|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Bioprinting of novel 3D tumor array chip for drug screening显示文摘Biomedical field has been seeking a feasible standard drug screening system consisting of 3D tumor model array for drug researching due to providing sufficient samples and simulating actual in vivo tumor growth situation,which is still a challenge to rapidly and uniformly establish though.Here,we propose a novel drug screening system,namely 3D tumor array chip with“layer cake”structure,for drug screening.Accurate gelatin methacryloyl hydrogel droplets(~0.1μL)containing tumor cells can be automatically deposited on demand with electrohydrodynamic 3D printing.Transparent conductive membrane is introduced as a chip basement for preventing charges accumulation during fabricating and convenient observing during screening.Culturing chambers formed by stainless steel and silicon interlayer is convenient to be assembled and recycled.As this chip is compatible with the existing 96-well culturing plate,the drug screening protocols could keep the same as convention.Important properties of this chip,namely printing stability,customizability,accuracy,microenvironment,tumor functionalization,are detailly examined.As a demonstration,it is applied for screening of epirubicin and paclitaxel with breast tumor cells to confirm the compatibility of the proposed screening system with the traditional screening methods.We believe this chip will potentially play a significant role in drug evaluation in the future. | Mingjun Xie Qing Gao Jianzhong Fu Zichen Chen Yong He | 2020 | Bio-Design and Manufacturing2020，3，3： | 3 |
| 2 | EXPERIMENTAL STUDY ON THE HOT EMBOSSING POLYMER MICROFLUIDIC CHIP显示文摘Experiments are used to study the fabrication of polymer microfluidic chip with hot embossing method.The pattern fidelity with respect to the process parameters is analyzed. Experiment results show that the relationship between the imprint temperature and the microchannel width is approximately exponential.However,the depth of micro channel isn't sensitive to the imprint temperature.When the imprint pressure is larger than 1 MPa and the imprint time is longer than 2 rain,the increasing of imprint pressure and holding time has little impact on the microchannel width. So over long holding time is not needed in hot embossing.Based on the experiment analysis,a series of optimization process parameters is obtained and a fine microfluidic chip is fabricated.The electrophoresis separation experiment are used to verify the microfluidic chip performance after bonding.The results show that 100bp-ladder DNA sample can be separated in less than 5 min successfully. | HE Yong FU Jianzhong CHEN Zichen | 2008 | Chinese Journal of Mechanical Engineering2008，21，3： | 2 |
| 3 | 12-Tungstophosphoric acid niched in Zr-based metal-organic framework:a stable and efficient catalyst for Friedel-Crafts acylation显示文摘Heteropoly acids(HPA) are well known for their versatile solid acid catalysis in diverse chemical reactions, however they suffer from low surface area(<10 m^2/g) and leaching into the reactions media, which reduce their prospects as industrial catalyst.Herein, a novel hybrid material HPW@Zr-BTC,composed of 12-tungstophoric acid(HPW) and Zr^(Ⅳ)-benzene tri-carboxylate(Zr-BTC) metal-organic framework(MOF), was prepared via one-pot solvothermal method. Excellent HPW loading up to 32.3 wt% was achieved, and HPW@Zr-BTC composite proved to be highly stable, besides the crystalline morphology of Zr-BTC was intact. The catalytic activity of the hybrid composite was explored via Friedel-Crafts acylation of anisole with benzoyl chloride.The 28.2 wt% HPW@Zr-BTC showed excellent catalytic performance, with 99.4% anisole conversion and 97.6% yield(pmethoxybenzophenone) under solvent free conditions. Excellent retention of catalytic activity was achieved after at least five consecutive runs due to non-observable HPW leaching. The promising activity and stability of the catalyst forecasted its potential industrial applications. | Latif Ullah Guoying Zhao Zichen Xu Hongyan He Muhammad Usman Suojiang Zhang | 2018 | Science China Chemistry2018，61，4： | 2 |
| 4 | Automatic visual inspection for leather manufacture 显示文摘 | HE Fuqiang WANG Wen CHEN Zichen | 2006 | Key Eng Mater2006，，12： | 1 |
