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| 1 | 离子通道、磷酸化和哺乳动物精子获能显示文摘有性生殖动物需要精子和卵子之间进行精心协调的交流才能产生新的个体。精子获能是发生在女性生殖系统中的生殖细胞成熟的一个复杂现象,让精子能够和卵子联结并融合,是哺乳动物生育的必要条件。精子获能过程包括了质膜重组、离子渗透调节、胆固醇减少和许多蛋白质磷酸化状态的变化。研究精子离子通道的新工具能用更好的时空解析度将细胞内的离子变化和蛋白图像化,这些工具正在一步步阐明离子运输和磷酸化状态中的一系列调节是如何引起获能的。最近的证据表明有两条平行的通路调节引起获能的磷酸化发生。其中一条通路要求蛋白激酶A活化,另一条通路需要丝氨酸/苏氨酸磷酸酶失活。本文综述了精子获能所要求的离子运输参与和磷酸化信号处理。理解导致生育的分子机制,对于人们应对男性不育率升高、开发安全的以雄性配子为基础的避孕药、通过辅助生殖策略保持生物多样性都至关重要。 | Pablo E Visconti Dario Krapf Jose Luis de la Vega-Beltran Juan Jose Acevedo Alberto Darszon | 2011 | Asian Journal of Andrology2011，13，3： | 19 |
| 2 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 3 | Feeder-free maintenance of hESCs in mesenchymal stem cell-conditioned media: distinct requirements for TGF-β and IGF-Ⅱ显示文摘 | Rosa Montes Gertrudis Ligero Laura Sanchez Purificacidn Catalina Teresa de la Cueva Ana Nieto Gustavo J Melen Ruth Rubio Javier Garcia-Castro Clara Bueno Pablo Menendez | 2009 | Cell Research2009，19，6： | 7 |
| 4 | Pulmonary vein stenosis:Etiology,diagnosis and management显示文摘Pulmonary vein stenosis(PVS) is rare condition characterized by a challenging diagnosis and unfavorable prognosis at advance stages. At present, injury from radiofrequency ablation for atrial fibrillation has become the main cause of the disease. PVS is characterized by a progressive lumen size reduction of one or more pulmonary veins that, when hemodynamically significant, may raise lobar capillary pressure leading to signs and symptoms such as shortness of breath, cough, and hemoptysis. Image techniques(transesophageal echocardiography, computed tomography, magnetic resonance and perfusion imaging) are essential to reach a final diagnosis and decide an appropriate therapy. In this regard, series from referral centers have shown that surgical and transcatheter interventions may improve prognosis. The purpose of this article is to review the etiology, assessment and management of PVS. | Pablo Pazos-López Cristina García-Rodríguez Alba Guitián-González Emilio Paredes-Galán María ángel De La Guarda álvarez-Moure Marta Rodríguez-álvarez José Antonio Baz-Alonso Elvis Teijeira-Fernández Francisco Eugenio Calvo-Iglesias Andrés íniguez-Romo | 2016 | World Journal of Cardiology2016，8，1： | 6 |
| 5 | A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C显示文摘 | Bruno Sangro Carlos Gomez-Martin Manuel de la Mata Mercedes I?arrairaegui Elena Garralda Pilar Barrera Jose Ignacio Riezu-Boj Esther Larrea Carlos Alfaro Pablo Sarobe Juan José Lasarte Jose L. Pérez-Gracia Ignacio Melero Jesús Prieto | 2013 | Journal of Hepatology2013，，： | 6 |
| 6 | 静脉血栓栓塞研究的既往与现今及未来显示文摘静脉血栓栓塞症(VTE)是继冠心病和中风后排名第三的最常见的心血管疾病。在过去的100年中,对于血液凝固过程及其调控机制的深入了解推进了VTE的诊断和治疗方法。1860年制定的魏尔肖三定律直今仍然是有效的,即VTE是由于血管壁受损、血液流动减慢和血液成分改变造成的。流行病学和临床科学现在也已经确定了V‘rE的多个后天获得性危险因素,如高龄、肿瘤、手术、外伤、固定、怀孕和使用口服避孕药等。随着遗传研究技术的快速发展,一些基因被确定与VTE的家族聚集性有关,与VTE相关的基因变异也逐渐被发现。遗传因素和后天获得性的危险因素在血栓的发展中相互作用。新型实验诊断项目能够帮助人们早期判断高凝状态。因此,为减少全球VTE负担,对VTE的预防,风险评估,诊断和治疗将更为重要。 | Bengt Zoller Pablo Garcia de Frutos Bjorn Dahlback 吴俊 | 2016 | 中华检验医学杂志2016，39，10： | 6 |
