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| 1 | Transient elastography improves detection of liver cirrhosis compared to routine screening tests显示文摘AIM:To investigate the diagnostic significance oftransient elastography(TE) in a daily routine clinical setting in comparison to clinical signs,laboratory parameters and ultrasound.METHODS:TE,ultrasound,laboratory parameters and cutaneous liver signs were assessed in 291 consecutive patients with chronic liver disease of various aetiologies who underwent liver biopsy in daily routine.RESULTS:Sensitivity of TE for the detection of liver cirrhosis was 90.4%,compared to 80.1% for ultrasound,58.0% for platelet count and 45.1% for cutaneous liver signs(P < 0.0001 for comparisons with histology).AUROC for TE was 0.760(95%CI:0.694-0.825).Combination of TE with ultrasound increased sensitivity to 96.1% and AUROC to 0.825(95%CI:0.768-0.882).TE correlated with laboratory parameters of cirrhosis progression like albumin(r =-0.43),prothrombin time(r =-0.44),and bilirubin(r = 0.34; P < 0.001 for each).Particularly,in patients with Child Pugh score A or normal platelet count TE improved sensitivity for the detection of liver cirrhosis compared to ultrasound by 14.1%(P < 0.04) and 16.3%(P < 0.02),respectively.CONCLUSION:Transient elastography is superior to routine diagnostic tests allowing detection of liver cirrhosis in additional 10%-16% of patients with chronic liver disease that would have been missed by clinical examinations. | Thomas Gobel Janine Schadewaldt-Tümmers Lucas Greiner Christopher Poremba Dieter Haussinger Andreas Erhardt | 2015 | World Journal of Gastroenterology2015，21，3： | 8 |
| 2 | 面粉灰分含量对其蒸煮品质影响的研究显示文摘给出面粉蒸煮品质的试验和评价方法,并选取不同灰分含量的面粉做蒸煮试验.结果表明:灰分含量在0.65%~0.75%的面粉具有好的蒸煮品质,而在1.21%时具有较差的蒸煮品质。 | 石满昌 J.M.Brmmer W.seibel | 1991 | 中国粮油学报1991，6，4： | 3 |
| 3 | Golimumab in real-world practice in patients with ulcerative colitis:Twelve-month results显示文摘BACKGROUND The introduction of biologics has revolutionized the management of the chronic inflammatory bowel disease,ulcerative colitis(UC),with many patients experiencing significant improvements not only in their symptoms but in other outcomes relevant to individuals and society as a whole.In Germany,there are no prospective data>3 mo that assess the work productivity,daily activities and quality of life(QoL)of patients with moderate-to-severe UC treated with golimumab.AIM To assess change in work productivity,capacity for daily activities and QoL in UC patients treated with golimumab in Germany.METHODS The validated Work Productivity Activity Impairment(WPAI)Questionnaire was used to analyze the change in work productivity,the capacity for daily activities after three months(primary endpoint)and disease specific and health related QoL(HRQoL)up to 1 year(secondary endpoints).The changes in work productivity and activity impairment were evaluated every three months until month twelve compared to baseline.Disease-specific and health-related QoL were assessed with the inflammatory bowel disease questionnaire and with the short-form 12 health survey questionnaire(SF-12).RESULTS This prospective non-interventional study included 287 patients.The analysis population was comprised of 282 patients who had completed at least two visits.At baseline,61%of patients had moderate UC and 18%had severe UC.Furthermore,75%of patients worked full-time or part-time at baseline.A total of 212 patients who were employed at the start of the study(employed population)were evaluated for the primary endpoint.Golimumab significantly reduced all WPAI sub-scores compared to baseline after three,six,nine and twelve months after the start of treatment(P<0.0001).In addition,disease-specific QoL and HRQoL,as measured by the SF-12 questionnaire,improved significantly with golimumab at all evaluation times(P<0.0001 in each case vs baseline).CONCLUSION Treatment of moderate-to-severe UC with golimumab leads to significant improvements in patient´s work productivity,daily activity and QoL over twelve months. | Niels Teich Harald Grümmer Eric Jorgensen Thomas Liceni Frank Holtkamp-Endemann Tim Fischer Susanne Hohenberger | 2020 | World Journal of Gastroenterology2020，26，21： | 3 |
