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| 1 | Experimental models for cancer brain metastasis显示文摘Brain metastases are a leading cause of cancer-related mortality.However,progress in their treatment has been limited over the past decade,due to an incomplete understanding of the underlying biological mechanisms.Employing accurate in vitro and in vivo models to recapitulate the complexities of brain metastasis offers the most promising approach to unravel the intricate cellular and physiological processes involved.Here,we present a comprehensive review of the currently accessible models for studying brain metastasis.We introduce a diverse array of in vitro and in vivo models,including cultured cells using the Transwell system,organoids,microfluidic models,syngeneic models,xenograft models,and genetically engineered models.We have also provided a concise summary of the merits and limitations inherent to each model while identifying the optimal contexts for their effective utilization.This review serves as a comprehensive resource,aiding researchers in making well-informed decisions regarding model selection that align with specific research questions. | Zihao Liu Shanshan Dong Mengjie Liu Yuqiang Liu Zhiming Ye Jianhao Zeng Maojin Yao | 2024 | Cancer Pathogenesis and Therapy2024，2，1： | 0 |
| 2 | Micropore engineering on hollow nanospheres for ultra-stable sodium-selenium batteries显示文摘Attracted by high energy density and considerable conductivity of selenium(Se),Na-Se batteries have been deemed promising energy-storage systems.But,it still suffers from sluggish kinetic behaviors and similar“shuttling effect”to S-electrodes.Herein,utilizing uniform hollow carbon spheres as precursors,Se-material is effectively loaded through vapor-infiltration method.Owing to the distribution of optimized pores,the content of microspores could be up to~60%(<2 nm),serving important roles for the physical confinement effect.Meanwhile,the rich oxygen-containing groups and N-elements could be noted,inducing the evolution of electron-moving behaviors.More significantly,assisted by the interfacial C-Se bonds and tiny Se distributions,Se electrodes are activated during cycling.Used as cathodes for Na-Se systems,the as-resulted samples display a capacity of 593.9 mA h g^(-1)after 100 cycles at the current density of 0.1 C.Even after 6000 cycles,the capacity could be still kept at about 225 mA h g^(-1)at 5.0 C.Supported by the detailed kinetic analysis,the designed microspores size induces the increasing redox reaction of nano Se,whilst the surface traits further render the enhancement of pseudo-capacitive contributions.Moreover,after cycling,the product Sex(x<4)in pores serves as the primary active material.Given this,the work is anticipated to provide an effective strategy for advanced electrodes for Na-Se systems. | Gongke Wang Yumeng Chen Yu Han Lixue Yang Wenqing Zhao Changrui Chen Zihao Zeng Shuya Lei Shaohui Yuan Peng Ge | 2023 | Journal of Energy Chemistry2023，，5： | 0 |
| 3 | Magnetostrictive alloys:Promising materials for biomedical applications显示文摘Magnetostrictive alloys have attracted increasing attention in biomedical applications because of the ability to generate reversible deformation in the presence of external magnetic fields.This review focuses on the advances in magnetostrictive alloys and their biomedical applications.The theories of magnetostriction are systematically summarized.The different types of magnetostrictive alloys and their preparation methods are also reviewed in detail.The magnetostrictive strains and phase compositions of typical magnetostrictive alloys,including iron based,rare-earth based and ferrite materials,are presented.Besides,a variety of approaches to preparing rods,blocks and films of magnetostriction materials,as well as the corresponding methods and setups for magnetostriction measurement,are summarized and discussed.Moreover,the interactions between magnetostrictive alloys and cells are analyzed and emphasis is placed on the transduction and transformation process of mechanochemical signals induced by magnetostriction.The latest applications of magnetostrictive alloys in remote microactuators,magnetic field sensors,wireless implantable devices and biodegradable implants are also reviewed.Furthermore,future research directions of magnetostrictive alloys are prospected with focus on their potential applications in remote cell actuation and bone repair. | Chengde Gao Zihao Zeng Shuping Peng Cijun Shuai | 2022 | Bioactive Materials2022，7，2： | 0 |
