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| 1 | Severe Mycoplasma Pneumonia in Child with Bilateral Parapneumonic Effusion Successfully Treated with Integrated Chinese and Western Medicine: A Case Report显示文摘Mycoplasma pneumonia is a common communityacquired pneumonia(CAP)in Asia.Children suffering from M.pneumoniae tend to progress quickly and develop severe pneumonia with a poor prognosis.(1)Effective management of M.pneumoniae infections include macrolides,tetracyclines or fluoroquinolones, | ZENG Wen-ying LI Yan XU Zhi-lan XIE Xiao-lei XU Feng-qin RUI Na | 2018 | Chinese Journal of Integrative Medicine2018，24，9： | 27 |
| 2 | Augmented reality technology for preoperative planning and intraoperative navigation during hepatobiliary surgery: A review of current methods显示文摘Background: Augmented reality(AR) technology is used to reconstruct three-dimensional(3D) images of hepatic and biliary structures from computed tomography and magnetic resonance imaging data, and to superimpose the virtual images onto a view of the surgical field. In liver surgery, these superimposed virtual images help the surgeon to visualize intrahepatic structures and therefore, to operate precisely and to improve clinical outcomes.Data Sources: The keywords 'augmented reality', 'liver', 'laparoscopic' and 'hepatectomy' were used for searching publications in the Pub Med database. The primary source of literatures was from peer-reviewed journals up to December 2016. Additional articles were identified by manual search of references found in the key articles.Results: In general, AR technology mainly includes 3D reconstruction, display, registration as well as tracking techniques and has recently been adopted gradually for liver surgeries including laparoscopy and laparotomy with video-based AR assisted laparoscopic resection as the main technical application. By applying AR technology, blood vessels and tumor structures in the liver can be displayed during surgery,which permits precise navigation during complex surgical procedures. Liver transformation and registration errors during surgery were the main factors that limit the application of AR technology.Conclusions: With recent advances, AR technologies have the potential to improve hepatobiliary surgical procedures. However, additional clinical studies will be required to evaluate AR as a tool for reducing postoperative morbidity and mortality and for the improvement of long-term clinical outcomes. Future research is needed in the fusion of multiple imaging modalities, improving biomechanical liver modeling,and enhancing image data processing and tracking technologies to increase the accuracy of current AR methods. | Rui Tang Long-Fei Ma Zhi-Xia Rong Mo-Dan Li Jian-Ping Zeng Xue-Dong Wang Hong-En Liao Jia-Hong Dong | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，2： | 27 |
| 3 | U-Pb zircon geochronology and Hf isotope study of metamorphosed basic-ultrabasic rocks from metamorphic basement in southwestern Zhejiang:The response of the Cathaysia Block to Indosinian orogenic event显示文摘A combined study using LA-ICP-MS U-Pb dating, Hf isotopes, trace elements and the Ti-in-zircon geo-thermometer was carried out on zircons from the metamorphosed basic-ultrabasic rocks in the meta-morphic basement of the Cathaysia Block, southwestern Zhejiang Province. The formation and meta-morphic ages of the rocks from the metamorphic basement of the Cathaysia Block were determined based on zircon U-Pb geochronology. The age for the magmatic crystalline zircons from the protolith is about 1.85 Ga. The εHf(t) values of the older zircons were from ?7 to ?3, with two-stage model Hf ages (TDM2LC) of about 2.9 to 3.4 Ga, indicating that the