| 7 | ZigID:Improving visibility in industrial environments by combining WSN and RFID显示文摘The objective of this work is to provide decision-making processes with an updated/real picture of the mobile resources in industrial environments through a constant feedback of information.The combination of identification technologies and wireless sensor networks(WSN) is proposed as a key development to guarantee an accurate and timely supply of online information regarding the localization and tracking of the mobile wireless devices.This approach uses a cooperative and distributed localization system,called ZigID,which is a WSN based on a Zigbee network with radio frequency identification(RFID) active tags as end nodes.The WSN can recover not only the ID information stored at the tags attached to mobile resources,but also any other useful data captured by specific sensors for acceleration,temperature,humidity and fuel status.This paper also shows the development of ZigID,including devices and information flows,as well as its implementation in ground handling operations at the Ciudad Real Central Airport,Spain. | Pablo GARCíA ANSOLA Andrés GARCíA Javier de las MORENAS Javier GARCíA ESCRIBANO Francisco Javier OTAMENDI | 2011 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2011，12，11： | 5 |
| 8 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 9 | A Bibliometric Analysis of Digital Innovation from 1998 to 2016显示文摘Digital technologies are ubiquitous in our everyday lives.They have been widely embedded into the core processes of services and products,as well as into the operations of many organizations.These digital technologies bring many changes to our work and lifestyles,to the organization of companies,and even to the structures of whole industries.Thus,digital innovation is a research hotspot.This study investigates the development of digital innovation research using a bibliometric method with visual mapping.The status of digital innovation research is analyzed through citation analysis.Influential references,authors,and top-tier journals are identified.The literature’s intellectual structure is mapped through co-word analysis.In addition,co-citation network analysis is used to describe the evolution of digital innovation research,and cluster analysis of the main research stream is conducted.Several research topics addressed by recent papers are also discussed.Finally,cross-country comparisons reveal that the US is currently taking the leading role and that China is a newcomer with potential contributions to make in this research area. | Xi Zhang Yao Meng Hui Chen Jiang Yu Yongqiang Sun Patricia Ordóñez de Pablos Joy Wei He | 2017 | Journal of Management Science and Engineering2017，2，2： | 3 |
| 10 | Developing Flexible Dual Master's Degree Programs at UPAEP (Universidad Popular Autonoma del Estado de Puebla) and OSU (Oklahoma State University)显示文摘 | Mafia G. Fabregas-Janeiro Pablo Nuno de la Parra | 2012 | US-China Education Review(A)2012，2，2： | 2 |
| 11 | TGF β /Activin/Nodal Pathway in Inhibition of Human Embryonic Stem Cell Differentiation by Mechanical Strain显示文摘 | Somen Saha Lin Ji Juan J. de Pablo Sean P. Palecek | 2008 | Biophysical Journal2008，，10： | 2 |
| 12 | Do current anti-cyberloafing disciplinary practices have a replica in research findings?: A study of the effects of coercive strategies on workplace Internet misuse显示文摘 | Pablo Zoghbi Manrique de Lara Domingo Verano Tacoronte Jyh-Ming Ting Ding | 2006 | Internet Research2006，，4： | 2 |
| 13 | Fear in organizations: Does intimidation by formal punishment mediate the relationship between interactional justice and workplace internet deviance?显示文摘 | Pablo Zoghbi Manrique de Lara | 2006 | Journal of Managerial Psychology2006，，6： | 2 |
| 14 | Effect of heavy metals and water content on the strength of magnesium phosphate cements显示文摘 | Irene Buj Josep Torras Daniel Casellas Miquel Rovira Joan de Pablo | 2009 | Journal of Hazardous Materials2009，，1： | 2 |