| 4 | Adaptive smoothing length method based on weighted average of neighboring particle density for SPH fluid simulation显示文摘Background In the smoothed particle hydrodynamics(SPH)fluid simulation method,the smoothing length affects not only the process of neighbor search but also the calculation accuracy of the pressure solver.Therefore,it plays a crucial role in ensuring the accuracy and stability of SPH.Methods In this study,an adaptive SPH fluid simulation method with a variable smoothing length is designed.In this method,the smoothing length is adaptively adjusted according to the ratio of the particle density to the weighted average of the density of the neighboring particles.Additionally,a neighbor search scheme and kernel function scheme are designed to solve the asymmetry problems caused by the variable smoothing length.Results The simulation efficiency of the proposed algorithm is comparable to that of some classical methods,and the variance of the number of neighboring particles is reduced.Thus,the visual effect is more similar to the corresponding physical reality.Conclusions The precision of the interpolation calculation performed in the SPH algorithm is improved using the adaptive-smoothing length scheme;thus,the stability of the algorithm is enhanced,and a larger timestep is possible. | Rongda ZENG Zihao WU Shengbang DENG Jian ZHU Xiaoyu CHI | 2021 | Virtual Reality & Intelligent Hardware2021，3，2： | 0 |
| 5 | Spent graphite regeneration:Exploring diverse repairing manners with impurities-catalyzing effect towards high performance and low energy consumption显示文摘Spent battery recycling has received considerable attention because of its economic and environmental potential.A large amount of retired graphite has been produced as the main electrode material,accompanied by a detailed exploration of the repair mechanism.However,they still suffer from unclear repair mechanisms and physicochemical evolution.In this study,spent graphite was repaired employing three methodologies:pickling-sintering,pyrogenic-recovery,and high-temperature sintering.Owing to the catalytic effect of the metal-based impurities and temperature control,the as-obtained samples displayed an ordered transformation,including the interlayer distance,crystalline degree,and grain size.As anodes of lithium ions batteries,the capacity of repaired samples reached up to 310 mA h g^(-1)above after 300loops at 1.0 C,similar to that of commercial graphite.Meanwhile,benefitting from the effective assembly of carbon atoms in internal structure of graphite at>1400℃,their initial coulombic efficiency were>87%.Even at 2.0 C,the capacity of samples remained approximately 244 mA h g^(-1)after 500 cycles.Detailed electrochemical and kinetic analyses revealed that a low temperature enhanced the isotropy,thereby enhancing the rate properties.Further,economic and environmental analyses revealed that the revenue obtained through suitable pyrogenic-recovering manners was approximately the largest value(5500$t^(-1)).Thus,this study is expected to clarify the in-depth effect of different repair methods on the traits of graphite,while offering all-round evaluations of repaired graphite. | Yu Dong Zihao Zeng Zhengqiao Yuan Bing Wang Hai Lei Wenqing Zhao Wuyun Ai Lingchao Kong Yue Yang Peng Ge | 2024 | Journal of Energy Chemistry2024，91，4： | 0 |
| 6 | Advances in Study of Natural Antibacterial Medicines显示文摘This paper introduce the advances in study of antibacterial effects of natural medicines in the past ten years.The antibacterial components of natural medicines mainly include flavonoids,terpenoids,alkaloids,lignans,phenols,etc..This paper is intended to provide data reference for the research and development of new natural antibacterial medicines. | Ainuan LI Xiao YANG Zihao MA Rui ZENG | 2020 | Medicinal Plant2020，11，2： | 0 |
| 7 | Scavenging Effects of Kaolin on Fine Ash Formation during Zhundong Coal Combustion显示文摘The previous work found that the additive kaolin could scavenge not only sodium(Na)but also calcium(Ca)and magnesium(Mg),which is the important ash fluxing agents in low rank coal combustion.Such scavenging effects of kaolin on fine ash formation were studied in the present work.A typical Zhundong coal and its blends with kaolin at dosages of 1,2 and 4 wt%were combusted in an electrically heated drop tube furnace(DTF)at 1300℃.The fine ashes generated were collected and size segregated by a low pressure impactor(LPI).The morphology and chemical composition of fine ash were analyzed by scanning electron microscopy equipped with an energydispersive spectrometer(SEM-EDS).In addition,char/ash particles were sampled at various positions of DTF to elucidate how kaolin additive affected the fine ash formation process.The results further showed that apart from the scavenging of volatile Na,kaolin additive could also strongly scavenge the refractory Ca,Mg and Fe in the fine ash during Zhundong coal combustion,which transformed the sintered particles with irregular shape into melted spherical particles,and finally resulted in the considerable decrease of these elements in both PM_(0.4)and PM_(0.4-10)by melting and agglomeration.The close contacts between kaolin particles and coal resulted from physically mixing were a key factor responsible for the reaction of kaolin with the refractory Ca,Mg and Fe. | Fangqi Liu Xianpeng Zeng Yimin Xia Zihao Wang Dunxi Yu | 2021 | Energy Engineering2021，118，3： | 0 |
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