source material was derived from anatexis and recy-cling of the Archean crust. The newly formed metamorphic zircons yielded U-Pb ages of 260―230 Ma. The metamorphic temperature calculated using the Ti-in-zircon geothermometer ranged from 610 to 720℃, consistent with the results from petrographic observations, indicating that the Cathaysia Block experienced an amphibolite facies metamorphism during the Indosinian. Results from this study pro-vided an important timeframe for the tectonic evolution in South China and the Southeast Asia during the Late Permian and Early Triassic times. | XIANG Hua ZHANG Li ZHOU HanWen ZHONG ZengQiu ZENG Wen LIU Rui JIN Song | 2008 | Science China Earth Sciences2008，51，6： | 24 |
| 4 | Paleoproterozoic reworking of ancient crust in the Cathaysia Block,South China:Evidence from zircon trace elements,U-Pb and Lu-Hf isotopes显示文摘A combined study of zircon LA-ICP-MS U-Pb dating, trace elements and Hf isotope was carried out for gneissic granite from the Sanzhishu area in Jingning, SW Zhejiang Province. Nearly all the zircons separated from the granite exhibited oscillatory zoning and high Th/U ratios (>0.1). The REE profile showed a pronounced positive Ce anomaly, negative Eu anomaly and an enrichment of HREE, which are typical characteristics of magmatic zircon. Thirteen concordant or nearly concordant analytical data yielded a weighted mean 207Pb/206Pb age of 1860±13 Ma (MSWD=0.084), representing the formation age of the granite. The magmatic zircons had negative εHf(t) values of -15.6 to -10.0 and two-stage Hf model ages of 3.1 to 3.4 Ga, indicating that the granites were formed by reworking of ancient crust. The major- and trace-element data indicate that the gneissic granites are metaluminous high-K calc-alkaline rocks and exhibit the same geochemical characteristics as aluminous A-type granites, implying the emplacement of the granite in a post-orogenic extensional tectonic setting. We conclude that the Pa-leoproterozoic crustal reworking event in the Cathaysia Block of South China marked the transition from assembly to break-up of the Columbia supercontinent. | LIU Rui ZHOU Han Wen ZHANG Li ZHONG ZengQiu ZENG Wen XIANG Hua JIN Song LU Xin Qian LI ChunZhong | 2009 | Chinese Science Bulletin2009，54，9： | 22 |
| 5 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 6 | Clinical significance of diabetes on symptom and patient delay among patients with acute myocardial infarction——an analysis from China Acute Myocardial Infarction(CAMI) registry显示文摘Background Diabetes is frequently associated with poor prognosis among acute myocardial infarction(AMI)patients.Patients with these comorbidities often have atypical symptoms and subsequent delay in treatment.Few studies have reported detailed AMI symptoms in patients with diabetes.This study compared AMI symptoms and presentation characteristics between diabetics and non-diabetics.Methods We included patients from the China AMI registry diagnosed with AMI between January 2013 and September 2014.Baseline characteristics,symptomology,and delay in treatment were compared between diabetics and non-diabetics.Multivariable logistic regression analysis was used to explore independent predictors of atypical symptoms.Results A total of 4450(20.2%)patients had diabetes.They were older,more often women,higher in body mass index,and more likely to have non-ST segment elevation myocardial infarction.Fewer diabetic patients presented with persistent precordial chest pain(63.1%vs.68%,P<0.0001),diaphoresis(60.1%vs.65.6%,P<0.0001),fatigue(16.7%vs.18.3%,P=0.0123),and incontinence(0.4%vs.0.7%,P=0.0093).Time to hospital presentation was longer among patients with diabetes than those without.In multivariable