| 5 | Aero-optical effects simulation technique for starlight transmission in boundary layer under high-speed conditions显示文摘Aero-optical effects for starlight transmission in the high-speed flow field will reduce the accuracy of the star sensor on an aircraft.Numerical simulations for aero-optical effects usually require plenty of calculations,which cause difficulties when designing a celestial navigation system for a high-speed aircraft.In this study,an Aero-Optical Simulator For Starlight Transmission(AOSST)in the boundary layer is developed.It effectively reduces the computational burden compared to that of the widely used CFD simulation,and it achieves satisfactory accuracy.In this simulator,gas ellipsoids satisfying certain design rules are used to simulate coherent density structures in boundary layers.Design rules for the gas ellipsoids are found from published experimental and high-fidelity CFD simulation results.The generated wavefront distortion by AOSST is anchored with the scale law for aero-optical distortion in the boundary layer by determining some control parameters,which enables the simulator to output reliable results over a wide range of flight states.Four numerical examples are provided to verify the performance of AOSST.The results demonstrate that AOSST is able to simulate the directional dependence of aero-optical distortions in boundary layers,the variation trend of distorted wavefront shapes with Reynolds number,and the grayscale distribution on the disturbed star map. | Bo YANG Zichen FAN He YU | 2020 | Chinese Journal of Aeronautics2020，33，7： | 1 |
| 6 | Near-infrared fluorophores with absolute aggregation-caused quenching and negligible fluorescence re-illumination for in vivo bioimaging of nanocarriers显示文摘Environment-responsive fluorophores with aggregation-caused quenching(ACQ)properties have been applied to track nanocarriers with reduced artefacts caused by unbound or free fluorophores but suffer from incomplete fluorescence quenching and significant re-illumination,which undermine bioimaging accuracy.Herein,through structural modifications to reinforce the hydrophobicity,planarity and rigidity of fluorophores with an aza-BODIPY framework,probes featuring absolute ACQ(aACQ)and negligible re-illumination are developed and evaluated in various nanocarriers.aACQ probes,FD-B21 and FD-C7,exhibit near-infrared emission,high quantum yield,photostability,water sensitivity,and negligible re-illumination in blood,plasma and 1%Tween-80 in contrast to ACQ probe P2 and conventional probe DiR.All nanocarriers can be labeled efficiently by the tested fluorophores.Polymeric micelles(PMs)labeled by different aACQ probes manifest similar biodistribution patterns,which however differ from that of DiR-labeled PMs and could be ascribed to the appreciable re-illumination of DiR.Significantly lower re-illumination is also found in aACQ probes(2%-3%)than DiR(20%-40%)in Caco-2,Hela,and Raw264.7 cells.Molecular dynamics simulations unravel the molecular mechanisms behind aggregation and re-illumination,supporting the hypothesis of planarity dependency.It is concluded that aACQ fluorophores demonstrate excellent water sensitivity and negligible fluorescence re-illumination,making themselves useful tools for more accurate bioimaging of nanocarriers. | Yifan Cai Xin Ji Yunsen Zhang Chang Liu Zichen Zhang Yongjiu Lv Xiaochun Dong Haisheng He Jianping Qi Yi Lu Defang Ouyang Weili Zhao Wei Wu | 2023 | Aggregate2023，4，2： | 0 |
| 7 | High-speed 2D beam steering based on a thin-film lithium niobate optical phased array with a large field of view显示文摘An on-chip optical phased array (OPA) is considered as a promising solution for next generation solid-state beam steering.However,most of the reported OPAs suffer from low operating bandwidths,making them limited in many applications.We propose and demonstrate a high-speed 2D scanning OPA based on thin-film lithium niobate phase modulators with traveling-wave electrodes.The measured modulation bandwidth is up to 2.5 GHz.Moreover,an aperiodic array combined with a slab grating antenna is also used to suppress the grating lobes of far-field beams,which enables a large field of view (FOV) as well as small beam width.A 16-channel OPA demonstrates an FOV of 50°×8.6°and a beam width of 0.73°×2.8°in the phase tuning direction and the wavelength scanning direction,respectively. | WENLEI LI XU ZHAO JIANGHAO HE HAO YAN BINGCHENG PAN ZICHEN GUO XIANG’E HAN JINGYE CHEN DAOXIN DAI YAOCHENG SHI | 2023 | Photonics Research2023，11，11： | 0 |
| 8 | A review of mobile robot motion planning methods:from classical motion planning workflows to reinforcement learning-based architectures显示文摘Motion planning is critical to realize the autonomous operation of mobile robots.As the complexity and randomness of robot application scenarios increase,the planning capability of the classical hierarchical motion planners is challenged.With the development of machine learning,the deep reinforcement learning(DRL)-based motion planner has gradually become a research hotspot due to its several advantageous feature.The DRL-based motion planner is model-free and does not rely on the prior structured map.Most importantly,the DRL-based motion planner achieves the unification of the global planner and the local planner.In this paper,we provide a systematic review of various motion planning methods.Firstly,we summarize the representative and state-of-the-art works for each submodule of the classical motion planning architecture and analyze their performance features.Then,we concentrate on summarizing reinforcement learning(RL)-based motion planning approaches,including motion planners combined with RL improvements,map-free RL-based motion planners,and multi-robot cooperative planning methods.Finally,we analyze the urgent challenges faced by these mainstream RLbased motion planners in detail,review some state-of-the-art works for these issues,and propose suggestions for future research. | DONG Lu HE Zichen SONG Chunwei SUN Changyin | 2023 | Journal of Systems Engineering and Electronics2023，34，2： | 0 |
