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| 1 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 2 | The Suitability of Using Leaf Area Index to Quantify Soil Loss under Vegetation Cover显示文摘Soil erosion by water under forest cover is a serious problem in southern China.A comparative study was carried out on the use of leaf area index(LAI) and vegetation fractional coverage(VFC) in quantifying soil loss under vegetation cover.Five types of vegetation with varied LAI and VFC under field conditions were exposed to two rainfall rates(40 mm h-1 and 54 mm h-1) using a portable rainfall simulator.Runoff rate,sediment concentration and soil loss rate were measured at relatively runoff stable state.Significant negative exponential relationship(p < 0.05,R2 = 0.83) and linear relationship(p < 0.05,R2 = 0.84) were obtained between LAI and sediment concentration,while no significant relationship existed between VFC and sediment concentration.The mechanism by which vegetation canopy prevents soil loss was by reducing rainfall kinetic energy and sediment concentration.LAI could better quantify such a role than VFC.However,neither LAI nor VFC could explain runoff rate or soil loss rate.Caution must be taken when using LAI to quantify the role of certain vegetation in soil and water conservation. | ZHANG Wentai YU Dongsheng SHI Xuezheng WANG Hongjie GU Zhujun ZHANG Xiangyan TAN Manzhi | 2011 | Journal of Mountain Science2011，8，4： | 7 |
| 3 | A Discrete State Event Driven Simulation based Losses Analysis for Multi-terminal Megawatt Power Electronic Transformer显示文摘At present,power electronic transformers(PETs)have been widely used in power systems.With the increase of PET capacity to the megawatt level.the problem of increased losses need to be taken seriously.As an important indicator of power electronic device designing,losses have always been the focus of attention.At present,the losses are generally measured through experiments,but it takes a lot of time and is difficult to quantitatively analyze the internal distribution of PET losses.To solve the above problems,this article first qualitatively analyzes the losses of power electronic devices and proposes a loss calculation method based on pure simulation.This method uses the Discrete State Event Driven(DSED)modeling method to solve the problem of slow simulation speed of large-capacity power electronic devices and uses a loss calculation method that considers the operating conditions of the device to improve the calculation accuracy.For the PET prototype in this article,a losses model of the PET is established.The comparison of experimental and simulation results verifies the feasibility of the losses model.Then the losses composition of PET was analyzed to provide reference opinions for actual operation.It can help pre-analyze the losses distribution of PET,thereby providing a potential method for improving system efficiency. | Jialin Zheng Zhengming Zhao Bochen Shi Zhujun Yu Jiahe Ju Zhiqiang Fan | 2020 | CES Transactions on Electrical Machines and Systems2020，4，4： | 5 |
| 4 | A Numerical Convex Lens for the State-Discretized Modeling and Simulation of Megawatt Power Electronics Systems as Generalized Hybrid Systems显示文摘Modeling and simulation have emerged as an indispensable approach to create numerical experiment platforms and study engineering systems.However,the increasingly complicated systems that engineers face today dramatically challenge state-of-the-art modeling and simulation approaches.Such complicated systems,which are composed of not only continuous states but also discrete events,and which contain complex dynamics across multiple timescales,are defined as generalized hybrid systems(GHSs)in this paper.As a representative GHS,megawatt power electronics(MPE)systems have been largely integrated into the modern power grid,but MPE simulation remains a bottleneck due to its unacceptable time cost and poor convergence.To address this challenge,this paper proposes the numerical convex lens approach to achieve state-discretized modeling and simulation of GHSs.This approach transforms conventional time-discretized passive simulations designed for pure-continuous systems into state-discretized selective simulations designed for GHSs.When this approach was applied to a largescale MPE-based renewable energy system,a 1000-fold increase in simulation speed was achieved,in comparison with existing software.Furthermore,the proposed approach uniquely enables the switching transient simulation of a largescale megawatt system with high accuracy,compared with experimental results,and with no convergence concerns.The numerical convex lens approach leads to the highly efficient simulation of intricate GHSs across multiple timescales,and thus significantly extends engineers’capability to study systems with numerical experiments. | Bochen Shi Zhengming Zhao Yicheng Zhu Zhujun Yu Jiahe Ju | 2021 | Engineering2021，7，12： | 3 |
