|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | ICP-AES测定湖泊沉积物中微量元素的样品微波消解研究显示文摘为正确测定鄱阳湖沉积物中微量元素而研究样品消解方法,采用密闭式微波消解系统处理样品,以ICP-AES法测定多种微量元素。分别从不同的消解液、用酸量、消解工序以及样品消解量等方面进行研究和优化,最终确定了一个最适合消解鄱阳湖沉积物的前处理消解体系为:消解样用量为0.5 g,180℃电热板上预处理约15 min,消解体系选择酸比例为4∶4∶2的HNO3-HF-H2O2体系和HNO3-HF-HClO4体系均可,消解工序为5 atm/3 min—10 atm/2 min—15 atm/5 min—20 atm/10 min的逐步加热工序。这种消解方法简单快速、效率高、劳动强度低,为以后鄱阳湖沉积物的测定做了样品准备工作。 | 弓晓峰 陈春丽 Barbara Zimmermann 赵晋 周文斌 | 2007 | 光谱学与光谱分析2007，27，1： | 33 |
| 2 | Heparanase activates the syndecan-syntenin-ALIX exosome pathway显示文摘 | Bart Roucourt Sofie Meeussen Jie Bao Pascale Zimmermann Guido David | 2015 | Cell Research2015，25，4： | 29 |
| 3 | Risk factors and outcome of bacterial infections in cirrhosis显示文摘Viable and non-viable pathological bacterial translocation promote a self-perpetuating circle of dysfunctional immune activation and systemic inflammation facilitating infections and organ failure in advanced cirrhosis.Bacterial infections and sepsis are now recognized as a distinct stage in the natural progression of chronic liver disease as they accelerate organ failure and contribute to the high mortality observed in decompensated cirrhosis.The increasing knowledge of structural,immunological and hemodynamic pathophysiology in advanced cirrhosis has not yet translated into significantly improved outcomes of bacterial infections over the last decades.Therefore,early identification of patients at the highest risk for developing infections and infectionrelated complications is required to tailor the currently available measures of surveillance,prophylaxis and therapy to the patients in need in order to improve the detrimental outcome of bacterial infections in cirrhosis. | Tony Bruns Henning W Zimmermann Andreas Stallmach | 2014 | World Journal of Gastroenterology2014，20，10： | 24 |
| 4 | Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump显示文摘AIM: To study the association of three common ABCB11 and ABCC2 polymorphisms (ABCB11: 1331T>C V444A; ABCC2: 3563T>A V1188E and 4544G>A C1515Y) with intrahepatic cholestasis of pregnancy (ICP) and contraceptive-induced cholestasis (CIC). METHODS: ABCB11 and ABCC2 genotyping data were available from four CIC patients and from 42 and 33 ICP patients, respectively. Allele-frequencies of the studied polymorphisms were compared with those in healthy pregnant controls and Caucasian individuals. Furthermore, serum bile acid levels were correlated with the presence or absence of the 1331 C allele.RESULTS: The ABCB11 1331T>C polymorphism was significantly more frequent in cholestatic patients than in pregnant controls: C allele 76.2% (CI, 58.0-94.4) vs 51.3% (CI 35.8-66.7), respectively (P = 0.0007); and CC allele 57.1% (CI 36.0-78.3) vs 20% (CI 7.6-32.4), respectively (P = 0.0065). All four CIC patients were homozygous carriers of the C allele. In contrast, none of the studied ABCC2 polymorphism was overrepresented in ICP or CIC patients. Higher serum bile acid levels were found in carriers of the 1331CC genotype compared to carriers of the TT genotype.CONCLUSION: Our data support a role for the ABCB11 1331T>C polymorphism as a susceptibility factor for the ←←← development of estrogen-induced cholestasis, whereas no such association was found for ABCC2. Serum bile acid and γ-glutamyl transferase levels might help to distinguish ABCB4- and ABCB11-related forms of ICP and CIC. | Yvonne Meier Tina Zodan Carmen Lang Roland Zimmermann Gerd A Kullak-Ublick Peter J Meier Bruno Stieger Christiane Pauli-Magnus | 2008 | World Journal of Gastroenterology2008，14，1： | 20 |
