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| 1 | Prokineticin 2/Bv8 is expressed in Kupffer cells in liver and is down regulated in human hepatocellular carcinoma显示文摘AIM: To study the implication of prokineticin 1 (PK1/EG- VEGF) and prokineticin 2 (PK2/Bv8) in hepatocellular carcinoma angiogenesis. METHODS: The gene induction of PK1/EG-VEGF and PK2/Bv8 was investigated in 10 normal, 28 fibrotic and 28 tumoral livers by using real time PCR. Their expression was compared to the expression of VEGF (an angiogenesis marker), vWF (an endothelial cell marker) and to CD68 (a monocyte/macrophage marker). Furthermore, the mRNA levels of PK1/EG-VEGF, PK2/Bv8, prokineticin receptor 1 and 2 were evaluated by real time PCR in isolated liver cell populations. Finally, PK2/Bv8 protein was detected in normal liver paraffin sections and in isolated liver cells by immunohistochemistry and immunocytochemistry. RESULTS: PK2/Bv8 mRNA but not PK1/EG-VEGF was expressed in all types of normal liver samples examined. In the context of liver tumor development, we reported that PK2/Bv8 correlates only with CD68 and showed a significant decrease in expression as the pathology evolves towards cancer. Whereas, VEGF and vWF mRNA were significantly upregulated in both fibrosis and HCC,as expected. In addition, out of all isolated liver cells examined, only Kupffer cells (liver resident macrophages) express significant levels of PK2/Bv8 and its receptors, prokineticin receptor 1 and 2. CONCLUSION: In normal liver PK2/Bv8 and its receptors were specifically expressed by Kupffer cells. PK2/Bv8 expression decreased as the liver evolves towards cancer and did not correlate with HCC angiogenesis. | Justin Monnier Claire Piquet-Pellorce Jean-Jacques Feige Orlando Musso Bruno Clément Bruno Turlin Nathalie Théret Michel Samson | 2008 | World Journal of Gastroenterology2008，14，8： | 4 |
| 2 | Enhanced indoleamine 2,3-dioxy- genase activity in patients with severe sepsis and septic shock 显示文摘 | Tattevin P Monnier D Tribut 0 | 2010 | J In- fect Dis2010，201，6： | 1 |
| 3 | Continuous glucose monitoring in patients with type 2 diabetes:Why? When? Whom?显示文摘 | MONNIER L COLETTE C BOEGNER C | 2007 | Diabetes Metab2007，33，4： | 1 |
| 4 | Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes显示文摘 | Monnier L Mas E Ginet C | 2006 | JAMA2006，295，14： | 1 |
| 5 | Point Defect,Ferromagnetism and Transport in Calcium Hexaboride显示文摘 | Monnier R Delley B | 2001 | Physical Review Letters2001，87，15： | 1 |
| 6 | Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes显示文摘 | MONNIER L MAS E GINET C | 2006 | JAMA2006，295，14： | 1 |
| 7 | Glycemic variability: should we and can we prevent it 显示文摘 | Monnier L Colette C | 2008 | Diabetes Care2008，312，： | 1 |
| 8 | Early onset of hypokalaemic pe-riodic paralysis caused by a novel mutation of the CACNA1S gene显示文摘 | Chabrier S Monnier N Lunardi J | 2008 | J Med Genet2008，45，10： | 1 |
| 9 | Mandibular osteoradione- crosis in squamous cell carcinoma of the oral cavity and orophar- ynx: incidence and risk factors 显示文摘 | Monnier Y Broome M Betz M | 2011 | Otolaryngol Head Neck Surg2011，144，5： | 1 |
| 10 | PROKR2 missense muta- tions associated with Kallmann syndrome impair receptor sig- nalling activity显示文摘 | Monnier C Dode C Fabre L | 2009 | Hum Mol Genet2009，18，1： | 1 |
| 11 | Characterizing nanoparticles in complex biological media and physiological fluids with depolarized dynamic light scattering显示文摘 | BALOG S RODRIGUEZ-LORENZO L MONNIER C A | 2015 | Nanoscale2015，7，14： | 1 |
| 12 | Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c)显示文摘 | Monnier L Lapinski H Colette C | 2003 | Diabetes Care2003，26，3： | 1 |
| 13 | Clinical management of adverse events in adjuvant therapy for hormone-responsive early breast cancer显示文摘 | MONNIER A | 2007 | Ann Oncol2007，18，8： | 1 |
| 14 | Graphites for lithium-ion cells:the correlation of the first-cycle charge loss with the brunauer-emmett-teller surface area显示文摘 | Winter M Novak P Monnier A | 1998 | J Electrochemical Society1998，145，2： | 1 |
| 15 | Immunohistochemical analysis of CD4^+ and CD8^+T-cell subsets in high-risk human papillomavirus-associated pre-maligant and maligant leisions of the uterine cervix 显示文摘 | Monnier Benoit S Mannvf F | 2006 | Gynecol Onco12006，102，1： | 1 |
| 16 | Graphites for lithium-ion cells:the Correlation of the first-cycle charge loss with the Brunauer-Emmett-Teller surface area显示文摘 | WINTER M NAVAK P MONNIER A | 1998 | J Electrochem Soc1998，145，： | 1 |
| 17 | Insulin sensitivity and stress显示文摘 | Avignon A Monnier L | 2001 | Diabetes Metab2001，27，22： | 1 |
| 18 | Production of high quality cetane enhancer from depitched tall oil显示文摘 | Liu D D Monnier J Torigny G | 1998 | Petroleum Science and Technology1998，16，56： | 1 |
| 19 | Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes显示文摘 | Monnier L Mas E | 2006 | JAMA2006，295，： | 1 |
| 20 | Integrating glycaemic vari- ability in the glycaemic disorders of type 2 diabetes: a move to- wards a unified glucose tetrad concept 显示文摘 | Monnier L Colette C Owens DR | 2009 | Diabetes Metab Res Rev2009，25，5： | 1 |
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