| 5 | Silicon alleviates salt stress and increases antioxidant enzymes activity in leaves of salt-stressed cucumber ( Cucumis sativus L.)显示文摘 | Zhujun Zhu Guoqiang Wei Juan Li Qiongqiu Qian Jingquan Yu | 2004 | Plant Science2004，，3： | 1 |
| 6 | Complex dynamics in a Permanent Magnet Synchronous Motor Model 显示文摘 | JING Zhujun YU Chang CHEN Guanrong | 2004 | Chaos Solitons &Fractals2004，22，4： | 1 |
| 7 | Com- plex dynamics in a permanent-magnet synchronous mo- tor model显示文摘 | JING Zhujun YU Chang CHEN Guangrong | 2004 | Chaos Solotons and Fractals2004，22，1： | 1 |
| 8 | Analysis of genetic diversity in cytoplasmic male sterility, and association of mitochondrial genes with petaloid-type cytoplasmic male sterility in tuber mustard (Brassica juncea var. tumida Tsen et Lee)显示文摘 | Xiaolin Yu Haiyu Lu Gang Lu Zhujun Chen Jiashu Cao Yutaka Hirata | 2010 | Molecular Biology Reports2010，，2： | 1 |
| 9 | Complex Dynamics in a Permanent-magnet Synchronous Motor Model显示文摘 | Zhujun Jing Chang Yu Guanrong Chen | 2004 | Chaos Solitions and Fractals2004，，22： | 1 |
| 10 | Bifurcation and chaos in discrete FitzHugh-Nagumo system 显示文摘 | JING Zhujun CHANG Yu GUO Boling | 2004 | Chaos Solitons Fractals2004，21，3： | 1 |
| 11 | Bifurcations, chaos, and system collapse in a three node power system显示文摘 | Jing Zhujun Xu Dashun Chang Yu | 2003 | J of Electrical Power and Energy Systems2003，25，6： | 1 |
| 12 | Complex dynamics in a permanent-magnet synchronous motor model显示文摘 | YU Chang CHEN Guanrong | 2004 | Chaos Solitons and Fractals2004，22，： | 1 |
| 13 | Complex dynamics in a permanent-magnet synchronous motor model 显示文摘 | JING Zhujun YU Chang Chen Guanrong | 2004 | Chaos Solitons & Fractals2004，，22： | 1 |
| 14 | Bifurcations? chaos,and system collapvse in a three node power system 显示文摘 | JING Zhujun? XU IDashun CHANG Yu? | 2003 | Int J Elec Power Energ Syst2003，25，6： | 1 |
| 15 | Complex dynamics in a permanent-magnet synchronous motor model 显示文摘 | JING Zhujun YU Chang CHEN Guanrong | 2004 | Chaos Solitons & Fractals2004，22，4： | 1 |
| 16 | Bifurcations,chaos,and system collapse in a three node power system显示文摘 | JING Zhujun XU Dashun CHANG Yu | 2003 | ElectricalPower and Energy Systems2003，25，6： | 1 |
| 17 | Complex dynamics in a permanent-magnet synchronous motor model显示文摘 | Jing Zhujun Yu Chang Chen Guanrong | 2004 | Chaos Solitions and Fractals2004，22，4： | 1 |
| 18 | Bifurcations,chaos,and system collapse in a three node power system显示文摘 | Zhujun Jing Dashun Xu Yu Chang | | 0，，： | 1 |
| 19 | Complex dynamics in a permanent-magnet synchronous motor model显示文摘 | Jing Zhujun Yu Chang Chen Guanrong | 2004 | Chaos Solitons and Fractals2004，22，： | 1 |
| 20 | Small-molecule anti-COVID-19 drugs and a focus on China's homegrown mindeudesivir(WV116)显示文摘The coronavirus disease 2019(COVID-19)pandemic has stimulated tremendous efforts to develop therapeutic agents that target severe acute respiratory syndrome coronavirus 2 to control viral infection.So far,a few small-molecule antiviral drugs,including nirmatrelvir-ritonavir(Paxlovid),remdesivir,and molnupiravir have been marketed for the treatment of COVID-19.Nirmatrelvir-ritonavir has been recommended by the World Health Organization as an early treatment for outpatients with mild-to-moderate COVID-19.However,the existing treatment options have limitations,and effective treatment strategies that are cost-effective and convenient for tackling COVID-19 are still needed.To date,four domestically developed oral anti-COVID-19 drugs have been granted conditional market approval in China.These drugs include azvudine,simnotrelvir-ritonavir(Xiannuoxin),leritrelvir,and mindeudesivir(VV11).Preclinical and clinical studies have explored the efficacy and tolerability of mindeudesivir and supported its early use in mild-to-moderate COVID-19 cases at high risk for progression.In this review,we discuss the most recent findings regarding the pharmacological mechanism and therapeutic effects focusing on mindeudesivir and other small-molecule antiviral agents for COVID-19.These findings will expand our understanding and highlight the potential widespread application of China's homegrown anti-COVID-19 drugs. | Qiuyu Cao Yi Ding Yu Xu Mian Li Ruizhi Zheng Zhujun Cao Weiqing Wang Yufang Bi Guang Ning Yiping Xu Ren Zhao | 2023 | Frontiers of Medicine2023，17，6： | 0 |
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