| 9 | Targeting LncRNA LLNLR-299G3.1 with antisense oligonucleotide inhibits malignancy of esophageal squamous cell carcinoma cells in vitro and in vivo显示文摘Accumulating evidence has indicated that long non-coding RNAs(lncRNAs)play critical roles in the development and progression of cancers,including esophageal squamous cell carcinoma(ESCC).However,the mechanisms of lncRNAs in ESCC are still incompletely understood and therapeutic attempts for in vivo targeting cancer-associated lncRNA remain a challenge.By RNA-sequencing analysis,we identified that LLNLR-299G3.1 was a novel ESCC-associated lncRNA.LLNLR-299G3.1 was up-regulated in ESCC tissues and cells and promoted ESCC cell proliferation and invasion.Silencing of LLNLR-299G3.1 with ASO(antisense oligonucleotide)resulted in opposite effects.Mechanistically,LLNLR-299G3.1 bound to cancerassociated RNA binding proteins and regulated the expression of cancer-related genes,including OSM,TNFRSF4,HRH3,and SSTR3.ChIRP-seq(chromatin isolation by RNA purification and sequencing)revealed that these genes contained enriched chromatin binding sites for LLNLR-299G3.1.Rescue experiments confirmed that the effects of LLNLR-299G3.1 on ESCC cell proliferation were dependent on interaction with HRH3 and TNFRSF4.Therapeutically,intravenous delivery of placental chondroitin sulfate A binding peptide-coated nanoparticles containing antisense oligonucleotide(pICSA-BP-ANPs)strongly inhibited ESCC tumor growth and significantly improved animal survival in vivo.Overall,our results suggest that LLNLR-299G3.1 promotes ESCC malignancy through regulating gene-chromatin interactions and targeting ESCC by pICSA-BP-ANPs may be an effective strategy for the treatment of lncRNA-associated ESCC. | LI TIAN YONGYI HUANG BAOZHEN ZHANG YI SONG LIN YANG QIANQIAN CHEN ZHENG WANG YILING WANG QIHAN HE WENHAN YANG SHUYONG YU TIANYU LU ZICHEN LIU KAIPING GAO XIUJUN FAN JIAN SONG RIHONG ZHAI | 2023 | Oncology Research2023，31，4： | 0 |
| 10 | Experiments and Analysis of Corona Inception Voltage Under Combined AC-DC Voltages at Various Air Pressure and Humidity in Rod to Plane Electrodes显示文摘As the effect of climate plays a significant role in corona discharge under combined voltages,the variation of corona inception voltage with different air pressure and humidities is studied.An experimental platform,based on a rod-to-plane electrode,is constructed with adjustable air pressure from 0.06 MPa to 0.10 MPa and with a relative humidity(RH)from 20%to 90%.The variation of ultraviolet(UV)photon count and corona inception voltage is obtained at various climate conditions under different applied voltages:the single AC,single DC,and combined AC-DC.It turns out that all the corona inception voltages decline with the drop of air pressure and the rise of humidity under different applied voltages.The influence between different voltages primarily relies on space charge,as more AC components make it easier to accumulate positive ions.The existence of AC makes ions move forward and backward while the existence of DC dominates the polarity of corona and general drift directions.At last the fitting formula of hybrid corona inception voltage combining air pressure and relative humidity is given. | Zichen He Junyu Zhu Jie Zhu Xingming Bian Boyang Shen | 2021 | CSEE Journal of Power and Energy Systems2021，7，4： | 0 |
| 11 | Erratum on “12-tungstophosphoric acid niched in Zr-BTC: a stable and efficient catalyst for Friedel-Crafts acylation” [Sci.China Chem., 2018, 61: 402–411]显示文摘Erratum to:Sci China Chem,2018,61:402-411,http://gffzzd3cc09b8251d45dfs9qb96xbcckox6w9b.ffgz.tsg.suse.edu.cn/10.1007/sll426-017-9182-0 For the above referenced publication[1],there is a correction in the Figure 9.Figure 9 Catalytic activity of pristine Zr-BTC(a),18.6 wt%HPW@Zr-BTC(b),25.2 wt%HPW@Zr-BTC(c). | Latif Ullah Guoying Zhao Zichen Xu Hongyan He Muhammad Usman Suojiang Zhang | 2021 | Science China Chemistry2021，64，8： | 0 |