analysis,diabetes was identified as an independent predictor of atypical symptoms(OR:1.112,95%CI:1.034?1.196).Conclusions Our study is the first large-scale study providing evidence that diabetics are less likely to present with typical chest pain and more likely to experience treatment delay when suffering from an AMI.Our results may increase clinician awareness of recognizing AMI patients rapidly to reduce diagnosis and treatment delay,particularly in the context of diabetes. | Rui FU Si-Dong LI Chen-Xi SONG Jing-Ang YANG Hai-Yan XU Xiao-Jin GAO Yi XU Jian-Ping ZENG Jun-Nong LI Ke-Fei DOU Yue-Jin YANG on behalf of the CAMI Registry study group Beijing,China | 2019 | Journal of Geriatric Cardiology2019，16，5： | 21 |
| 7 | Bacterial community in sediment from the Western Pacific 'Warm Pool' and its relationship to environment显示文摘Total DNAs were extracted from different sections of deep sea sediment core sample collected from the Western Pacific 'Warm Pool'. The bacterial 16S ribosomal DNA (rDNA) clone libraries were constructed and analyzed by PCR-restriction fragment length polymorphism (RFLP) and DNA sequencing. The bacterial communities in these samples and their relationship to environment were analyzed consequently. The results indicated that among eight main bacterial groups found in these sediments, members of the γ-Proteobacteria were most abundant in each section of sediment core sample and the genus Colwellia belonging to γ-Proteobacteria was dominant in this area. Members of the α-Proteobacteria were found commonly existing in these samples, while members belonging to β-Proteobacteria were seldom detected. The diversity of bacterial communities from different sections of sediment core sample was δ- and ε-Proteo- bacteria and the bacterial group including genera Cytopahga, Flexibacteria and Bacteroides (CFB group). These bacteria all were inversely proportional to the depth of sediment. Phylogenetic analysis showed that there were 18%-30% and 15%-25% of total bacterial communities related to methane and sulfur metabolism respectively in each section of core sample, implicating that the metabolism of sulfur and methane played an important role in the substance and energy cycles of the Western Pacific 'Warm Pool'. | ZENG Runying ZHAO Jing ZHANG Rui LIN Nianwei | 2005 | Science China Earth Sciences2005，48，2： | 21 |
| 8 | Caledonian reworking of Paleoproterozoic basement in the Cathaysia Block: Constraints from zircon U-Pb dating, Hf isotopes and trace elements显示文摘A combined study of zircon U-Pb dating, Hf isotopes and trace elements has been carried out for granodioritic neosomes of migmatites from the Tianjingping area in northwestern Fujian Province. Zircons are characterized by zoning, higher Th/U ratios (mostly ≥0.1), HREE enrichment, and positive Ce and negative Eu anomalies, and show features similar to magmatic or anatectic zircons. Apparent 206Pb/238U ages for the zircons are 447±2 Ma (95% conf., MSWD = 0.88), corresponding to a Caledonian event. εHf(t) values are ?13.3 to ?9.7, indicating a crustal source. Two-stage Hf model ages are 1.7 to 1.9 Ga, suggesting that protolith of the migmates was probably formed in the Paleoproterozoic. The granodioritic neosomes have the characteristics of peraluminous calc-alkaline granite, and their REE patterns and trace elements spidergrams show features of middle to upper crustal rocks. Together with previous studies, we conclude that the protolith of the Cathaysia basement in the Tianjingping area was likely formed in the middle-late Paleoproterozoic and experienced partial melting during the Caledonian period. The recognition of Caledonian reworking of the Paleoproterozoic basement in the Cathaysia Block provides a new insight into the tectonic evolution of the Cathaysia Block in the Caledonian pe- riod and the interaction between the Cathaysia Block and the Yangtze Block. | ZENG Wen ZHANG Li ZHOU HanWen ZHONG ZengQiu XIANG Hua LIU Rui JIN Song LU XinQian LI ChunZhong | 2008 | Chinese Science Bulletin2008，53，6： | 21 |