| 5 | 库克诺你果汁提取物体外清除自由基及抗氧化活性研究(英文)显示文摘本文对诺你果汁多糖、乙醇溶出物和乙酸乙酯萃取物体外对超氧阴离子(O2·)、羟自由基(·OH)、DPPH和脂质过氧化(LPO)的抑制作用进行了研究。超氧阴离子(O2·)由邻苯三酚自氧化产生;羟自由基(·OH)由Fenton反应产生;利用Fe2+诱发卵黄脂蛋白产生丙二醛(MDA),TBA法测定。所有测定均为分光光度法。结果表明,与已知抗氧化剂L抗坏血酸相比,乙醇溶出物和乙酸乙酯萃取物均有明显的捕捉自由基和抗氧化能力,而多糖捕捉自由基和抗氧化能力很低,且对O2·没有抑制作用,反而会增加其生成速度。 | 李昌 谢明勇 聂少平 陈军辉 Barbara Zimmermann | 2006 | 天然产物研究与开发2006，18，3： | 18 |
| 6 | 微波消解-ICP-AES测定鄱阳湖流域沉积物中微量元素显示文摘为了研究鄱阳湖沉积物中微量元素近几年来随季节、年度及沿程的变化情况,对2003年和2005年不同季节采集的鄱阳湖流域各采样点底泥进行了ICP-AES测定。结果表明,鄱阳湖沉积物中各元素的含量随着季节和年度变化而发生一定改变,枯水期普遍大于丰水期;南矶山2005年Cu和Pb含量较2003年有所降低;蔡家湾则与南矶山相反;姚公渡2005年Cu含量也较2003年低,Pb含量则高于2003年;与鄱阳湖流域底泥背景值相比,所测几个样点的Cu,Pb,Cr和Zn含量均在一定程度上超标;除大坞河外,其余各样点As含量均在背景值范围内;从饶河到鄱阳湖入湖口处,各元素含量呈逐渐降低趋势。文章提出的研究方法操作简便,效率高,劳动强度低。 | 弓晓峰 陈春丽 赵晋 Barbara Zimmermann 崔秀丽 周文斌 | 2007 | 光谱学与光谱分析2007，27，8： | 14 |
| 7 | Let’s talk about Secs: Sec61, Sec62 and Sec63 in signaltransduction, oncology and personalized medicine显示文摘The heterotrimeric Sec61 complex and the dimeric Sec62/Sec63 complex are located in the membrane of the human endoplasmic reticulum(ER)and play a central role in translocation of nascent and newly synthesized precursor polypeptides into the ER.This process involves targeting of the precursors to the membrane and opening of the polypeptide conducting Sec61 channel for translocation.Apart from this central role in the intracellular transport of polypeptides,several studies of the last decade uncovered additional functions of Sec proteins in intracellular signaling:Sec62 can induce ER-phagy in the process of recovery of cells from ER stress and the Sec61 channel can also act as a passive ER calcium leak channel.Furthermore,mutations,amplifications and an overexpression of the SEC genes were linked to various diseases including kidney and liver diseases,diabetes and human cancer.Studies of the last decade could not only elucidate the functional role of Sec proteins in the pathogenesis of these diseases,but also demonstrate a relevance of Sec62 as a prognostic and predictive biomarker in head and neck cancer,prostate and lung cancer including a basis for new therapeutic strategies.In this article,we review the current understanding of protein transport across the ER membrane as central function of Sec proteins and further focus on recent studies that gave first insights into the functional role and therapeutic relevance of Sec61,Sec62 and Sec63 in human diseases. | Maximilian Linxweiler Bernhard Schick Richard Zimmermann | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 8 |
| 8 | 拉曼技术在药物逆向工程中的应用显示文摘逆向工程以目标产品进行逆向分析及研究,是仿制药开发过程中的一个重要环节,在目前的仿制药一致性评价中发挥显著功效。尽管物理、化学方法众多,但原研制剂的逆向工程分析仍然极具挑战、极其耗时。逆向工程的最终目的不仅是确定原研制剂中所有可能的化学成分,还要深入揭示其制剂原则和药物释放机制。而如何高效合理地应用各种分析技术,是深入了解原研药的第一步。文章概述了一种光谱技术——拉曼光谱在药物逆向分析工程中的实用性,特别介绍在某些情况下,当其他常用固态分析技术如X射线粉末衍射、差示扫描量热法等不适用时,拉曼光谱对原研制剂中药物活性成分(API)晶型的鉴定。文章通过对拉曼光谱在某些特定条件下应用的具体案例的演示,展示了分子振动相关光谱分析手段在药物逆向分析工程中的应用前景。 | 田芳 ZIMMERMANN Anne MCGOVERIN Cushla 王霆 冯敏 林华庆 洪建文 林生文 | 2016 | 药学进展2016，40，12： | 8 |
