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| 1 | Role of microparticles in endothelial dysfunction and arterial hypertension显示文摘Microparticles are small cell vesicles that can be released by almost all eukaryotic cells during cellular stress and cell activation. Within the last 1-2 decades it has been shown that microparticles are useful blood surrogate markers for different pathological conditions, such as vascular inflammation, coagulation and tumour diseases. Several studies have investigated the abundance of microparticles of different cellular origins in multiple cardiovascular diseases. It thereby has been shown that microparticles released by platelets, leukocytes and endothelial cells can be found in conditions of endothelial dysfunction, acute and chronic vascular inflammation and hypercoagulation. In addition to their function as surrogate markers, several studies indicate that circulating microparticles can fuse with distinct target cells, such as endothelial cells or leukocyte, and thereby deliver cellular components of their parental cells to the target cells. Hence, microparticles are a novel entity of circulating, paracrine, biological vectors which can influence the phenotype, the function and presumably even the transcriptome of their target cells.This review article aims to give a brief overview about the microparticle biology with a focus on endothelial activation and arterial hypertension. More detailed information about the role of microparticles in pathophysiology and disease can be found in already published work. | Thomas Helbing Christoph Olivier Christoph Bode Martin Moser Philipp Diehl | 2014 | World Journal of Cardiology2014，6，11： | 14 |
| 2 | Chip-based digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction patients显示文摘miRNAs 为尖锐心肌的梗塞(AMI ) 作为潜在的 biomarkers 显示出诺言。然而,当前的使用的量的即时 PCR (qRT-PCR ) 完全为 nucleic 酸的相对表示允许,它产生日常可变性,它限制了把 miRNAs 用作 biomarkers 的有效性。在这研究,我们探索了技术质量和一种新技术的诊断潜力,基于薄片的数字 PCR,在确定在有 AMI 和 ischaemia-reperfusion 损害(I/R ) 的病人的 miRNAs。在合成 C.elegans-miR-39 的一个冲淡系列,基于薄片的数字 PCR 与 qRT-PCR 相比显示了变化(8.9% 对 46.3%) 和察觉(0.2 copies/L 对 1.1 copies/L ) 的更低的限制的一个更低的系数。在从有圣举起心肌的梗塞( STEMI )的 24 个病人和有稳定的冠的动脉疾病( CAD )的 20 个病人镇定的浆液在经皮的冠的干预(一种总线标准)以后的病人,我们使用了 qRT-PCR 和多路的基于薄片的数字 PCR 确定他们在优先的研究在 AMI 被验证了的 miRNA-21 和 miRNA-499 的浆液层次。在 STEMI, I/R 损害经由圣片断分辨率(ST-R ) 的测量被估计。基于薄片的数字 PCR 处于在稳定的 CAD 和 STEMI 组之间的 miR-21 层次的差别揭示了统计意义(118.8 copies/L 对 59 copies/L;P=0.0300 ) ,而 qRT-PCR 是不能的到达意义(136.4 copies/L 对 122.8 copies/L;P=0.2273 ) 。为 miR-499 层次,基于薄片的数字 PCR 和 qRT-PCR 揭示了稳定的 CAD 和 STEMI 组之间的统计上重要的差别(2 copies/L 对 8.5 copies/L, P=0.0011;0 copies/L 对 19.4 copies/L;P < 0.0001 ) 。在 miR-21/499 层次和 ST-R 之间没有协会一种总线标准以后。我们的结果证明基于薄片的数字 PCR 展出优异技术质量和诺言是一个优异方法因为确定的 miRNA 在发行量铺平,它可以为直接确定成为一个更精确、可再现的方法 miRNAs,特别地为在大多中心的使用临床的试用。 | Samuel ROBINSON Marie FOLLO David HAENE Maximilian MAULER Daniela STALLMANN Lukas Andreas HEGER Thomas HELBING Daniel DUERSCHMIED Karlheinz PETER Christoph BODE Ingo AHRENS Marcus HORTMANN | 2018 | Acta Pharmacologica Sinica2018，39，7： | 5 |
| 3 | Generation of intense, carrier-envelope phase-locked few-cycle laser pulses through filamentation显示文摘 | C.P. Hauri W. Kornelis F.W. Helbing A. Heinrich A. Couairon A. Mysyrowicz J. Biegert U. Keller | 2004 | Applied Physics B2004，，6： | 2 |
| 4 | Simulating Dynamical Features of Escape Panic显示文摘 | Helbing D Farkas I Vicsek T | 2000 | Nature2000，407，6803： | 1 |
| 5 | Simulating dyna-mical features of escape panic显示文摘 | D Helbing I Farkas T Vicsek | 2000 | Nature2000，407，28： | 1 |
| 6 | Experiment, theory, and simulation of the evacuation of a room without visibility 显示文摘 | Isobe M Helbing D Nagatani T | 2004 | Physical Review E2004，69，06： | 1 |
| 7 | Sinmlating dynamical features of escape panic显示文摘 | Helbing D Farkas I Vicsek T | 2000 | Nature2000，407，6803： | 1 |
| 8 | Simulating dynamical features of escape panic显示文摘 | HELBING D FARKAS 1 VICSEK T | 2000 | Nature2000，407，6803： | 1 |
| 9 | MicroRNA-100 regulates neovascularization by suppres- sion of mammalian target of rapamycin in endothelial and vas- cular smooth muscle cells 显示文摘 | Grundmann S Hans FP Kirmiry S Heinke J Helbing T Blubm F et 02 | 2011 | Circulation2011，123，9： | 1 |
| 10 | The Mycobacterium tu- berculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol显示文摘 | Colangeli R Helb D Sridharan S | 2005 | Molecular Microbiology2005，，： | 1 |
| 11 | Self-organizing pedestrian movement显示文摘 | Dirk Helbing Peter Molnar Illes J Farkas | | 0，，： | 1 |
| 12 | Congested traffic states in empirical observations and microscopic simulations显示文摘 | Treiber M Hemecke A Helbing D | 2000 | Physical Review E2000，62，2： | 1 |
| 13 | Simulating dynamical features of escape panic显示文摘 | Dirk Helbing Llles Farkas Tamas Vicsek | 2000 | Nature2000，407，： | 1 |
| 14 | Information and material flows in complex networks 显示文摘 | HELBING D | 2006 | Physica A: Statistical Mechanics and its Applications2006，363，1： | 1 |
| 15 | Traffic and related self-driven many-particle system 显示文摘 | Helbing D | 2001 | Rev Mod Phy2001，2001，： | 1 |
| 16 | Self-Organized Pedestrian Crowd Dynamics:Experiments,Simulations,and Design Solutions显示文摘 | Dirk Helbing Lubos Buzna Anders Johansson T W | | 0，，01： | 1 |
| 17 | Self-organized pe- destrian crowd dynamics : Experiments, simulations, and design solutions 显示文摘 | Helbing D BuznaL Johansson A | 2005 | Transportation science2005，39，1： | 1 |
| 18 | Social force model for pedestrian dynamics显示文摘 | Helbing D MoLnr P | 1995 | Physical Review E1995，，51： | 1 |
| 19 | Scaling laws in urban supply networks 显示文摘 | KUHNERT C HELBING D | 2006 | Physica A: Statistical Mechanics and its Applications2006，363，1： | 1 |
| 20 | Phylogenetic analysis of the ING family of PHD finger proteins 显示文摘 | HE G H HELBING C C WAGNER M J | 2005 | Mol Biol Evol2005，22，： | 1 |
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