos Aristides S Charonis Ilias H Alexandris Iris Spiliopoulou Konstantinos C Thomopoulos Vassiliki N Nikolopoulou Chrisoula D Scopa | 2006 | World Journal of Gastroenterology2006，12，21： | 21 |
| 6 | DNA methylation in hepatocellular carcinoma显示文摘As for many other tumors,development of hepatocellular carcinoma(HCC)must be understood as a multistep process with accumulation of genetic and epigenetic alterations in regulatory genes,leading to activation of oncogenes and inactivation or loss of tumor suppressor genes(TSG).In the last decades,in addition to genetic alterations,epigenetic inactivation of(tumor suppressor) genes by promoter hypermet hylation has been recognized as an important and alternative mechanism in tumorigenesis.In HCC,aberrant methylation of promoter sequences occurs not only in advanced tumors, it has been also observed in premalignant conditions just as chronic viral hepatitis B or C and cirrhotic liver. This review discusses the epigenetic alterations in hepatocellular carcinoma focusing DNA methylation. | Iris Tischoff Andrea Tannapfel | 2008 | World Journal of Gastroenterology2008，14，11： | 17 |
| 7 | Intraductal neoplasm of the intrahepatic bile duct: Clinicopathological study of 24 cases显示文摘AIM: To investigate the clinicopathological features of intraductal neoplasm of the intrahepatic bile duct (INihB). METHODS: Clinicopathological features of 24 cases of INihB, which were previously diagnosed as biliary papillomatosis or intraductal growth of intrahepatic biliary neoplasm, were reviewed. Mucin immunohistochemistry was performed for mucin (MUC)1, MUC2, MUC5AC and MUC6. Ki-67, P53 and β-catenin immunoreactivity were also examined. We categorized each tumor as adenoma (low grade), borderline (intermediate grade), and malignant (carcinoma in situ , high grade including tumors with microinvasion). RESULTS: Among 24 cases of INihB, we identified 24 tumors. Twenty of 24 tumors (83%) were composed of a papillary structure; the same feature observed in intraductal papillary neoplasm of the bile duct (IPNB). In contrast, the remaining four tumors (17%) showed both tubular and papillary structures. In three of the four tumors (75%), macroscopic mucin secretion was limited but microscopic intracellular mucin was evident. Histologically, 16 tumors (67%) were malignant, three (12%) were borderline, and five (21%) were adenoma. Microinvasion was found in four cases (17%). Immunohistochemical analysis revealed that MUC1 was not expressed in the borderline/adenoma group but was expressed only in malignant lesions (P = 0.0095). Ki-67 labeling index (LI) was significantly higher in the malignant group than in the borderline/adenoma group (22.2 ± 15.5 vs 7.5 ± 6.3, P < 0.01). In the 16 malignant cases, expression of MUC5AC showed borderline significant association with high Ki-67 LI (P = 0.0622). Nuclear expression of β-catenin was observed in two (8%) of the 24 tumors, and these two tumors also showed MUC1 expression. P53 was negative in all tumors. CONCLUSION: Some cases of INihB have a tubular structure, and are subcategorized as IPNB with tubular structure. MUC1 expression in INihB correlates positively with degree of malignancy. | Yoshiki Naito Hironori Kusano Osamu Nakashima Eiji Sadashima Satoshi Hattori Tomoki Taira Akihiko Kawahara Yoshinobu Okabe Kazuhide Shimamatsu Jun Taguchi Seiya Momosaki Koji Irie Rin Yamaguchi Hiroshi Yokomizo Michiko Nagamine Seiji Fukuda Shinichi Sugiyama Naoyo Nishida Koichi Higaki Munehiro Yoshitomi Masafumi Yasunaga Koji Okuda Hisafumi Kinoshita Masayoshi Kage Masamichi Nakayama Makiko Yasumoto Jun Akiba Hirohisa Yano | 2012 | World Journal of Gastroenterology2012，18，28： | 16 |