| 12 | A Content-Based Recommendation Framework for Judicial Cases显示文摘Under the background of the Judicial Reform of China, big data of judicial cases are widely used to solve the problem of judicial research. Similarity analysis of judicial cases is the basis of wisdom judicature. In view of the necessity of getting rid of the ineffective information and extracting useful rules and conditions from the descriptive document, the analysis of Chinese judicial cases with a certain format is a big challenge. Hence, we propose a method that focuses on producing recommendations that are based on the content of judicial cases. Considering the particularity of Chinese language, we use “jieba” text segmentation to preprocess the cases. In view of the lack of labels of user interest and behavior, the proposed method considers the content information via adopting TF-IDF combined with LDA topic model, as opposed to the traditional methods such as CF (Collaborative Filtering Recommendations). Users are recommended to compute cosine similarity of cases in the same topic. In the experiments, we evaluate the performance of the proposed model on a given dataset of nearly 200,000 judicial cases. The experimental result reveals when the number of topics is around 80, the proposed method gets the best performance. | Zichen Guo Tieke He Zemin Qin Zicong Xie Jia Liu | 2019 | 国际计算机前沿大会会议论文集2019，，1： | 0 |
| 13 | Experimental studies on effects of surface morphologies on corona characteristics of conductors subjected to positive DC voltages显示文摘As the surface conditions play a significant role on corona discharge and its related effects of the conductors,the influence of fine particulate matter on positive-polarity,direct-current conductors was studied experimentally in this study.The surface morphologies of the conductor could be discovered from the experiments.The typical morphologies are the parallel chains of particles.To evaluate the surface condition quantitively,the surface roughness of the conductors is measured.It is found that the applied voltage and testing time have a great influence on the surface condition.After that,the corona characteristics of conductors are tested.It reveals that the total ground level electric field and ion flow density increases with the surface roughness growing. | Zhu Jie He Zichen Wu Jiale Bian Xingming | 2020 | High Voltage2020，5，4： | 0 |
| 14 | Development of UAV-based shot seeding device for rice planting显示文摘In order to realize the high-quality row seeding operation with unmanned aerial vehicle(UAV)in paddy field,a shot seeding device that can sow five rows of pelleted rice seeds at the same time was designed.The shot seeding device mainly consists of an external grooved wheel seed metering device and five shot seeding modules.The designed external grooved wheel seed metering device can take the seeds out of the seed box and divide the seeds into five parts.The shot seeding module can accelerate the pelleted rice seeds to reduce the impact of the UAV wind on the direction of seed movement.Furthermore,an angle adjustment mechanism for the shot seeding module was used to change the row spacing.The seed metering device test verified that when the speed of the seed metering wheel was 15 r/min,the coefficient of variation of the discharge rate of each row(C.V1)and total seed discharge rate stability(C.V2)were 1.70%and 1.04%,respectively.Image processing technique was used to test the UAV seeding performance.The distribution characteristics of seeds on the ground showed that the number of seeds in each row gradually increased from both sides to the middle in the width direction.According to the statistics,there were 60%-70%of the seeds in each row in the 100 mm width range.The field test showed that when the working height was 1.5 m and the seeding quantity was 38.56 kg/hm^(2),the performance of sowing in rows was obvious,the deviation rate of seeding quantity was 1.89%.After 16 d of sowing,the seeds’emergence rate was stable,and the average emergence rate was 82.63%and the yield was 6775.50 kg/hm^(2). | Wei Liu Shuaishuai Zou Xuelang Xu Qingyu Gu Weizhuo He Jun Huang Junhao Huang Zichen Lyu Jianqin Lin Zhiyan Zhou Rui Jiang Xiwen Luo | 2022 | International Journal of Agricultural and Biological Engineering2022，15，6： | 0 |
| 15 | Pulse-burst laser-based 10kHz Thomson scattering measurements显示文摘Thomson scattering (TS), as a popular and reliable diagnostic technique, has successfully measured electron temperatures and electron number densities of plasmas for many years. However, conventional TS techniques using Nd:YAG lasers operate only at tens of hertz. Here, we present the development of a high-repetition-rate TS instrument based on a high-speed, pulse-burst laser system to greatly increase the temporal resolution of measurements. Successful instrument prototype testing was carried out by collecting TS light from laboratory helium and argon plasmas at 10 kHz. Calibration of the instrument detection sensitivity using nitrogen/ oxygen rotational Raman scattering signal is also presented. Quantitative electron number densities and electron temperatures of the plasma were acquired at 10 kHz, for stable plasma discharges as, respectively,~0.9 eV and ~5.37×10^21 m^-3 for the argon plasma, and ~1 eV and ~6.5×10^21 m^-3 for the helium plasma. | Zichen HE Cary SMITH Zhili ZHANG Theodore M BIEWER Naibo JIANG Paul S HSU Sukesh ROY | 2019 | Plasma Science and Technology2019，21，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员