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| 1 | Endoscopic full-thickness resection: current status显示文摘Conventional endoscopic resection techniques such as endoscopic mucosal resection or endoscopic submucosal dissection are powerful tools for treatment of gastrointestinal neoplasms. However,those techniques are restricted to superficial layers of the gastrointestinal wall. Endoscopic full-thickness resection(EFTR) is an evolving technique,which is just about to enter clinical routine. It is not only a powerful tool for diagnostic tissue acquisition but also has the potential to spare surgical therapy in selected patients. This review will give an overview about current EFTR techniques and devices. | Arthur Schmidt Benjamin Meier Karel Caca | 2015 | World Journal of Gastroenterology2015，21，31： | 14 |
| 2 | Expression of c-kit receptor in human cholangiocarcinoma and in vivo treatment with imatinib mesilate in chimeric mice显示文摘瞄准:与额外的肝的 cholangiocarcinoma (CC ) 从病人在胆道癌症房间线和组织学的节调查 c 工具包表示并且与 imatinib mesilate 评估在试管内和在试管内治疗的功效。方法:在从有额外的肝的 CC 的 19 个病人的人的胆道癌症房间线 Mz-ChA-2 和 EGI-1 和组织学的节的 c 工具包的蛋白质表示被免疫弄污,免疫细胞化学,和免疫组织化学估计。胆道癌症房间线 Mz-ChA-2 和 EGI-1 上的 imatinib mesilate 的 anti-proliferative 效果是由自动化房间数的学习在试管内。另外,免疫缺乏的 NMRI 老鼠(Taconic ) 皮下地与 5x10 (6 ) 被注射房间线 MzChA-2 和 EGI-1 的房间。在到达了 200 mm3 的瘤体积以后,每日的治疗在 50 mg/kg 或生理盐水(NS ) 的剂量以 imatinib mesilate intraperitoneally 被开始。肿瘤体积与游标 caliper 被计算。在 14 d 以后,老鼠被牺牲,肿瘤和决定的肿瘤质量切除了。结果:Immunoblotting 在 EGI-1 房间在 Mz-ChA-2 和缺席揭示了 c 工具包的存在。有 c 工具包抗体的 Immunocytochemistry 在 EGI-1 房间在 Mz-ChA-2 房间和 c 工具包的缺席显示了 cytoplasmatic 和受体蛋白质的膜的本地化。c 工具包在 19 中的 7 个被表示(37%) 额外的肝的人的 CC 织物取样, 2 出现了一中等并且染色的 5 一相当弱的免疫。在 5 micromol/L 的低集中的 Imatinib mesilate 在 c 工具包引起了重要生长抑制积极房间线 Mz-ChA-2 (31%) ,然而并非在 c 工具包 negative,房间衬里 EGI-1 (0%)(P<0.05 ) 。在 10 micromol/L 的中间的集中的 Imatinib mesilate 禁止了两根细胞线(51% 对 57%) 的细胞的生长。在 20 micromol/L 的更高的集中的 Imatinib mesilate 似乎在两根房间线上有一般有毒的效果。IC50 价值分别地是 9.7 micromol/L 和 11 micromol/L。在有 imatinib mesilate 的在试管内处理的 14 d 以后,使用妄想的老鼠模型,积极 Mz-ChA-2 肿瘤有的 c 工具包显著地减少的体积和团作为与 NS 处理(P<0.05 ) 相比。与那相对照,忍受 c 工具包 negative EGI-1 肿瘤的鼠标的处理没作为与 NS 处理相比导致肿瘤体积和质量的任何变化。结论:c 工具包表示是可检测的在一对在胆道癌症的低蛋白质水平中等。Imatinib mesilate 在肿瘤生长在试管内和 c 工具包表示诚实的在试管内依赖者上施加显著效果。 | Thomas Kamenz Karel Caca Thilo Blüthner Andrea Tannapfel Joachim Mssner Marcus Wiedmann | 2006 | World Journal of Gastroenterology2006，12，10： | 7 |
| 3 | Inhibition of histone deacetylase for the treatment of biliary tract cancer:A new effective pharmacological approach显示文摘瞄准:调查在试管内和在活体内治疗学的效果嘘胆道癌症上的一 deacetylase 禁止者 NVP-LAQ824 和 NVP-LBH589。方法:由 NVP-LAQ824 和 NVP-LBH589 的房间生长抑制是在由 MTT 试金的 7 根人的胆道癌症房间线的学习在试管内。另外, NVP-LBH589 的 anti-tumoral 效果在一个妄想的老鼠模型被学习。Anti-tumoral 药机制被为 MIB-1 为 acH4 和 p21 弄污 WAF-1/CIP-1, PARP 试金,房间周期分析, TUNEL 试金,和 immunhistochemistry 的免疫估计。结果:有两混合物的在试管内治疗显著地压制了所有癌症房间线的生长[吝啬的 IC50 ( 3 d ) 0.11 和 0.05 mumol/L ,分别地],并且与 nucleosomal 的 hyperacetylation 被联系嘘一 H4 , p21 WAF-1/CIP-1 的增加的表示, apoptosis ( PARP 劈开)感应,并且房间周期在 G2/M 逮捕检查点。在 28 d 以后, NVP-LBH589 显著地减少了在 66% 集体的肿瘤(胆汁管癌) 并且 87%( 胆囊癌症) 与安慰剂相比的在活体内,并且加强 gemcitabine 的功效。揭示的肿瘤标本的进一步的分析由 TUNEL 试金增加了 apoptosis 并且减少了房间增长(MIB-1 ) 。结论:我们的调查结果建议 NVP-LBH589 和 NVP-LAQ824 对人的胆道癌症是活跃的在试管内。另外, NVP-LBH589 表明了重要在活体内活动并且加强 gemcitabine 的功效。因此,为胆道癌症的治疗的这新药的进一步临床的评估被推荐。 | Thilo Bluethner Manuel Niederhagen Karel Caca Frederik Serr Helmut Witzigmann Christian Moebius Joachim Mossner Marcus Wiedmann | 2007 | World Journal of Gastroenterology2007，13，35： | 5 |