| 9 | Measuring reliability under epistemic uncertainty:Review on non-probabilistic reliability metrics显示文摘In this paper,a systematic review of non-probabilistic reliability metrics is conducted to assist the selection of appropriate reliability metrics to model the influence of epistemic uncertainty.Five frequently used non-probabilistic reliability metrics are critically reviewed,i.e.,evidencetheory-based reliability metrics,interval-analysis-based reliability metrics,fuzzy-interval-analysisbased reliability metrics,possibility-theory-based reliability metrics(posbist reliability) and uncertainty-theory-based reliability metrics(belief reliability).It is pointed out that a qualified reliability metric that is able to consider the effect of epistemic uncertainty needs to(1) compensate the conservatism in the estimations of the component-level reliability metrics caused by epistemic uncertainty,and(2) satisfy the duality axiom,otherwise it might lead to paradoxical and confusing results in engineering applications.The five commonly used non-probabilistic reliability metrics are compared in terms of these two properties,and the comparison can serve as a basis for the selection of the appropriate reliability metrics. | Kang Rui ZhangQingyuan Zeng Zhiguo Enrico Zio Li Xiaoyang | 2016 | Chinese Journal of Aeronautics2016，29，3： | 18 |
| 10 | Single-cell transcriptomic analysis defines the interplay between tumor cells,viral infection,and the microenvironment in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an Epstein-Barr virus(EBV)-associated malignancy with a complex tumor ecosystem.How the interplay between tumor cells,EBV,and the microenvironment contributes to NPC progression and immune evasion remains unclear.Here we performed single-cell RNA sequencing on^104,000 cells from 19 EBV^+NPCs and 7 nonmalignant nasopharyngeal biopsies,simultaneously profiling the transcriptomes of malignant cells,EBV,stromal and immune cells.Overall,we identified global upregulation of interferon responses in the multicellular ecosystem of NPC.Notably,an epithelial–immune dual feature of malignant cells was discovered and associated with poor prognosis.Functional experiments revealed that tumor cells with this dual feature exhibited a higher capacity for tumorigenesis.Further characterization of the cellular components of the tumor microenvironment(TME)and their interactions with tumor cells revealed that the dual feature of tumor cells was positively correlated with the expression of co-inhibitory receptors on CD8^+tumor-infiltrating T cells.In addition,tumor cells with the dual feature were found to repress IFN-γproduction by T cells,demonstrating their capacity for immune suppression.Our results provide new insights into the multicellular ecosystem of NPC and offer important clinical implications. | Shanzhao Jin Ruoyan Li Ming-Yuan Chen Chao Yu Lin-Quan Tang Yan-Min Liu Jiang-Ping Li Yi-Na Liu Yi-Ling Luo Yifan Zhao Yu Zhang Tian-Liang Xia Shang-Xin Liu Qi Liu Guan-Nan Wang Rui You Jing-Yun Peng Jiang Li Feng Han Jianwei Wang Qiu-Yan Chen Li Zhang Hai-Qiang Mai Benjamin E.Gewurz Bo Zhao Lawrence S.Young Qian Zhong Fan Bai Mu-Sheng Zeng | 2020 | Cell Research2020，30，11： | 16 |