| 9 | 欧洲合同法原则第三部分显示文摘 | Reinhard Zimmermann 朱岩 | 2004 | 华东政法学院学报2004，，6： | 5 |
| 10 | 2017年至2018年十大可穿戴技术与功能展望显示文摘本文将讨论未来两年间可穿戴设备、技术及软件提供商的产品规划师不可忽视的十项可穿戴设备技术与功能。我们选择这些技术的依据包括更加广泛的重要性、对创新及更具吸引力的可穿戴设备用户体验的影响力,以及为推广可穿戴设备而开展用户互动并最终为可穿戴技术提供商创造业务价值的新机会。 | Roberta Cozza Michele Reitz Annette Zimmermann 邓雅君 | 2016 | 电子产品世界2016，23，9： | 5 |
| 11 | Genevestigator Transcriptome Meta-Analysis and Biomarker Search Using Rice and Barley Gene Expression Databases显示文摘到学习植物 transcriptomes 的 microarray 技术的普遍使用导致了重要发现并且盖住大量不同纸巾,发展阶段,不安,和遗传型到介绍数据的累积。查询很多 microarray 实验能提供不能被分析单个实验获得的卓见。然而,如此的元分析关于数据提出重要挑战相似性和正规化,系统的样品注解,和分析工具。Genevestigator 用一个大 curated 表达式数据库和在因特网上是可存取的一套明确地发达的分析工具处理这些问题。这联合已经证明了基于 Arabidopsis 数据的一个大集合在植物研究的区域有用(Grennan, 2006 ) 。这里,我们在场 Genevestigator 米饭的版本和包含质量控制、好的注解 microarray 的大麦基因表示数据库试验使用本体论。数据库当前从病理,植物营养,不能生活的压力,荷尔蒙处理,遗传型,和空间或时间的分析包括实验,但是被期望作为更试验性的数据盖住研究区域的一个宽广变化变得可得到。模型种类米饭和大麦的 transcriptome 元分析被期望交付能在谷物被用于功能的 genomics 和 biotechnological 应用程序的结果。 | Philip Zimmermann Oliver Laule Josy Schmitz Tomas Hruz Stefan Bleuler Wilhelm Gruissema | 2008 | Molecular Plant2008，1，5： | 5 |
| 12 | Analysis of the Vibrissa Parametric Resonance Causing a Signal Amplification during Whisking Behaviour显示文摘 | Tatiana Volkova Igor Zeidis Hartmut Witte Manuela Schmidt Klaus Zimmermann | 2016 | Journal of Bionic Engineering2016，13，2： | 4 |
| 13 | Correlation of lumbar lateral recess stenosis in magnetic resonance imaging and clinical symptoms显示文摘AIM To assess the correlation of lateral recess stenosis(LRS) of lumbar segments L4/5 and L5/S1 and the Oswestry Disability Index(ODI).METHODS Nine hundred and twenty-seven patients with history of low back pain were included in this uncontrolled study.On magnetic resonance images(MRI) the lateral recesses(LR) at lumbar levels L4/5 and L5/S1 were evaluated and each nerve root was classified into a 4-point grading scale(Grade 0-3) as normal,not deviated,deviated or compressed.Patient symptoms and disability were assessed using ODI.The Spearman's rank correlation coefficient was used for statistical analysis(P < 0.05).RESULTS Approximately half of the LR revealed stenosis(grade 1-3;52% at level L4/5 and 42% at level L5/S1) with 2.2% and 1.9% respectively reveal a nerve root compression.The ODI score ranged from 0%-91.11% with an arithmetic mean of 34.06% ± 16.89%.We observed a very weak statistically significant positive correlation between ODI and LRS at lumbar levels L4/5 and L5/S1,each bilaterally(L4/5 left:rho < 0.105,P < 0.01;L4/5 right:rho < 0.111,P < 0.01;L5/S1 left:rho 0.128,P < 0.01;L5/S1 right:rho < 0.157,P < 0.001).CONCLUSION Although MRI is the standard imaging tool for diagnosing lumbar spinal stenosis,this study showed only a weak correlation of LRS on MRI and clinical findings.This can be attributed to a number of reasons outlined in this study,underlining that imaging findings alone are not sufficient to establish a reliable diagnosis for patients with LRS. | Annina SplettstoBer M Fawad Khan Bernd Zimmermann Thomas J Vogl Hanns Ackermann Marcus Middendorp Adel Maataoui | 2017 | World Journal of Radiology2017，9，5： | 4 |
| 14 | Event Specific Transgene Detection in Bt11 Corn by Quantitative PCR at the Integration Site显示文摘 | Andreas Zimmermann Jürg Lüthy Urs Pauli | 2000 | LWT - Food Science and Technology2000，，3： | 4 |