| 8 | 肝素酶和碱性成纤维细胞生长因子与非小细胞肺癌转移和预后的关系显示文摘 目的 探讨肝素酶 (heparanase)和碱性成纤维细胞生长因子 (bFGF)在人非小细胞肺癌(NSCLC)组织中表达的临床意义及其与肺癌转移和预后的关系。方法 采用免疫组织化学、原位杂交和Westernblot方法,检测 115例人NSCLC石蜡切片和 45例新鲜肺癌及对应癌旁正常组织中肝素酶和bFGF的表达情况。采用χ2 检验、t检验、生存曲线和Cox比例风险回归等方法分析肝素酶和bFGF分别表达及共表达的意义。结果 免疫组织化学染色证实肝素酶 ( 91 /115 )和bFGF( 89 /115 )主要表达在癌细胞质和(或)细胞膜中,在正常肺泡上皮和支气管上皮中则呈阴性表达。Westernblot也证实肝素酶在肺癌中的表达明显增高(P=0 .041)。统计分析结果显示:肝素酶和bFGF的表达具有明显的一致性(P=0 .000 1),二者单独表达和共表达均与肺癌的分期、血管侵袭、淋巴结转移、微血管密度和预后有关,其中,二者共表达时与分期和微血管密度的相关性更显著;另外,bFGF还与肺癌的分化程度有关。多因素分析结果显示,肺癌的分化程度、血管浸润、淋巴结转移和bFGF的表达可以作为判断肺癌预后的危险因素,但肝素酶不是影响预后的独立因素。结论 肝素酶和bFGF均与肺癌的转移、血管生成和预后密切相关。 | 于敏 李姝玉 于湛 邱雪杉 侯萍 王恩华 PECKER Iris | 2005 | 中华病理学杂志2005，34，1： | 15 |
| 9 | Pancreatic stents for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis should be inserted up to the pancreatic body or tail显示文摘AIM To investigate the location to which a pancreatic stent should be inserted to prevent post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis(PEP).METHODS Over a ten-year period at our hospital, 296 patients underwent their first ERCP procedure and had a pancreatic stent inserted; this study included 147 patients who had ERCP performed primarily for biliary investigation and had a pancreatic stent inserted to prevent PEP. We dividedthese patients into two groups: 131 patients with a stent inserted into the pancreatic head(head group) and 16 patients with a stent inserted up to the pancreatic body or tail(body/tail group). Patient characteristics and ERCP factors were compared between the groups.RESULTS Pancreatic amylase isoenzyme(p-AMY) levels in the head group were significantly higher than those in the body/tail group [138.5(7.0-2086) vs 78.5(5.0-1266.5), P = 0.03] [median(range)]. No cases of PEP were detected in the body/tail group [head group, 12(9.2%)]. Of the risk factors for post-ERCP hyperamylasemia(≥ p-AMY median, 131 IU/L), procedure time ≥ 60 min [odds ratio(OR) 2.65, 95%CI: 1.17-6.02, P = 0.02) and stent insertion into the pancreatic head(OR 3.80, 95%CI: 1.12-12.9, P = 0.03) were identified as independent risk factors by multivariate analysis.CONCLUSION Stent insertion up to the pancreatic body or tail reduces the risk of post-ERCP hyperamylasemia and may reduce the risk of PEP. | Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi Yuichi Waragai Mika Takasumi Takuto Hikichi Hiromasa Ohira | 2018 | World Journal of Gastroenterology2018，24，22： | 13 |
| 10 | Stem cell mechanisms during left ventricular remodeling post-myocardial infarction:Repair and regeneration显示文摘Post-myocardial infarction(MI),the left ventricle(LV)undergoes a series of events collectively referred to as remodeling.As a result,damaged myocardium is replaced with fibrotic tissue consequently leading to contractile dysfunction and ultimately heart failure.LV remodeling post-MI includes inflammatory,fibrotic,and neovascularization responses that involve regulated cell recruitment and function.Stem cells(SCs)have been transplanted post-MI for treatment of LV remodeling and shown to improve LV function by reduction in scar tissue formation in humans and animal models of MI.The promising results obtained from the application of SCs post-MI have sparked a massive effort to identify the optimal SC for regeneration of cardiomyocytes and the paradigm for clinical applications.Although SC transplantations are generally associated with new tissue formation,SCs also secrete cytokines,chemokines and growth factors that robustly regulate cell behavior in a paracrine fashion during the remodeling process.In this review,the different types of SCs used for cardiomyogenesis,markers of differentiation,paracrine factor secretion,and strategies for cell recruitment and delivery are addressed. | Rogelio Zamilpa Mary M Navarro Iris Flores Sy Griffey | 2014 | World Journal of Cardiology2014，6，7： | 11 |