| 11 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 12 | Purified polysaccharide from Ginkgo biloba leaves inhibits P-selectin-mediated leucocyte adhesion and inflammation显示文摘目的: 由禁止白细胞 adhesion.Methods 调查白果树 biloba 叶子(PGBL ) 的多糖的反煽动性的机制: 不平的 PGBL 被孤立并且净化。净化的 PGBL (p-PGBL ) 的反煽动性的效果是由混合二甲苯和急性腹膜炎模型在老鼠导致的耳朵浮肿的 assayed。禁止在 P-selectin 和它的 ligands 之间的相互作用上的 p-PGBL 的效果被流动血细胞计数调查,流动 chamber.Results:p-PGBL 能有效地处于静态的条件与对 P-selectin 的 HL-60 房间,一根人的白血球过多症房间线,或 neutrophils 的粘附在老鼠和interfere 禁止急性炎,象到在一个剂量家属处于流动条件表示人的 P-selectin 和人的脐的静脉 endothelial 的中国仓鼠卵巢房间的 neutrophils 的粘附一样, manner.Conclusions:p-PGBL 能通过防碍在 P-selectin 和它的 ligands 之间的相互作用禁止煽动性的过程。 | Rui EEI Yu EEI Sheng ZHENG Yan-guang GAO Hong-xia SUN Xian-lu ZENG | 2008 | Acta Pharmacologica Sinica2008，29，4： | 12 |
| 13 | Improving grain yield, nitrogen use efficiency and radiation use efficiency by dense planting, with delayed and reduced nitrogen application, in double cropping rice in South China显示文摘Improving both grain yield and resource use efficiencies simultaneously is a major challenge in rice production.However,few studies have focused on integrating dense planting with delayed and reduced nitrogen application to enhance grain yield,nitrogen use efficiency (NUE) and radiation use efficiency (RUE) in rice (Oryza sativa L.) in the double rice cropping system in South China.A high-yielding indica hybrid rice cultivar (Yliangyou 143) was grown in field experiments in Guangxi,South China,with three cultivation managements:farmers’practice (FP),dense planting with equal N input and delayed N application (DPEN) and dense planting with reduced N input and delayed N application (DPRN).The grain yields of DPRN reached 10.6 and 9.78 t ha^(–1) in the early and late cropping seasons,respectively,which were significantly higher than the corresponding yields of FP by 23.9–29.9%.The grain yields in DPEN and DPRN were comparable.NUE in DPRN reached 65.2–72.9 kg kg^(–1),which was 61.2–74.1% higher than that in FP and 24.6–30.2% higher than that in DPEN.RUE in DPRN achieved 1.60–1.80 g MJ^(–1),which was 28.6–37.9% higher than that in FP.The productive tiller percentage in DPRN was 7.9–36.2% higher than that in DPEN.Increases in crop growth rate,leaf area duration,N uptake from panicle initiation to heading and enhancement of the apparent transformation ratio of dry weight from stems and leaf sheaths to panicles all contributed to higher grain yield and higher resource use efficiencies in DPRN.Correlation analysis revealed that the agronomic and physiological traits mentioned above were significantly and positively correlated with grain yield.Comparison trials carried out in Guangdong in 2018 and 2019 also showed that DPRN performed better than DPEN.We conclude that DPRN is a feasible approach for simultaneously increasing grain yield,NUE and RUE in the double rice cropping system in South China. | FU You-qiang ZHONG Xu-hua ZENG Jia-huan LIANG Kai-ming PAN Jun-feng XIN Ying-feng LIU Yan-zhuo HU Xiang-yu PENG Bi-lin CHEN Rong-bing HU Rui HUANG Nong-rong | 2021 | Journal of Integrative Agriculture2021，20，2： | 12 |
| 14 | Small RNAs, emerging regulators critical for the development of horticultural traits显示文摘Small RNAs(sRNAs)have been recently recognized as key genetic and epigenetic regulators in various organisms,ranging from the modification of DNA and histone methylations to the modulation of the abundance of coding or non-coding RNAs.In plants,major regulatory sRNAs are classified as respective microRNA(miRNA)and small interfering RNA(siRNA)species,with the former primarily engaging in posttranscriptional regulation while the latter in transcriptional one.Many of these characterized sRNAs are involved in regulation of diverse biological programs,processes,and pathways in response to developmental cues,environmental signals/stresses,pathogen infection,and pest attacks.Recently,sRNAs-mediated