| 4 | Effects of vernal and allergic conjunctivitis on severity of keratoconus显示文摘AIM: To demonstrate the effects of two different types of allergic conjunctivitis on severity of keratoconus (KC). ·METHODS: We retrospectively reviewed the medical records of 171 KC patients referred between June 2010 and June 2011. The KC patients were divided into 3 groups as KC (group A), KC with vernal keratoconjunctivitis (VKC) (group B) and KC with allergic conjunctivitis (AC) (group C). Main outcome measures were demographic and ocular clinical features including age at presentation, gender, spherical equivalent (SE), best spectacle corrected visual acuity (BCVA), mean keratometric measurement (Km), central corneal thickness (CCT), and intraocular pressure (IOP). Groups were compared in term of study variables. · RESULTS: The median age at presentation was significantly lower in group B (P <0.001). According to the median SE (P =0.003), BCVA(P =0.022), Km(P <0.001), CCT (P =0.015) and Amsler-Krumeich classification (P < 0.001), KC was more severe in group B. There was no significant difference in terms of IOP and corrected IOP among the groups (P =0.44), however there were 4 patients who had increased corrected IOP developed after topical corticosteroid use in group B. The differences among the groups persisted even after controlling for age and gender. · CONCLUSION: Our findings demonstrated a more severe KC in VKC patients despite their younger age which suggests evaluation of VKC patients as a separate group in keratoconus disease. | Abdullah Kursat Cingu Yasin Cinar Fatih Mehmet Turkcu Alparslan Sahin Seyhmus Ari Harun Yuksel Muhammed Sahin Ihsan Caca | 2013 | International Journal of Ophthalmology(English edition)2013，6，3： | 4 |
| 5 | Endoscopic full-thickness resection of gastric subepithelial tumors: a single-center series显示文摘 | Arthur Schmidt Markus Bauder Bettina Riecken Daniel von Renteln Helmut Muehleisen Karel Caca | 2014 | Endoscopy2014，，： | 3 |
| 6 | 661 USE OF EARLY-TIPS FOR HIGH-RISK VARICEAL BLEEDING. RESULTS OF A POST-RCT SURVEILLANCE STUDY显示文摘 | M. Di Pascoli J.C. García-Pagan K. Caca W. Laleman C. Bureau B. Appenrodt A. Luca A. Zipprich J.G. Abraldes F. Nevens J.P. Vinel J. Bosch | 2012 | Journal of Hepatology2012，，： | 3 |
| 7 | Experimental treatment of pancreatic cancer with two novel histone deacetylase inhibitors显示文摘AIM:To investigate in vitro and in vivo treatment with histone deacetylase inhibitors NVP-LAQ824 and NVP-LBH589 in pancreatic cancer. METHODS:Cell-growth inhibition by NVP-LAQ824 and NVP-LBH589 was studied in vitro in 8 human pancreatic cancer cell lines using the 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide(MTT) assay. In addition,the anti-tumoral effect of NVP-LBH589 was studied in a chimeric mouse model. Anti-tumoral activity of the drugs was assessed by immunoblotting for p21WAF-1,acH4,cell cycle analysis,TUNEL assay,and immunohistochemistry for MIB-1. RESULTS:In vitro treatment with both compounds significantly suppressed the growth