| 15 | Treatment of Travelers’ Diarrhea: Randomized Trial Comparing Rifaximin, Rifaximin Plus Loperamide, and Loperamide Alone显示文摘 | Herbert L. Dupont Zhi–Dong Jiang Jaime Belkind–Gerson Pablo C. Okhuysen Charles D. Ericsson Shi Ke David B. Huang Margaret W. Dupont Javier A. Adachi F. Javier De La Cabada David N. Taylor Sridvya Jaini Francisco Martinez Sandoval | 2007 | Clinical Gastroenterology and Hepatology2007，，4： | 2 |
| 16 | Concurrent use of aromatase inhibitors and hypofractionated radiation therapy显示文摘AIM: To retrospectively assess the acute and long-term toxicity using aromatase inhibitors (AI) therapy concurrently with hypofractionated radiotherapy (HFRT) in breast cancer patients. METHODS: From November 1999 to October 2007, 66 patients were treated with breast HFRT and concurrent AI. In 63 patients (95.5%), HFRT delivered a total dose of 32.5 Gy to the whole breast within 5 wk (five fractions, one fraction per week). Other fractionations were chosen in three patients for the patients' personal convenience. A subsequent boost to the tumor bed was delivered in 35 patients (53.0%). Acute toxicities were scored according to the Common Toxicity Criteria for Adverse Events v3. Late toxicity was defined as any toxicity occurring more than 6 mo after completion of HFRT and was scored according to the Late Effects Normal Tissue Task Force-Subjective, Objective, Management and Analytic scale. RESULTS: At the end of the HFRT course, 19 patients (28.8%) had no irradiation-related toxicity. Acute grade 1-2 epithelitis was observed in 46 patients (69.7%). One grade 3 toxicity (1.5%) was observed. With a median follow-up of 34 mo (range: 12-94 mo), 31 patients (47%) had no toxicity, and 35 patients (53%) presented with grade 1-2 fibrosis. No grade 3 or greater delayed toxicity was observed. CONCLUSION: We found that AI was well tolerated when given concurrently with HFRT. All toxicities were mild to moderate, and no treatment disruption was necessary. Further prospective assessment is warranted. | Cyrus Chargari Pablo Castro-Pena Ivan Toledano Marc A Bollet Alexia Savignoni Paul Cottu Fatima Laki Franois Campana Patricia De Cremoux Alain Fourquet Youlia M Kirova | 2012 | World Journal of Radiology2012，4，7： | 2 |
| 17 | Diabetes insipidus and adipsic hypermatremia in a patient with a craniopharyngioma显示文摘 | Macias Batista A Martinez Martin F J de Pablos Velasco PL | 1999 | An Med Interna1999，16，2： | 1 |
| 18 | Influence of thermal treatment on the ' in vitro' bioactivity of wollastonite materials显示文摘 | Miguel A de la Casa-Lillo Pablo Velasquez Piedad N De Aza | 2011 | Journal of Materials Science-Materials in Medicine2011，22，4： | 1 |
| 19 | Proinsulin/in- sulin is synthesized locally and prevents caspase - and cathepsin -mediated cell death in the embryonic mouse retina显示文摘 | Valenciano AI Corrochano S de Pablo F | 2006 | J Neu- rochem2006，99，2： | 1 |
| 20 | How do work-family balance practices affect work-family conflict? The differential roles of work stress显示文摘这份报纸调查在工作家庭平衡惯例和工作家庭冲突的雇员感觉之间的关系。它作为主考检验挑战应力和阻碍者应力的角色。基于在北京从 841 个公务员收集的调查数据,我们发现察觉的工作家庭平衡惯例可以减少工作家庭冲突,当挑战和阻碍者工作压力是时断然与工作家庭有关冲突。另外,挑战和阻碍者压力差别节制了在察觉的工作家庭惯例和工作家庭冲突之间的关系。当挑战应力当时高时,工作家庭平衡惯例将减少工作家庭冲突。在高阻碍者应力下面,然而,工作家庭平衡惯例将服务减少工作家庭冲突更少。工作家庭平衡惯例(工作灵活性,和雇员和家庭好照顾) 的 configurational 尺寸的更多的详细分析也被测试。这研究为未来研究提供另外的卓见进工作家庭接口和提议想法的管理。 | Xiaoxi Chang Yu Zhou Chenxi Wang Carmen de Pablos Heredero | 2017 | Frontiers of Business Research in China2017，11，2： | 1 |
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