regulations have also been extensively investigated in horticultural plants,with many novel mechanisms unveiled,which display far more mechanistic complexity and unique regulatory features compared to those studied in model species.Here,we review the recent progress of sRNA research in horticultural plants,with emphasis on mechanistic aspects as well as their relevance to trait regulation.Given that major and pioneered sRNA research has been carried out in the model and other plants,we also discuss ongoing sRNA research on these plants.Because miRNAs and phased siRNAs(phasiRNAs)are the most studied sRNA regulators,this review focuses on their biogenesis,conservation,function,and targeted genes and traits as well as the mechanistic relation between them,aiming at providing readers comprehensive information instrumental for future sRNA research in horticulture crops. | Chengjie Chen Zaohai Zeng Zongrang Liu Rui Xia | 2018 | Horticulture Research2018，5，1： | 12 |
| 15 | Antiviral treatment of hepatitis B virus-transgenic mice by a marine organism, Styela plicata显示文摘瞄准:在肝炎 B 搬运人的一个鼠科的模型评估 Styela plicata 的有效成分的抗病毒的效果。方法:HBV 转基因的老鼠被划分成 3 个组(控制组, lamivudine 处理组和 Styela plicata 处理组的有效成分) 并且分配了收到正常饮食, lamivudine 或 Styela plicata 的有效成分连续星期。浆液肝炎 B 表面抗原被连接酶的免疫检测吸着剂试金(ELISA ) 方法。浆液 HBV DNA 被即时聚合酶链反应(RT-PCR ) 检测。浆液 T 助手(h) 1 cytokine interleukin (IL )-2 和 Th2 cytokine IL-6 被量的三明治酶免疫分析技术检测。另一组 HBV 转基因的老鼠被分配收到 Styela plicata 的有效成分连续星期。肝组织的组织学在治疗前后被评估。结果:12 个星期在开始治疗以后,浆液肝炎 B 表面抗原显著地在 Styela plicata 被降低与收到正常饮食的老鼠相比对待老鼠和对待 lamivudine 的老鼠(F (12wk )= 88.81, P (12wk )= 0.000 <0.01 ) 。浆液 HBV DNA 显著地在 Styela plicata 被降低与收到正常饮食的老鼠相比对待老鼠和对待 lamivudine 的老鼠(F (12wk )= 20.71, P (12wk )= 0.000 <0.01 ) 。然而, Styela plicata 的有效成分象 lamivudine 一样,不能完全禁止 HBV 的复制。在重量的单位的肝炎 B 表面抗原和 HBV DNA 的回缩现象一 could 在药的退却以后被发现 4 wk。八个星期在开始治疗以后,在 IL-2 的 Styela plicata 处理前后的浆液层次是 2.41 +/- 0.38 和 10.56 +/- 0.78 ng/L,分别地(t (8wk )=-16.51, P (8wk )= 0.000 <0.01 ) 。与在正常对待食谱的老鼠的 IL-2 的浆液层次相比(2.48+/-0.17 ng/L;t (8wk )= 13.23, P (8wk )= 0.000 <0.01 ) 。在 IL-6 的 Styela plicata 处理前后的浆液层次是 63.62 +/- 分别地, 6.22 ng/L 在正常对待食谱的老鼠 IL-6 与浆液相比铺平的 6.31 和 54.52 +/-(60.84 +/- 4.21 ng/L ) 。从 Styela 对待 plicata 的 HBV 转基因的老鼠的肝的组织学的分析也在发炎和肝炎 B 表面抗原显示出下降地位。结论:Styela plicata 可以是在对待长期的肝炎 B 的有效的抗病毒的药。 | Rui Wang Zhen-Lan Du Wen-Jun Duan Xin Zhang Fan-Lin Zeng Xin-Xiang Wan | 2006 | World Journal of Gastroenterology2006，12，25： | 12 |
| 16 | Synthesis and curing of a novel amino-containing phthalonitrile derivative显示文摘A novel phthalonitrile derivative containing an amino group, 3,5-bis(3,4-dicyanophenoxy)aniline (CPA), was synthesized via a nucleophilic displacement of 4-nitrophthalonitrile and 5-aminoresorcinol hydrochloride. The structure of CPA was confirmed by Fourier transform infrared spectra (FT-IR) and nuclear magnetic resonance (1H NMR). Thermal analysis performed on CPA revealed that the novel phthalonitrile derivative showed a self-promotion curing behavior and the resulting polymer exhibited outstanding heat-resistance. | Ke Zeng Ke Zhou Wen Rui Tang Yan Tang Hong Fei Zhou Tao Liu Yi Peng Wang Hai Bing Zhou Gang Yang | 2007 | Chinese Chemical Letters2007，18，5： | 12 |
| 17 | Impact of one satellite outage on ARAIM depleted constellation configurations显示文摘Advanced Receiver Autonomous Integrity Monitoring(ARAIM) is a new technology that will provide worldwide coverage of vertical guidance in aviation navigation. The ARAIM performance and improvement under depleted constellations is a practical problem that needs to be faced and researched further. It is a shortcut that improves the availability in position domain whose key idea is to replace the conventional least squares process with a non-least-squares estimator to lower