| 11 | Association of autoimmune type atrophic corpus gastritis with Helicobacter pylori infection显示文摘AIM:To study the association between Helicobacter pylori(H.pylori)infection and autoimmune type atrophic gastritis. METHODS:Twenty-three patients with different grades of atrophic gastritis were analysed using enzyme immunoassay-based serology,immunoblot-based serology,and histology to reveal a past or a present H.pylori infection.In addition,serum markers for gastric atrophy(pepsinogenⅠ,pepsinogenⅠ/Ⅱand gastrin)and autoimmunity[parietal cell antibodies(PCA), and intrinsic factor(IF),antibodies]were determined. RESULTS:Of the 14 patients with severe gastricatrophy,as demonstrated by histology and serum markers,and no evidence for an ongoing H.pylori infection,eight showed H.pylori antibodies by immunoblotting.All eight had elevated PCA and 4/8 also had IF antibodies.Of the six immunoblot-negative patients with severe corpus atrophy,PCA and IF antibodies were detected in four.Among the patients with low to moderate grade atrophic gastritis(all except one with an ongoing H.pylori infection),serum markers for gastric atrophy and autoimmunity were seldom detected.However,one H.pylori negative patient with mild atrophic gastritis had PCA and IF antibodies suggestive of a pre-atrophic autoimmune gastritis. CONCLUSION:Signs of H.pylori infection in autoimmune gastritis,and positive autoimmune serum markers in H.pylori gastritis suggest an etiological role for H.pylori in autoimmune gastritis. | Lea Irene Veijola Aino Mirjam Oksanen Pentti Ilmari Sipponen Hilpi Iris Kaarina Rautelin | 2010 | World Journal of Gastroenterology2010，16，1： | 10 |
| 12 | Inflammatory bowel disease serology in Asia and the West显示文摘AIM:To study serological antibodies in Caucasians and Asians,in health and inflammatory bowel disease(IBD),in Australia and Hong Kong(HK).METHODS:Anti-glycan antibodies[anti-chitobioside(ACCA),anti-laminaribioside(ALCA)],and anti-mannobioside(AMCA),anti-Saccharomyces cervisiae(gASCA);and atypical perinuclear anti-neutrophil cytoplasmic antibody(pANCA)were tested in IBD patients,their unaffected relatives,and healthy controls in Australia and HK(China).Antibody status(positive or negative)and titre was compared between subjects of different geography,ethnicity and disease state.RESULTS:Ninety subjects were evaluated:21 Crohn’s disease(CD),32 ulcerative colitis(UC),29 healthy controls,and 8 IBD patient relatives.Forty eight subjects were Australian(29 Caucasian and 19 ethnic Han Chinese)and 42 were from HK(all Han Chinese).Caucasian CD patients had a significantly higher antibody prevalence of gASCA(67%vs 3%,P<0.001),ALCA(44%vs 6%,P=0.005),and AMCA(67%vs 15%,P=0.002),whereas HK CD patients had a higher prevalence of only AMCA(58%vs 25%,P=0.035),when compared with UC and healthy subjects in both countries.Caucasian CD had significantly higher gASCA prevalence(67%vs 0%,P<0.001)and titre(median59 vs 9,P=0.002)than HK CD patients.Prevalence and titres of ALCA,ACCA and AMCA did not differ between CD in the two countries.Presence of at least one antibody was higher in Caucasian than HK CD patients(100%vs 58%,P=0.045).pANCA did not differ between countries or ethnicity.CONCLUSION:Serologic CD responses differ between HK Asian and Australian Caucasian patients.Different genetic,environmental or disease pathogenic factors may account for these differences. | Lani Prideaux Michael A Kamm Peter De Cruz Daniel R van Langenberg Siew C Ng Iris Dotan | 2013 | World Journal of Gastroenterology2013，19，37： | 10 |
| 13 | Relaxin prevents the development of severe acute pancreatitis显示文摘瞄准:为了调查尖锐胰腺炎(AP ) 的严厉,被联系到白血球激活,煽动性的起来规定和联系到 ischemia-reperfusion 损害的微循环混乱的紧张。支持 inflammatory 调停人的 Microvascular 完整和抑制在 AP 的进化是关键因素的。松弛激素是被归因的像胰岛素的荷尔蒙经由氮的氧化物小径的 vasorelaxant 性质当作为糖皮质激素受体收缩筋表现时。方法:AP 被 bilio 胰腺的 duct-outlet-exclusion closed-duodenal-loops 模型导致。有松弛激素的处理在不同时间点被做。由由 mifepristone 的阻塞被考虑的 L 名字和糖皮质激素受体(GR ) 的氮的氧化物 synthase 抑制。AP 严厉被生物化学、组织病理学说的分析估计。结果:有松弛激素的处理减少了浆液淀粉酶,脂肪分解酵素, C 反应的蛋白质, IL-6, IL-10, hsp72, LDH 和 8-isoprostane 象一样胰腺并且肺 myeloperoxidase。腺泡和脂肪坏死,出血和 neutrophil 渗透也被减少。当 caspases 2-3-8 和 9 项活动被增加时, ATP 弄空和 ADP/ATP 比率被减少。L 名字和 mifepristone 减少了松弛激素的效率。结论:松弛激素结果在当保存微发行量并且在坏死上赞成 apoptosis 时,联合 GR 收缩筋的性质的 AP 的处理有益。 | Laura Iris Cosen-Binker Marcelo Gustavo Binker Rodica Cosen Gustavo Negri Osvaldo Tiscornia | 2006 | World Journal of Gastroenterology2006，12，10： | 10 |