| 4 | PCDDs/PCDFs, PCBs, and Organochlorine Pesticides in Eggs of Eurasian Sparrowhawks (Accipiter nisus), Hobbies (Falco subbuteo), and Northern Goshawks (Accipiter gentilis) Collected in the Area of Berlin-Brandenburg, Germany显示文摘 | T. Wiesmüller P. S?mmer M. Volland B. Schlatterer | 2002 | Archives of Environmental Contamination and Toxicology2002，，4： | 1 |
| 5 | The impact of market and policy instability on price transmission between wheat and flour in Ukraine显示文摘 | Bernhard Brü mmer Stephan von Cramon-Taubadel Sergiy Zorya | 2009 | European Review of Agricultural Economics2009，，2： | 1 |
| 6 | Heavy metal species,mobility and availability in soils显示文摘 | Brümmer G W Gerth J Herms U | 2007 | Zeitschrift für Pflanzenern hrung und Bodenkunde2007，149，4： | 1 |
| 7 | Animal models in endometriosis research显示文摘 | Grümmer R | 2006 | Hum Reprod Update2006，12，5： | 1 |
| 8 | A study of recovery and recrystallization of plastically deformed ct + 13 brass by positron annihilation显示文摘 | Dlubek G Br u mmer O Alam A | 1979 | Phys Status Solid A1979，52，1： | 1 |
| 9 | The role of arthroscopy in the assessment and treatment of tibial plateau fractures显示文摘 | FOWBLE CD ZI MMER JW SCHEPSIS AA | 1993 | Arthroscopy1993，9，5： | 1 |
| 10 | Heat transfer in opacified aerogel powders显示文摘 | H MMER E LU X RETTELBACH T | 1992 | J Non-Cryst Solids1992，145，13： | 1 |
| 11 | Targeting of pancreatic and prostate cancer stem cell characteristics by Crambe crambe marine sponge extract显示文摘 | SabineOttinger AnneKl?ppel VanessaRausch LiLiu GeorgiosKallifatidis WolfgangGross Martha‐MariaGebhard FranzBrümmer IngridHerr | 2012 | Int J Cancer2012，，7： | 1 |
| 12 | Isoform-specific alanine aminotransferase measurement can distinguishhepatic from extrahepatic injury in humans显示文摘 | Ingalill Rafter Truls Gr?berg Anna Kotronen Lovisa Str?mmer C. Mattson Ray Kim Ewa Ehrenborg H?kan Andersson Hannele Yki-J?rvinen Ina Schuppe-Koistinen Bj?rn Ekblom Ian Cotgreave Bj?rn Glinghammar | 2012 | International Journal of Molecular Medicine2012，，5： | 1 |
| 13 | Working Memory and Response Inhibition as One Integral Phenotype of Adult ADHD? A Behavioral and Imaging Correlational Investigation显示文摘 | Martin Schecklmann Ann-Christine Ehlis Michael M. Plichta Thomas Dresler Monika Heine Andrea Boreatti-Hümmer Marcel Romanos Christian Jacob Paul Pauli Andreas J. Fallgatter | 2013 | Journal of Attention Disorders2013，，6： | 1 |
| 14 | Einfluβ organischer Substanzen auf Lsslichkeit, Bindung und Umwandlung mineralischer Bodenkomponenten显示文摘 | | 1978 | Mitteilung der Deutschen Bodenkundichen Gesellschaft1978，27，17： | 1 |
| 15 | Scaling laws in the spatial structure of urban road networks显示文摘 | Stefan L?mmer Bj?rn Gehlsen Dirk Helbing | 2006 | Physica A: Statistical Mechanics and its Applications2006，，1： | 1 |
| 16 | An orthogonal proteomicgenomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome显示文摘 | Bürckstümmer T Baumann C Blüml S | 2009 | Nat Immunol2009，10，3： | 1 |
| 17 | Parallel generation of triangular and quadrileteral meshes显示文摘 | Lmmer L Burghardt M | 2000 | Advances in Engineering Software2000，31，： | 1 |
| 18 | Eliolqgy Of small bowel obstruction 显示文摘 | Mmer G Bomafl J shrier I | 2000 | Am J Surg2000，180，1： | 1 |
| 19 | Increased MMP-2 activity during intervertebral disc degeneration is correlate d to MMP-14 levels显示文摘 | Rutges J Ku mmer J Verbout A | | 0，，： | 1 |
| 20 | Advances in the management of major airway collapse显示文摘 | Mmer D Forte V | 2000 | Otolaryngol Clin North Am2000，33，： | 1 |
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