the integrity risk in exchange for a slight increase in nominal position error. The contributions given in this paper include two parts: First, the impacts of one satellite outage on different constellations are analyzed and compared. The conclusion is that GPS is more sensitive and vulnerable to one satellite outage. Second, a constellation weighted ARAIM(CW-ARAIM)position estimator is proposed. The position solution is replaced by a constellation weighted average solution to eliminate the constellation difference. The new solution will move close to the constellation solutions with respect to the accuracy requirement. The simulation results under baseline GPS and Galileo dual-constellation show that the one GPS satellite outage will knock the availability from 91% to only 50%. The performance remains stable with one Galileo satellite outage. With the assistance of the CW-ARAIM method, the availability can increase from 50% to more than80% under depleted GPS configurations. Even without any satellite outage, the proposed method can effectively improve the availability from 91.29% to 98.75%. The test results under optimistic constellations further verify that a balanced constellation is more important than more satellites on orbit and the superiority of CW-ARAIM method is still effective. | Qian MENG Jianye LIU Qinghua ZENG Shaojun FENG Rui XU | 2019 | Chinese Journal of Aeronautics2019，32，4： | 11 |
| 18 | Predictive value of antiplatelet resistance on early stent thrombosis in patients with acute coronary syndrome显示文摘 | LI Lei LI Hai-yan QIAO Rui YU Hai-yi ZENG Hui GAO Wei ZHANG Jie | 2013 | Chinese Medical Journal2013，，4： | 11 |
| 19 | Characteristics and formation mechanism of regional haze episodes in the Pearl River Delta of China显示文摘To investigate the characteristics and the specific mechanism of continuous haze,comprehensive measurements were conducted from 15 October to 19 November in the Atmospheric Environment Monitoring Super-Station in Heshan of Guangdong province.Five haze episodes occurred in October and November 2014 in the Pearl River Delta(PRD)region. The meteorological parameters, gas data, chemical compositions, and optical parameters of the aerosols were obtained. Among these events, the second haze episode,with the highest concentration of PM2.5 of 187.51 μg/m^3, was the most severe. NO^3-was always higher than SO_4^(2-), which indicated that motor vehicles played an important role in the haze, even though the oxidation rate from SO_2 to SO_4^(2-)was faster than that of NOXto NO_3^-. The difference between the hourly averages of Na+and K+during the haze episode and clean days was small, implying that straw combustion and sea salt had no significant effect on the occurrence of haze, and the backward trajectories of the air masses also conformed with this result. The air pollutants were difficult to disperse because of the significant decrease in the planetary boundary layer(PBL) height. Relative humidity played a crucial role in the formation of haze by leading to hygroscopic growth of the diameter of aerosols. | Wenguang Li Xingang Liu Yuanhang Zhang Kang Sun Yusheng Wu Rui Xue Limin Zeng Yu Qu Junling An | 2018 | Journal of Environmental Sciences2018，30，1： | 11 |
| 20 | Synthesis of a benzoxazine monomer containing maleimide and allyloxy groups显示文摘新奇 benzoxazine 单体 3-(4-allyloxy )phenyl-3,4-dihydro-2H-6-(N-maleimido )-1,3-benzoxazine (AMB ) 被综合,结构被英尺红外证实,(1 ) H NMR。AMB 的热分析(DSC ) 证明烯丙氧基组的介绍减少了熔点并且展出了一扇狭窄、对称的治好的发热的窗户。 | Yan Tang Qing Lai Zhao Ke Zeng Pei Kai Miao Ke Zhou Wen Rui Tang Hong Fei Zhou Tao Liu Yi Peng Wang Gang Yang | 2007 | Chinese Chemical Letters2007，18，8： | 10 |
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