of all cancer cell lines and was associated with hyperacetylation of nucleosomal histone H4,increased expression of p21WAF-1,cell cycle arrest at G2/M-checkpoint,and increased apoptosis. In vivo,NVP-LBH589 alone significantly reduced tumor mass and potentiated the efficacy of gemcitabine. Further analysis of the tumor specimens revealed slightly increased apoptosis and no significant reduction of cell proliferation.CONCLUSION:Our findings suggest that NVP-LBH589 and NVP-LAQ824 are active against human pancreatic cancer,although the precise mechanism of in vivo drug action is not yet completely understood. Therefore,further preclinical and clinical studies for the treatment of pancreatic cancer are recommended. | Martin Haefner Thilo Bluethner Manuel Niederhagen Christian Moebius Christian Wittekind Joachim Mossner Karel Caca Marcus Wiedmann | 2008 | World Journal of Gastroenterology2008，14，23： | 2 |
| 8 | Endoscopic full-thickness resection in the colorectum with a novel over-the-scope device: first experience显示文摘 | Arthur Schmidt Peter Bauerfeind Christoph Gubler Michael Damm Markus Bauder Karel Caca | 2015 | Endoscopy2015，，： | 2 |
| 9 | Endoscopic Full-Thickness Resection Using a Novel Over-the-Scope Device显示文摘 | Arthur Schmidt Michael Damm Karel Caca | 2014 | Gastroenterology2014，，4： | 2 |
| 10 | Modeling fracture flow with a stochastic discrete fracture network:calibration and validation 1,flow model显示文摘 | Cacas M C Ledoux E de Marsily G | 1990 | Water Resources Research1990，26，3： | 1 |
| 11 | Long term failure of engdoscopic gastroplication(Endocinch)显示文摘 | Schiefke I Zabel-Langhennig A Neumann S Feisthammel J Moessner J Caca K | 2005 | Gut2005，54，： | 1 |
| 12 | 网络世界的新军:智能化汽车设计显示文摘通过视觉智能驾驶系统概念跑车车型的研发,宝马集团奉献出了一个未来智能汽车的理想主义解决方案。该车以两座跑车为基础,是一款集成网络设计和技术创新的智能化汽车。 | caca | 2011 | 设计2011，24，3： | 1 |
| 13 | Diagnosis and phenotypic classification of Wilson disease 显示文摘 | Ferenci P Caca K Loudianos G | 2003 | Liver Int2003，23，3： | 1 |
| 14 | Molecularly targeted therapy for gastrointestinal cancer显示文摘 | Wiedmann MW Caca K | 2005 | Curr Cancer Drug Targets2005，5，3： | 1 |
| 15 | Neoadjuvant photodynamic therapy as a new approach to treating hilar cholangiocarcinoma:a phase Ⅱ pilot sludy显示文摘 | Wiedmann M Caca K Berr F | 2003 | Cancer2003，97，11： | 1 |
| 16 | Endoscopic GIST resection using FlushKnife ESD and subsequent perforation closure by means of endoscopic full-thickness suturing显示文摘 | D. von Renteln B. Riecken B. Walz H. Muehleisen K. Caca | 2008 | Endoscopy (S )2008，，02： | 1 |
| 17 | Molecularly targeted therapy for gastrointestinal cancer 显示文摘 | Wiedmann MW Caca K | 2005 | Curt Cancer Drug Targets2005，5，3： | 1 |
| 18 | Successful photodynamic therapy for nonresectable cholangiocarcinoma: a randomized prospective study 显示文摘 | Ortner ME Caca K Berr F | 2003 | Gastroenterology2003，125，5： | 1 |
| 19 | the flow model显示文摘 | Cacas M C E Ledoux G Marsily B Modeling fracture flow with a stochastic discrete fracture network: Calibration and validation 1 | 1990 | Water Resources Research1990，26，： | 1 |
| 20 | The diagnosis and treatment of cholangiocarcinoma 显示文摘 | Vogel A Wege H Caca K | 2014 | Dtsch Arztebl Int2014，111，44： | 1 |
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