| 14 | Cytomegalovirus positive ulcerative colitis:A single center experience and literature review显示文摘AIM:To compare the clinical outcome of cytomegalovirus(CMV)-positive ulcerative colitis(UC) patients with and without antiviral therapy.METHODS:This was a retrospective case-controlled study.The database of UC patients in our institution was scanned for documented presence of CMV on colonic biopsies.Demographics,clinical data,endoscopy findings and pathology reports were extracted from the patients' charts and electronic records.When available,the data from colonoscopies preceding and following the diagnosis of colonic CMV infection were also ex-tracted.The primary outcomes of the study were colectomy/death during hospitalization and the secondary outcomes were colectomy/death through the course of the follow-up.RESULTS:Thirteen patients were included in the study,7(53.5%) of them were treated with gancyclovir and 6(46.5%) were not.Patients treated with antivirals presented with a more severe disease and 57% of them were treated with cyclosporine or infliximab before initiation of gancyclovir,while none of the patients without antivirals required rescue therapy.One patient died and another patient underwent urgent colectomy during hospitalization,both of them from the gancyclovir-treatment group.For the entire follow-up time(13 ± 13 mo),a total of 3 colectomies and one death occurred,all among the antiviral-treated patients(for colectomy:3/7 vs 0/6 patients,P = 0.19;for combined adverse outcome:4/7 vs 0/6 patients,P = 0.07).In 9/13 patients,immunohistochemistry for CMV was performed on biopsies obtained during a subsequent colonoscopy and was positive in one patient only.CONCLUSION:Gancyclovir-treated patients had a more severe disease and outcome,probably unrelated to antiviral therapy.Immunohistochemistry-CMV-positive patients with mild disease may recover without antiviral therapy. | Uri Kopylov Gila Sasson Bella Geyshis Michal Tepperberg Oikawa Iris Barshack Rami Eliakim Shomron Ben-Horin | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，1： | 10 |
| 15 | 皇家墨尔本理工大学中医孔子学院传播中医文化的探索与实践显示文摘皇家墨尔本理工大学中医孔子学院是全球第二所中医孔子学院,由澳大利亚皇家墨尔本理工大学和中国南京中医药大学合作建立。2008年10月签署协议。2010年6月20日,时任中华人民共和国国家副主席习近平亲自揭牌。正式运营以来,在中国语言文化国际传播的总体背景与框架下,皇家墨尔本理工大学中医孔子学院就中医文化的海外传播进行了多方面的探索与实践。 | 周延松 赵亭 Tony Zhang Iris Zhou 刘嵚 Charlie Xue | 2014 | 世界中西医结合杂志2014，9，8： | 10 |
| 16 | Metastatic pattern in esophageal and gastric cancer:Influenced by site and histology显示文摘BACKGROUND Detailed information on metastatic patterns in of patients with esophageal and gastric cancer is limited.Early recognition of metastases is important to avoid futile locoregional treatments.Furthermore,knowledge on metastatic patterns is necessary for further development of personalized treatment modalities.AIM To gain insight into the metastatic pattern of gastroesophageal cancer.METHODS A nationwide retrospective autopsy study of 3876 patients with adenocarcinoma(AC)or squamous cell carcinoma(SCC)of the esophagus or stomach between 1990 and 2017 was performed.Only patient with metastases were included for analysis.The metastatic pattern was analyzed according to the primary tumor location and histological subtype.RESULTS Metastatic disease was found in 268 esophageal and 331 gastric cancer patients.In esophageal cancer,the most common metastatic locations were liver(56%),distant lymph nodes(53%)and lung(50%).Esophageal AC showed more frequently metastases to the peritoneum and bone compared with esophageal