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| 1 | Effects of human immunodeficiency virus on the erythrocyte and megakaryocyte lineages显示文摘Anaemia and thrombocytopenia are haematological disorders that can be detected in many human immunodeficiency virus(HIV)-positive patients during the development of HIV infection. The progressive decline of erythrocytes and platelets plays an important role both in HIV disease progression and in the clinical and therapeutic management of HIV-positive patients. HIV-dependent impairment of the megakaryocyte and erythrocyte lineages is multifactorial and particularly affects survival, proliferation and differentiation of bone marrow(BM) CD34+ haematopoietic progenitor cells, the activity of BM stromal cells and the regulation of cytokine networks. In this review, we analyse the ma-jor HIV-related mechanisms that are involved in the genesis and development of the anaemia and thrombocytopenia observed in HIV positive patients. | Davide Gibellini Alberto Clò Silvia Morini Anna Miserocchi Cristina Ponti Maria Carla Re | 2013 | World Journal of Virology2013，2，2： | 2 |
| 2 | Diabetic neuropathy: An evaluation of the use of quercetin in the cecum of rats显示文摘AIM:To investigate the effect of quercetin supplementation on the myenteric neurons and glia in the cecum of diabetic rats.METHODS:Total preparations of the muscular tunic were prepared from the ceca of twenty-four rats divided into the following groups:control(C),control supplemented with quercetin(200 mg/kg quercetin body weight)(CQ),diabetic(D)and diabetic supplemented with quercetin(DQ).Immunohistochemical double staining technique was performed with HuC/D(general population)/nitric oxide synthase(nNOS),HuC-D/S-100and VIP.Density analysis of the general neuronal population HuC/D-IR,the nNOS-IR(nitrergic subpopulation)and the enteric glial cells(S-100)was performed,and the morphometry and the reduction in varicosity population(VIP-IR)in these populations were analyzed.RESULTS:Diabetes promoted a significant reduction(25%)in the neuronal density of the HuC/D-IR(general population)and the nNOS-IR(nitrergic subpopulation)compared with the C group.Diabetes also significantly increased the areas of neurons,glial cells and VIP-IR varicosities.Supplementation with quercetin in the DQ group prevented neuronal loss in the general population and increased its area(P<0.001)and the area of nitrergic subpopulation(P<0.001),when compared to C group.Quercetin induced a VIP-IR and glial cells areas(P<0.001)in DQ group when compared to C,CQ and D groups.CONCLUSION:In diabetes,quercetin exhibited a neuroprotective effect by maintaining the density of the general neuronal population but did not affect the density of the nNOS subpopulation. | Paulo Emilio Botura Ferreira Cláudia Regina Pinheiro Lopes Angela Maria Pereira Alves der Paulo Belato Alves David Robert Linden Jacqueline Nelisis Zanoni Nilza Cristina Buttow | 2013 | World Journal of Gastroenterology2013，19，38： | 2 |
| 3 | Thyroid gland:US in patients with Hodgkin's disease treated with radiation therapy in childhood显示文摘 | David CL Eftekhari F | 1989 | Radiology1989，172，1： | 1 |
| 4 | Adrenal and extra-adrenal retroperito- neal ganglioneuroma:imaging finding in 13 adults 显示文摘 | Radin R David CL Goldfard H | 1997 | Radiology1997，，： | 1 |
| 5 | Vascular involvement in pancreatic adenocarcinoma: reassessment by thin-section CT显示文摘 | Loyer EM David CL Dubrow RA | 1996 | Abdom Imaging1996，21，： | 1 |
| 6 | Beta-catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain tumor Committee显示文摘 | David WE Olabisi EO Janet CL | 2005 | J Clin Oncol2005，23，： | 1 |
| 7 | Potentially respectable pancreatic ductal adenocarcinoma and perampullary carcinoma:analysis of enhancement characteristics on biphasic and triphasic helical CT显示文摘 | Dubrow RA Houston CL David SK | 1997 | RSNA1997，205，： | 1 |
| 8 | Vascular Involvement in Pancreatic Adenocarcinoma: Reassessment by Thin-section CT显示文摘 | David CL Dubrow RA | 1996 | Abdom Imaging1996，21，3： | 1 |
| 9 | Vascular involvement in pancreatic adenocarcinoma: reassessment by thinsection CT 显示文摘 | Loyer EM David CL Dubrow RA | 1996 | Abdom Imaging1996，21，3： | 1 |
| 10 | Vascular involvement in pancreaticcarcinoma:reassessment by thin-section CT显示文摘 | Loyer EM David CL Dubrow RA | 1996 | Abdom Imaging1996，207，： | 1 |
| 11 | Vascular in- volvement in pancreatic adenocarcinoma: reassessment by thin-section CT 显示文摘 | Loyer EM David CL Dubrow RA | 1996 | A JR1996，21，3： | 1 |
| 12 | Comparison of Angioplasty with Stenting, with or without Abciximab显示文摘 | Stone GW Grines CL David A | 2002 | Acute Myocardial Infarction2002，346，12： | 1 |
| 13 | Vascular involvement in pancreatic adenocarcinoma:reassessment by thin-section CT显示文摘 | Loyer EM David CL Dubrow RA | 1996 | Abdom Imaging1996，21，3： | 1 |
| 14 | Vascular involvement in pancreatic adenocarcinoma:reassessment by thin-section CT显示文摘 | Loyer EM David CL Dubrow RA | 1996 | Abdom Imaging1996，21，： | 1 |
| 15 | Azetidinones as vasopressin V1a antagonists显示文摘 | Christophe D. Guillon Gary A. Koppel Michael J. Brownstein Michael O. Chaney Craig F. Ferris Shi-fang Lu Karine M. Fabio Marvin J. Miller Ned D. Heindel David C. Hunden Robin D.G. Cooper Stephen W. Kaldor Jeffrey J. Skelton Bruce A. Dressman Michael P. Cl | 2006 | Bioorganic & Medicinal Chemistry2006，，5： | 1 |
| 16 | Vascular involvement in pancreatic adenocarcinoma: reassessment by thin-section CT 显示文摘 | Loyer EM David CL Dubrow RA | 1996 | Abdom Imaging1996，21，3： | 1 |
| 17 | Adrenal and Extra- adrenal RetroperitionealGanglioneuroma:Imaging Findings in 13 Adults显示文摘 | Radin R david CL Goldfarb H | 1997 | Radiology1997，202，1： | 1 |
| 18 | Vascular involvement in pancreatic adenocarcinoma : reassessment by thin - section CT 显示文摘 | Layer EM David CL Dubrow RA | 1996 | Abdom Imaging1996，21，1： | 1 |
| 19 | Vascular involvement in pancreatic adenocarcinoma:reassessment by thin-section CT显示文摘 | Loyer EM David CL Dubrow RA | 1996 | Abdominal Imaging1996，21，： | 1 |
| 20 | High resolution humanleukocyte antigen (HLA) class I and class II allele typing inMexican mestizo women with sporadic breast cancer: case-control study显示文摘 | David CL Delia PM Vemica V | 2009 | BMC Cancer2009，9，： | 1 |
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