| 15 | Statistical analyses of Global U-Pb Database 2017显示文摘The method of obtaining zircon samples affects estimation of the global U-Pb age distribution.Researchers typically collect zircons via convenience sampling and cluster sampling.When using these techniques,weight adjustments proportional to the areas of the sampled regions improve upon unweighted estimates.Here,grid-area and modern sediment methods are used to weight the samples from a new database of 418,967 U-Pb ages.Preliminary tests involve two age models.Model-1 uses the most precise U-Pb ages as the best ages.Model-2 uses the^(206)Pb/^(238)U age as the best age if it is less than a1000 Ma cutoff,otherwise it uses the^(207)Pb/^(206)Pb age as the best age.A correlation analysis between the Model-1 and Model-2 ages indicates nearly identical distributions for both models.However,after applying acceptance criteria to include only the most precise analyses with minimal discordance,a histogram of the rejected samples shows excessive rejection of the Model-2 analyses around the1000 Ma cutoff point.Because of the excessive rejection rate for Model-2,we select Model-1 as the preferred model.After eliminating all rejected samples,the remaining analyses use only Model-1 ages for five rock-type subsets of the database:igneous,meta-igneous,sedimentary,meta-sedimentary,and modern sediments.Next,time-series plots,cross-correlation analyses,and spectral analyses determine the degree of alignment among the time-series and their periodicity.For all rock types,the U-Pb age distributions are similar for ages older than 500 Ma,but align poorly for ages younger than 500 Ma.The similarities(>500 Ma)and differences(<500 Ma)highlight how reductionism from a detailed database enhances understanding of time-dependent sequences,such as erosion,detrital transport mechanisms,lithification,and metamorphism.Time-series analyses and spectral analyses of the age distributions predominantly indicate a synchronous period-tripling sequence of^91-Myr,~273-Myr,and^819-Myr among the various rock types. | Stephen J.Puetz Carlos E.Ganade Udo Zimmermann Glenn Borchardt | 2018 | Geoscience Frontiers2018，9，1： | 4 |
| 16 | 聚氯乙烯在燃烧裂变过程的在线单光子离子化/共振增强多光子离子化飞行时间质谱显示文摘用单光子离子化 (SPI) /共振增强的多光子离子化 (REMPI) 飞行时间质谱法对PVC材料的燃烧裂变过程进行了在线研究 ,发现与其它有机材料不同 ,PVC涂层材料在 30 0℃时即发生裂变 ,生成苯系物、萘及少量多环芳烃。在空气条件下 ,产生酚类有机污染物。在 70 0℃和 80 0℃的低流速空气环境中检测到了二英的前体物———氯代苯 (MCB)、氯代酚及氯乙烯单体 ,预示着二英的形成 ,并可间接在线监测二英的浓度。在各温度条件下都有多环芳烃 (PAHs)产生 ,但在 70 0℃~ 80 0℃时 ,产生的数量最多。提高空气流速可大大降低MCB和PAHs的产生。在 1 0 0 0℃~ 1 1 90℃时 。 | 曹磊 Ralf Zimmermann Antonius Kettrup 王海舟 | 2004 | 分析化学2004，32，6： | 4 |
| 17 | Dynamical behavior of a mobile system with two degrees of freedom near the resonance显示文摘The design of mobile robots that can move without wheels or legs is an important engineering and technological problem.Self-propelling mechanisms consisting of a body that has contact with a rough surface and moveable internal masses are considered.Mathematical models of such systems are presented in this paper.First,a model of a vibration driven robot that moves along a rough horizontal plane with isotropic dry friction is studied.It is shown that by changing