SCC.In gastric cancer,the most common metastatic locations were distant lymph nodes(56%),liver(53%)and peritoneum(51%).Intestinal-type AC of the stomach showed metastases to the liver more frequently,whereas metastases to the bone,female reproductive organs and colorectum were observed more frequently in diffuse-type gastric AC.CONCLUSION This study showed differences in metastatic patterns of patients with esophageal and gastric cancer according to the primary tumor location and histological subtype. | Moniek HP Verstegen Mitchell Harker Carlijn van de Water Jolanda van Dieren Niek Hugen Iris D Nagtegaal Camiel Rosman Rachel S van der Post | 2020 | World Journal of Gastroenterology2020，26，39： | 9 |
| 17 | 根据血压等级确定脑卒中和冠状动脉粥样硬化性心脏病死亡的终生风险:日本EPOCH(观察队列的心血管预防证据)研究显示文摘在亚洲人群中.很少研究关注根据血压分类确定脑卒中和冠状动脉粥样硬化性心脏病(coronary heartdisease,CHD)的终生风险。该研究旨在用一个包含个体参与者数据的荟萃分析大数据库来评估它。该荟萃分析纳入来源于13个队列的107 737名日本人(男性占42.4%,平均年龄55.1岁)。在平均(15.2±5.3)年(1 559 136人年)的随访期.1922人死于脑卒中,913人死于CHDO研究者在调整其他死亡危险因素后估计风险。 | 陈嘉睿(译) 练桂丽(审校) Satoh M Ohkubo T Asayama K Murakami Y Sugiyama D Yamada M Saitoh S Sakata K Irie F Sairenchi T Ishikawa S Kiyama M Ohnishi H Miura K Imai Y Ueshima H Okamura T EPOCH-JAPAN research group | 2019 | 中华高血压杂志2019，27，4： | 9 |
| 18 | Functional findings in irritable bowel syndrome显示文摘IBS 的病理生理学复杂、仍然不完全地知道。中央、外部的因素,包括的精神分析聚会因素,反常官方补给的活动性和分泌物,和内脏的超敏性,被认为贡献 IBS 的症状。几研究在 IBS 病人表明了改变的官方补给的运动机能,模式基于占优势的肠模式在 IBS 亚群之间不同。很少研究到目前为止在 IBS 探讨了官方补给的分泌物,但是有一些证据,在 IBS 病人的小肠支持改变的分泌物。内脏的超敏性当前被认为也许是在 IBS 的最重要的 pathophysiological 因素。重要地,几个外部、内部的因素能调制内脏的敏感,以及官方补给的活动性,并且在官方补给的道以内提高应答的海角到例如,应力和营养素在 IBS 病人被表明了。今天 IBS 被看在之上,包含在伤寒的反常功能是所谓的大脑勇气轴的 dysregulation 的混乱,自治或中枢神经系统,与可能在一些病人并且在其它的从圆周的信号的扰乱的中央处理统治的外部改变。 | Iris Posserud Amanda Ersryd Magnus Simrén | 2006 | World Journal of Gastroenterology2006，12，18： | 9 |
| 19 | Immunogenetic characteristics of patients with autoimmune gastritis显示文摘AIM:To explore whether predisposition to autoimmune gastritis (AIG) is found in human leukocyte antigen (HLA), cytokine or killer cell immunoglobulin-like receptor (KIR) gene variations.METHODS: Twelve Finnish patients with autoimmunetype severe atrophy of the gastric corpus were included. The patients' serum was analyzed for pepsinogen-interleukin (IL)-1 gene cluster, IL-2, IL-4, IL-6, IL-10, IL-12, interferon γ, transforming growth factor β, and tumor necrosis factor α. Variation in KIR genes was also explored. The results were compared with prevalence of the polymorphisms in Finnish or European populations.RESULTS: All patients had pepsinogen-CONCLUSION: As explored with modern DNA-based methods, HLA-DRB1*04 and DQB1*03 alleles, but not HLA-B8-DRB1*03, may predispose to AIG. | Aino Mirjam Oksanen Katri Eerika Haimila Hilpi Iris Kaarina Rautelin Jukka Antero Partanen | 2010 | World Journal of Gastroenterology2010，16，3： | 8 |
| 20 | Management and therapy of vasovagal syncope: A review显示文摘Vasovagal syncope is a common cause of recurrent syncope. Clinically, these episodes may present as an isolated event with an identifiable trigger, or manifest as a cluster of recurrent episodes warranting intensive evaluation. The mechanism of vasovagal syncope is incompletely understood. Diagnostic tools such as implantable loop recorders may facilitate the identification of patients with arrhythmia mimicking benign vasovagal syncope. This review focuses on the management of vasovagal syncope and discusses the non-pharmacological and pharmacological treatment options, especially the use of midodrine and selective serotonin reuptake inhibitors. The role of cardiac pacing may be meaningful for a subgroup of patients who manifest severe bradycardia or asystole but this still remains controversial. | Muhammet Ali Aydin Tushar V Salukhe Iris Wilke Stephan Willems | 2010 | World Journal of Cardiology2010，2，10： | 8 |
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