the off-resonance frequency detuning in sign,one can control the direction of motion of the system.In addition,a locomotion system which moves in an environment with anisotropic viscous friction is considered.For all models,the method of averaging to obtain an algebraic equation for the steady-state'average'velocity of the system is used. Prototypes were constructed to compare the theoretical results with experimental ones. | Klaus Zimmermann Igor Zeidis | 2011 | Acta Mechanica Sinica2011，27，1： | 3 |
| 18 | Micro‐RNA profiling reveals a role for miR‐29 in human and murine liver fibrosis显示文摘 | Christoph Roderburg Gerd‐Willem Urban Kira Bettermann Mihael Vucur Henning Zimmermann Sabine Schmidt J?rn Janssen Christiane Koppe Percy Knolle Mirco Castoldi Frank Tacke Christian Trautwein Tom Luedde | 2011 | Hepatology2011，，1： | 3 |
| 19 | Stereotactic radiotherapy of histologically proven inoperable stage I non-small cell lung cancer: Patterns of failure显示文摘 | Nicolaus Andratschke Frank Zimmermann Eva Boehm Sabine Schill Christine Schoenknecht Reinhard Thamm Michael Molls Carsten Nieder Hans Geinitz | 2011 | Radiotherapy and Oncology2011，，2： | 3 |
| 20 | Contemporary meta-analysis of short-term probiotic consumption on gastrointestinal transit显示文摘AIM: To determine the efficacy of probiotic supplementation on intestinal transit time(ITT) in adults and to identify factors that influence these outcomes. METHODS: We conducted a systematic review of randomized controlled trials of probiotic supplementation that measured ITT in adults. Study quality was assessed using the Jadad scale. A random effects meta-analysis was performed with standardized mean difference(SMD) of ITT between probiotic and control groups as the primary outcome. Meta-regression and subgroup analyses examined the impact of moderator variables on SMD of ITT.RESULTS: A total of 15 clinical trials with 17 treatment effects representing 675 subjects were included in this analysis. Probiotic supplementation was moderately efficacious in decreasing ITT compared to control, with an SMD of 0.38(95%CI: 0.23-0.53, P < 0.001). Subgroup analyses demonstrated statistically greater reductions in ITT with probiotics in subjects with vs without constipation(SMD: 0.57 vs 0.22, P < 0.01) and in studies with high vs low study quality(SMD: 0.45 vs 0.00, P = 0.01). Constipation(R^2 = 38%, P < 0.01), higher study quality(R^2 = 31%, P = 0.01), older age(R^2 = 27%, P = 0.02), higher percentage of female subjects(R^2 = 26%, P = 0.02), and fewer probiotic strains(R^2 = 20%, P < 0.05) were predictive of decreased ITT with probiotics in meta-regression. Medium to large treatment effects were identified with B. lactis HN019(SMD: 0.67, P < 0.001) and B. lactis DN-173 010(SMD: 0.54, P < 0.01) while other probiotic strains yielded negligible reductions in ITT relative to control.CONCLUSION: Probiotic supplementation is moderately efficacious for reducing ITT in adults. Probiotics were most efficacious in constipated subjects, when evaluated in high-quality studies, and with certain probiotic strains. | Larry E Miller Angela K Zimmermann Arthur C Ouwehand | 2016 | World Journal of Gastroenterology2016，22，21： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员